Lewis's film appearances include roles in
Finding Nemo,
Finding Dory,
Mouse Hunt,
Godzilla,
Pushing Tin,
Breakfast of Champions,
The Ugly Truth and ''I'll Do Anything''. On television, Lewis starred as Beth in the critically acclaimed series
NewsRadio for five seasons on NBC from 1995-1999, followed by
Three Sisters also for NBC. Her prolific television career has included roles on
Curb Your Enthusiasm,
Modern Family,
Grey’s Anatomy,
Bones,
How I Met Your Mother,
The Goldbergs,
See Dad Run,
Dirt,
Seinfeld,
Doll and Em,
Murphy Brown,
Home Improvement,
Caroline in the City,
The Norm Show,
Grace Under Fire,
Phenom,
The 5 Mrs. Buchanans,
Surviving Suburbia,
Disney Channel's
Sonny with a Chance,
The Middle,
Making History,
Still the King,
Angie Tribeca and
The Blacklist. She has voiced a myriad of characters for animated projects including Deb and Flo in Pixar's 2003 film
Finding Nemo and the 2016 sequel
Finding Dory. She voiced Wonder Woman in
Justice League Heroes,
Rugrats Pre-School Daze,
King of the Hill,
Hercules,
An Extremely Goofy Movie,
Ben 10,
Phineas and Ferb,
Justice League: The New Frontier,
Alpha and Omega and
its sequel. Lewis had her Broadway debut in
Do Black Patent Leather Shoes Really Reflect Up? (in 1982), as Velma Kelly in
Chicago (in 2000 and 2001), as Gloria Thorpe in
Damn Yankees (in 1994) and Mary Warren in
The Crucible at The Roundabout theatre (in 1990). She also appeared off-Broadway in
I Can Get It For You Wholesale (1991) and
Snoopy!!! The Musical (1982). In 1995, Lewis performed as a soloist with the
New York Pops at
Carnegie Hall, Pal Joey for City Center Encores. Lewis won the 2007
Ovation Award for Best Featured Actress in a Musical for the world premiere of
Michael John LaChiusa's ''Hotel C'est L'amour''. In the same year, she appeared as Trina in a one-off benefit performance of the musical "
Falsettos" opposite
Jason Alexander and
Malcolm Gets, during which her rendition of "I'm Breaking Down" received a spontaneous one-minute-long ovation mid-show. In 2018, she starred on Broadway as Countess Lily in
Anastasia, directed by
Darko Tresnjak. In 2022 she performed six roles (Ms. Winx/Mrs. Brown/Kyrie/Jessamyn Jacobs/Lady in Waiting) in the original Off-Broadway production of
Between The Lines for which she was nominated for the Outer Critic’s Circle Award. Most recently, in 2024, she starred as Maria Callas in Terrance McNally’s Masterclass at The Bay Street Theatre directed by Lisa Peterson. Her debut solo album
East of Midnight was released in May 2010. The eclectic rock album has songs penned by Lewis as well as three
cover songs. Lewis considered the writing to be "dauntingly destructive and spiritually bereft. Locked in my office in
Malibu, California I wrote what would become a self-fulfilling prophecy – it would also prove to be the making of me." ==Personal life==