Corpus Christi Sharks In 2008, he signed with the
Corpus Christi Sharks of the
af2, after being out of football for two years. He couldn't complete the season after being arrested and sent to the state prison
C. A. Holliday Transfer Facility.
Dallas Vigilantes In 2010, he signed with the
Dallas Vigilantes of the
Arena Football League (AFL). On September 1, 2012, he was released.
St. Louis Rams On September 2, 2012, he was claimed off waivers by the
St. Louis Rams. On August 31, 2013, he was waived injured.
New Orleans Saints On January 6, 2014, the
New Orleans Saints signed Nsekhe to a reserve/futures contract. The Saints released Nsekhe on August 25, 2014, then placed on the injured reserve list after clearing waivers. On September 9, 2014, the Saints waived Nsekhe from injured reserve list on a no-recall basis.
Washington Redskins (first stint) in 2017 On February 10, 2015, Nsekhe signed with the
Washington Redskins. He was waived by the Redskins on May 4.
Los Angeles Kiss On May 6, 2015, Nsekhe was assigned to the
Los Angeles Kiss of the AFL.
Washington Redskins (second stint) On May 11, 2015, he was re-signed by the Redskins. He was the backup swing tackle, making two starts at left tackle in place of an injured
Trent Williams and also getting some playing time at right tackle. In 2016, he served as the team's swing tackle. He was forced to start four straight games (three at left tackle and one at right tackle), following the suspension of
Pro Bowler Trent Williams for using performance-enhancing drugs. On February 28, 2017, Nsekhe re-signed with the Redskins. He appeared in 11 games with five starts both at left tackle and right tackle. On March 12, 2018, the Redskins placed a second-round restricted free agent tender on Nsekhe. He appeared in 14 games with five starts. He had three consecutive starts at left tackle and two at left guard.
Buffalo Bills On March 13, 2019, Nsekhe signed a two-year, $14.5 million deal including $7.7 million in guarantees with the
Buffalo Bills.
Dallas Cowboys On March 22, 2021, Nsekhe signed a one-year contract with the
Dallas Cowboys. He was signed to replace veteran
Cam Erving as the team's backup swing tackle. He was also used in jumbo packages to play alongside the starting tackles. He appeared in 12 games. He missed the Week 2, Week 3 and Week 4 games, while recovering from
heat exhaustion. He wasn't re-signed after the season.
Indianapolis Colts (second stint) On October 11, 2022, Nsekhe was signed to the Colts practice squad.
Los Angeles Rams (first stint) On October 18, 2022, Nsheke was signed by the
Los Angeles Rams off the practice squad of the Colts. He was signed to provide depth after a string of injuries on the offensive line. He started in 10 games last season. He wasn't re-signed after the season.
Cleveland Browns On September 12, 2023, Nsekhe was signed to the
Cleveland Browns practice squad. He was not signed to a reserve/future contract by the team after the season and thus became a free agent upon the expiration of his practice squad contract.
Los Angeles Rams (second stint) On September 10, 2024, Nsekhe was signed to the Los Angeles Rams practice squad and was released one week later. ==Personal life==