Decades after the introduction of a cancer cure, the children of its users develop "Duryea-Gode Disease" (DGD), a genetic disease whose symptoms include
dissociative states, obsessive
self-mutilation, and violent
psychosis. DGD patients can delay the onset of symptoms by means of rigid dietary restrictions. However, the intense social isolation they face, as well as the knowledge that the eventual onset of symptoms is inevitable, makes some of the second-generation patients wonder whether these efforts are worth it. Lynn Mortimer, the female protagonist, is a double DGD (she has the disease from both her parents), and learns how to deal with the disease and the oppression that she felt since she was growing up. She witnesses what DGDs are capable of when she visits Dilg, a retreat center where out-of-control DGDs are placed. At Dilg, instead of being restrained, the patients are engaged in making art and inventing technology. In an afterword to the story, Butler described constructing DGD from the symptoms of three other genetic diseases:
Huntington's disease,
phenylketonuria, and
Lesch-Nyhan disease, to which she added reactivity to pheromones and the delusion of being trapped in one's own flesh. ==Themes==