•
Kristina Sabaliauskaitė (born 1974), Lithuanian writer and art historian. •
Kristina Saltanovič (born 1975), Lithuanian athlete. •
Lew Sapieha (1557–1633),
Polish–Lithuanian Commonwealth politician and military commander. •
Maciej Kazimierz Sarbiewski (1595–1640), Polish poet. •
Šarūnas Sauka (born 1958), Lithuanian postmodern painter. •
Andrew Schally (1926–2024), Polish-American endocrinologist and Nobel Prize laureate. •
Kalman Schulman (1819–1899), Jewish writer and translator. •
Žydrūnas Savickas (born 1975), Lithuanian Strongman champion. •
Lasar Segall (1891–1957), Brazilian Jewish painter, engraver and sculptor. •
Esther Shalev-Gerz (born 1948), Jewish contemporary artist. •
Kazimierz Siemienowicz (c. 1600 – c. 1651),
Polish–Lithuanian Commonwealth military commander, engineer, theorist of artillery and pioneer of rocketry. •
Deividas Sirvydis (born 2000), Lithuanian basketball player in the NBA. •
Konstantinas Sirvydas (1579–1631), Lithuanian lexicographer, writer. •
Piotr Skarga (1536–1612), Polish theologian, writer and the first rector of the Wilno Academy. •
Francysk Skaryna (c. 1490 – 1552), Belarusian humanist, physician, and translato, publisher of first printed Ruthenian Bible. •
Boris Skossyreff (1896–1989), Russian adventurer, international swindler and pretender, King of Andorra. •
Mykolas Sleževičius (1882–1939), Lithuanian lawyer, political and cultural figure, and journalist, Prime Minister of Lithuania. •
Juliusz Słowacki (1809–1849), Polish poet. •
Antanas Smetona (1874–1944), Lithuanian intellectual, journalist and the first publicist, President of Lithuanian Republic. •
Elijah ben Solomon,
Gaon mi Vilna (1720–1797), Lithuanian Jewish scholar and Kabbalist. •
Blessed Michał Sopoćko (1888–1975), Polish
Apostle of Divine Mercy. •
Jędrzej Śniadecki (1768–1838), Polish writer, physician, chemist, biologist and philosopher. •
Audrius Stonys (born 1966), Lithuanian renowned documentary filmmaker. •
Vytautas Straižys (1936–2021), Lithuanian astronomer, developer of Vilnius photometric system. •
Władysław Syrokomla (1823–1862), Polish poet, writer and translator. •
Deividas Šemberas (born 1978), Lithuanian football player. •
Algirdas Šemeta (born 1962), Lithuanian economist and the European Commissioner for Taxation and Customs Union, Audit and Anti-Fraud. •
Stasys Šilingas (1885–1962), Lithuanian lawyer and statesman, significant figure in the history of Lithuania's independence. •
Wenzel Sukowaty (1746–1810), music copyist •
Tadas Šuškevičius (born 1985), Lithuanian athlete. ==T==