PR 346 begins in the
Municipality of Killarney-Turtle Mountain at an intersection with
PTH 3 (
Boundary Commission Trail) just south of
Ninga. It heads north as a paved two-lane highway for to enter the hamlet at an intersection with
PR 443. Traveling along the western edge of town, the highway crosses a railroad and has an intersection with Railway Street before the pavement turns to gravel, and the highway leaves Ninga to head north through rural farmland. Entering the
Rural Municipality of Prairie Lakes, PR 346 goes through a switchback before having a junction with
PTH 23 and traveling through
Margaret, where it has a brief paved section. The highway becomes slightly narrower as it goes through switchbacks and hairpin curves for the next several kilometers down a mountain pass into a river valley, where it crosses a narrow one-lane bridge over the
Souris River. Climbing back out of the valley, though much straighter this time, it enters the
Municipality of Oakland-Wawanesa and comes to an end shortly thereafter at a junction with
PTH 2 (
Red Coat Trail) just on the outskirts of
Nesbitt. ==History==