•
Michael J. Fox as Stuart Little, a young
anthropomorphic mouse adopted as part of the Little family. •
Wayne Brady as Reeko, a smooth-talking anthropomorphic
skunk and the Beast's former servant who befriends Stuart, but is disliked by the forest animals because of his attitude. •
Kevin Schon as Snowbell, the family's
Persian cat who is Stuart's best friend. He reprises his role from the
animated series, replacing
Nathan Lane from the first two films. •
Geena Davis as Mrs. Eleanor Little, the
matriarch of the Little family and Frederick's wife. •
Hugh Laurie as Mr. Frederick Little: the
patriarch of the Little family and Eleanor's husband. • Corey Padnos as George Little, the eldest son of the Little family and Stuart's older brother. He replaces
Jonathan Lipnicki from the first two films. •
Virginia Madsen as the Beast, a ferocious and ruthless female
cougar, Reeko's master and the tyrannical ruler of the forest of Lake Garland. •
Rino Romano as Monty, a gray
tabby cat who is Snowbell's best friend. He replaces
Steve Zahn from the first two films. •
Peter MacNicol as Troopmaster Bickle, the slightly overweight, clumsy, comical, yet well-intentioned leader of the Lake Scouts. •
Tara Strong as Brooke, an experienced Lake Scout at Lake Garland who is George's love interest. •
Charlie Adler as Beaver, one of the forest animals of Lake Garland who dislikes Reeko. •
Kath Soucie as Cottontail, a
rabbit and one of the forest animals of Lake Garland who dislikes Reeko. Martha Little (Stuart and George's younger sister) appears in the film, but her voice actress is unknown. Additional voices include
Garry Chalk,
Tom Kenny,
Sophia Paden,
Kath Soucie and
Tara Strong. ==Reception==