Madame Zodiac is first introduced as a "crime broker" for
Poison Ivy and
Catwoman. Zodiac promises both the criminals that they will come into conflict with the
Earth-Two Huntress (Helena Wayne),
Batwoman (Kathy Kane), and
Batgirl (
Barbara Gordon), while in the commission of their crimes, but they would succeed. At the end of the story Poison Ivy and Catwoman are defeated but Zodiac evades capture after stealing a powerful mystical artifact. In ''
World's Finest Comics'',
Batman begins to experience strange blackouts, and
Superman experiences a prophetic dream in which he witnesses Batman lying on an altar beneath the Zodiac Idol of Doctor Zodiac. Superman briefs Batman on his vision, but when he uses his X-ray vision to check on Doctor Zodiac, he realizes that the criminal is still in prison. Madame Zodiac reveals to Doctor Zodiac that she has begun testing Batman, and that she believes that Bruce Wayne is Batman. Superman and Batman consult with
Zatanna and give her several of Doctor Zodiac's mystical Zodiac Coins, hoping that she can use them to track down the Zodiac Idol. Zatanna loses control the moment she touches the coins, and mentions a "dark cloud" before eventually lapsing into a coma.
Wonder Woman takes Zatanna to
Paradise Island for medical treatment, and Madame Zodiac reveals that she freed Doctor Zodiac from prison and left an illusion in his place. She freed him because she had his Zodiac Idol, but wanted access to the Zodiac Coins that provide its power. She uses Doctor Zodiac's mystical connection to the twelve
Atlantean coins to steal them from the coin collectors who currently own them. Now possessing all twelve coins, she is able to activate the Zodiac Idol. It is also revealed that Theo (Doctor Zodiac) and Marissa (Madame Zodiac) are romantically involved. Theo discovers that she has used the Zodiac Idol to contact an ancient other-dimensional evil she refers to as her "master". Meanwhile, a dark cloud begins appearing in various cities, including
Metropolis and
Gotham City. Everywhere the cloud appears, it inspires
hate crimes, including the defilement of a Jewish
synagogue and the near-
lynching of
Lucius Fox. The being whom Madame Zodiac refers to as the "Adored One" possesses Batman's body, with magical duplicates of Batman being created for when the Adored One burns out his body. The possessed Batman briefly spars with Superman before being freed from the Adored One's control. Madame Zodiac is subdued by Superman, and Doctor Zodiac tells him about the mysterious prisoner. Superman shatters the walls of the cell, revealing the real Madame Zodiac chained to a wall. The Madame Zodiac who Doctor Zodiac had fallen in love with was a magical clone created by the Adored One. Madame Zodiac, Doctor Zodiac, and Superman confront the duplicate and the Adored One. Madame Zodiac is apparently killed by her evil duplicate, and both her duplicate and Doctor Zodiac are killed by the Adored One. Batman uses the Zodiac Idol to destroy the Adored One's containment sphere, dispersing it. A woman claiming to be the original Madame Zodiac reappears in
Trinity #12 (August 2008). The story has the
Riddler (Edward Nigma) consulting with Madame Zodiac in order to uncover the secret behind a pattern of mysterious thefts; while there, an antique gargoyle from Castle Branek (home of
Morgaine le Fey) comes to life and attempts to kill him. Madame Zodiac destroys the statue and adds its cost to her fee. ==Julie Madison==