Frederick Francis was first married to
Princess Augusta Reuss of Köstritz (26 May 1822 – 3 March 1862) on 3 November 1849 in
Ludwigslust. They had six children: •
Frederick Francis III, Grand Duke of Mecklenburg-Schwerin (19 March 1851 – 10 April 1897) he married
Grand Duchess Anastasia Mikhailovna of Russia on 24 January 1879. They had three children. •
Duke Paul Frederick of Mecklenburg-Schwerin (19 September 1852 – 17 May 1923) he married
Princess Marie of Windisch-Graetz on 5 May 1881. They had five children. •
Duchess Marie of Mecklenburg-Schwerin (14 May 1854 – 5 September 1920) she married
Grand Duke Vladimir Alexandrovich of Russia on 28 August 1874. They had five children. • Duke Nikolaus of Mecklenburg-Schwerin (18 August 1855 – 23 January 1856) died at 5 months old. •
Duke Johann Albrecht of Mecklenburg-Schwerin (8 December 1857 – 16 February 1920) he married
Princess Elisabeth Sybille of Saxe-Weimar-Eisenach (28 February 1854 – 10 July 1908) on 6 November 1886. He remarried
Princess Elisabeth of Stolberg-Rossla on 15 December 1909. • Duke Alexander of Mecklenburg-Schwerin (13 August 1859 – 13 August 1859) Frederick Francis married for a second time in
Darmstadt to
Princess Anna of Hesse and by Rhine (25 May 1843 – 16 April 1865) on 4 July 1864. They had one daughter: • Duchess Anna of Mecklenburg-Schwerin (7 April 1865 – 8 February 1882) died at the age of 16. His third wife was
Princess Marie of Schwarzburg-Rudolstadt on 4 July 1868. They had four children: •
Duchess Elisabeth Alexandrine of Mecklenburg-Schwerin (10 August 1869 – 3 September 1955) she married
Frederick Augustus II, Grand Duke of Oldenburg on 24 October 1896. They had five children. • Duke Friedrich Wilhelm of Mecklenburg-Schwerin (5 April 1871 – 22 September 1897) died at the age of 26. •
Duke Adolf Friedrich of Mecklenburg-Schwerin (10 October 1873 – 5 August 1969) he married Princess Viktoria Feodora of
Reuss zu Schleiz (21 April 1889 – 18 December 1918) on 24 April 1917. They had one daughter
Duchess Woizlawa Feodora of Mecklenburg-Schwerin (1918–2019), later Princess
Reuß zu Köstritz. After the death of his first wife, Adolf Friedrich remarried
Princess Elisabeth of Stolberg-Rossla on 15 October 1924. •
Duke Heinrich of Mecklenburg-Schwerin (19 April 1876 – 3 July 1934) he married Queen
Wilhelmina of the Netherlands on 7 February 1901. They had one daughter:
Queen Juliana. ==Honours==