The new alliance launched a two-pronged offensive against the Ottomans: a Venetian army, under the
Captain General of the Sea Alvise Loredan, landed in the Morea, while Matthias Corvinus invaded Bosnia. They then proceeded to besiege the fortress of the
Acrocorinth, which controlled the northwestern Peloponnese. The Venetians engaged in repeated clashes with the defenders and with Ömer Bey's forces, until they suffered a major defeat on 20 October 1463, which resulted in the wounding and subsequent death of the Marquis (son of
Taddeo d'Este). The Venetians were then forced to lift the siege and retreat to the Hexamilion and to Nauplia (
Nafplion). Ottoman reaction was swift and decisive: Sultan
Mehmed II dispatched his
Grand Vizier,
Mahmud Pasha Angelović, with an army against the Venetians. To confront the
Venetian navy, which had taken station outside the entrance of the
Dardanelles Straits, the Sultan further ordered the creation of the new shipyard of Kadirga Limani in the
Golden Horn (named after the "kadirga" type of
galley), and of two forts to guard the Straits,
Kilidulbahr and
Sultaniye. The Morean campaign was a swift victory for the Ottomans: although messages received from Ömer Bey had warned of the strength and firepower of the Venetian position at the Hexamilion, Mahmud Pasha decided to march on, hoping to catch them unawares. The Ottoman army razed the Hexamilion, and advanced into the Morea. Argos fell, and several forts and localities that had recognized Venetian authority reverted to their Ottoman allegiance.
Zagan Pasha was re-appointed governor of the Morea, while Ömer Bey was given Mahmud Pasha's army and tasked with taking the Republic's holdings in the southern Peloponnese, centered around the two forts of Coron and Modon (
Methoni). '' Sigismondo Malatesta, Lord of Rimini. His tenure in command of the land forces in the Morea (July 1464 to January 1466) failed to reverse the Republic's fortunes. In the meantime, for the upcoming campaign of 1464, the Republic had appointed
Sigismondo Malatesta, the ruler of
Rimini and one of the ablest Italian generals, as land commander in the Morea. The forces available to him along with mercenaries and
stratioti, however, were limited, and in his tenure in the Morea he was unable to achieve much. Upon his arrival in the Morea in mid-summer, he launched attacks against Ottoman forts, and engaged in a siege of
Mistra in August–October. He failed to take the castle, however, and had to abandon the siege at the approach of a relief force under Ömer Bey. Small-scale warfare continued on both sides, with raids and counter-raids, but a shortage of manpower and money meant that the Venetians remained largely confined to their fortified bases, while Ömer Bey's army roamed the countryside. The mercenaries and stratioti in Venice's employ were becoming disgruntled at the lack of pay, while increasingly, the Morea was becoming desolate, as villages were abandoned and fields left untended. The bad supply situation in the Morea forced Ömer Bey to withdraw to Athens in fall 1465. Malatesta himself, disenchanted by the conditions he encountered in the Morea and increasingly anxious to return to Italy and attend to his
family's affairs and the ongoing feud with the Papacy, remained largely inactive throughout 1465, in spite of the relative weakness of the Ottoman garrisons following the withdrawal of Ömer Bey from the peninsula. In the Aegean, the new Venetian admiral,
Orsato Giustinian, tried to take
Lesbos in the spring of 1464, and besieged the capital
Mytilene for six weeks, until the arrival of an Ottoman fleet under Mahmud Pasha on 18 May 1464 forced him to withdraw. Another attempt to capture the island shortly after also failed, and Giustinian died at Modon on 11 July. His successor,
Jacopo Loredan, spent the remainder of the year in ultimately fruitless demonstrations of force before the Dardanelles. Soon after, the Venetians were embroiled in a conflict with the
Knights Hospitaller of
Rhodes, who had attacked a Venetian convoy carrying Moorish merchants from the
Mamluk Sultanate. This event enraged the Mamluks, who imprisoned all Venetian subjects living in the
Levant, and threatened to enter the war on the Ottoman side. The Venetian fleet, under Loredan, sailed to Rhodes under orders to release the Moors, even by force. In the event, a potentially catastrophic war between the two major Christian powers of the Aegean was avoided, and the merchants were released to Venetian custody. In 1470, Sultan
Mehmed II campaigned against Negroponte (Chalcis) on the island of
Euboea. After a
protracted and bloody siege (10 July – 5 August 1470), the well-fortified city was taken by the Ottoman troops. The whole island came under Ottoman control. == War in Albania, 1466–1467 ==