Lane made her film debut in the critically acclaimed and award-winning
American Honey (2016), a film about magazine crews, written and directed by
Andrea Arnold, starring opposite
Shia LaBeouf and
Riley Keough. Arnold spotted Lane sunbathing on a beach while on spring break. Lane said in an interview that she "felt Arnold's vibe and decided to trust Arnold for an audition." The film had its world premiere on May 15, 2016, at the
Cannes Film Festival, where it won the
Prix du Jury. The film was released in a
limited release on September 30, 2016, by
A24. In 2017, Lane starred in
Born in the Maelstrom, a short film directed by Meryam Joobeur. In 2018, Lane starred in
Hearts Beat Loud, opposite
Nick Offerman and
Kiersey Clemons, directed by
Brett Haley, and
The Miseducation of Cameron Post directed by
Desiree Akhavan.
The Miseducation of Cameron Post won Top Prize at the
2018 Sundance Film Festival and has been praised for its “sensitive, understated portrayal of adolescent self-doubt and discovery.” In 2019, Lane played Alice Monaghan in
Hellboy, directed by
Neil Marshall. She appeared in horror thriller film ''
Daniel Isn't Real'' (2019), directed by
Adam Egypt Mortimer. In 2020, Lane starred in an episode of
Amazing Stories for
Apple TV+ executive produced by
Steven Spielberg. She then starred in
Utopia created by
Gillian Flynn, an American remake of the British television show
of the same name for
Amazon Prime Video. In May 2020, she was cast in
Loki, which premiered in June 2021. In February 2021, she was cast in
Conversations with Friends, an adaptation of
Sally Rooney's
2017 debut novel. She appeared in
Twisters, directed by
Lee Isaac Chung. ==Personal life==