Main • Pepper Ann Pearson (voiced by
Kathleen Wilhoite) is the titular
protagonist of the series, who is a bespectacled, quirky 12-year-old girl whose emotions come out in fantasies. Her conscience, Alter-Ego, often drives her insecurities through misguided advice. She is of Jewish faith from her mother's side (as stated in "A Kosher Christmas"). • Nicky Anais Little (voiced by
Clea Lewis) is Pepper Ann's female best friend, a very intelligent and sensible, yet soft-spoken
overachiever, who often serves as a confidant for Pepper Ann. She can be prone to sudden outbursts and struggles to keep her composure when she feels she is overlooked. Being health conscious, Nicky keeps to a
pescetarian diet, to which she occasionally breaks. She often struggles with her perfectionism. • Milo Kamalani (voiced by
Danny Cooksey) is Pepper Ann's male best friend, a laid-back and mellow artist who prides himself in his artistic "talent". Milo is driven by passion, which can sometimes ostracize him from his peers. In early seasons, he is often her partner in crime with her schemes. • Lydia Pearson (voiced by
April Winchell) is the mother of Pepper Ann and Moose and the ex-wife of Chuck. She is a salesclerk working with the fashion store "It's You!" at Hazelnut Mall. • Margaret Rose "Moose" Pearson (voiced by
Pamela Adlon) is Pepper Ann's stoic younger 7-year-old sister with an
androgynous appearance, whose favorite pastime is skateboarding. • Craig Bean (voiced by
Jeff Bennett) is a "cool" 8th grader whom the 7th graders admire. He serves as Pepper Ann's main love interest, as they both have hidden crushes on each other.
Recurring • Dieter Liederhosen (voiced by Jeff Bennett) is a German student in Pepper Ann's class with an articulate appreciation for food. • Trinket St. Blair (voiced by
Jenna von Oÿ) is a spoiled, rich, popular girl who often serves as a foil to Pepper Ann. • Cissy Rooney (voiced by
Kath Soucie) is an air-headed popular girl who is Trinket's best friend. • Tessa and Vanessa James (both voiced by
Cree Summer) are two gossipy black twin sisters who finish each other's sentences. • Janie Lilly Diggity (voiced by
Susan Tolsky) is the aunt of Pepper Ann and Moose and Lydia's sister. A former member of the Peace Corps, she spends her time as an activist. • Jo Jo Diggity (voiced by
Tino Insana) is Pepper Ann and Moose's uncle and Janie's husband, who works as a cop. • Nedward "Ned" Diggity (voiced by Jeff Bennett) is the socially inept son of Janie and Jo Jo, and Pepper Ann's cousin, who has an affinity for cheese. • Lillian Lilly (voiced by April Winchell) is the mother of Lydia and Janie, and Pepper Ann's grandmother. In her youth, she used to be a performer and actress. • Leo Lilly (voiced by Jeff Bennett) is Lillian's husband and Pepper Ann's grandfather. • Peter "Pink-Eye Pete" Ogilvy (voiced by Jeff Bennett) is a nerdy kid who suffers from
pink eye. • Alice Kane (voiced by
Lauren Tom) is Pepper Ann's pompous (sometimes egomaniacal) academic rival. She presents a superficially mature attitude in spite of being just as competitive as Pepper Ann. • Gwen Mezzrow (voiced by
Kimmy Robertson) is a bubbly girl who constantly alternates between pining for Milo and being entirely uninterested in him in favor of Dieter, who is indifferent to her affection. • Stuart Walldinger (voiced by
Luke Perry in Season 2 and
Cam Clarke from Season 3 onwards) is Nicky's bookish boyfriend, whose main hobby is RC car-racing. He holds a reserved attitude but has a tendency to act out and bottle his emotions. • Constance Goldman (voiced by
Candi Milo) is a shy, awkward girl who looks up to Pepper Ann. • Shelf McClain (voiced by Jeff Bennett) is a large, academically stunted Scottish student in Pepper Ann's class who bullies other students and steals their lunch money. • Chuck Pearson (voiced by
Maurice LaMarche) is the estranged ex-husband of Lydia and father of Pepper Ann and Moose. He works as a blimp pilot and speaks with a
Mid-Atlantic accent. • Sherrie Spleen (voiced by April Winchell) is the TV anchorwoman for Channel 96 in Hazelnut. • Supermodel Mindy (voiced by Kath Soucie) is an airheaded celebrity and host of several popular Hazelnut television shows. • Mick Snot, real name Harry Schnitzer (voiced by
Jess Harnell &
Rob Paulsen) is the frontman of the band Flaming Snot. He went to the same Community College as Lydia prior to forming his band; Harry's fame has caused a strain between their friendship. • Emmit Swink (voiced by
Max Casella & Jeff Bennett) is the owner of BrainDead arcade and a waiter at Greezy N' Cheezy, a pizzeria often visited by Pepper Ann and her friends. • Margot Lesandre (voiced by
Kathy Najimy) is a snooty saleswoman who is rivals with Lydia and Janie. • "Shouty Kid" Sean Lesandre (voiced by Pamela Adlon) is the son of Margot, and Moose's crush. He is most recognizable for his booming voice. • Crash (voiced by
Adam Wylie) is Moose's neurotic best friend, whose name Pepper Ann never remembers. • Crying Girl (typically voiced by Cree Summer & Kath Soucie) is an unfortunate girl who often breaks down in tears at the slightest mishap, most often Pepper Ann's misadventures. • Sketch (voiced by
Karen Duffy) is an 8th grader whom Pepper Ann admires for her "coolness". She values loyalty but is shown to be somewhat aloof.
Minor • Lamar Abu-Dabe (voiced by
Kenny Blank) is a 7th grader and a classmate of Pepper Ann's whom Constance has a crush on. • Brenda (voiced by
Tara Strong) is Pepper Ann's former best friend. She is bubbly and overbearing to the point that Pepper Ann finds her insufferable. • Hush (voiced by Pamela Adlon) is a mute 8th grader who is friends with Sketch. She has a begrudging respect for Pepper Ann. • Tank & Poison (voiced by
Brittany Murphy &
Meredith Scott Lynn) are carefree, nonchalant 8th graders who are friends with Sketch. • Wayne Macabre (voiced by
Wallace Langham) is an 8th grade critic whose opinionated and misogynistic comments put him at odds with Pepper Ann. • Mean Girl (voiced by Kath Soucie) is a social climbing
punk who often brings trouble to Pepper Ann. • Effie Shrugg (voiced by
Hedy Burress) is an intellectual 8-year-old girl who uses her brawn and large size to intimidate others. • Bud (voiced by
Jason Marsden) is a member of the HMS football team who once had a crush on Pepper Ann, after her stint as the only girl on the team. • Becky Little (voiced by
Glenne Headly) is the older sister of Nicky Little. Like her sister, Becky is academically strong and shares a fear of swans. • Alf (voiced by
Will Ferrell) is the leader of the HMS chess club. • Cameron Landisburg (voiced by
John O'Hurley) is a film director who challenged Pepper Ann to create her own film after she gave his a poor review in the school paper. • Fuzzy (voiced by
Sue Rose) is a fictional cartoon hairball popular within Hazelnut who stars in a series of comics, television shows, stage plays and theme parks. • Klaus (voiced by
Russi Taylor) is a German cartoon monkey which Dieter is a fan of. • Tundra Woman (voiced by
Nicole Sullivan) is a fictional heroine whom Moose admires for her selflessness and courage. •
Mark Hamill is a celebrity who often visits Hazelnut. He was elected class president of HMS and would later appear as a guest (after being elected
President of the United States) for a HMS reunion. •
Evel Knievel is a daredevil whom Moose campaigned for to receive his own statue in Hazelnut's Lupkin Park;
Patrick Swayze received one instead. •
Alex Trebek was the host of
Jeopardy! and was once recruited by Pepper Ann for a heist. He would eventually marry Lydia Pearson and become the father-in-law of Pepper Ann.
Hazelnut Middle School • Principal Herbert Hickey (voiced by
Don Adams) is the school's tough disciplinarian with zero tolerance for Pepper Ann's shenanigans. His distinctive feature is a wart on his face that has a hair growing out of it. This was Adams's final role before his death in 2005. • Ms. Vera Schwartz (voiced by
Paddi Edwards) is the school's
secretary. • Mr. Roland Carter (voiced by
Jim Cummings) is a science teacher who is passionate about what he teaches. He is known for giving Pepper Ann detention slips but does believe that she can be a good student even when she successfully does her assignments. • Ms. Abriola Stark (voiced by April Winchell) is the math teacher who is also in charge of the drama club. • Ms. Bronte Bladdar (voiced by
Bebe Neuwirth) is a stoic English teacher (who often substitutes for art teacher Ms. Ford) who speaks in deadpan-monotone mannerisms. • Mr. Sherm Finky (voiced by
Don Lake) is the social studies teacher. He presents a hip (if not
out-of-touch) demeanor, but is no-nonsense when it comes to shirking projects. • Ms. Carlotta Sneed (voiced by
Julia Sweeney) is the economics teacher whose main hobby is knitting. • Mr. Owen Clapper (voiced by
James Avery) is the music teacher. He tends to clash with Ms. Stark concerning school plays. • Mr. Reason (voiced by
Kurtwood Smith) is the stern woodshop teacher. • Coach Doogan (voiced by Kathy Najimy) is the physical education teacher, and the head of the school's soccer team. • Coach Bronson (voiced by
Tom Wilson) is the football coach. • Nurse Oomla (voiced by
Ellen Cleghorne) is the
Jamaican-accented school nurse. • Moira the
Lunch Lady (voiced by Sue Rose) is a maladjusted lunchlady with low standards for sanitation. • Ernie the Janitor (voiced by
Billy West) is the absent-minded, albeit sociable janitor of HMS. ==Broadcast and home media==