"Boss Bitch" was met with positive reviews from music critics. Patrick Johnson at
Hypebeast described Doja's rendition as "a club-leaning single that features dubbing synths, unexpected cowbells and an undeniable chorus" and commented on her performance as "exuding the confidence and anti-good girl swagger of the film's protagonist
Harley Quinn". James Dinh at
iHeartRadio compared Doja's charisma to early
Nicki Minaj with lyrics that "give the rising star more reason to gain attention", while Brendan Wetmore from
Paper stated that the song was more reminiscent of
Azealia Banks' "more bass-heavy works". As part of the soundtrack review, Jazz Tangcay of
Vulture labeled the album opener as "declaratory" with a hook that exudes the singer's "bad-ass determination". In June 2020, the song was listed as the 27th best song of 2020 so far by
Billboard.
NME named it the 12th best song of 2020 in December. ==Music video==