Cooperative Affairs and Governance: 2021–2024 On 5 August 2021, President
Cyril Ramaphosa announced Nkadimeng's appointment as
Deputy Minister of Cooperative Governance and Traditional Affairs. Sworn in on 10 August, she resigned both as Polokwane mayor and as SALGA president; John Mpe replaced her as mayor. The following year, in December 2022, the ANC's
55th National Conference elected Nkadimeng to a five-year term on the party's
National Executive Committee (NEC). She received 1,681 votes across the 4,029 ballots cast, making her the 15th-most popular member of the 80-member committee. She was also elected to the party's
National Working Committee, appointed as the chairperson of the NEC's subcommittee on legislature and governance, and appointed to an NEC task team that was mandated with developing the party's approach to
coalition government. In the aftermath of the 55th National Conference, Nkadimeng succeeded
Nkosazana Dlamini-Zuma as
Minister of Cooperative Governance and Traditional Affairs in a cabinet reshuffle on 6 March 2023. One of two ministers appointed to
the cabinet from outside the
National Assembly, she was reportedly hand-picked for the promotion by Ramaphosa. Parks Tau and
Zolile Burns-Ncamashe were appointed as her deputies. Upon her appointment, Nkadimeng said that one of her top priorities as minister would be the stability of municipalities, especially those governed by coalitions. In this vein she
Gazetted as regulation a code of conduct for local councillors and introduced into Parliament the Local Government: Municipal Structures Amendment Bill, 2023.'
Adriaan Basson of News24 commended her "sober and mature approach to coalition governments". She also introduced the Intergovernmental Monitoring, Support, and Interventions Bill, 2023, which included measures for national government intervention in dysfunctional municipalities, and introduced regulations for institutionalising the District Development Model.' Meanwhile, her ministry authorised
states of disaster in multiple provinces after
extreme weather events, and Nkadimeng was involved in negotiations with the
South African Municipal Workers' Union over a strike in
Matjhabeng.
Justice and Human Settlements: 2024–present In the
May 2024 general election, Nkadimeng was elected to a seat in the National Assembly, the lower house of the
South African Parliament. On 30 June, President Ramaphosa announced her appointment to
his third cabinet as
Minister of Justice and Constitutional Development, with
Andries Nel (a fellow ANC MP) as her deputy. They were sworn as minister and deputy minister on 3 July 2024. This followed the formation of a
Government of National Unity (GNU) through a
grand coalition, after the ANC lost its absolute majority in the election. The ministry previously had authority also for the
Department of Correctional Services, which was established as a freestanding ministry within the GNU to accommodate members of coalition parties as ministers. Simelane was reshuffled to Minister of Human Settlements in December 2024. == Legal issues ==