Main • Todd Bartholomew Daring (voiced by
Nancy Cartwright) is Riley's 11-year-old younger brother. Todd is the lazy, troublemaking, and selfish one of the siblings. He and Riley are the adoptive children of Agent K and Dick Daring. Todd usually uses the Fleemco phone to replace people for selfish purposes. He is best friends with Jacobo and Shelton. Todd loves the Monkey Cop film series and playing the GameCone (a parody of
Nintendo GameCube) video game console. He also loves playing games with Jacobo, Shelton, Buzz, Donny, Zephremiah, and Silent Joe. He dislikes school, learning, and reading, which forces him to replace the librarian in one episode. • Riley Eugene Daring (voiced by
Grey DeLisle) is Todd's 13-year-old older sister. She is the kinder, more caring, and reliable sibling who enjoys school. She generally uses the Fleemco phone to help others or to replace unfair adults who do not take her seriously. She enjoys horses and
equestrianism, Hornet Hive Scouts (a
Girl Scout-type of
youth group), and any form of sugar. She loves playing games with Tasumi, Abbey, and Sierra. She has a crush on Johnny Hitswell, and they became a couple in the second season, but Johnny breaks up with her because of her jealousy. • Karen "Agent K" Daring (voiced by
Kath Soucie) resembles
Emma Peel. She is the siblings' adoptive British mother and a spy. From an outside view, it seems she does not care for her kids nor husband, but in fact, she loves them devotedly, even though she may express it through a recording or videotape. If something seems unfair, she fixes it very quickly. As a downside of her career as a spy, Agent K is prone to
paranoia and can be quite strict (particularly towards Todd). Karen's mother is also a secret agent. • Richard Marion "Dick" Daring (voiced by
Daran Norris) is the siblings' adoptive father and the world's greatest daredevil. Dick's appearance resembles that of
Evel Knievel. He, like Todd, is not very smart, and is also very immature, as he owns a teddy bear known as "Evel Bearnievel". He thinks that C.A.R. is his best friend, though C.A.R. does not see it that way. • C.A.R.T.E.R. (also known as C.A.R.) (voiced by
David McCallum) is the high-tech family car with a British accent. He can do just about anything but is not always prepared to do something for the family, especially not for Dick. He never lets Dick drive him (presumably under the assumption that Dick's daredevil habits would wreck him) and scares Dick using "The Oslo Option", which consists of C.A.R. pulling out a spinning buzzsaw from his hood. • Conrad Fleem (voiced by
Jeff Bennett) is the mysterious owner of the
Canton, Ohio-based Fleemco company. He processes Todd and Riley's requests whenever they call him. His face is never shown until the series finale "Irreplaceable," where he is revealed to be Todd and Riley's uncle.
Supporting • Tasumi (voiced by
Lauren Tom) is Riley's Japanese-American best friend, who has a crush on Jacobo, as revealed in one episode when she kissed him. In the episode "Tasumi Unmasked", it is revealed that Tasumi is a Japanese pop star who moved to Pleasant Hills from her native country, in order to escape the constant adoration of her fans and live a peaceful life, as Pleasant Hills was voted as the least culturally aware town in the world and she believed that no one would recognize her. • Abbey Willson (voiced by
Erica Hubbard in season 1 and
Tempestt Bledsoe in season 2) is Riley's
African-American best friend. Even though she hates the popular girls such as Sierra, she is seen wanting to be a part of them so bad, and habitually tells Sierra she is cool, even though she does not mean to. She has a younger sister named Tiffany who dated Todd in the episode "A Little Tiff". • Jacobo Jacobo (voiced by
Candi Milo) is Todd's
Mexican-American best friend. Jacobo loves mystery books and has a secret talent for singing. He has a crush on Agent K and is always trying to win her affections, even in the last episode "Irreplaceable," when he begins to date Tasumi. • Shelton Gunnar Klutzberry (voiced by
Jeff Bennett impersonating
Jerry Lewis) is Todd's Eastern European-American friend and a stereotypical nerd. He is
afraid of girls, and once had a relationship with Celebrity Starr. He also has an imaginary girlfriend named Zelda (since an imaginary girlfriend is all that he can handle). He often thinks of himself as cool and calls the others nerds. He becomes very muscular and handsome when he takes his glasses off, but this is not to his advantage because he cannot use contacts, and has to have heavy glasses (which causes him to appear weak and scrawny). • Buzz Winters (voiced by
Grey DeLisle) is a wannabe bully and is Todd's nemesis. He usually makes silly jokes then laughs at them. Although he is normally a bully in some episodes they have put their differences aside and even become friends. Deep down Buzz is jealous of Todd and Riley because their father is cooler than his is, as Buzz's father used to be the coolest in the neighborhood until Todd and Riley came along. • Donny Rottweiler (voiced by
Jess Harnell) is a professional bully who is much taller than Todd, but still attends his school. He is Buzz's mentor and Todd's other nemesis, feared because of his giant size. • Johnny Hitswell (voiced by
Dee Bradley Baker) is the subject of Riley's affection and her middle school sweetheart. Even though every girl in the school is all over him, he tends to always ignore them, except for his annual Kumquat Day card readings. He enjoys basketball and baseball, and plays on the same baseball team as Todd and Riley. • Sierra McCool (voiced by
Tara Strong) is the popular girl at school, and is Riley's nemesis. She is constantly competing with Riley for the affections of Johnny Hitswell. In the second season, when Riley and Johnny become a couple, her crush on him persists, and her aim becomes to break them up so she can be Johnny's girlfriend. She has her own posse (Jennifer and Claudia) and a huge, conceited ego. • Principal Cutler (voiced by
Jeff Bennett) is the Alaskan Native principal of George Stapler Middle School. Since he is originally from Alaska, he allows school on major snow days until Todd and Riley changed it one time. He is also very cheap and cares about money over the students, the school, and the faculty. • Prince Cinnamon Boots (voiced by
Daran Norris) is the Daring Family's pet mule. He was originally given to Riley by her father when she asked for a show horse. • Shelly Klutzberry (voiced by
Candi Milo) is Shelton's older sister. • Jennifer (voiced by
Lauren Tom) and Claudia (voiced by
Erica Hubbard/
Tempestt Bledsoe) are two blonde-haired twin girls who are usually seen with Sierra McCool.
Recurring • Phil Mygrave (voiced by
Rob Paulsen) is Dick's stunt coordinator and brother and Riley and Todd's uncle. He is not very good with measurements, as he does not use proper units of measurements, rather just "tweaking the thingy on the whatchimacallit a smidge". He has also been married several times, and has poor advice for maintaining a relationship. • Agent B (voiced by
Carolyn Seymour) is Agent K's mother and Todd and Riley's grandmother. She is the headmistress of the Royal Academy of Spies. She seems to not get along with K before the episode "London Calling", but in the episode they reconcile and B becomes a loving grandmother to Riley and Todd. • Agent G (voiced by
Michael York) is Agent K's father and Todd and Riley's grandfather. He is the chief inventor of the Royal Academy of Spies. • Gordo Glideright (voiced by
Bruce Campbell) is Dick's stunt rival. He is always trying to steal Dick's stunt secrets. • Dustin Dreamlake (voiced by
Jason Marsden) is a parody of pop star
Justin Timberlake and Riley's idol. • Ace Palmero (voiced by
Dee Bradley Baker) – A news reporter who refers to himself as "I, Ace Palmero". A recurring gag involves only his profile being shown on TV, with the camera changing whenever he turns to face it. • Dr. Hans Herkmer (voiced by
Jeff Bennett) is a scientist who works for the space program. • Amanda McMurphy (voiced by
Candi Milo) is a hard-hitting investigator reporter who helped Riley with the school newspaper. • Fabian Le'Tool (voiced by
Rob Paulsen) is a professional hairstylist. • Davey Hunkerhoff (voiced by
Zac Efron) is a handsome lifeguard and parody of
David Hasselhoff who Riley used to make Johnny Hitswell jealous in the episode "Davey Hunkerhoff". • Skye Blossoms (voiced by
Tara Strong) is a prevalent replacement. A hippie who refuses to judge people and believes the answers to all of your questions are "what you feel the answer is." • Mr. Vanderbosh (voiced by
Rob Paulsen) is Riley's stern teacher. • The Kelpmans (voiced by
Chip Chinery and
Mary Elizabeth McGlynn) are next-door neighbors to the Darings. They were once replaced on Halloween by the Zupecks. • Lady Lady (voiced by
Grey DeLisle) is a professional wrestler who settled Tasumi and Riley's feud for Todd in "Best Friends For-Never?". Lady also appears as one of Dr. Scorpius' minions in "Irreplaceable". • Wrestler Announcer (voiced by
Jim Cummings) announces the wrestling matches since Riley and Tasumi's end-of-friendship argument in "Best friends For-Never". He announced Lady Lady's Marriage to Canadian Knucklehead in "Serf's Up". • Celebrity Starr (voiced by
Miley Cyrus in the first season and
Jessica DiCicco in the second season) – This famous teen was first found replacing Shelton's imaginary girlfriend, Zelda because Shelton had defended Riley when Sierra put a love note in Riley's locker saying it was from Shelton. Riley felt poor and had Zelda replaced with Celebrity who liked nearsighted nerds. In the end, Todd turned her plan around and protected his friend. Celebrity also appears as one of Scorpius' minions in "Irreplaceable". • Zephremiah and Silent Joe (both voiced by
Dee Bradley Baker) are twins who are friends of Todd's. They were both in Todd's boy choir. Zephremiah apparently likes sports. His twin brother, Silent Joe, is apparently sensitive and rarely talks. • Splatter Train is a fictional character in a recurring scary movie throughout the series. • Tiny Evil (voiced by
Jason Marsden) – An enemy of Agent K. • Doctor Skorpius (voiced by
Dave Wittenberg) – Archenemy of Agent K and the main antagonist of the series. He has a scorpion tail-shaped beard and is usually seen trying to take over the world in some way. • Goober (voiced by
Dee Bradley Baker) and T-Bone (voiced by
Jess Harnell) are radio DJs whom Todd idolizes. • Buck Spikes (voiced by
John DiMaggio) is a tough baseball coach who replaced Todd and Riley's old coach, Pops. Spikes keeps pushing kids to the limit, and when they strike out, he cruelly throws them into a cage. Spikes also appears as one of Doctor Scorpius's minions in "Irreplaceable." • 'Puter Dude 13 (voiced by
Jeff Bennett) is a "cool and mysterious recluse" who runs the online interactive game Fleemster. He is secretly a nerd. • Heather Hartley is the "Her Girl" for Teen Swoon Magazine. She has an outrageous hairstyle and usually carries around her pet turtle on a leash. • Petrov (voiced by
Dee Bradley Baker) is an enemy of Agent K. • Dr. Clonemaster is a rival of Agent K. He was seen only in the episode, "The Means Justify the Trend", in a flashback. • Dingo McGee (voiced by
Jeff Bennett and
Carlos Alazraqui) is the replacement sent by Fleemco when Todd got sick of an archaeologist treating them like babies on a field trip in the episode "Field Trippin'". He's an adventurous, usually reckless, explorer who plays the
didgeridoo. • Robo Fleem SGX (voiced by
Diedrich Bader) is a giant security robot that replaced the incompetent security guard at Todd's school in "The Insecurity Guard". However, the robot later went crazy and tried to destroy Riley when she tried to return it to Fleemco. In the last episode "Irreplaceable", Dr. Scorpius creates a second Robo Fleem SGX to destroy Todd's friends. • Mrs. Shusher (voiced by
Tara Strong) is the shush-happy librarian at George Stapler Middle School. Todd got sick of her forcing everyone to be quiet, and later replaced her with a librarian who was the complete opposite of her. She returned later in the episode when her replacement was returned by Todd and Riley. • Gammazor, Mecha-Gammazor, and Grammazor – All rumored enemies of Tasumi. There are pictures of them on her "list" whenever she brings it out and threatens to put Riley on it. • Garth (voiced by
Dee Bradley Baker) is a school janitor who is constantly being replaced by Todd and Riley when they need a quick replacement. Garth is not very enthusiastic about his job and is fully lazy. Garth also appears as one of Doctor Scorpius's minions in "Irreplaceable." • Mrs. Fragile (voiced by
Kath Soucie) is a replacement who is very emotionally fragile, anxious and very easy to upset. ==Broadcast==