Guilfoyle appeared in
Three Men and a Baby, and in an early episode of
Crime Story, where he played a criminal who takes a hostage, getting into a shootout with the Major Crimes Unit. He has since become one of the industry's leading character actors specializing in roles on both the good and bad side of law enforcement. His television appearances most notably include guest roles on
Miami Vice,
Law & Order,
Wiseguy,
New York Undercover,
Ally McBeal and
Justice League Unlimited as Travis Morgan, the
Warlord. His film credits are numerous, spanning nearly three decades. His appearances in notable films include
Howard the Duck,
Wall Street,
Celtic Pride,
Beverly Hills Cop II,
Quiz Show,
Final Analysis,
Hoffa,
Mrs. Doubtfire,
Air Force One,
Striptease,
Amistad,
The Negotiator,
Extreme Measures,
Session 9,
Primary Colors, and
L.A. Confidential. Guilfoyle also appears in
Alter Bridge's video for their single "
Broken Wings", and the HBO original film
Live from Baghdad. Guilfoyle is best known for his role as
L.V.P.D. Captain James "Jim" Brass in the
CBS police drama
CSI: Crime Scene Investigation, which he performed from the show's inception in 2000. In 2014, it was announced that Guilfoyle would be leaving
CSI: Crime Scene Investigation after 14 years, but returned in 2015 for the two-hour series finale "
Immortality". In 2020, he guest-starred on
Star Trek: Discovery in the two-part story "
Terra Firma", as Carl, the humanoid avatar of the
Guardian of Forever. ==Personal life==