Phosphine

Philippe Gengembre (1764–1838), a student of Lavoisier, first obtained phosphine in 1783 by heating white phosphorus in an aqueous solution of potash (potassium carbonate). Perhaps because of its strong association with elemental phosphorus, phosphine was once regarded as a gaseous form of the element, but Lavoisier (1789) recognised it as a combination of phosphorus with hydrogen and described it as ''phosphure d'hydrogène'' (phosphide of hydrogen). In 1844, Paul Thénard, son of the French chemist Louis Jacques Thénard, used a cold trap to separate diphosphine from phosphine that had been generated from calcium phosphide, thereby demonstrating that is responsible for spontaneous flammability associated with , and also for the characteristic orange/brown color that can form on surfaces, which is a polymerisation product. He considered diphosphine's formula to be , and thus an intermediate between elemental phosphorus, the higher polymers, and phosphine. Calcium phosphide (nominally ) produces more than other phosphides because of the preponderance of P-P bonds in the starting material. The name "phosphine" was first used for organophosphorus compounds in 1857, being analogous to organic amines (). The gas was named "phosphine" by 1865 (or earlier). ==Structure and reactions==

is a trigonal pyramidal molecule with C3v molecular symmetry. The length of the P−H bond is 1.42 Å, the H−P−H bond angles are 93.5°. The dipole moment is 0.58 D, which increases with substitution of methyl groups in the series: , 1.10 D; , 1.23 D; , 1.19 D. In contrast, the dipole moments of amines decrease with substitution, starting with ammonia, which has a dipole moment of 1.47 D. The low dipole moment and almost orthogonal bond angles lead to the conclusion that in the P−H bonds are almost entirely and phosphorus 3s orbital contributes little to the P-H bonding. For this reason, the lone pair on phosphorus is predominantly formed by the 3s orbital of phosphorus. The upfield chemical shift of its 31P NMR signal accords with the conclusion that the lone pair electrons occupy the 3s orbital (Fluck, 1973). This electronic structure leads to a lack of nucleophilicity in general and lack of basicity in particular (pKaH = −14), as well as an ability to form only weak hydrogen bonds. The aqueous solubility of is slight: 0.22 cm3 of gas dissolves in 1 cm3 of water. Phosphine dissolves more readily in non-polar solvents than in water because of the non-polar P−H bonds. It is technically amphoteric in water, but acid and base activity is poor. Proton exchange proceeds via a phosphonium () ion in acidic solutions and via phosphanide () at high pH, with equilibrium constants Kb = and Ka = . Phosphine reacts with water only at high pressure and temperature, producing phosphoric acid and hydrogen: Burning phosphine in the air produces phosphoric acid: ==Preparation and occurrence==

Phosphine may be prepared in a variety of ways. Industrially it can be made by the reaction of white phosphorus with sodium or potassium hydroxide, producing potassium or sodium hypophosphite as a by-product. Alternatively, the acid-catalyzed disproportionation of white phosphorus yields phosphoric acid and phosphine. Both routes have industrial significance; the acid route is the preferred method if further reaction of the phosphine to substituted phosphines is needed. The acid route requires purification and pressurizing. Laboratory routes It is prepared in the laboratory by disproportionation of phosphorous acid: Alternative methods include the hydrolysis of zinc phosphide: Some other metal phosphides could also be used, including aluminium phosphide or calcium phosphide. Pure samples of phosphine, free from , may be prepared using the action of potassium hydroxide on phosphonium iodide: Occurrence Phosphine is a worldwide constituent of the Earth's atmosphere at very low and highly variable concentrations. It may contribute significantly to the global phosphorus biochemical cycle. The most likely source is reduction of phosphate in decaying organic matter, possibly via partial reductions and disproportionations, since environmental systems do not have known reducing agents of sufficient strength to directly convert phosphate to phosphine. It is also found in Jupiter's atmosphere. Possible extraterrestrial biosignature In 2020 a spectroscopic analysis was reported to show signs of phosphine in the atmosphere of Venus in quantities that could not be explained by known abiotic processes. Later re-analysis of this work showed interpolation errors had been made, and re-analysis of data with the fixed algorithm do not result in the detection of phosphine.{{cite journal|last1=Snellen|first1=I. A. G.|title=Re-analysis of the 267-GHz ALMA observations of Venus No statistically significant detection of phosphine|journal=Astronomy and Astrophysics|volume=644|page=L2|year=2020 ==Applications==

Organophosphorus chemistry Phosphine is a precursor to many organophosphorus compounds. It reacts with formaldehyde in the presence of hydrogen chloride to give tetrakis(hydroxymethyl)phosphonium chloride, which is used in textiles. The hydrophosphination of alkenes is versatile route to a variety of phosphines. For example, in the presence of basic catalysts adds of Michael acceptors. Thus with acrylonitrile, it reacts to give tris(cyanoethyl)phosphine: Acid catalysis is applicable to hydrophosphination with isobutylene and related analogues: where R is , alkyl, etc. Microelectronics Phosphine is used as a dopant in the semiconductor industry, and a precursor for the deposition of compound semiconductors. Commercially significant products include gallium phosphide and indium phosphide. Fumigant (pest control) Phosphine is an attractive fumigant because it is lethal to insects and rodents, but degrades to phosphoric acid, which is non-toxic. As sources of phosphine, for farm use, pellets of aluminium phosphide (AlP), calcium phosphide (), or zinc phosphide () are used. These phosphides release phosphine upon contact with atmospheric water or rodents' stomach acid. These pellets also contain reagents to reduce the potential for ignition or explosion of the released phosphine. An alternative is the use of phosphine gas itself which requires dilution with either or or even air to bring it below the flammability point. Use of the gas avoids the issues related with the solid residues left by metal phosphide and results in faster, more efficient control of the target pests. One problem with phosphine fumigants is the increased resistance by insects. esoteric--> ==Toxicity and safety==

Deaths have resulted from accidental exposure to fumigation materials containing aluminium phosphide or phosphine. It can be absorbed either by inhalation or transdermally. Phosphine appears to be mainly a redox toxin, causing cell damage by inducing oxidative stress and mitochondrial dysfunction. Resistance in insects is caused by a mutation in a mitochondrial metabolic gene. According to the 2009 U.S. National Institute for Occupational Safety and Health (NIOSH) pocket guide, and U.S. Occupational Safety and Health Administration (OSHA) regulation, the 8 hour average respiratory exposure should not exceed 0.3 ppm. NIOSH recommends that the short term respiratory exposure to phosphine gas should not exceed 1 ppm. The Immediately Dangerous to Life or Health level is 50 ppm. Overexposure to phosphine gas causes nausea, vomiting, abdominal pain, diarrhea, thirst, chest tightness, dyspnea (breathing difficulty), muscle pain, chills, stupor or syncope, and pulmonary edema. Phosphine has been reported to have the odor of decaying fish or garlic at concentrations below 0.3 ppm. The smell is normally restricted to laboratory areas or phosphine processing since the smell comes from the way the phosphine is extracted from the environment. However, it may occur elsewhere, such as in industrial waste landfills. Exposure to higher concentrations may cause olfactory fatigue. Fumigation hazards Phosphine is used for pest control, but its usage is strictly regulated due to high toxicity. Gas from phosphine has high mortality rate and has caused deaths in Sweden and other countries. Because the previously popular fumigant methyl bromide has been phased out in some countries under the Montreal Protocol, phosphine is the only widely used, cost-effective, rapidly acting fumigant that does not leave residues on the stored product. Pests with high levels of resistance toward phosphine have become common in Asia, Australia and Brazil. High level resistance is also likely to occur in other regions, but has not been as closely monitored. Genetic variants that contribute to high level resistance to phosphine have been identified in the dihydrolipoamide dehydrogenase gene. Identification of this gene now allows rapid molecular identification of resistant insects. Explosiveness Phosphine gas is denser than air and hence may collect in low-lying areas. It can form explosive mixtures with air, and may also self-ignite. ==In fiction==

Anne McCaffrey's Dragonriders of Pern series features genetically engineered dragons that breathe fire by producing phosphine by extracting it from minerals of their native planet. In the 2008 pilot of the crime drama television series Breaking Bad, Walter White poisons two rival gangsters by adding red phosphorus to boiling water to produce phosphine gas. However, this reaction in reality would require white phosphorus instead, and for the water to contain sodium hydroxide. ==See also==