Schedule Note: Intra-division opponents are in
bold text.
Game summaries Week 1: vs. New York Jets With the defending Super Bowl champion
New England Patriots losing 42–27 to the
Kansas City Chiefs to kick off the 2017 NFL season and
Hurricane Irma delaying the game between the
Miami Dolphins and the
Tampa Bay Buccaneers to Week 11, the Bills hoped to take advantage and grab first place in the AFC East by beating the Jets, who swept them in 2016. Quarterback
Tyrod Taylor threw 1-yard touchdown passes to both tight end
Charles Clay and wide receiver
Andre Holmes, while fullback
Mike Tolbert rushed for a third touchdown. With Tolbert's score, the Bills recorded a rushing touchdown in 13 straight games, tying a team record set in
1980 and extending the longest active streak in the NFL. Safeties
Jordan Poyer and
Micah Hyde both got their first takeaways as Bills in the fourth quarter, with Hyde's interception ending any hope of a Jets rally. With the win, the Bills opened the season at 1–0 and in first place in the AFC East heading into their Week 2 matchup with head coach
Sean McDermott's former team, the
Carolina Panthers.
Week 2: at Carolina Panthers Looking for their first 2–0 start since
2014, the Bills traveled to
Bank of America Stadium for an inter-conference matchup with the Panthers. Many former Panthers players and personnel made their return to Carolina as members of the Bills, including fullback
Mike Tolbert, cornerback
Leonard Johnson, wide receiver
Kaelin Clay, general manager
Brandon Beane and head coach
Sean McDermott. Unfortunately, despite the defense sacking Panthers quarterback
Cam Newton six times and only allowing three field goals from
Graham Gano, the Bills offense could not take advantage, only managing a 45-yard field goal from
Steven Hauschka in the fourth quarter, the team's lowest points since losing 45–3 to the
San Francisco 49ers in 2012. A potential game-winning touchdown pass from quarterback
Tyrod Taylor to rookie WR
Zay Jones on 4th-and-11 with 9 seconds remaining sailed off Jones’ fingertips, putting the game away for the Panthers. The Bills fell to 1–1 with the loss.
Week 3: vs. Denver Broncos Following a close loss to the Panthers, the Bills returned home to host the
Denver Broncos. Despite running back
LeSean McCoy only amassing 21 rushing yards, the Bills still managed to score with quarterback
Tyrod Taylor passing for 213 yards and two touchdowns and kicker
Steven Hauschka kicking four field goals, including two from beyond 50 yards. The Bills defense intercepted quarterback
Trevor Siemian twice as the team won a close-fought game 26–16. An unsportsmanlike-conduct penalty against linebacker
Von Miller allowed the Bills to continue a stalled drive in the fourth quarter and ice the game with Hauschka's fourth field goal. With the win, the Bills improved to 2–1 heading into their Week 4 matchup against the defending NFC Champion
Atlanta Falcons. Prior to the game, several members of both teams knelt during the national anthem in the wake of President
Donald Trump's comments regarding NFL players who
protested.
Week 4: at Atlanta Falcons Looking to continue their winning ways after upsetting the Broncos the previous week, the Bills traveled to Atlanta to take on the
Atlanta Falcons, who made it to the Super Bowl the previous season, as fullback
Patrick DiMarco made his first return to Atlanta since signing with the Bills in free agency. The Bills defense held the Falcons in check for most of the game and tight end
Charles Clay recorded his first 100-yard receiving game since
2015. A key highlight was a fumble from Falcons quarterback
Matt Ryan that arguably looked like a forward pass, but was ruled a fumble and returned for a 52-yard touchdown by rookie cornerback
Tre'Davious White. With the win, the Bills improve to 3–1 for the first time since
2011 and regained sole possession of first place in the
AFC East with the Patriots losing 33–30 to the Panthers, but lost starting receiver
Jordan Matthews and starting linebacker
Ramon Humber to multi-week thumb injuries.
Week 5: at Cincinnati Bengals Looking to continue their winning ways after upsetting the Falcons the week prior, the Bills traveled down to Cincinnati to take on the
Bengals, who got their first win of the season when they defeated their rival
Cleveland Browns 31–7 the previous week. Already missing wideout Jordan Matthews, the Bills offense sputtered for the most part after tight end Charles Clay suffered a knee injury in the second quarter and was ruled out the rest of the game. The Bengals rallied behind strong performances from quarterback
Andy Dalton and receiver
A. J. Green despite the duo committing three turnovers, and won a close-fought game in the rain 20–16. With the loss, Buffalo fell to 3–2 going into their bye week.
Week 7: vs. Tampa Bay Buccaneers Fresh off their bye week, the Bills returned home to host the
Tampa Bay Buccaneers.
LeSean McCoy scored his first two touchdowns of the season as the Bills won a shootout match 30–27, with their final 10 points coming in the last three minutes of the game. With Tampa Bay taking the lead after forcing McCoy to fumble and capitalizing with a
Mike Evans touchdown pass from
Jameis Winston,
Tyrod Taylor led the Bills 75 yards downfield, connecting with newly signed receiver
Deonte Thompson for 44 yards to help set up McCoy's second touchdown.
Tre'Davious White then forced the Buccaneers to fumble on their ensuing drive, setting up
Steven Hauschka's game winning field goal. The Bills improve to 4–2 with the win. Note: Former Bills
Garrison Sanborn and
Ryan Fitzpatrick made their first return to
New Era Field since signing with the Buccaneers in free agency.
Week 8: vs. Oakland Raiders The Bills hosted the
Oakland Raiders in week 8. This was the first week they were without All-Pro defensive lineman
Marcell Dareus, who was traded to the Jacksonville Jaguars for a sixth-round draft pick just two days prior to the game. Nonetheless, the defense was still able to limit a potent Raiders offense to just 14 points, causing four turnovers in the process. LeSean McCoy led the team with over 180 yards from scrimmage and rookie linebacker
Matt Milano also scored off a fumble recovery. With the win, the Bills improved to 5–2 for the third time since 2008.
Week 9: at New York Jets Coming off the convincing win against Oakland, the Bills traveled to New York for a Thursday Night rematch against their division rivals, the
New York Jets. Though heavily favored to win, the Bills played poorly on defense and allowed the Jets to run for 194 yards and three rushing touchdowns. The offense surrendered three fumbles which ultimately influenced the course of the game, despite receivers
Zay Jones and
Deonte Thompson catching their first touchdowns as members of the Bills. With the loss, the Bills fell to 5–3.
Week 10: vs. New Orleans Saints For the second consecutive week, the Bills run defense under-performed, allowing 296 rushing yards and six rushing touchdowns against the
New Orleans Saints. To make matters worse, the offense was unable to stay on the field, attaining only five first downs and a field goal prior to rookie quarterback
Nathan Peterman replacing Tyrod Taylor late in the fourth quarter. With the blowout loss, the Bills fall to 5–4.
Week 11: at Los Angeles Chargers Nathan Peterman started in Tyrod Taylor's place. Peterman was benched at halftime after going 6 of 14 for 66 yards with 5 interceptions.
Week 12: at Kansas City Chiefs After consecutive weeks of playing bad defense, the Bills were finally able to rebound, holding
Kansas City to just 10 points as Tyrod Taylor returned to the starting lineup on offense. Tre'Davious White sealed the win for Buffalo in the fourth quarter with an interception off Chiefs quarterback
Alex Smith. With the win, the Bills snap their three-game losing streak and improve to 6–5.
Week 13: vs. New England Patriots Though Buffalo was able to hold the potent
New England Patriots offense to just nine first-half points, it was not enough to beat them, as the Patriots won 23–3. Multiple Bills starters were injured, including Tyrod Taylor and
Shaq Lawson. Perhaps the defining moment of the game occurred in the fourth quarter, when Tre'Davious White intercepted a pass intended for
Rob Gronkowski. Upset that no pass interference penalty was called on White, Gronkowski reacted by jumping elbow-first onto White, who was still on the ground. The play resulted in White landing on the concussion protocol and Gronkowski receiving a one-game suspension as a result of his actions.
Week 14: vs. Indianapolis Colts The game against Indianapolis, called the "
Snow Bowl" by the media, was notable for being held in the midst of a
lake-effect snow storm that left over a foot of snow on the stadium's turf. The heavy snow and strong winds caused severe complications, making it difficult for CBS to televise the game due to low visibility and prompting both teams to run the ball far more often and make more fourth-down conversion attempts than would otherwise have been attempted, since kicking the ball was less reliable. The amount of snow on the ground did prove to be an advantage for the punters, since the ball did not bounce upon landing, making precision
coffin corner punts easier. Nathan Peterman made his second start with Tyrod Taylor injured, and was able to post a respectable performance before leaving in the third quarter with a concussion. The low-scoring game went into overtime, and did not end until LeSean McCoy rushed for a touchdown with under two minutes to go in the extra period. The Bills improved to 7–6 with the win.
Week 15: vs. Miami Dolphins LeSean McCoy surpassed 10,000 rushing yards during the game, becoming just the 30th NFL running back to do so.
Week 16: at New England Patriots A play near the end of the second quarter proved to be particularly controversial. Receiver
Kelvin Benjamin caught a pass in the closing seconds of the second quarter that was initially ruled a touchdown by the on-field officials; however, the league's replay official,
Alberto Riveron, determined that Benjamin did not have control of the ball until after his foot left the turf and Riveron overturned the touchdown, forcing the Bills to settle for a field goal. Bills owner
Terrence Pegula indicated he would protest the decision. Though the first half was close, the Patriots outscored the Bills 24–3 in the second half, culminating in a 37–16 loss for Buffalo, and a 2–0 season sweep for New England.
Week 17: at Miami Dolphins The Bills started off the game up 10–0 by halftime and 19–0 by the time the Dolphins added a field goal. The Bills then fought off a comeback, including a fight that saw
Jarvis Landry and
Kenyan Drake get ejected. After a Miami touchdown that left them down six, history from the Bills–Dolphins game two weeks prior repeated itself: the Dolphins recovered an onside kick, then threw an interception with a minute to go to seal the game. With the win, Buffalo improved to 9–7, earning its first winning season since
2014. At the end of the game, the Bills were still waiting for the final outcome between the
Cincinnati Bengals and the
Baltimore Ravens to determine their fates for the season. With 49 seconds left in that game, Bengals quarterback
Andy Dalton threw a 49-yard go-ahead touchdown pass to
Tyler Boyd on a 4th-and-12 play to go up 31–27. The Ravens were unable to respond on the following drive, sealing the win for the Bengals. The Bengals' victory ended the Ravens season with a 9–7 record. This allowed the Bills, also 9–7, to enter the playoffs with the tiebreaker over the Ravens, thus reaching the postseason for the first time in 17 years. After the game, thousands of grateful Bills fans donated money to Dalton's personal charity. Most of the donations were in $17 increments in honor of the Bills breaking their 17-year playoff drought. In the first 72 hours after the game, over 11,000 people donated a combined over $250,000 to the Andy & Jordan Dalton Foundation, while Tyler Boyd's charity of choice, the Western Pennsylvania Youth Athletic Association, received $50,000 in donations from Bills fans. Relatedly, the Bills organization announced that they were sending
Buffalo wings from
Duff's Famous Wings to the Bengals organization, where they were consumed by residents of The Children's Home of Cincinnati. Retired punter
Brian Moorman, who punted for the Bills through most of the 17-year playoff drought, also saw an uptick in $17 donations to his charity, the P.U.N.T. Foundation, which has extensive operations in Western New York. As a result of Buffalo making it into the NFL playoffs for the first time since 1999, ending the longest active playoff drought in all of North American professional sports, the
Cleveland Browns then held the longest NFL postseason drought, 15 seasons at the time and eventually 17 seasons, until they reached the playoffs in
2020.
MLB's
Seattle Mariners then held the longest such drought in all North American sports at 17 seasons at the time, and eventually 21 years, until they reached the playoffs in
2022.
Standings Division Conference ==Postseason==