Santangelo co-hosted a sports radio
talk show called "The Rise Guys" on
KHTK-1140 AM in
Sacramento from 2006 to 2008. On November 21, 2008, he was fired immediately after concluding his show for the day. KHTK gave low ratings and cost-cutting as the explanation. He said he felt "stabbed in the back" by the station. On March 1, 2010, Santangelo became the host of San Francisco's
KNBR-680 AM SportsPhone680 in the 7–10 pm time slot. He also worked as a reporter and fill-in game announcer for Giants broadcasts on
CSN Bay Area and the
Giants Radio Network. During his tenure with 680 AM, Santangelo made his point known that he preferred to see players hit home runs as opposed to players who used "small-ball" strategy, while also stating "steroid-induced home runs are way more entertaining than strategic runs." On January 6, 2011, Santangelo was named the
color analyst for the
Washington Nationals' telecasts on the
Mid-Atlantic Sports Network (MASN), returning to the organization with which he spent over half his playing career (the Montreal Expos relocated to Washington, D.C., in 2005). He was paired with play-by-play announcer
Bob Carpenter. After Santangelo's first season as a broadcaster with the Nationals,
The Washington Post sports columnist Tracee Hamilton noted that the Carpenter-Santangelo team improved over 2011, and
The Washington Post sports blogger Dan Steinberg wrote about Santangelo's performance and how he sought to be educational, not outrageous, in the broadcast booth. Santangelo's signature line as an announcer is a reverse play off the superstition of never speaking about a no-hitter when it is in progress. Whenever the first Nationals hit of the game occurs, Santangelo says flatly "There goes the no-hitter." Santangelo has explained that he says it as a tribute to his former manager
Felipe Alou, who as manager of the Expos always said it when the Expos got their first hit in game. He was able to use the line in every game he called with the team, with the closest he came to not be able to say it was when
Michael Wacha was an out away in September 2013 before
Ryan Zimmerman broke up the bid with an infield single. When
Michael Lorenzen pitched a no-hitter against the Nationals in August 2023, after Santangelo was no longer a color analyst for the team, Santangelo reacted to it on Twitter by referencing the phrase as a hashtag. Santangelo does not use the line when the opposing team gets its first hit, but on September 28, 2014, moments after
Jordan Zimmermann pitched the first no-hitter in Washington Nationals history, Santangelo announced, "And there
is the no-hitter!". He made the same remark after Max Scherzer's no-hitters on June 20 and October 3, 2015. Santangelo returned to San Francisco in 2022, where he hosted the pregame show for the
San Francisco Giants on
KNBR, as well as the station's late-night call-in show
KNBR Tonight. In 2023, Santangelo teamed up with Joe Ritzo to fill in for
Jon Miller and
Dave Flemming on
KNBR for
Giants broadcasts. On Nov. 29, 2023, he was one of several hosts fired in a station shakeup. Santangelo said
KNBR Tonight was canceled due to budget cuts, and would be replaced with syndicated programming.
Misconduct allegation Santangelo was absent from the MASN broadcasts of three Nationals games between April 30 and May 2, 2021, returned for the broadcasts of May 4 and 5. He then was absent from a
YouTube broadcast of the game of May 6, despite the Nationals having aired promotional spots on MASN for his scheduled appearance as a color commentator during the YouTube broadcast, and did not return for MASN broadcasts on or after May 7. MASN referred the matter to
Major League Baseball's Department of Investigations for assistance in the investigation. In a statement on May 8, Santangelo denied the allegations, ==Personal life==