Downame published
Thomas Sutton's
Lectures upon the Eleventh Chapter to the Romans, London, 1632. He also edited his brother George's
Treatise of Prayer, London, 1640, the third impression of J. Heydon's
Mans Badnes and Gods Goodnes, London, 1647, and Archbishop
James Ussher's
Body of Divinitie (attributed), London, 1647. Downame was commissioned by parliament along with
John Ley,
William Gouge,
Meric Casaubon, Francis Taylor,
Daniel Featley, and
John Reading, to imitate and supplement the 1637
Dutch Annotations on the Whole Bible as a complement to the work of the
Westminster Assembly. With the exceptions of Downame, Casaubon, and Reading, these divines were all members of the Assembly. It is presumed that Downame served as the chief editor and compiler for their work:
Annotations upon all the Books of the Old and New Testament, London, 1645. The text came to be known as ''The Assembly's Annotations
or The English Annotations'' (in distinction from the earlier Dutch). His own writings comprise: • ''Spiritual Physick to Cure the Diseases of the Soul, arising from Superfluitie of Choller, prescribed out of God's Word'', London, 1600. •
Lecture on the First Four Chapters of Hosea, London, 1608. •
The Christian Warfare Against the Devil, World and Flesh, 4 parts, London, 1609–18. This is his best-known work, and reached a fourth edition, 4 parts, fol. London, 1634, 33. •
Foure Treatises tending to disswade all Christians from the Abuses of Swearing, Drunkennesse, Whoredome, and Bribery, . . . Whereunto is annexed a Treatise of Anger, 2 parts, London, 1613. •
The Plea of the Poore. Or a Treatise of Beneficence and Almes-deeds: teaching how these Christian duties are rightly to be performed, London, 1616. •
Guide to Godliness, or a Treatise of a Christian Life, London, 1622. •
The Summe of Sacred Divinitie Briefly and Methodically Propounded, . . . more largely and cleerly handled, London (1630?). •
A Brief Concordance to the Bible, . . . alphabetically digested, and allowed by authority to be printed and bound with the Bible in all volumes, London, 1631. Ten editions were published during the author's lifetime. •
A Treatise against Lying, London, 1636. • ''A Treatise tending to direct the Weak Christian how he may rightly Celebrate the Sacrament of the Lord's Supper'', London, 1645. ==Family==