Cast table Main cast The five characters who are first introduced in the
series premiere as surgical interns are Meredith Grey, Cristina Yang, Izzie Stevens, Alex Karev, and George O'Malley. They are initially mentored by Dr. Miranda Bailey, a senior resident who becomes the hospital's Chief Resident, and later an attending
general surgeon, in Season 6. The surgical program is initially headed by Richard Webber, the Chief of Surgery, who has a pre-existing personal relationship with Meredith, having had an
affair with her mother, famed general surgeon Ellis Grey, when Meredith was a child. In Webber's employ are attending neurosurgeon Derek Shepherd, dubbed 'McDreamy' by the residents, and attending cardiothoracic surgeon Preston Burke. Shepherd is introduced as Meredith's love-interest, while Burke begins a relationship with Cristina. Introduced in the show's
second season are
obstetrician-gynecologist and
neonatal surgeon, Addison Montgomery,
plastic and
ENT surgeon Mark Sloan (nicknamed 'McSteamy' by the interns), from New York, and
orthopedic surgeon Callie Torres. Montgomery is Shepherd's estranged wife who arrives in Seattle seeking reconciliation with him, Sloan is Shepherd's former best friend, who aided the breakdown of his marriage by having an affair with Montgomery, while Torres is introduced as a love-interest, and eventual wife for O'Malley. The penultimate episode of
Season 3 introduces Lexie Grey, Meredith's half-sister who unexpectedly decides to pursue her internship at Seattle Grace Hospital after her mother's sudden death, and begins an
on-again, off-again relationship with Sloan. Burke and Yang, having been engaged, endeavor to plan their wedding, while Montgomery departs the show in the
Season 3 finale, relocating to California, seeking a new life, thus becoming the lead character of the spin-off
Private Practice. The Season 3 finale also shows Burke's exit from the show, after leaving Yang at the
altar on their
wedding day. Grey, Yang, Stevens, and Karev are all promoted to residents in the
Season 4 premiere, while O'Malley is forced to repeat his internship year, following his failing of the intern exam. Early in the
fourth season, cardiothoracic surgeon Erica Hahn becomes Torres's love-interest. During the
fifth season, Hahn departs from the series after a disagreement with Torres, and O'Malley retakes his intern exam, passes and joins his fellow physicians as a resident. Two new characters are introduced, former United States Army
trauma surgeon Dr. Owen Hunt, and
pediatric surgeon Dr. Arizona Robbins. Hunt becomes a love-interest for Yang, while Robbins begins a relationship with Torres. When Stevens is diagnosed with
Stage 4 metastatic melanoma, she and Karev
get married at the conclusion of the fifth season. In addition, Meredith and Shepherd marry, with their vows written on a blue
post-it note. O'Malley dies in the
Season 6 premiere, due to injuries sustained from saving a woman from being hit by a bus, New characters are introduced as Seattle Grace Hospital merges with Mercy West Hospital. Residents April Kepner and Jackson Avery transfer to Seattle Grace Hospital from Mercy West Hospital, and Avery has a brief relationship with Lexie, until she reunites with Sloan. Subsequently, Teddy Altman is introduced as the new Chief of Cardiothoracic Surgery. Ben Warren is also introduced in the
sixth season, who becomes a romantic interest for Bailey throughout the series, eventually marrying her. In the
Season 6 finale, a deceased patient's grieving husband embarks on a shooting spree at the hospital, injuring Karev, Shepherd, and Hunt. In the shooting's emotional reverberations, Yang and Hunt abruptly marry, not wanting to risk separation. Torres and Robbins eventually wed, in
Season 7, officiated by Bailey. As the final year of residency for Meredith, Yang, Karev, Kepner and Avery is coming to a close, the doctors are all planning to relocate to different hospitals to pursue their specialty careers. However, all plans are put on hold when several doctors from Seattle Grace Mercy West Hospital are engaged in a plane crash, which kills Lexie and endangers Meredith, Shepherd, Yang, Sloan and Robbins in the
Season 8 finale. The season finale also sees Altman being courteously fired by Hunt as she struggles to decide whether or not to take the job as Chief at the
United States Army Medical Command (MEDCOM). The doctors who were on the plane win the lawsuit, but the payout bankrupts the hospital. They all club together and buy Seattle Grace Mercy West, with the help of the Harper Avery Foundation, and they become the Board of Directors, once being called the "Grey-Sloan 7". One of the changes they implement is renaming the hospital to Grey Sloan Memorial Hospital in memory of Lexie Grey and Mark Sloan. Robbins cheats on Torres with a visiting
facial reconstruction surgeon and Webber gets electrocuted in the
Season 9 finale, although survives the incident. ''Grey's Anatomy
saw the departure of one of its major players, Cristina Yang, played by Sandra Oh, as well as the departure of interns Murphy and Ross, in the Season 10 finale. Amelia Shepherd, the sister of Derek, joined the main cast in Season 11, transitioning over from being a main character of the spin-off series, Private Practice'' which had recently ended. The 11th season also saw the introduction of the new Chief of Cardiothoracic Surgery, Maggie Pierce, Richard's secret daughter with Ellis Grey. Towards the end of the 11th season, Derek Shepherd witnesses a car accident and pulls over to help the injured, but his car is hit by a truck with him inside as he attempts to leave the scene. He
later dies at another hospital following the doctors' mishandling of his injuries.
Season 12 saw Andrew DeLuca join the main cast as a new intern at the hospital, as well as Nathan Riggs as a new cardiothoracic surgeon with a pre-existing off-screen history with Hunt. The
Season 12 finale saw the departure of one of the show's longest-running characters, Callie Torres, played by Sara Ramirez. Edwards departed at the end of
Season 13, deciding to quit her job as a surgeon after surviving a major fire at the hospital. Riggs departed and Altman returned to Seattle toward the beginning of
Season 14. The fourteenth season also saw the introduction of Tom Koracick who worked as a new neurosurgeon alongside Amelia Shepherd, Levi Schmitt who is a new intern at the hospital, as well as Andrew's sister, Carina DeLuca, an obstetrician who enters into a relationship with Robbins. During the fourteenth season, Warren transitions out to become a main character of the series' second spin-off,
Station 19, after his character decides to quit working at the hospital to become a firefighter. Carina DeLuca eventually joins him as a main character of that spin-off series. Long-time characters, Robbins and Kepner depart the series in the
Season 14 finale to pursue other career opportunities.
Season 15 saw the introduction of Atticus "Link" Lincoln, as a new orthopedic surgeon, while
Season 16 saw the introduction of Cormac Hayes, a new pediatric surgeon, and Winston Ndugu, a new cardiothoracic surgeon. The sixteenth season was the last to feature Alex Karev, who moved to
Kansas to reunite with Stevens, leaving Grey as the last remaining intern from the original cast.
Season 17 saw Nick Marsh, a transplant surgeon, join the ensemble of main characters as a new romantic interest for Meredith Grey. The seventeenth season also saw the departure of Andrew DeLuca, after he was stabbed and ultimately died after pursuing a sex trafficker, and was also the last season to feature both Jackson Avery, who moved to
Boston in order to run a family foundation and Koracick, who also moved to Boston to assist Avery, as main characters. Hayes departed the series in
Season 18 after deciding to return to
Ireland with his kids.
Season 19 saw the introduction of five new interns with Simone Griffith, Mika Yasuda, Benson Kwan, Jules Millin and Lucas Adams, the latter of which is revealed to be a nephew of Amelia and Derek Shepherd. Meredith Grey, one of the last remaining original characters of the series, as well as Pierce, both depart Seattle during the course of
Season 19 and appear in recurring and guest capacities afterwards, respectively. Yasuda and Schmitt depart in season 21, with Schmitt moving to Texas for his ped's fellowship and Yasuda quits the program following her sister's death.
Recurring With the drama's setting being a hospital, numerous medical personnel appear regularly on the show, as well as several other recurring characters. Joe (
Steven W. Bailey) is first shown as the owner of the Emerald City Bar and Grill, across the street from the hospital, which is a common relaxation area for the physicians. who makes frequent appearances on ''Grey's Anatomy'', until their divorce in season 5. and makes occasional appearances until the fifth season. with Susan making appearances until her death in season 3, and Thatcher continuing to appear in the series until his death in season 15. Adele Webber (
Loretta Devine), is introduced as Richard's wife, who eventually acquires Alzheimer's, in the seventh season, and continued to make appearances until her death in season 9. Introduced as Preston's mother, Jane Burke (
Diahann Carroll) makes occasional appearances until the fourth season.
Denny Duquette (
Jeffrey Dean Morgan), a patient with
congestive heart failure, originates as one of Burke's patients, who goes on to propose to Stevens, after weeks of bonding between the two. Facing death, Stevens cuts Duquette's
left ventricular assist device (LVAD), to elevate his position on the
United Network for Organ Sharing (UNOS) transplant list. This ultimately ends in his death in the
season 2 finale, marking his initial departure from the show, Initially conceived as a veterinarian hired for Shepherd's dog, Doc, Dandridge is included in a multi-episode story arc in seasons 2 and 3, consisting of 9 episodes, ending when Meredith reunites with Shepherd. 's character was introduced in the
third season and was promoted to series regular in
season 4.|alt= A photo of Chyler Leigh In season 3, George's father, Harold O'Malley (
George Dzundza), is diagnosed with cancer and dies, with his wife Louise (
Debra Monk) and George's brothers Jerry (
Greg Pitts) and Ronny (
Tim Griffin) by his side. Louise goes on to appear occasionally, and was last seen in season 8. A ferryboat accident brings along Rebecca Pope (
Elizabeth Reaser), who is initially introduced as a pregnant
amnesiac
Jane Doe patient. Pope eventually embarks on a relationship with Karev, until she is diagnosed with a personality disorder in season 4, and makes her final departure. Within the limbo, Meredith is entertained by deceased acquaintances Duquette and Dylan Young (
Kyle Chandler), who was killed during a bomb crisis in the second season, until eventually being resuscitated. Seeking a cure to her depression, Meredith undergoes therapy sessions with the hospital psychiatrist, Dr. Katharine Wyatt (
Amy Madigan), who in addition serves as a psychiatrist to Hunt. The season 4 premiere introduces several new interns, to be trained under Meredith, Yang, Stevens, Karev, and eventually O'Malley. Among them are Dr. Steve Mostow (
Mark Saul), who continues to make appearances, Harris is fired in the fifth season, due to not actually having a
medical degree, and departs the show immediately after. and once she is lucid, he departs, marking his final appearance. but eventually accepts it, The hospital's merging with Mercy West introduces new residents: Dr. Reed Adamson (
Nora Zehetner) and Dr. Charles Percy (
Robert Baker), and eventual husband to Dr. Miranda Bailey, While in Malawi, Robbins is replaced by Dr. Robert Stark (
Peter MacNicol), a pediatric surgeon with an interest in Dr. April Kepner, who appears occasionally until season 8. Following the breakdown of Dr. Torres's relationship with Dr. Robbins, Dr. Torres becomes pregnant with Dr. Sloan's baby. Torres's relationship with Robbins is subsequently mended, and the couple endeavors to raise their new daughter, Sofia Robbin Sloan Torres, with the help of Dr. Sloan. Dr. Lucy Fields (
Rachael Taylor), an obstetrician-gynecologist, is introduced in the seventh season, and serves as a love-interest for Dr. Alex Karev, until eventually taking up Robbins' job in Africa. Shepherd and Meredith also become new parents, with their adoption of Zola, a baby girl from Malawi. until he dies while undergoing heart surgery in season 8. Dr Catherine Avery (played by Debbie Allen), a urologist, is introduced in the show's eighth season and subsequently makes recurring appearances in all subsequent seasons thus far. Her character becomes a romantic interest for Dr Richard Webber, and eventually his second wife following the death of his first wife, Adele. In the season 9 premiere, interns Dr. Jo Wilson (
Camilla Luddington), Dr. Shane Ross (
Gaius Charles), Dr. Stephanie Edwards (
Jerrika Hinton), Dr. Leah Murphy (
Tessa Ferrer) and Dr. Heather Brooks (
Tina Majorino) are introduced.
Steven Culp and
William Daniels play Dr. Parker and Dr. Craig Thomas, respectively. Dr. Parker is Chief of Cardiothoracic Surgery and Dr. Craig Thomas (
William Daniels) is an
attending cardiothoracic surgeon at
Mayo Clinic, where Cristina worked temporarily. Dr. Alana Cahill (
Constance Zimmer) introduced in season 9 is appointed to cut costs at the hospital and she eventually decides the best course of action would be to seek out a new buyer until the 4 crash survivors and Torres on the behalf of Sloan pool their money together in a bid to purchase the hospital themselves. Kepner starts dating a paramedic named Matthew Taylor (
Justin Bruening) and they form a deep relationship over the course of seasons 9 and 10 and she eventually agreed to marry before reconciling with Avery in the middle of her wedding ceremony to Matthew. Lauren Boswell (
Hilarie Burton) is introduced as a craniofacial surgeon consulting on a case at Grey Sloan Memorial who showed romantic interest in Arizona and eventually ended up having a one-night stand with her. Dr. Heather Brooks dies in the premiere of season 10. She goes to search for Dr. Webber and finds him lying in the basement of the hospital. Trying to save Dr. Webber, she accidentally steps into a puddle and electrocutes herself while hitting her head as she falls. Also introduced in season 10 was Dr. Karev's estranged father Jimmy Evans (
James Remar) who tries to form a relationship with his son but fails repeatedly, and dies in a botched surgery. The conclusion of season 10 has Cristina leaving Grey Sloan for Dr. Burke's job as head of Klausman Institute for Medical Research in Zurich, while Dr. Ross makes a last-minute decision to follow her in order to study under her. Dr. Maggie Pierce (
Kelly McCreary) unknowingly drops a bombshell that she is the child of Dr. Webber and the late Dr. Grey, and was given up at birth for adoption. Dr. Meredith Grey has to accommodate another half-sister in her life. Also, Dr. Yang privately gives her shares in the hospital to Dr. Karev, also giving him her seat on the board. But Dr. Webber all but promises the seat to Dr. Bailey, so the board has to decide between them. Season 11 begins with new surgical residents coming to the hospital. Introduced in season 11 is Dr. Nicole Herman (
Geena Davis), who is Chief of Fetal Surgery at Grey Sloan Memorial. Dr. Herman selects Robbins for a fetal surgery fellowship and becomes her mentor. Herman features in a 12-episode arc before departing in episode 14. Season 14 sees the introduction of Taryn Helm (played by Jaicy Elliot), a new intern who eventually becomes a resident, with recurring appearances in the series in all subsequent seasons thus far. ==Production and development==