Green Bay Packers Guy was selected in the seventh round (233rd overall) of the
2011 NFL draft by the
Green Bay Packers. He spent the season on
injured reserve. Guy was one of the final cuts of the
2012 season, but he was re-signed to the
practice squad on September 3, 2012.
Indianapolis Colts On October 17, 2012, the
Indianapolis Colts signed Guy from the Packers' practice squad. In 9 games with the Colts, he recorded 21 tackles (15 solo) and 1 sack.
San Diego Chargers On October 8, 2013, Guy was claimed off waivers by the
San Diego Chargers. Guy appeared in 10 games for the Chargers in 2013 where he had 16 tackles. In 2014 Guy appeared in just 3 games before being waived by the team.
Baltimore Ravens On September 24, 2014, Guy was claimed off waivers by the
Baltimore Ravens after spending the first 3 weeks of the regular season with the Chargers. On October 11, 2015, in a home game against the
Cleveland Browns Guy recorded two sacks on quarterback
Josh McCown. Guy finished the 2015 season with 46 tackles and 4.5 sacks. During the 2016 season Guy recorded 28 tackles, 1 sack and 1 forced fumble.
New England Patriots On March 11, 2017, Guy signed a four-year, $20 million contract with the
New England Patriots. In Guy's first season with the Patriots, he recorded 58 tackles and 1 sack. In the divisional round of the playoffs, Guy recorded 2 tackles in the victory over the
Tennessee Titans. In the AFC Championship Game against the
Jacksonville Jaguars, Guy had 6 tackles and 1 sack to help the Patriots reach the Super Bowl. In
Super Bowl LII, Guy recorded 6 tackles, but the Patriots lost 41–33 to the
Philadelphia Eagles. Throughout the 2018 season, Guy appeared in all 16 games starting 15 of them. He recorded 59 tackles, 1 sack and 1 forced fumble. Guy helped the Patriots reach
Super Bowl LIII where they defeated the
Los Angeles Rams 13–3. During Week 8 of the 2019 season, Guy recorded his first career interception off of a botched shovel pass by Browns quarterback
Baker Mayfield in the 27–13 win. In week 9 against the Ravens, Guy recovered a fumble forced by teammate
Kyle Van Noy on running back
Mark Ingram II in the 37–20 loss. In week 11 against the Eagles, Guy recovered a fumble forced by teammate
Danny Shelton on
Carson Wentz in the 17–10 win. In Week 7 of the 2020 season against the
San Francisco 49ers, Guy recorded his first sack of the season on former teammate
Jimmy Garoppolo during the 33–6 loss. On March 30, 2021, Guy signed a four-year, $11.5 million contract extension with the Patriots. He started all 17 games, recording 60 tackles and 1.5 sacks. Guy returned as a starting defensive tackle in 2022. He started 14 games, recording 46 tackles and two sacks. Guy started in 14 games and played in all 17 games for the 2023 season. He recorded 38 tackles. He was released on February 19, 2024.
Cincinnati Bengals On September 17, 2024, Guy was signed by the
Cincinnati Bengals. He was released on November 2.
Retirement On October 24, 2025, Guy announced his retirement from football and signed a
one-day contract with the New England Patriots to retire with the team. ==NFL career statistics==