in Downtown NewarkRoute 21 heads north from the
Newark Airport Interchange with
US 1/9 in
Newark near
Newark Airport on a six-lane
freeway known as McCarter Highway. This portion of Route 21 serves to connect Newark Liberty with
downtown Newark. The route interchanges with
I-78 and
US 22 and then crosses over
Conrail Shared Assets Operations' Greenville Running Track,
Lehigh Line, and
Passaic and Harsimus Line and then
Amtrak's
Northeast Corridor rail line on a viaduct, coming to an interchange with Broad Street that provides access to Frelinghuysen Avenue (
Route 27). The route continues north, paralleling the elevated Northeast Corridor tracks that lead up to
Newark Penn Station, which serves Amtrak and
NJ Transit trains and
PATH's
Newark–World Trade Center line. At the intersection with Emmet Street, Route 21 becomes a four-lane surface road and intersects with Murray Street, which provides access to the
Ironbound neighborhood of Newark. This section of Route 21 through the southern part of Newark has a high accident rate due to the heavy concentration of businesses and traffic lights along this portion of road. The road widens to six lanes and the route intersects with Market Street (
CR 510) near Newark Penn Station and continues north into
Downtown Newark, splitting from the Northeast Corridor rail line. It crosses the intersection with
Raymond Boulevard and the route meets the intersection with Center Street (
CR 508), which it forms a
concurrency. Route 21 and CR 508 head along the west bank of the
Passaic River, passing by the
New Jersey Performing Arts Center. CR 508 splits from Route 21 by heading east on Bridge Street, crossing the Passaic River, and Route 21 continues north, passing by the former site of
Bears & Eagles Riverfront Stadium. After passing under NJ Transit's
Montclair-Boonton Line/
Morris & Essex Lines and interchanging with
I-280, the route intersects with Clay Street (
CR 506 Spur). Past the intersection with 3rd Avenue, Route 21 becomes a six-lane
freeway again. After about a quarter mile, the northbound side swings under the southbound side and the freeway becomes double-decker, passes by Mt. Pleasant Cemetery, and returns to single-decker configuration. It then interchanges with Chester Avenue and Riverside Avenue with a southbound exit and northbound entrance before passing over
Norfolk Southern Railway's Newark Industrial Track line. Route 21 comes to a northbound exit and southbound entrance for Grafton Avenue and Mill Street; this interchange actually connects with the original McCarter Highway, a street that retains this name and acts as a service road to Route 21 for a few blocks in this area, near several industries. Route 21 briefly becomes a double-decker freeway again past the latter interchange and passes under Norfolk Southern Railway's
Boonton Line, before crossing into
Belleville at the
Second River crossing. The freeway features a southbound exit for Mill Street and a northbound exit for Rutgers Street/Belleville Turnpike (
Route 7 and
CR 506) as it passes by houses on the left side of the freeway. Route 21 features an interchange with Main Street that has a southbound exit and an entrance in both directions. It enters
Nutley where the freeway interchanges with County Route 646 (Park Avenue), continuing north through residential areas along the Passaic River. As Route 21 crosses into
Clifton,
Passaic County, it passes under NJ Transit's
Main Line and comes to an interchange with
Route 3. North of this point, the freeway comes to a northbound exit and southbound entrance for southbound River Road (
CR 624), passing through residential neighborhoods, and enters
Passaic. In Passaic, Route 21 interchanges with Brook Avenue (
CR 608), Van Houten Avenue (
CR 614), and River Drive (CR 624). The route features an interchange with River Drive (CR 624) and Main Avenue (
CR 601) and meets State Street at a partial interchange with a northbound exit and southbound entrance. This interchange provides access to the
Union Avenue Bridge over the Passaic. Route 21 heads farther to the west of the Passaic River, passing through industrial and residential areas of Passaic. The freeway briefly enters
Wallington and comes to an interchange that provides access to Market Street (
CR 619), Dayton Avenue, and Monroe Street. Route 21 continues to the north and resumes along the west bank of the Passaic River, narrowing to four lanes and crossing back into Clifton. Upon entering Clifton, the route comes to an interchange with Ackerman Avenue. The freeway heads to the northwest, passing by a park and featuring a southbound exit and northbound entrance for Lexington Avenue before ending at an interchange with
US 46. ==History==