MarketHaplogroup H (mtDNA)
Company Profile

Haplogroup H (mtDNA)

Haplogroup H is a human mitochondrial DNA (mtDNA) haplogroup. The clade was believed to have originated in West Asia, near present-day Syria, around 20,000 to 25,000 years ago. However, a specimen has been found in South Italy from 28,000 years ago, in Paglicci Cave. Mitochondrial haplogroup H is today predominantly found in Europe, and is believed to have evolved before the Last Glacial Maximum (LGM). It first expanded in the northern Near East and Southern Caucasus, and later migrations from Iberia suggest that the clade reached Europe before the Last Glacial Maximum. The haplogroup has also spread from West Asia to parts of Africa, Siberia and Inner Asia. Today, around 40% of all maternal lineages in Europe belong to haplogroup H.

Origin
Haplogroup H is a descendant of haplogroup HV. The Cambridge Reference Sequence (CRS), which until recently was the human mitochondrial sequence to which all others were compared, belongs to haplogroup H2a2a1. Several independent studies conclude that haplogroup H probably evolved in Western Asia c. 25,000 years ago. In July 2008 ancient mtDNA from an individual called Paglicci 23, whose remains were dated to 28,000 years ago and excavated from Paglicci Cave (Apulia, Italy), were found to be identical to the Cambridge Reference Sequence in HVR1. This once was believed to indicate haplogroup H, but researchers now recognize that CRS HVR1 also appears in U or HV, because there are no HVR1 mutations that separate CRS from the haplogroup R founder. Haplogroup HV derives from the haplogroup R0, which in turn derives from haplogroup R, which is a descendant of macro-haplogroup N, which like its sibling M is a descendant of haplogroup L3. MtDNA H had frequency of 19% among Neolithic Early European Farmers and virtually absent among Mesolithic European hunter gatherers. MtDNA H was also present in the Cucuteni–Trypillia culture. The clade has been observed among ancient Egyptian mummies excavated at the Abusir el-Meleq archaeological site in Middle Egypt, which date from the pre-Ptolemaic/late New Kingdom and Ptolemaic periods. Additionally, haplogroup H has been found among specimens at the mainland cemetery in Kulubnarti, Sudan, which date from the Early Christian period (AD 550–800). ==Distribution==
Distribution
Haplogroup H is the most common mtDNA clade in Europe. It is found in approximately 41% of native Europeans. The lineage is also common in North Africa and the Middle East. The majority of the European populations have an overall haplogroup H frequency of 40–50%, with frequencies decreasing in the southeast. The clade reaches 20% in the Near East and Caucasus, 17% in Iran, and <10% in the Arabian Peninsula, Northern India and Central Asia. Undifferentiated haplogroup H has been found among Palestinians (14%), Syrians (13.6%), 14.7% in Gurna), Saudis (5.3–10%), Nubians (1.3%), and Yemenis (0–13.9%). ==Subclades==
Subclades
Among all these clades, the subhaplogroups H1 and H3 have been subject to a more detailed study and would be associated to the Magdalenian expansion from SW Europe c. 13,000 years ago: H1 H1 encompasses an important fraction of Western European mtDNA lineages, reaching its local peak among contemporary Basques (27.8%). The clade also occurs at high frequencies elsewhere in the Iberian Peninsula, as well as in the Maghreb (Tamazgha). The haplogroup frequency is above 10% in many other parts of Europe (France, Sardinia, parts of the British Isles, Alps, large portions of Eastern Europe), and surpasses 5% in nearly all of the continent. , the highest frequency of the H1 subclade has been found among the Tuareg inhabiting the Fezzan region in Libya (61%). The basal H1* haplogroup is found among the Tuareg inhabiting the Gossi area in Mali (4.76%). The rare H1cb subclade is concentrated among Fulani groups inhabiting the Sahel. Haplogroup H has been found in various fossils that were analysed for ancient DNA, including specimens associated with the Linearbandkeramik culture (H1e, Halberstadt-Sonntagsfeld, 1/22 or ~5%; H1 or H1au1b, Karsdorf, 1/2 or 50%), Germany Middle Neolithic (H1e1a, Esperstedt, 1/1 or 100%), Iberia Early Neolithic (H1, El Prado de Pancorbo, 1/2 or 50%), Iberia Middle Neolithic (H1, La Mina, 1/4 or 25%), and Iberia Chalcolithic (H1t, El Mirador Cave, 1/12 or ~8%). Haplogroup H has been observed in ancient Guanche fossils excavated in Gran Canaria and Tenerife on the Canary Islands, which have been radiocarbon-dated to between the 7th and 11th centuries CE. At the Tenerife site, these clade-bearing individuals were found to belong to the H1cf subclade (1/7; ~14%); at the Gran Canaria site, the specimens carried the H2a subhaplogroup (1/4; 25%). Additionally, ancient Guanche (Bimbaches) individuals excavated in Punta Azul, El Hierro, Canary Islands were all found to belong to the H1 maternal subclade. These locally born individuals were dated to the 10th century and carried the H1-16260 haplotype, which is exclusive to the Canary Islands and Algeria. ; Frequencies of haplogroup H1 in the world (Ottoni et al. 2010) H3 H3 is found throughout the whole of Europe and in the Maghreb, Studies have suggested haplogroup H3 is highly protective against AIDS progression. Example of H3 sub-groups are: H2, H6 and H8 The H2, H6 and H8 haplogroups are somewhat common in Eastern Europe and the Caucasus. and in Norway, Ireland and Slovakia. H6a1a1a is common among Ashkenazi Jews. H4 H4 is often found in the Iberian Peninsula, H7 The H7 subhaplogroup is present in both Europe and West Asia. Its subclade H7c1 is present in Druze people and in Saudi Arabia. H7c2 is present in such peoples as Ashkenazi Jews, Sardinians, and Dutch people. H7a1b is found today in Scotland, England, Denmark, Finland and Sardinia. H7b1 is found in Lithuanians. H9 H9 is present in Yemenis. The subclade H9a exists in Welsh people, Calabrians and Crimean Karaites. H9a samples were recovered from two ancient people in Lebanon. H10 Haplogroup H10 is subclade which came into existence between 6,300 and 10,900 years ago. Its descendant branches are H10a, H10b, H10c, H10d, H10e, H10f, H10g, and H10h. Haplogroup H10e has been found at a Neolithic site, namely the Bom Santo cave near Lisbon. This is the oldest sample of H10 which has ever been found and it has been dated to 3735 BCE (±45 years). H11 H11 is commonly found in Central Europe. and Calabria. H13 The H13 subhaplogroup is present in both Europe and West Asia. H13 is also found in the Caucasus; H13c was found in a 9,700 year old sample in Mesolithic Georgia and H13a2a and H13a2b are found in Armenians in Armenia. H13a1a2a and H13a1d are present among Lithuanians. Sardinians from Italy, and Persian Jews and Iraqi Jews. The branch H14a2 is present among Romani people from Spain and Croats and is common in Iran. Persians and Armenians from Iran, and people in Tuscany (central Italy), Switzerland, Germany, Ireland, Spain, and Qatar. and people from Armenia, Turkey, Saudi Arabia, Italy, and Scotland. H15b is present in Armenians, Druze, Ashkenazi Jews, Danes, and other peoples of Europe and the Near East. H16 H16 is encountered in numerous European populations, such as Norway and England. and in Germany, Scotland, and the Netherlands. H16b is another common branch and among other places is present in Sardinia. H16c was found in archaeological human remains from Iron Age cemetery in Lejasbitēni, Latvia; it is currently found in Sweden, Great Britain, Lithuania, Poland, Germany, Latvia and elsewhere. and Lithuania. H20 and H21 These haplogroups are both found in the Caucasus region. as well as in Germany, Ireland, Scotland, and England. Its subclade H45a is especially found in Finland but also found in Sweden. Scotland, England, and Germany. Its subclade H47a is exclusively European, being found in such countries as England, Ireland, Czechia, and Bulgaria. and Poland and as far east as Xinjiang in western China (among Uyghurs). H69 is a European branch found in Finns, Irish people, and inhabitants of Sweden, Germany, and Switzerland. H96 and above These were the most recently discovered and named major branches of H. H105 is found in Italy and Hungary. H176 is a human mitochondrial DNA haplogroup and a subclade of haplogroup H. H176 is estimated to have formed around c. 7900 BCE. Based on the earliest known maternal origins currently reported for sampled descendants, a likely point of origin is in or near Anatolia (modern-day Turkey) or the eastern Mediterranean; however, the small number of documented complete mitochondrial genomes in some downstream branches makes this inference provisional. Today, H176 appears to be rare in publicly accessible genealogical datasets. In one documented descendant branch, the earliest known maternal origins reported by testers include Turkey, while some origins are not specified, and downstream coalescence dates extend into the Common Era. Later population movements during the Bronze Age, including steppe-derived migrations often discussed in connection with Indo-European migrations, reshaped West Eurasian genetic variation and may have contributed to the dispersal of rare maternal lineages where they were present. ==Tree==
Tree
This phylogenetic tree of haplogroup H subclades is based on Build 17 (February 2016) of the Phylotree, an internationally accepted standard. The full tree can be viewed at Phylotree. ==Genetic traits==
Genetic traits
Haplogroup H was found as a possible increased risk factor for ischemic cardiomyopathy development. ==Popular culture==
Popular culture
• In his popular book The Seven Daughters of Eve, Bryan Sykes named the originator of this mtDNA haplogroup Helena. Stephen Oppenheimer uses the very similar name Helina in his book The Origins of the British. • Palaeoanthropologist Meave Leakey is a carrier of haplogroup H. • Professional genealogist Megan Smolenyak carries haplogroup H. • Commentator David Brooks has a mtDNA haplogroup within H. • Actress Kyra Sedgwick belongs to haplogroup H1. • Dr. Mehmet Oz is a member of haplogroup H2a1. • Actor Kevin Bacon belongs to haplogroup H6. • Author and journalist A.J. Jacobs belongs to haplogroup H7. • Actress Mila Kunis belongs to haplogroup H7. • Politician Bernie Sanders carries haplogroup H11a. == See also ==
tickerdossier.comtickerdossier.substack.com