Global Justice •
Dr. Betty Director (voiced by
Felicity Huffman) is the head of the Global Justice Network, a worldwide espionage organization. She stays behind the scenes for the most part, although Kim has other dealings with Global Justice, usually in the form of rides to her destinations and backup on missions. Director's role and appearance are reminiscent of
Marvel Comics character
Nick Fury. •
Team Impossible are a group of operatives who initially only operate for money, charging money to anyone they save. Wade later convinces them to join Global Justice and operate for non-profit. They consist of
Dash (voiced by
Gary Dourdan),
Crash (voiced by
Eric Close), and
Burn (voiced by
Adam Rodriguez). •
Will Du (voiced by
BD Wong) is a top agent at Global Justice. He initially clashes with Kim before working with her to stop Duff Killigan.
Yamanouchi Yamanouchi is a secret ninja school, located atop a mountain in Japan. It was founded by Toshimiru, a master of
Monkey Kung Fu. He carved the school out of the mountain using a sword called the Lotus Blade. Since its creation in 338 AD, the school has guarded the blade, which can only be used by those who possess Mystical Monkey Power. •
Master Sensei (voiced by
George Takei) is a martial artist and the headmaster of the Yamanouchi school. He guides Ron in mastering his Mystical Monkey Powers and becoming the Ultimate Monkey Master. •
Yori (voiced by
Keiko Agena) is a ninja who is sent to guide Ron to the Yamanouchi School. Since her introduction, she has appeared as a potential
love interest for Ron, piquing his romantic interest at first sight and gradually developing feelings for him.
Team Go Team Go are a sibling team who protect Go City and obtained superpowers after a multicolored comet crashed into their tree house when they were young. Shego was originally a member of the team before leaving. They are each themed after a specific color and are named after pronouns, with "go" added at the end. Hego is blue, Mego is purple, the Wego twins are red, and Shego is green. •
Hego (voiced by
Christopher McDonald) is the oldest member of Team Go, who possesses superhuman strength. As a civilian, he manages a Bueno Nacho. Hego sincerely believes that despite her actions, Shego is still a good person, only to be proven wrong when she betrays and blasts him. It is such behavior that seems to make Hego the brother Shego is most annoyed by. •
Mego (voiced by
Jere Burns) is a member of Team Go who can shrink to the size of a doll. He possesses a large ego and is defensive of his seemingly useless power. • The
Wego twins (voiced by
Fred Savage) are twin members of Team Go who can duplicate themselves.
Others •
M.C. Honey (voiced by
Sherri Shepherd) is a rapper loosely based on female rappers like
Queen Latifah and
MC Lyte. She gives Kim a ride in her yacht as thanks for retrieving her demo tape when it was stolen in "Hidden Talent"'. She reappears in "Rappin' Drakken" and "Trading Faces". •
Britina (voiced by
Tara Strong) is a teen musician who has her own line of merchandise, including a magazine and dolls. Like most pop singers, she is fodder for tabloids and is notable for her relationships; she dated Oh Boyz singer Nicky Nick, but they have since broken up. Her name is an allusion to
Britney Spears and
Christina Aguilera. •
Nakasumi (voiced by
Clyde Kusatsu) is an esteemed toy developer, and
Miss Kyoko (voiced by
Lauren Tom) is his secretary and assistant. He is the victim of theft by Drakken and Shego in "Crush", but Kim recovers what was stolen, and in return, Nakasumi gives her a ride in "A Very Possible Christmas" and
So the Drama. •
Amelia (voiced by
Carly Pope, later
Tara Strong) is a senior who is implied to be the school's beauty queen, and presumably graduates after season two. She constantly brushes off Ron's attempts at flirting, but welcomes him into her popular circle during the episodes "All the News" and "The New Ron", and accepts money from him in "Ron Millionaire". •
Bobo the Chimpanzee is Camp Wannaweep's mascot. He is only seen in flashbacks describing Ron's unpleasant experiences at the camp. •
Doctor Cyrus Bortel (voiced by
Enrico Colantoni) is a selfish inventor who developed the Moodulators and Mind Control Chips. •
Doctor Vivian Porter (voiced by
Shawnee Smith) is a roboticist who created the android Oliver, among other inventions. James Possible later offers her a job at the Middleton Space Center's robotics lab. •
François (voiced by
Rob Paulsen) is a French hairstylist who styles Ron's hair in "The New Ron". He later appears in "Rufus in Show", when he lends Kim and Ron his prize-winning
pedigree poodle when they need to infiltrate an exclusive
dog show, and in "Two to Tutor" as one of the targets of a string of heists committed by Shego and Señor Senior Junior. •
Hirotaka (voiced by
Brian Tochi) is a Japanese student who appears in the episode "Exchange" as a participant in the titular exchange program. •
Ned (voiced by
Eddie Deezen) is an assistant manager at Bueno Nacho. •
Elsa Cleeg (voiced by
Wendie Malick) is a famous fashion critic with her own television fashion report program, which Monique is a fan of. She is an influential authority on fashion, even influencing Club Banana. She was inspired by the aesthetics of Kim's mission clothes to create the "KimStyle", which became a nationwide clothing sensation, including spin-off clothing lines "KimForHim" and one for pets. •
Oh Boyz are a
boy band consisting of Robby, Nicky Nick, Ryan, and Dexter, whose fame suddenly vanished, leaving Ron as their only fan. They are on the verge of breaking up when the Señor Seniors kidnap them to fulfill Junior's dream of becoming a pop star, inadvertently restoring their popularity. The four are respectively voiced by
Lance Bass,
Joey Fatone,
Jason Marsden, and
Justin Shenkarow. •
Pain King and
Steel Toe (respectively voiced by
Bill Goldberg and
Test) are the star wrestlers of the GWA (Global Wrestling Association), who are rivals in the ring but friends outside it. They are distinguished by their costumes, which allude to their stage names – Pain King wears a gold
coronet and mask, while Steel Toe's right shoe is supposedly made of titanium. •
Wally (voiced by
Rob Paulsen) is the spoiled and arrogant prince of Rodeghan. Kim was charged with protecting him from the Knights of Rodeghan in "Royal Pain" because of his ancestor's tyrannical behavior toward them. Wally runs for
class president against Kim and Brick Flagg, inspiring him to convert Rodeghan into a democracy. •
Private Cleotus Dobbs (voiced by
Dan Castellaneta) is a
private in the
Army who was charged with guarding a Neutronalizer Ray. Dr. Drakken kidnaps Dobbs and switches minds with him to steal the Neutronalizer. •
Professor Acari (voiced by
Maurice LaMarche) is an
insectologist who invented the "roflex", a device that can enlarge insects. He is named for
Acariformes, an order of mite. •
Professor Ramesh (voiced by
Brian George) is an astronomer and old friend of James Possible. •
Professor Robert Chen (voiced by
Gedde Watanabe) is an astronomer and old friend of James Possible and Dr. Drakken. •
Rabbi Katz (voiced by
Peter Bonerz) is a rabbi who oversees Ron's
bar mitzvah. •
Roachie (vocal effects provided by
Frank Welker) is a cockroach who Chester Yapsby enlarges to the size of a small dog using the roflex, an invention he stole from Professor Acari. Ron befriends him despite his fear of insects. •
Tara (voiced by
Tara Strong) is a cheerleader and one of Bonnie's
sycophants. She has dated numerous characters, including Josh Mankey and Jason Morgan. •
Timothy North (voiced by
Adam West) is a former television actor who played the role of the titular character on the TV show
The Fearless Ferret. Over the years, North becomes delusional and begins to believe he is the Fearless Ferret. At a Retro-TV convention, he reunites with Rudolph Farnsworth, who played the villain White Stripe and had also become delusional. This brings the two back to reality and reunites them as friends. North's name and persona are based on West's role as
Batman in the
1960s series of the same name. •
Zita Flores (voiced by
Nika Futterman) is a Hispanic student at Middleton High, who works at a
multiplex theater in Middleton and is usually seen in the ticket booth wearing the name tag "Annie" until hers can be made. Ron has a crush on her, and so attends every film showing to chat with her, which evidently piques her interest.
Rides Minor characters in Kim's network whom she has helped during past missions and provide transportation to her missions. As of season four, Kim uses rides less because she has her own vehicle, but calls upon them when it is out of service. •
Baxter – In "Mind Games", he lets Kim and Ron ride two of his donkeys into the Grand Canyon in return for Kim performing an emergency delivery for his donkey Buttercup. He is voiced by
Dan Castellaneta. •
Bernice – In "Naked Genius", she gives Kim a ride as thanks for saving her town from a leaking dam. She also appears in "Team Impossible", having apparently started working with jets. She is voiced by
April Winchell. •
Captain Louis – In "A Very Possible Christmas", he gives Ron a ride to Dr. Drakken's base. The episode reveals that Kim saved his boat from sinking, but that Ron exacerbated the trouble, which he does not remember. He is voiced by
John DiMaggio. •
Dallas – In "Attack of the Killer Bebes", he gives Kim a lift to Mount Middleton after she aids him during a car chase. He is voiced by
Rob Paulsen. •
Mr. Geminini – He works for Doctor Bortle, and in "The Twin Factor" gives Kim, Ron, and her brothers a ride to Bortle's lab. He has a twin, but his brother is in prison. He is voiced by
Dan Castellaneta. •
Gustavo – In "Tick-Tick-Tick", he gives Kim and Ron a ride in his plane as thanks for them saving his village from a flood, which it is hinted Ron caused. •
Heinrich – In "Crush", he gives Kim a ride after she saves his village from an avalanche that Ron accidentally caused which he still holds a grudge on him for. He reappears in "Team Impossible". He is voiced by
John DiMaggio. •
Joe – A helicopter pilot who in "Queen Bebe" gives Kim and Ron a ride to the Bebe's hive island off the Gulf Coast of Florida. •
Judd – A camera man who in "Oh Boyz" gives Kim a ride to the Seniors' island. Kim had rescued Judd from a rhino stampede while he was filming a program entitled "Teasing Wild Animals". •
Mr. Magnifico – In "Bonding", he and his circus company give Kim a ride to a top-secret research facility on their train. They did this in return for Kim acting as a substitute acrobat after the original performer twisted her ankle. •
Mr. Morrow - He is voiced by
Clancy Brown. •
Mrs. Mahoney – A woman who gave Kim her first ever ride as payment for saving her cat, as seen in
A Sitch in Time. •
Mr. Parker – In "Bueno Nacho", he flies Kim to Wisconsin in his
crop duster after she saves his business by going organic, allowing her to para-drop onto the world's largest Swiss cheese wheel. •
Ricardo – In "Gorilla Fist", he gives Kim a ride to South America in his plane as thanks for saving his chicken farm from a mudslide. •
Unnamed Marine Colonel – In "Monkey Fist Strikes", he gives Kim a ride to Cambodia in a military transport plane after she tips him off to an incoming assault. ==Main villains==