•
William Douglas, Lord of Liddesdale (c. 1300–1353), Scottish nobleman and soldier, cousin of the 1st Earl of Douglas • Sir
William Douglas of Nithsdale (c. 1370–c. 1392), Scottish knight • Sir
William Douglas of Drumlanrig (died 1427), Scottish knight, grandson of the 1st Earl of Douglas • Sir
William Douglas of Glenbervie (c. 1473–1513), Scottish knight killed at the Battle of Flodden •
William Douglas, 2nd Lord Mordington (1626–c. 1671), Scottish nobleman, grandson of the 10th Earl of Angus • Sir
William Douglas of Kelhead (died 1673), Scottish Covenanter colonel, son of the 1st Earl of Queensberry •
William Hamilton, Duke of Hamilton (born Lord William Douglas, 1634–1694), Scottish nobleman and politician, son of the 1st Marquess of Douglas •
William Douglas, 14th of Cavers (c. 1688–1748), Scottish landowner and politician, MP for Roxburghshire 1715–22, 1727–34, 1742–47, and for Dumfries Burghs 1722–27 •
Sir William Douglas, 4th Baronet (c. 1730–1783), Scottish landowner and politician, MP for Dumfries Burghs, great-great-grandson of Sir William Douglas of Kelhead •
Sir William Douglas, 1st Baronet (died 1809), Scottish mill owner, landowner and founder of Castle Douglas •
Lord William Douglas (1783–1859), Scottish politician and landowner, son of Sir William Douglas, 4th Baronet ==Arts==