During Shkreli's time at
Cramer, Berkowitz and Company, he recommended
short-selling the stock of
Regeneron Pharmaceuticals, a biotech company testing a weight-loss drug. When its price dropped in accordance with Shkreli's prediction, Cramer's hedge fund profited. Shkreli's prediction drew the attention of the
Securities and Exchange Commission, which investigated Shkreli's knowledge about the stock but was unable to prove wrongdoing on his part.
MSMB Capital Management After four years as an associate at Cramer Berkowitz, Shkreli worked as a financial analyst for Intrepid Capital Management and
UBS Wealth Management. He then started his first hedge fund, Elea Capital Management, in 2006. In 2007,
Lehman Brothers sued Elea in New York state court for failing to cover a '
put option transaction' in which Shkreli bet the wrong way on a broad market decline. When stocks rose, Shkreli did not have the money to cover his losses. In October 2007, Lehman Brothers won a $2.3 million default judgment against Shkreli and Elea, but
Lehman collapsed before it could collect on the ruling. which took its name from the initials of the two. The stock price rebounded; MSMB could not cover the position, although it had told Merrill Lynch that it could. Merrill Lynch lost $7 million on the trade and MSMB Capital was virtually wiped out.
Retrophin's 2015 SEC Complaint contended Shkreli had created MSMB Healthcare and Retrophin "so that he could continue trading after MSMB Capital became insolvent and to create an asset that he might be able to use to placate his MSMB Capital investors." In 2011, MSMB made an unsolicited cash bid for AMAG Pharmaceuticals at a price of $378 million. Matthew Herper of
Forbes wrote that the attempted
hostile takeover was "done for the specific purpose of firing the company's management and stopping a proposed merger with Allos Therapeutics. When the merger plans stopped, so did Shkreli."
Retrophin Shkreli founded Retrophin (a
portmanteau of "Recombinant
dystrophin") in 2011 under the MSMB umbrella and ran it as a portfolio company with an emphasis on biotechnology, to create treatments for
rare diseases. In December 2012, Shkreli was chosen for the
Forbes 30 Under 30. The publication regretted it eleven years later, placing Shkreli in its "Hall of Shame", a list of ten notably bad picks. Retrophin's board decided to replace Shkreli in September 2014, and he resigned from the company the following month. He was replaced by Stephen Aselage. During Shkreli's tenure as CEO, the company's employees used alias Twitter accounts to make gangster rap jokes and encourage short selling of other biotech stocks. After Shkreli's departure, Retrophin filed a lawsuit against him in August 2015, claiming that he had breached his duty of loyalty to the biopharmaceutical company in a long-running dispute over his use of company funds and "committed stock-trading irregularities and other violations of securities rules." The lawsuit alleged that Shkreli had threatened and harassed a former MSMB employee and his family. Shkreli and some of his business associates have been under criminal investigation by the
U.S. Attorney for the Eastern District of New York since January 2015. Shkreli invoked his
Fifth Amendment right against
self-incrimination in order to avoid testifying during civil depositions. Shkreli's name is on two patents held by Retrophin for drugs to treat
PKAN. In November 2020, Eric Dube, Retrophin's new chief executive, announced the company would be rebranded as Travere Therapeutics Inc. in an effort to further distance the company from Shkreli, and said the company is no longer working on treatments for the disease from which the company takes its name.
Views on Shkreli's leadership In July 2017, at Shkreli's criminal trial, Aselage, who was hired by Shkreli in October 2012, and replaced him at Retrophin in 2014, testified "He's a brilliant intellect, visionary" but also someone who was called a "
Pied Piper" and whom Aselege "worried about not always getting 'straight answers' from".
Thiola price hike In May 2014, Shkreli had difficulty accessing public markets for capital, but received a $4 million
series A funding round and a
PIPE deal valued at $10 million underwritten by
Roth Capital Partners. After obtaining the financing, Shkreli was able to acquire rights to market
tiopronin (brand name Thiola), a drug used to treat the rare disease
cystinuria, and another drug Chenodal, and subsequently raised the price of each drug substantially, with Thiola being marked up about 20 fold, from $1.50 to $30 per pill (patients must take 10 to 15 pills a day), and Chenodal about fivefold. Retrophin did not lower the price of these drugs after Shkreli's departure. In 2016,
Imprimis Pharmaceuticals introduced a lower cost version of Thiola marketed as a
compounded drug.
Turing Pharmaceuticals Shkreli founded
Turing Pharmaceuticals in February 2015, after his departure from Retrophin. He launched Turing with three drugs in development acquired from Retrophin: An
intranasal version of
ketamine for depression, an intranasal version of
oxytocin, and
Vecamyl for
hypertension. Shkreli set a business strategy for Turing: To obtain licenses on out-of-
patent medicines, and reevaluate the pricing of each in pursuit of
windfall profits for the new company, without the need to develop and bring its own drugs to market. As markets for out-of-patent drugs are often small, and obtaining regulatory approval to manufacture a generic version is expensive, Turing calculated that with closed distribution for the product and no competition, it could set high prices. from
Impax Laboratories for . The drug's most prominent use as of late 2015 was as an
anti-malarial and an
antiparasitic, in conjunction with
leucovorin and
sulfadiazine, to treat patients with both AIDS-related and AIDS-unrelated
toxoplasmosis. The
patent for Daraprim had expired, but no
generic version was available. The Turing–Impax deal included the condition that Impax remove the drug from regular wholesalers and pharmacies, reported on a letter from the
Infectious Diseases Society of America and the HIV Medicine Association to executives at Turing, questioning a new pricing for Daraprim. The price increase was initially criticized, jointly, by the
Infectious Diseases Society of America and the HIV Medicine Association, and soon thereafter by
presidential candidates Hillary Clinton,
Bernie Sanders, and
Donald Trump. A subsequent organized effort called on Turing to return pricing to pre-September levels and to address several matters relating to the needs of patients, an effort that garnered endorsements from more than 160 medical‑specialty and patient‑related organizations (, 164 organizations from 31 states, the
District of Columbia, and
Puerto Rico). In response to the controversy, the record label
Collect Records publicly ended its business relationship with Shkreli, who had invested in the company. In a September 2015 interview with
Bloomberg Markets, Shkreli said that despite the price increase, patient co-pays would actually be lower, that many patients would get the drug at no cost, that Turing had expanded its free drug program, and that it sold half of its drugs for one dollar. He defended the price hike by saying, "If there was a company that was selling an
Aston Martin at the price of a bicycle, and we buy that company and we ask to charge Toyota prices, I don't think that that should be a crime." A few days later, Shkreli announced that he planned to lower the price by an unspecified amount, "in response to the anger that was felt by people." Following a request by Senator Bernie Sanders and Representative
Elijah Cummings for details of Turing Pharmaceuticals' finances and price-setting practices in September 2015, the company hired four
lobbyists from
Buchanan, Ingersoll & Rooney with backgrounds in health care legislation and pharmaceutical pricing. In addition to lobbyists, Shkreli hired a crisis public relations firm to help explain the pricing decision. On October 22, 2015, Mark L. Baum, CEO of
Imprimis Pharmaceuticals, announced that his company would provide a combination product containing pyrimethamine (the active ingredient in Daraprim) and leucovorin at "$1-a-pill" as a cheaper and more efficient alternative to Daraprim. This product was intended to be used alongside sulfadiazine in the standard protocol to treat
toxoplasmosis typically seen in
AIDS patients. Turing issued a statement that it was not as important to cut the list price as to reduce the cost to hospitals, where most patients get their initial treatment. The company pledged that no patient needing Daraprim would ever be denied access.
Vyera/Phoenixus After Shkreli was imprisoned, Turing changed its name to Vyera in 2017 to avoid negative publicity; in 2019, it was called Phoenixus AG. In March 2019,
The Wall Street Journal reported that Shkreli "steers his old company from prison." Using a contraband cellphone from his prison ward in
Fort Dix, New Jersey, Shkreli was effectively directing the renamed firm, and was reported to have terminated the employment of executive Kevin P. Mulleady. After this news was reported in various news outlets, Shkreli was moved to the Metropolitan Detention Center in Brooklyn in advance of a subsequent move to a federal prison in Pennsylvania. He was also facing a Bureau of Prisons investigation into his breaking federal prison rules, since federal inmates are prohibited both from running a business from prison and from possessing cell phones. In May 2023, Vyera Pharmaceuticals declared Chapter 11 bankruptcy in Delaware court, listing between $10 million and $50 million in assets and between $1 million and $10 million in liabilities. The company cited "declining profits, increased competition for generic drugs, and litigation alleging that Vyera suppressed competition for its most valuable drug, Daraprim" per Reuters. Shkreli's shares in Vyera had earlier been ordered seized by federal court related to an FTC judgment against him.
FTC v. Vyera Pharmaceuticals In January 2020 the FTC filed a case against Vyera "alleging an elaborate anticompetitive scheme to preserve a monopoly for the life-saving drug, Daraprim". A settlement was reached in December 2021. According to
AP News, the settlement "requires Vyera and Phoenixus to provide up to $40 million in relief over 10 years to consumers who allegedly were fleeced by their actions and requires them to make Daraprim available to any potential generic competitor at the cost of producing the drug." Kevin Mulleady "agreed to a seven-year ban on working for or holding more than an 8% share in most pharmaceutical companies."
KaloBios Pharmaceuticals In November 2015, an investor group led by Shkreli acquired a majority stake in KaloBios Pharmaceuticals (), a
biopharmaceutical company based in
South San Francisco, California. Shkreli was named CEO of the company and also planned to continue in the role of CEO of Turing Pharmaceuticals. After his December 2015 arrest, KaloBios Pharmaceuticals terminated him as CEO. On December 29, 2015, KaloBios filed for
Chapter 11 bankruptcy. This followed
NASDAQ delisting its shares, and the resignation of two directors.
Gödel Systems, Inc Shkreli founded Gödel Systems in August 2016 as "a professional software company that aims to be the leading information provider of data, workflow, and communications solutions for financial, law, and scientific professionals." By February 2017, Gödel Systems was looking to raise $1 million through a debt offering, and had raised $50,000 out of the $1 million in debt it began issuing in mid-January 2017, according to regulatory filings. Ralph Holzmann, a former senior engineer at
Twitter, is the firm's
chief technology officer.
Druglike and Martin Shkreli Inu coin Following his release from prison, in 2022, a planned software platform named Druglike controlled by Shkreli was announced with a stated aim of supporting the development of new pharmaceutical drugs. A related
cryptocurrency project, the Martin Shkreli Inu coin, had been launched but in August lost 90% of its value (recovering shortly afterwards to a 55% loss) after an account believed to belong to Shkreli sold its Inu coin holdings. An account believed to belong to Shkreli claimed, in explanation, to have been hacked. ==Testimony before Congress==