Prinsloo debuted as a Prada/Miu Miu Exclusive. Soon after, Juergen Teller photographed her for her debut ad campaign, Marc by
Marc Jacobs, and
David Sims for
W Magazine. Prinsloo has walked in fashion shows for
Alexander Wang,
Louis Vuitton,
Miu Miu,
Versace, and other brands. She has been on the covers of
Vogue Spain,
Vogue Turkey,
Vogue Brasil,
Vogue Mexico,
Vogue Russia,
Vogue Thailand,
Elle France,
Elle Spain,
Elle Italia,
Elle Sweden, ''
L'Officiel Netherlands
, Marie Claire Greece
, Marie Claire South Africa
, i-D Magazine, V Magazine, Russh Magazine, 10 Magazine, The Edit
, Jalouse, and So It Goes Magazine''. Her ad campaigns include I Love Juicy Couture Fragrance, I Am Juicy Couture Fragrance, Juicy Couture Black Label, Tommy Hilfiger, Alexander Wang 'Do Something', T by Alexander Wang, Marc by Marc Jacobs,
Nina Ricci,
The Gap,
Aquascutum,
M Missoni,
Sportmax,
DKNY Jeans,
Pepe Jeans, Lancaster, Stefanel,
Esprit,
Lacoste,
Desigual,
Seafolly,
Nine West, and Raw Spirit Fragrance. In 2010, Prinsloo designed "Behati Loves Pink" swimsuit capsule collection for Victoria's Secret. In 2014, she designed a line of denim for THVM. Most recently, she designed a fashion and accessories collection for Juicy Couture. Models.com ranks Prinsloo on their lists of 'The Top Sexiest Models' as well as their list of 'The Money Girls'. The night before the 4 December 2012 airing of the annual
Victoria's Secret Fashion Show, Prinsloo and fellow
Victoria's Secret models
Jacquelyn Jablonski and
Jasmine Tookes guest starred on the 3 December "Ha'awe Make Loa" episode of CBS'
Hawaii Five-0 playing themselves. In June 2014, Prinsloo made a cameo appearance in a preview of
Missy Elliott protégée
Sharaya J's "Shut It Down" via a
T by Alexander Wang campaign. Prinsloo appeared in various music videos such as
The Virgins' "
Rich Girls" and
Maroon 5's "
Animals", "
Girls Like You", and "All Night". After taking a two-year hiatus from the Victoria's Secret Fashion show, Prinsloo returned to walk in the brand's 2018 show. Prinsloo was among the models and celebrities who made appearances modeling lingerie at
Rihanna's
Savage x Fenty Vol. 3 fashion show in 2021. ==Philanthropy==