2020–21: Freshman season Clark entered her freshman season as Iowa's starting
point guard. She assumed a leading role alongside starting
center Monika Czinano; the duo was nicknamed "
The Law Firm" by analyst
Christy Winters-Scott. On November 25, 2020, she made her collegiate debut, recording 27 points, eight rebounds, and four assists in a 96–81 win over
Northern Iowa. In her second game, on December 2, she posted her first
double-double with 30 points and 13 assists in a 103–97 victory over
Drake. On December 22, in a 92–65 victory over
Western Illinois, she registered the first
triple-double by an Iowa player since
Samantha Logic did so in 2015. Despite shooting 3-of-15 from the field, Clark had 13 points, 13 rebounds, and 10 assists during the game. On January 6, 2021, she recorded 37 points, 11 rebounds and four assists in a 92–79 win against
Minnesota. Clark posted a season-high 39 points, 10 rebounds and seven assists in an 88–81 win over
Nebraska on February 11, breaking the single-game scoring record for
Pinnacle Bank Arena, the home venue of Nebraska. On February 28, she scored 18 points and had a season-high 14 assists in an 84–70 win over
Wisconsin. At the end of the regular season, Clark was a unanimous
Big Ten Freshman of the Year and first-team All-Big Ten selection. She was a 13-time Big Ten Freshman of the Week, setting a conference record, and led the Big Ten with five Player of the Week awards. Clark helped Iowa achieve a runner-up finish at the
Big Ten tournament, where she was named to the all-tournament team and recorded 37 assists, the most in the event's history. In the second round of the
NCAA tournament, she posted 35 points, seven rebounds and six assists in an 86–72 win over
Kentucky. She broke program single-game records for points and three-pointers (6) in the tournament. Iowa reached the Sweet 16, where Clark scored 21 points in a 92–72 loss to first-seeded
UConn. She was named a first-team
All-American by the
United States Basketball Writers Association (USBWA), a second-team All-American by the
Associated Press (AP) and made the
Women's Basketball Coaches Association (WBCA) Coaches' All-America team. Clark became the first freshman to win the
Dawn Staley Award, which honors the best Division I
guard. She shared two major Division I freshman of the year awards with
Paige Bueckers of
UConn: the
Tamika Catchings Award, presented by the USBWA, and the
WBCA Freshman of the Year award. As a freshman, Clark averaged 26.6 points, 7.1 assists, and 5.9 rebounds per game. She led the
NCAA Division I in scoring and ranked second in assists and three-pointers per game. Her totals in points, assists,
field goals and three-pointers also led Division I. She set program freshman records for points and assists and had the fourth-highest scoring average in Iowa history. On January 2, 2022, she posted 44 points and eight assists in a 93–56 win over
Evansville. Clark broke the
Carver–Hawkeye Arena women's single-game scoring record and surpassed
Kelsey Mitchell of
Ohio State as the fastest Big Ten player to reach 1,000 career points. On January 16, 2022, she recorded her fourth career triple-double, with 31 points, 10 rebounds and 10 assists in a 93–83 victory over
Nebraska. In her next game, four days later, Clark posted 35 points, 13 rebounds and 11 assists in a 105–49 win over Minnesota. She became the first Division I men's or women's player to record consecutive triple-doubles with at least 30 points and the first women's player in Big Ten history with consecutive triple-doubles. On January 25, Clark had 18 assists, which set program and tied conference single-game records, in addition to 20 points and seven rebounds in a 107–79 win against
Penn State. On February 6, Clark scored a season-high 46 points, including 25 in the fourth quarter, and had 10 assists in a 98–90 loss to
Michigan. She set the women's single-game scoring record for
Crisler Center, the home arena of Michigan. After leading Iowa to a share of the Big Ten regular season title, she was unanimously named
Big Ten Player of the Year and first-team All-Big Ten by the league's coaches and media. On March 5, 2022, in the semifinals of the
Big Ten tournament, Clark recorded 41 points and nine rebounds in an 83–66 win over Nebraska. She led Iowa to the title and was named the tournament's most outstanding player (MOP). She was a unanimous first-team All-American: she earned first-team All-American honors from the AP and the USBWA, and was a WBCA Coaches' All-America Team selection. For her sophomore year, she was named a first-team
Division I Academic All-American by the College Sports Information Directors of America, since renamed
College Sports Communicators (CSC). Clark became the first back-to-back recipient of the Dawn Staley Award and won the
Nancy Lieberman Award as the top Division I point guard. As a sophomore, she averaged 27 points, eight rebounds and eight assists per game. Clark was the first women's player to lead Division I in points and assists per game in a single season. She also led Division I in total points,
free throws and triple-doubles. On November 18, 2022, she suffered an ankle injury with 3.8 seconds left in an 84–83 loss to
Kansas State, where she recorded 27 points, 10 rebounds and seven assists. She played in Iowa's next game against
Belmont on November 20, scoring 33 points in a 73–62 victory. On December 1, she scored a season-high 45 points in a 94–81 loss to
NC State. Three days later, Clark posted her seventh career triple-double, with 22 points, 10 rebounds and 10 assists in a 102–71 win over
Wisconsin. She surpassed Samantha Logic as the Big Ten career leader in triple-doubles. On December 21, in her 75th game, Clark tied
Elena Delle Donne of
Delaware as the fastest Division I women's player to reach 2,000 career points since the 1999–2000 season, scoring 20 points in a 92–54 win over
Dartmouth. On January 23, 2023, Clark recorded 28 points, 15 assists and 10 rebounds in an 83–72 win over
AP No. 2 Ohio State, who were previously unbeaten. On February 2, she had 42 points, eight assists and seven rebounds in a 96–82 victory over
Maryland. On February 26, Clark recorded 34 points, nine rebounds and nine assists, making a game-winning three-pointer at the buzzer, in an 86–85 win against AP No. 2 Indiana. At the end of the regular season, she repeated as Big Ten Player of the Year in a unanimous vote and was named first-team All-Big Ten by the league's coaches and media. at the
2023 Big Ten tournament|alt=Clark handles the ball for Iowa Clark led Iowa to its second consecutive
Big Ten tournament championship, where she earned MOP honors. In the title game, she recorded 30 points, 17 assists and 10 rebounds in a 105–72 win over Ohio State, the first triple-double in the final of the tournament. She moved to second in Division I women's history behind
Sabrina Ionescu of
Oregon with her tenth career triple-double. In the Elite Eight of the
NCAA tournament, she recorded 41 points, 12 assists and 10 rebounds in a 97–83 win over
Louisville. She became the first player in men's or women's tournament history to record a 30 or 40-point triple-double. During the game, Clark became the first Division I player to record at least 900 points and 300 assists in a single season. For her performance, Clark was named the Seattle 4 Regional Most Outstanding Player and to the regional all-tournament team as Iowa reached its first Final Four since
1993. In the Final Four, she posted 41 points, eight assists, and six rebounds in a 77–73 upset win over undefeated defending champion
South Carolina, ending their 42-game winning streak. Clark also surpassed the program and Big Ten single-season scoring records held by
Megan Gustafson. With the win, Iowa advanced to their first women's basketball championship game in program history. Though Clark had 30 points and eight assists against
LSU in the
national championship, Iowa lost the game, 102–85. She made eight three-pointers, the most by a men's or women's player in the title game. Near the end of the game, LSU star
Angel Reese followed Clark, making a "
you can't see me" gesture implying that Clark could not keep up with her, and also pointing to her ring finger in reference to LSU's imminent
championship ring. Reese received considerable criticism for the gestures, which many in the media viewed as
unsportsmanlike. However, many also defended Reese's gestures and
trash talk, highlighting a double standard, as Clark had made the same gesture at a previous game and did not face similar criticism. Clark herself defended Reese over criticism about the gesture. In coverage of this incident, journalists and the public have commented on the roles of race and gender in perceptions of sportsmanship. The incident has also been described as the origin of a
rivalry between Clark and Reese. With 191 points in the tournament, Clark broke the men's and women's scoring records for a single NCAA tournament. Her 60 assists were the most by a player in women's tournament history. Clark won the Nancy Lieberman Award for a second time and became the first three-time winner of the Dawn Staley Award. She was a unanimous first-team All-American for a second straight season, earning first-team recognition from the AP and USBWA and making the WBCA Coaches' All-America Team. Clark was again honored by the CSC as the 2023 Division I
Women's Basketball Academic All-American of the Year, before winning the same award for all Division I sports in 2023. As a junior, Clark averaged 27.8 points, 8.6 assists and 7.1 rebounds per game, leading Division I in assists and ranking second in scoring. She set Big Ten single-season records in points, assists, three-pointers and free throws, and tied her own conference record with five triple-doubles. Following the season, Clark won the
Best Female College Athlete ESPY Award and the
Honda Cup, both honoring the top women's college athlete, and the
James E. Sullivan Award, presented annually by the AAU to the top college or Olympic athlete in the United States. She was selected as the
Big Ten Female Athlete of the Year.
2023–24: Senior season with
Gabbie Marshall in 2023|alt=Clark on the sidelines with her Iowa teammates Entering her senior season, Clark was named preseason Big Ten Player of the Year and earned unanimous AP preseason All-American honors. On October 15, 2023, she played in
Crossover at Kinnick, a preseason
exhibition game against
DePaul at
Kinnick Stadium, and had a triple-double of 34 points, 11 rebounds and 10 assists in a 94–72 win. The game had an attendance of 55,646, which set the women's basketball record. In her second regular season game, on November 9, Clark posted 44 points, eight rebounds and six assists in an 80–76 win over AP No. 8
Virginia Tech. In Iowa's third game, a 94–53 blowout of Northern Iowa on November 12, Clark recorded her 12th career triple-double, with 24 points, 11 assists and 10 rebounds. She became Iowa's all-time leading scorer, passing Megan Gustafson, and became only the second player in Division I history with a triple-double in four different seasons, joining Ionescu. One week later, she recorded 35 points, 10 assists, six rebounds and seven steals in a 113–90 win over Drake, passing
Kelsey Plum of
Washington for the most 30-point games in women's Division I history. On December 6, 2023, Clark became the 15th Division I player to reach 3,000 career points and was the second-fastest to reach the mark, posting 35 points, nine rebounds and five assists in a 67–58 victory over Iowa State. On December 16, she scored 38 points and made nine three-pointers in a 104–75 win over
Cleveland State. Three days later, she shared
Sporting News Athlete of the Year honors with Angel Reese. Later that week, Clark was announced as the runner-up to gymnast
Simone Biles for the
AP Female Athlete of the Year award. On December 21, in Iowa's final non-conference game, she recorded a triple-double of 35 points, 17 rebounds, and 10 assists in the Hawkeyes' 98–69 win over
Loyola Chicago. In her next game, on December 30, Clark posted 35 points and 10 assists in a 94–71 victory against Minnesota, surpassing
Samantha Prahalis of Ohio State to become the Big Ten's all-time leader in assists. During the game, she also eclipsed Samantha Logic's mark for the program record in the same category. On January 2, 2024, Clark scored 40 points and made a long, game-winning three-pointer as time expired in a 76–73 win over
Michigan State. Three days later, she posted 29 points, 10 rebounds and 10 assists in a 103–69 win over
Rutgers. On January 8, Clark was named Big Ten Player of the Week for the 24th time in her career, breaking the conference record held by Gustafson. In her following game, she registered her second consecutive triple-double, with 26 points, 10 rebounds and 10 assists in a 96–71 victory against
Purdue. On January 21, Clark recorded 45 points and seven assists in a 100–92 overtime loss to AP No. 18 Ohio State. After the game, as Ohio State fans were
rushing the court, she was knocked down in a collision with a fan but did not suffer an injury, despite initially appearing to be in pain. final On January 31, 2024, Clark posted 35 points and 10 assists in a 110–74 win over
Northwestern, breaking the Big Ten all-time scoring record held by Kelsey Mitchell of Ohio State. In February,
Fox began devoting a camera, called the "Caitlin Cam", to record Clark during its broadcasts of Iowa games and to stream on
TikTok. She became the sixth Division I women's player with 1,000 career assists during the Hawkeyes' 82–79 loss at
Nebraska on February 11, where she tallied 31 points, 10 assists and eight rebounds. On February 15, Clark became the
NCAA Division I women's career scoring leader, surpassing Kelsey Plum, during a 106–89 win over Michigan. She finished the game with a career-high 49 points, 13 assists and five rebounds, eclipsing Gustafson for the program single-game scoring record. Between her points and assists, Clark was responsible for 79 of her team's points, the most by any Division I women's player in at least 25 seasons. On February 28, Clark passed
Lynette Woodard, who played for
Kansas in the era when the
Association of Intercollegiate Athletics for Women governed women's college sports, to become the all-time leader in points among major women's college players. During the game, she posted her second straight triple-double, with 33 points, 12 assists and 10 rebounds, leading the Hawkeyes to a 108–60 win over Minnesota. She also set the Big Ten career record for three-pointers, surpassing Kelsey Mitchell, and the NCAA single-season record in the same category, previously held by Taylor Pierce of
Idaho. In her final regular season game, on March 3, Clark became the NCAA Division I all-time leading scorer among men's or women's players, eclipsing
Pete Maravich, who had set the men's scoring record in three seasons with
LSU. She tallied 35 points, nine assists and six rebounds in a 93–83 win over AP No. 2 Ohio State. She finished the regular season as the unanimous Big Ten Player of the Year and earned first-team All-Big Ten honors from the league's coaches and media. During the Hawkeyes' quarterfinal win over
Penn State at the
2024 Big Ten tournament, Clark surpassed
Stephen Curry of
Davidson and
Darius McGhee of
Liberty for the most three-pointers in a single season by any Division I player regardless of gender. In a semifinal win over Michigan, she became the first Division I women's player to score at least 1,000 points in two different seasons and passed Mitchell as the career leading scorer in the
Big Ten tournament. Clark led Iowa to its third straight Big Ten tournament title and was named MOP after recording 34 points, 12 assists and seven rebounds in a 94–89 overtime win over Nebraska in the final. In the second round of the
NCAA tournament, Clark scored 32 points and surpassed Kelsey Plum for the most points in a single season in Division I women's history, leading Iowa to a 64–54 win over
West Virginia. The Elite Eight saw a rematch of the
2023 national championship game against
LSU, where Clark had 41 points, 12 assists and seven rebounds in a 94–87 victory, leading the Hawkeyes to their second straight Final Four and a school-record 33 wins and being named Albany 2 Regional MOP. Her nine three-pointers tied the most by a player in an NCAA tournament game. She surpassed Taylor Robertson's record of 537, set in five seasons at
Oklahoma, to become the all-time Division I leader in three-pointers. Clark also broke NCAA tournament career marks in assists and three-pointers, held by
Temeka Johnson of LSU and
Diana Taurasi of UConn, respectively. In the Final Four, she posted 21 points, nine rebounds and seven assists in a 71–69 win over
UConn, as Iowa reached the
national championship game for a second consecutive season. Clark had 30 points, eight rebounds and five assists in an 87–75 loss to South Carolina, the number one overall seed, in the title game. She scored 18 points in the first quarter, the most by a player in a single period in championship game history. She also surpassed
Chamique Holdsclaw of
Tennessee for the NCAA tournament career scoring record. Clark was named national player of the year for her second straight season, receiving AP Player of the Year, the Honda Sports Award, the John R. Wooden Award, Naismith College Player of the Year, USBWA National Player of the Year and the Wade Trophy. For a third time, she won the Nancy Lieberman Award as the top Division I point guard and was named a unanimous first-team All-American. At the end of her senior year, Clark again was named the CSC's Division I Academic All-American of the Year in both women's basketball and all sports, completing her college career with a 3.64 GPA. In her senior season, Clark averaged 31.6 points, 8.9 assists and 7.4 rebounds per game, leading Division I in scoring and assists. She finished with the highest career scoring average (28.42) in Division I history, passing
Patricia Hoskins of
Mississippi Valley State. Clark left Iowa with the most career points (3,951) and three-pointers (548), the second-most triple-doubles (17) and the third-most assists (1,144) in Division I history. For a second straight season, Clark won the Honda Cup and the James E. Sullivan Award, becoming the first two-time winner in the Sullivan Award's 94-year history. She also became the third athlete to repeat as Big Ten Female Athlete of the Year. In June 2024, Clark was nominated for three
ESPY Awards. At the
2024 ESPY Awards held on July 11, 2024, Clark won the
Best Female College Athlete ESPY Award for a second time, became the first female athlete to win the
Best Record-Breaking Performance ESPY Award, but lost out on the
Best Female Athlete ESPY Award to two-time
WNBA MVP and two-time
WNBA champion,
A'ja Wilson. On February 29, 2024, Clark announced that she would declare for the
2024 WNBA draft, forgoing her fifth season of eligibility, which was granted to all players during the
2020–21 season due to the
COVID-19 pandemic. She was projected to be the
first overall pick in the
2024 WNBA draft by many publications, including
ESPN,
USA Today and
CBS Sports. Following the conclusion of Clark's senior season, it was announced that Iowa would
retire her jersey number, making her the third player in program history to receive the honor. On February 2, 2025, following the
Hawkeyes' win over No. 4
USC, Clark's
No. 22 jersey was retired by the University of Iowa. In October 2025, the
Associated Press selected Clark as one of the greatest collegiate players in the women’s poll era alongside
Cheryl Miller,
Diana Taurasi,
Candace Parker, and
Breanna Stewart as the starting five players. ==Professional career==