'' pollen Ragweed pollen is a common
allergen. A single plant may produce about a billion grains of pollen per season, and the pollen is transported on the wind. It causes about half of all cases of pollen-associated allergic rhinitis in North America, where ragweeds are most abundant and diverse. Concentration of ragweed pollen—in the absence of significant rainfall, which removes pollen from the air- is the lowest in the early morning hours (6:00 AM), when emissions starts. Pollen concentration peaks at midday. Ragweed pollen can remain airborne for days and travel great distances, and can even be carried out to sea. Eastern Europe, particularly
Hungary, has been badly affected by ragweed since the early 1990s, when the dismantling of Communist collective agriculture led to large-scale abandonment of agricultural land, and new building projects also resulted in disturbed, un-landscaped areas. The major allergenic compound in the pollen has been identified as
Amb a 1, a 38 k
Da nonglycosylated protein composed of two
subunits. It also contains other allergenic components, such as
profilin and
calcium-binding proteins. Ragweed allergy sufferers may show signs of
oral allergy syndrome, a food allergy classified by a cluster of allergic reactions in the mouth in response to the consumption of certain fruits, vegetables, and nuts. Foods commonly involved include
beans,
celery,
cumin,
hazelnuts,
kiwifruit,
parsley,
potatoes,
bananas,
melons,
cucumbers, and
zucchini. Because cooking usually
denatures the proteins that cause the reaction, the foods are more allergenic when eaten raw; exceptions are celery and nuts, which may not be safe even when cooked. Signs of reaction can include itching, burning, and swelling of the mouth and throat, runny eyes and nose,
hives, and, less commonly, vomiting, diarrhea,
asthma, and
anaphylaxis. These symptoms are due to the abnormal increase of IgE antibodies which attach to a type of immune cell called mast cells. When the ragweed antigen then attaches to these antibodies the mast cells release histamine and other symptom-evoking chemicals.
Merck & Co, under license from
allergy immunotherapy (AIT) company
ALK, has launched a ragweed allergy immunotherapy treatment in sublingual tablet form in the US and Canada. As of 2006, research into allergy immunotherapy treatment involved administering doses of the allergen to accustom the body to induce specific long-term tolerance. ==Control and eradication==