In athletics, the Knights had been long members of the
Toledo City League before joining the
Three Rivers Athletic Conference in 2011. In 2023, the Knights joined the Catholic High School League. The school's colors are red and blue. Their athletic rivals include the neighboring all-boys school
St. John's Jesuit and area Co-Ed
Central Catholic. Knight Swimming and Diving, as well as Water Polo, stand out in the athletic venue. Known locally as the "AquaKnights," the swim team placed second in the state for three out of five years (2010, 2011, 2014). The swim team has a particularly strong history, winning 42 straight Northwest Ohio District Championships beginning in 1966 spanning until their defeat by rival St. John's in February 2008, a national record. The AquaKnights have a well-known rivalry with Cincinnati St. Xaiver. The Water Polo team has consistently placed in the top four teams in the state for the last ten years, and secured the state title in 2023.
Ohio High School Athletic Association State Championships The St. Francis Knights hold more state titles than any other Catholic school in the Diocese of Toledo, and any other high school in the greater Toledo area. •
Football - 1984, 2001 •
Wrestling - 1964,1970 •
Basketball – 1983 •
Swimming – 1967, 1968, 1996, 1998 •
Ice Hockey – 2011, 2015, 2021
Other State Championships •
Water Polo - 1973, 1974, 1975, 1982, 1986, 1988, 1989, 1990, 1995, 1996, 1997, 1998, 1999, 2001, 2023 •
Tennis - 2001, 2002
Soccer The 2003 soccer team were the Division I runner up, compiling a final record of 20–1–1, with their only loss coming in the state finals. Head coach John B. Orozco earned coach of the year honors that same year.
The Irish Knight The Irish Knight is awarded to the winner of the Central Catholic High School and St. Francis de Sales High School football game. The winning school receives and hosts the Irish Knight in their school, along with bragging rights. CCHS currently holds the Irish Knight after winning this past fall, and leads the series 36–28–1. There has only been one overtime game, which occurred in 2003.
All-Sports Trophy Since 1974, when the All-Sports Trophy was introduced, the Knights of St. Francis de Sales High School have held or shared the trophy ten times. They held the trophy in 1975, 1983, 1984, 1987, 1992, 1994, 2001, and 2005, and they shared with
St. John's Jesuit in 2000 and 2002. ==Alma Mater==