(early second millennium ) Before the ancient Romans and Greeks (about 2612
BCE), older representations from Syria and India of sticks and animals looking like serpents or worms are interpreted by some as a direct representation of traditional treatment of
dracunculiasis, the
Guinea worm disease. While there is ample historical evidence of the use of the Caduceus, or Herald's Staff, to represent
Hermes or
Mercury (and by extension commerce and negotiation), early evidence of any symbolic association between the Caduceus and medicine or medical practice is scarce and ambiguous. It is likely linked to the alchemical "universal solvent",
Azoth, the symbol of which was the caduceus. The
Guildhall Museum in London holds a 3rd-century
oculist's seal with Caduceus symbols both top and bottom. The seal was apparently used to mark preparations of eye medicine. It is believed likely that rather than being evidence of a medical association
per se, this is rather an allusion to the words of the Greek poet
Homer who described the Caduceus as "possessing the ability to charm the eyes of men", which relates to the business of an oculist. [...] although these various factors may link Hermes/Mercury, along with his Caduceus, with alchemical medicine, they may just as well link all the other non-medical aspects of alchemy with Hermes/Mercury and the Caduceus". Despite a long tradition of (the tendency of the ancient Greeks to identify foreign deities with their own gods), determination of the equivalence of deities is a complex matter. The role of Hermes in the afterlife was limited to guiding souls of the deceased, whereas the powerful
Egyptian god Thoth was truly lord of the underworld and master of death. Together with
Osiris, he presided over the panel of forty-two divine judges that assessed the souls of the deceased for reward or punishment in the afterlife. Thoth was at times depicted with two staves encircled by one cobra each, which might well have influenced the iconography of Hermes' caduceus. However, in ancient Egypt the snake staff represented the attribute of a powerful sorcerer, not a merchant or messenger. Compared to Hermes, Thoth was associated much more with magic and with potent actions preserving balance in the divine world, than with the unpredictable whims of a trickster deity.
Depictions similar to the caduceus also occurred in bronze age
Mesopotamia as devotional emblems for various
major or minor deities, or as snakes embodying the deity itself. Ancient examples of attributes similar to the caduceus, or to aspects of Hermes' portfolio of divine roles, include the Sumerian messenger and snake god
Nirah, the occasional depictions of the major goddess
Innana holding a scepter with two winding snakes (which lacked the wings of a caduceus), and the benevolent Egyptian goddess
Wadjet who was often depicted as a winged cobra. If the caduceus was inspired by and adapted from an amalgam of serpent depictions in other cultures, probably with changes in explanatory myths and divine prerogatives, then Greek mythology might well have created an exaggerated impression that the origins of the caduceus were entirely separate from those of the rod of asclepius. From the perspectives of ethnography and literary history, their cultural and iconographic origins were probably deeply entwined as part of the complex and artistically fluid history of
snakes as deities or as divine symbols for healing, magic and protective rituals. == Medieval times ==