AEK Athens At the age of 17, Zisis moved to
Athens and to the
Greek League team
AEK, where he began his
professional basketball career. With AEK, he won the
Greek Cup in 2001 and also the
Greek League championship in 2002. He also won the
Greek League Best Young Player award in 2002.
Benetton Treviso After playing with the Greek club
AEK Athens, Zisis moved to
Treviso,
Italy, and played on the
Italian League team
Benetton Treviso. With Treviso, he won the
Italian Super Cup and the
Italian League championship in the year 2006, and also the
Italian Cup in the year 2007. He then left Italy and moved to
Moscow,
Russia.
CSKA Moscow On June 13, 2007, Zisis signed a 3-year contract worth
€5 million euros
net income with the Russian team
CSKA Moscow. With CSKA, Zisis won the
EuroLeague championship at the
2008 EuroLeague Final Four. He also played in the
2009 EuroLeague Final with CSKA. While he was a member of CSKA, he also won two
Russian League championships (2008, 2009).
Montepaschi Siena In 2009, Zisis left
CSKA Moscow, and signed a 2-year contract worth
€1.6 million euros
net income with the Italian League club
Montepaschi Siena. In 2010, he signed a 2-year extension with Montepaschi. With Siena, he won three
Italian League championships (2010, 2011, 2012), three
Italian Cups winner (2010, 2011, 2012), and three
Italian Cup Supercups (2010, 2011, 2012).
Bilbao Basket In 2012, Zisis signed a 2-year contract, with the second year being an optional year, with the
Spanish League club
Bilbao.
UNICS Kazan After spending a season with the Spanish club
Bilbao Basket, Zisis moved to the Russian
VTB United League club
UNICS Kazan, in July 2013. With UNICS, he played in the
2014 Eurocup Finals. With UNICS, he also won the
2014 edition of the
Russian Cup.
Fenerbahçe On December 29, 2014, the
Turkish Super League club
Fenerbahçe Ülker acquired Zisis. With Zisis playing an average of 23.5 minutes per game with Fenerbahçe in the
2014–15 EuroLeague season, the team advanced to the
2015 EuroLeague Final Four. It was the first time in the team's history that they made it to the
EuroLeague Final Four. However, on May 15, 2015, they lost in the EuroLeague semifinals to the Spanish club
Real Madrid, by a score of 96–87.
Brose Bamberg On July 16, 2015, Zisis signed a two-year contract with the German
Basketball Bundesliga (BBL) club
Brose Bamberg. In 2017, he extended his contract with Brose, through the year 2019. With Bamberg, he won two
German BBL League championships (
2016,
2017), two
German Cups (
2017,
2019), and the
German Supercup (
2015). In the
2019 German Cup Final, Zisis hit the game-winner, with 2.4 seconds left in the game, to give Bamberg an 83–82 win over
Alba Berlin. On September 7, 2019, Bamberg
retired Zisis' number 6 jersey.
Joventut Badalona On July 15, 2019, Zisis signed a two-year deal with the Spanish
Liga ACB club
Joventut Badalona.
Return to AEK Athens In January 2020, Zisis left the Spanish club
Joventut Badalona, and signed with his former club
AEK Athens, of the
FIBA Champions League. With AEK, Zisis won the
2020 edition of the
Greek Cup, in which he was also named the
Greek Cup MVP. Zisis announced his retirement from playing professional club basketball in June 2021. ==National team career==