Overview Main •
Freddie Highmore as
Dr. Shaun Murphy, an autistic and troubled surgeon. His skills include near-photographic recall and the ability to note minute details and changes. His hiring created a divided opinion among the board. At the end of season 5, he marries Lea Dilallo. In season 6, he becomes a surgical attending after having completed his residency. At the end of season 6, Lea gives birth to their son Steven Aaron Murphy. In a flashforward in the series finale, Shaun becomes the Chief of Surgery and runs the Dr. Aaron Glassman Foundation for Neurodiversity in Medicine with Claire. Shaun and Lea also have a daughter together (named Maddie after Dr. Glassman's deceased daughter). He is portrayed in flashbacks to his teen years by
Graham Verchere (season 1, guest seasons 2, 3, 5) and his child years by Kashton Brostl (guest season 7). guest seasons 5 and 7 His niece Dr. Olivia Jackson is one of the surgical residents in season 4. and he is reinstated as hospital president after the Ethicure acquisition is called off. It is also revealed in the same season that he is
dyslexic. At the end of season 6, he resigns his position when the board calls for a meeting to discuss his questionable decisions while entering a relationship with nurse Villanueva. In season 7, he is mentioned to be touring the world. •
Richard Schiff as Dr. Aaron Glassman, former President of San Jose St. Bonaventure Hospital and now
attending neurosurgeon, who has been a mentor and good friend of Shaun since he was 14. In season 2, he steps down as hospital president when he is diagnosed with cancer and Shaun tries to help improve his health. In season 3, he is reinstated after Andrews is fired and marries barista Debbie, but they divorce in season 4 following a series of arguments. In season 6, Shaun finds out that Glassman suffered a ministroke that leaves him unable to perform further surgeries, but Glassman feels betrayed and hurt when he tries to intervene and is absent when Lea gives birth to Steven, but still sends a gift for the baby. In season 7, he and Lim become the co-interim presidents of the hospital following Andrews' departure, while making amends with Shaun. His cancer also returns in the penultimate episode, and he eventually dies of it in the series finale. •
Tamlyn Tomita as Allegra Aoki (seasons 1–2; guest, season 3), Chairwoman of the San Jose St. Bonaventure Hospital Board and Vice President of the foundation that controls the hospital's funding. In season 4, she switches from surgery to internal medicine due to the damage she inflicted on her hands at the end of season 3. In season 6, Morgan works on becoming a mother, eventually adopting an orphaned baby named Eden in the series finale. In "Unconditional", she and Park get married. •
Will Yun Lee as Dr. Alex Park (seasons 2–7; recurring, season 1), a surgical resident and a former police officer from
Phoenix, Arizona who decided to become a doctor. In season 4, he starts a relationship with Morgan before breaking up with her in season 6 after she turns down at the last minute a job offer at New York. He also becomes a surgical attending along with Shaun. In "Unconditional", he and Morgan get married. •
Christina Chang as Dr. Audrey Lim (seasons 2–7; recurring, season 1), an
attending trauma surgeon in charge of the
ER and surgical residents and later the Chief of Surgery. In season 4, she develops
post-traumatic stress disorder from her experiences with treating the
COVID-19 pandemic. In the season 5 finale, Lim is stabbed and severely wounded and, although Andrews, Glassman, Shaun, Jordan, Jerome and Lea manage to save her life, Lim is left paralyzed from the waist down, likely as a result of Shaun's risky surgery to save her
liver. After another surgery, Lim regains the ability to walk, albeit with the aid of a cane. In season 7, following the departure of Andrews, she and Glassman become the co-interim presidents of the hospital. Lim also no longer needs her cane, having fully recovered her ability to walk. In the series finale, Lim leaves the hospital to help out with medical treatment in
Ukraine. •
Paige Spara as Lea Dilallo-Murphy (seasons 2–7; recurring, season 1), Shaun's love interest until she left to pursue her dream. Later after she returned, they decide to be platonic close friends and roommates, but they finally became a couple in the season 3 finale. In season 4, she and Shaun were expecting a baby girl together before she has a miscarriage due to a medical problem. In the season 4 finale, Lea gets engaged to Shaun. In the season 5 finale, they get married. In season 6, she and Shaun are expecting a baby boy and she gives birth to Steven in the finale. In a flashforward in the series finale, Shaun and Lea have a daughter together as well. Lea worked as an automotive engineer in the first two seasons before becoming Glassman's assistant in season 3. In season 4, she has become the head of the hospital's IT department. •
Jasika Nicole as Dr. Carly Lever (season 3; recurring seasons 1–2), the hospital's head and board certified pathologist introduced in season 1 who becomes Shaun's co-worker in season 2 and girlfriend in season 3. However, Carly breaks up with Shaun near the end of season 3 after realizing that he is in love with Lea. • Bria Samoné Henderson as Dr. Jordan Allen (seasons 5–7; guest season 4), a Mexican-American surgeon whom the team meets in
Guatemala and who decides to return to the United States afterwards. He begins forming a romantic relationship with Lim during their time together in Guatemala. He is soon transferred to San Jose General by Salen Morrison and loses touch with Lim shortly afterwards. •
Brandon Larracuente as Dr. Daniel "Danny" Perez (season 6; and later dreams and visions. He also portrays Evan Gallico, a boy in the present (Season 1) that resembles Shaun's brother and is suffering from stage 4
osteosarcoma. • Elfina Luk as Nurse Dalisay Villanueva. In season 5, she is revealed to be domestically abused by her partner Owen, which makes her fail to catch up to her shifts. At the end of season 5, she is stabbed by Owen, but Andrews and Glassman manage to save her life. Owen is arrested for her attempted murder, but he expresses remorse for his actions to Asher Wolke, almost committing
suicide by cop out of guilt. She is shown to have fully recovered and returned to work by the time of Lim's return three months later. In season 6, she and Andrews develop a romantic relationship. •
Teryl Rothery as Dr. Jan Lancaster (seasons 1–5, 7), an anesthesiologist and one of the doctors who is often seen helping out in surgery. In "Claire", her full name is given as Jan Lancaster. •
Marsha Thomason (season 1) and
Golden Brooks (guest season 6) as Dr. Isabel Barnes, a doctor at St. Bonaventure and the ex-wife of Andrews. In season 1, they are shown to have trouble having kids and go to a therapist for help. At the end of season 4, during the trip to Guatemala, Andrews reveals that he and Isabel are getting a divorce as she is seeing someone else. In season 6, she returns to take over the case of a woman pregnant with sextuplets. •
Eric Winter as Dr. Matt Coyle (season 1), an attending surgeon who sexually harasses Claire when they work together on a case, resulting in Jared getting fired when he finds out and assaults him. He is also revealed to have done the same to other female employees who haven't spoken against him out of fear of risking their jobs. Without any evidence of his actions, Coyle is transferred to another department and two of his former residents, Morgan Reznick and Alex Park, are incorporated into Melendez's team. Jared also files a lawsuit against the hospital for racism when they refuse to rehire him, which he wins, but ends up losing the respect of Melendez and Andrews in the process. •
Chris D'Elia as Kenny (season 1): Shaun's new neighbor, who moves into Lea's apartment. Shaun mentioned that he was arrested when Lea returned. •
Kirby Morrow (season 1) and
Michael Trucco (guest season 3 and 7) as Ethan Murphy, Shaun's abusive father. In season 3, he is reunited years later with his son when he is diagnosed with terminal
pancreatic cancer to make amends, but after Shaun forgives him, Ethan throws hurtful words at Shaun before succumbing to his cancer thirty minutes later. • Rebecca Husain (season 1),
Joanna Going (guest season 3) and Patricia Cullen (guest season 7) as Marcie Murphy, Shaun's mother, who despite loving her son, never did anything to help Shaun and stand up to her abusive husband. In season 3, she is reunited with Shaun years later when Ethan is diagnosed with terminal pancreatic cancer. She ends up becoming a widow after Ethan dies, and Shaun cuts her out of his life for good. In season 5, after Shaun and Lea get engaged and start mailing the invitations for their wedding, Lea decides against inviting Marcie, not wanting Shaun to be reminded of his traumatic past. •
Sheila Kelley as hospital barista Debbie Wexler (seasons 1–4), a love interest for Dr. Glassman and later his fiancée and wife. After getting fired in the third season, she becomes Glassman's office manager. In season 4, they separate after a series of arguments. In real life, Kelley is married to Richard Schiff, who plays Glassman. •
Lisa Edelstein as Dr. Marina Blaize (season 2), an oncologist •
Holly Taylor (season 2) and Audrey Wise Alvarez (guest season 1 and 6) as Maddie Glassman, Aaron's estranged daughter who died of a drug overdose at 19. •
Daniel Dae Kim as Dr. Jackson Han (season 2), is a Neonatal Cardiac Surgeon and former Chief of Surgery of San Jose St. Bonaventure Hospital, who had trouble with Shaun's behavior and autism, especially his inability to communicate. Against Shaun's wishes, he has him transferred to Pathology where he can help patients without interacting with them, but Han fires him when he keeps on demanding his old job as a surgeon back. Andrews, as president of the hospital, eventually fires Han to save Shaun, but gets himself fired as well. Lim takes over his vacant position in season 3 and rehires Andrews as an attending surgeon. •
Karin Konoval as Donna Petringa (season 2–4), a scrub nurse at St. Bonaventure who is often seen assisting in surgeries or monitoring patients. She dies of
COVID-19 in "
Frontline Part Two" in season four. She has been a nurse for forty years and has a son and granddaughter. • April Cameron as Alyssa Hawks (seasons 3, 5–7; guest, season 4), a young nurse who works at the hospital. As revealed in season 6, she suffered from an addiction of some sort in the past as she attends Danny Perez's NA meeting. • Brian Marc as Dr. Enrique "Ricky" Guerin (season 4): One of the new surgical residents who has a laid-back attitude and is
polyamorous. He is assigned as one of Claire's junior residents. Enrique eventually decides to leave St. Bonaventure in order to join a program that will allow him to help out in needy areas of the world. • Hollis Jane Andrews as Sophie (season 5), a documentarist with a form of
dwarfism who takes an interest in Shaun and Lea • Giacomo Baessato as Jerome Martel (season 5–7), a male nurse who begins dating Asher. As revealed in "Second Chances and Past Regrets", he has been
HIV-positive for years. In "Who at Peace", he intended to propose to Asher, who was killed by two anti-semites that very same night. In the series finale, he is shown to have moved on from Asher's death and married another man. •
Savannah Welch as Dr. Danica "Danni" Powell (season 6), one of the new residents in season 6. She is a former US Navy Lieutenant who lost her right leg following a flight deck accident. In "The Good Boy", especially due to her constant pattern of disobedience, she is fired after an unauthorized surgery to save her friend on parole Vince, which she had dragged Asher into, who gets a two-month probation, along with Perez for his relapse. •
Michael Patrick Thornton as Dr. Clay Porter (season 6), a disabled pediatrician whom Powell sets Lim up with. They start a relationship and proposes to Lim, only for her to turn him down and suggest they move in together instead. In season 7, it is revealed that because of Lim's indecisiveness to marry Clay, he broke off the relationship and moved to Chicago for a fellowship. •
Kayla Cromer as Charlotte 'Charlie' Lukaitis (season 7), an
autistic medical student who idolizes Shaun and was inspired to become a surgeon by the video of Shaun saving a young boy in the series premiere. While she isn't a
savant like Shaun, she can
hyperfocus. She seems to have a
special interest in
Taylor Swift. In a flashforward in the series finale, Charlie has become an attending at the hospital. • Wavyy Jonez as Dominick 'Dom' Hubank (season 7), a medical student who is squeamish around blood. In a flashforward in the series finale, Dom has opened his own clinic and is no longer has a
fear of blood. •
Bess Armstrong as Eileen Lim (season 7), Audrey's mother • Ruby Kelley as Hannah (season 7), a patient with a
drug addiction who bonds with Dr. Glassman as Hannah reminds Glassman of his deceased daughter Maddie. Ruby Kelley is the daughter of
Richard Schiff and
Sheila Kelley who play Dr. Glassman and his former wife Debbie. ==Episodes==