Georgia Tech While deciding who would be the starting quarterback two weeks before the opener, Weis, wanting to keep the
Yellow Jackets guessing, would only tell the media that the quarterback and his backup knew their roles.
Demetrius Jones started the game, with
Evan Sharpley and
Jimmy Clausen both seeing action as quarterback. Giving up nine sacks and two fumbles, and having negative 8-yards rushing, the Irish lost 33–3 in their most lopsided season opening loss in the history of the program.
Penn State After the opening loss, Weis named freshman Jimmy Clausen the starting quarterback. Clausen would become the eighth Notre Dame freshman to start at quarterback since 1951 and would be the earliest to start when he faced the 15th ranked
Penn State Nittany Lions in Happy Valley. The Nittany Lions won the game 31–10. The Irish ended the game with no rushing yards, and had only 144 total yards. They also amassed 97 yards in penalties.
Michigan With both teams starting the season 0–2, for the first time ever a combined 0–4, the Irish next faced the
Michigan Wolverines. Michigan played without their starting quarterback
Chad Henne due to a leg injury. Michigan senior running back
Mike Hart guaranteed a victory over the Irish. Quarterback Demetrius Jones did not board a bus for the trip to Michigan. Charlie Weis issued a statement saying, "At 2:30 today, while boarding the bus to Michigan, I was notified that Demetrius Jones had decided not to make the trip. I have not spoken to Demetrius and can only say that he missed the team bus. Any additional comment would be without all the facts." On game day, it was reported that he had enrolled at
Northern Illinois University, however, he later revealed that he was transferring to the
University of Cincinnati. Michigan won 38–0, tying their largest-ever win over Notre Dame set during the 2003 season. For only the second time in school history, Notre Dame opened the season with three losses.
Michigan State Despite scoring their first two offensive touchdowns of the season (the first resulting from a fumble by MSU's quarterback,
Brian Hoyer, at the 9-yard line), Notre Dame fell to
Michigan State 31–14. For the first time in 119 seasons of Notre Dame football, the Irish had started a season 0–4. Michigan State also became the first opponent to win six in a row at Notre Dame Stadium.
Purdue Despite outgaining the
Boilermakers in total yards (426–371) and Clausen throwing his first collegiate touchdown, the Irish fell to 0–5 on the season to Purdue by a score of 33–19. Down 23–0 at halftime, the Irish came out in the second half and drove to a 37-yard touchdown drive with Clausen's pass to John Carlson. Clausen left the game afterwards with an undisclosed injury. Evan Sharpley replaced him and threw his first collegiate touchdown in the fourth quarter and later threw another to put the Irish down by a touchdown, but they wouldn't score again. The Irish had much trouble in their kicking game with only one extra point made on three attempts and a blocked field goal.
UCLA UCLA was without its two starting quarterbacks. UCLA starter
Ben Olson went out with a knee injury late in the first quarter, which left freshman walkon redshirt
McLeod Bethel-Thompson to lead the Bruins. This was the first appearance for the Irish in the Rose Bowl stadium since the
1925 Rose Bowl. The Irish were able to capitalize on Bruin offensive mistakes to recover loose balls. This ended one of the worst slumps in Fighting Irish football, and prevented the Irish from equaling their longest losing streak in their history. The
1960 Notre Dame Fighting Irish football team lost eight straight games. The biggest cheer during the entire game came when the score of the
2007 Stanford vs. Southern California football game was announced. Fighting Irish and Bruins fans, who together are arch-rivals of the Trojans, cheered together.
Boston College In a battle between the two Catholic schools, the unbeaten Boston College Eagles and Heisman-hopeful
Matt Ryan faced off against the struggling Notre Dame Fighting Irish. Faced with constant blitzes from the Irish defense, Ryan used a short passing attack to lead the Eagles to a 20–0 lead early in the third quarter. Just as the game appeared headed for another blowout, Evan Sharpley, replacing an ineffective Jimmy Clausen, threw a touchdown pass to wide receiver Robby Parris followed by a pick six of Ryan during the next possession. With the score suddenly 20–14, the Eagles took advantage of good starting field position to answer with their own touchdown for the game's final score of 27–14.
USC In what was the largest margin victory the Trojans have put forth on the Irish to date, Notre Dame was shut out by USC for the first time since 1998. USC came into this game
5–1, while Notre Dame came in 1–6. Notre Dame head coach Charlie Weis announced during that summer that his team would wear throwback green jerseys for the matchup, signifying the 30-year anniversary of the Irish beating the Trojans in their green jerseys in 1977, when Weis was a senior at Notre Dame. Because of
John David Booty's injured finger, USC back-up quarterback,
Mark Sanchez, was the starter. In his second game as a starter, Sanchez managed to complete 21 of 38 passes with a combined total of 235 yards and 4 touchdown passes.
Navy Notre Dame came into the game with 43 consecutive wins against Navy since the last loss in 1963. In triple overtime, Navy (5–4) scored a touchdown and successful
two-point conversion on their possession. Notre Dame (1–8) likewise scored a touchdown, but failed to make their own two-point conversion on a rush attempt.
Air Force ESPN reported, "A week after the Midshipmen eked out a triple overtime victory against the Fighting Irish for the first time since 1963, Air Force beat Notre Dame 41–24 for its worst loss to a service academy since that Navy victory 44 years ago...It was the largest margin of victory for Air Force in six wins over the Irish and the biggest by a military academy since Navy beat the Irish 35–14 in 1963 behind
Roger Staubach."
Duke Notre Dame garnered its second win of the season in a game between what ESPN's
Lee Corso called the two worst teams in major college football. Notre Dame was led with three Jimmy Clausen touchdown passes of 25, 25 and 9 yards each.
Stanford The Irish concluded their season on a high note, winning its second straight game and its second win on the road. Robert Hughes ran for 136 yards and the go-ahead 6-yard touchdown with 6:06 remaining in the 4th quarter to help the Irish beat Stanford 21–14. Jimmy Clausen went 19–32 for 196 yards and one touchdown. The game was one of missed field goals, turnovers and controversial calls against the Irish. The Cardinal missed 4 field goals and turned the ball over twice. Notre Dame, meanwhile, committed 4 turnovers, including 3 fumbles and an interception. Notre Dame would have added a score in the 3rd quarter, but a touchdown pass from Clausen to David Grimes was overturned on inconclusive evidence, despite the ruling on the field of a touchdown. Notre Dame almost added another score on what would have been a spectacular finish to the half. David Bruton intercepted Stanford quarterback Tavita Pritchard's last-play heave at the 3-yard line and began a three-lateral return to the end zone that was called back on a personal foul on Notre Dame defensive lineman Trevor Laws. Safety Tom Zbikowski ran the final 30 yards after a lateral from Darrin Walls. ==Post season==