Empoli Hysaj played for the
Empoli Primavera (under-19) side during the 2011–12 season, where he made 21 appearances and scored one goal. Hysaj received his first call-up to the Empoli senior squad during the 9th matchday of the
2011–12 Serie B season, for the game against
Varese on 9 October 2011, where he remained an unused substitute throughout the match. Later in the season, he was included in the matchday squad on two more occasions, in March and April 2012, but again did not feature on the field. He made his professional debut for the first team on 24 November 2011 in a
Coppa Italia match against
Fiorentina, playing the full 90 minutes in a 2–1 defeat.
2012–13 season Hysaj made his league debut on 20 October 2012 during matchday 10 against
Virtus Lanciano, which ended in a 0–3 away victory for Empoli, coming on as a substitute in the 67th minute. Empoli finished the 2012–13 season in 4th place, thus qualifying for the
promotion playoffs. In the semi-finals against
Novara, Hysaj played the full 90 minutes in both legs — first on 22 May 2013, a 1–1 away draw, and then on 26 May 2013, when Empoli secured a 4–1 home win. In the two-legged final against
Livorno, Hysaj once again played the entire match in both legs. The first leg on 29 May 2013 ended in a 1–1 draw, while the second leg on 2 June 2013 finished in a 1–0 defeat, meaning Livorno earned promotion to the
2013–14 Serie A with a 2–1 aggregate victory. Hysaj completed his first full season with Empoli making 35 appearances in all competitions — 30 in the league, one in the
Coppa Italia, and four in the promotion playoffs — and providing one assist.
2013–14 season On 19 September 2013, Hysaj renewed his contract with Empoli, extending it until 2015. He scored his first professional goal on 17 April 2014 in a match against
Virtus Lanciano. The goal came in the 4th minute after he received the ball near the edge of the penalty area, dribbled past three opponents in a zig-zag move, and fired a left-footed shot into the net. Despite his effort, Empoli lost the match 2–1, but the goal was noted by the media for its individual quality and technical execution. On 30 May 2014, Empoli secured promotion to
Serie A after a six-year absence, finishing the campaign among the top teams in
Serie B. By the end of the campaign, Hysaj had gathered a total of 34 appearances and 1 goal across league and cup competitions, establishing himself as a key part of Empoli’s defence ahead of their return to Serie A. On 31 October, Hysaj signed a new contract keeping him at the club until June 2017, with his annual salary increasing from €170,000 to €200,000. During the season, Hysaj further developed his technical and tactical abilities, becoming known for his versatility to play on both flanks and his increasing involvement in attacking phases through overlapping runs and accurate ball distribution from the back. In February 2015, he provided two consecutive assists in Serie A matches — the first in a 2–0 home victory over
Cesena, and the second a decisive pass in a 1–1 draw against
Milan. Following consistent performances throughout the campaign, he was selected in the Serie A Team of the Week for matchday 17 after a goalless draw against
Verona. In the 2014–15 campaign, his final season with Empoli, Hysaj made a total of 36 league appearances, including 33 as a starter,
Napoli In July 2015, Hysaj transferred to
Napoli, joining his former Empoli coach Maurizio Sarri and teammate
Mirko Valdifiori. On 3 August 2015, he completed the move and signed a five-year contract for a reported fee of €5 million. The transfer made Hysaj the second most expensive Albanian international player at the time, behind
Lorik Cana’s €6.75 million move from
Galatasaray to
Lazio in July 2011.
2015–16 season Hysaj made his competitive debut for Napoli on 23 August 2015 in the opening Serie A match against
Sassuolo, which ended in a 2–1 away defeat. He soon established himself as a regular starter, playing the full 90 minutes in most matches and often preferred to the more experienced
Christian Maggio. On 17 September 2015, he made his European debut in the
UEFA Europa League group stage, in a 5–0 home victory over
Club Brugge. Napoli went on to win all six group matches, finishing first in Group D and advancing to the Round of 32. On 8 February 2016, sports journalist
Gianluca Di Marzio included Hysaj in his “Best Serie A Under-23 XI”, praising his consistency and tactical discipline among young talents such as
Paul Pogba,
Paulo Dybala,
Mauro Icardi, and
M'Baye Niang. The same year, Calciomercato.it named him the best right-back in Serie A for the season. By the end of the season Hysaj, as one of Napoli’s most consistent performers, had featured in 37 of 38 Serie A matches, all as a starter, missing only one game due to suspension after accumulating four yellow cards.
2016–17 season On 13 September 2016, Hysaj made his
UEFA Champions League debut in a 2–1 away win against
Dynamo Kyiv. Napoli topped their group but were eliminated in the Round of 16 by
Real Madrid, losing both legs 3–1. Hysaj played seven of Napoli’s eight matches in the competition, completing the full 90 minutes each time. By season’s end, his market value was estimated at €18 million, making him the most valuable player of the
Albania national team. Napoli finished the Serie A campaign in third place behind Juventus and
Roma. Under Sarri’s 4-3-3 system, Hysaj was increasingly deployed as a modern full-back capable of both defending solidly and contributing to the attack, reflecting his tactical versatility within Napoli’s setup. On 21 October, he made his 100th appearance in all competitions for Napoli in the goalless home draw against
Internazionale. In European competition, he played ten matches across the
UEFA Champions League group stage and the
qualifying play-off rounds. After finishing third in their group, Napoli entered the
UEFA Europa League knockout phase, where they were eliminated by
RB Leipzig on the away goals rule. However, his agent valued him at €60 million. Around that time, Hysaj was regarded as one of the best right-backs in the world. With the arrival of manager
Carlo Ancelotti, Hysaj retained his place as a first-team regular, though he featured less frequently than in previous seasons as Ancelotti often rotated the right-back position with
Nikola Maksimović and
Kévin Malcuit.
2019–20 season In the 2019–20 season campaign, he lost his regular right-back starting position to
Giovanni Di Lorenzo, but following the arrival of manager
Gennaro Gattuso he was still deployed 17 times as a starter in Serie A, including several appearances as a left-back ahead of
Mário Rui. Hysaj scored his first goal for Napoli on 25 July 2020, in a league match against
Sassuolo. He featured once in the domestic cup and appeared in seven European matches (Champions League and Europa League), with Napoli reaching the quarter-finals of the Europa League. He rejoined team training in early December after testing negative alongside his teammates. During his absence, Napoli were eliminated from the
Europa League in the intermediate stage. In the domestic cup, he featured in Napoli’s run to the semi-finals of the
Coppa Italia, where they were eliminated by
Atalanta. During the season, discussions also emerged regarding Hysaj’s contract situation, as he entered the final year of his deal with Napoli. Reports in December 2020 suggested that while the club still considered him an important squad member, renewal talks had stalled, raising the possibility of a departure at the end of the campaign. At the conclusion of the 2020–21 season, Hysaj left Napoli upon the expiration of his contract after six years at the club. His agent confirmed that repeated attempts to reach a renewal agreement had failed, making his departure inevitable. Hysaj himself stated that he was ready for a new challenge and that his cycle at Napoli had come to an end.
Lazio On 1 July 2021, Hysaj joined
Lazio on a free transfer, signing a four-year contract and reuniting with his former Napoli coach Maurizio Sarri, who himself insisted for him, confirming his intent to deploy Hysaj as a full-back in his 4-3-3 system. During his introduction to the squad, he performed the partisan song
Bella ciao as part of his initiation, which provoked criticism from a section of Lazio ultras due to its political associations. The club publicly condemned the offensive reactions and expressed full support for the player.
2021–22 season Hysaj made his debut in the opening match of the
2021–22 Serie A season on 21 August 2021 against his former side Empoli, with Lazio winning 3–1 away. He scored his first goal for Lazio in the following week against
Spezia, contributing to a 6–1 home victory. Hysaj quickly established himself as a regular starter, completing nearly all of his appearances, with occasional rotation among full-backs due to a congested calendar and Lazio's participation in the
UEFA Europa League that season. During February 2022, he lost his regular starting position as coach Sarri rotated his full-backs, and after week 30 he played less than 30 minutes in all matches, reflecting the reduced role. Lazio finished the season as Serie A runners-up, achieving their highest league placement since the 1999–2000 title-winning campaign and their first top-two finish since 1998–99. In the
Champions League, Hysaj made five appearances as a starter, helping Lazio progress from the group stage. The team was later eliminated in the round of 16 by
Bayern Munich. Hysaj played 60 minutes in the first leg, a 1–0 home victory for Lazio, but did not feature in the second leg, which ended in a 3–0 defeat. As of mid-season, he made only a few appearances, being omitted from both the Serie A and Europa League squads for extended periods. According to club statistics, Hysaj recorded 11 appearances in Serie A, three cup appearances and two European games, amounting to 583 minutes in all competitions. == International career ==