CIA documents suggest that they investigated "chemical, biological, and radiological" methods of mind control as part of MKUltra. They spent an estimated $10 million or more, roughly $87.5 million adjusted for inflation. During a hearing by the
Senate Health Subcommittee, a testimony by the deputy director of the CIA stated that over 30 institutions and universities were involved in the experimentation program of testing drugs on unknowing citizens "at all social levels, high and low, native Americans and foreign." Several of these tests involved the issuing of LSD to unaware subjects in social situations. Files discovered in 1977 containing 700 pages of new information showed that experiments had continued until Gottlieb ordered the program halted on July 10, 1972.
LSD In 1938,
LSD was isolated by
Albert Hofmann at the Sandoz Laboratories in Basel, Switzerland. The early directors of MKUltra became aware of the existence of LSD and sought to use it for "mind-control". In the early 1950s, MKUltra director Sidney Gottlieb arranged for the CIA to buy the entire supply of LSD for $240,000, which in 2024, would be $4,227,079. This LSD supply gave Gottlieb the ability to fulfill his experiment by spreading LSD to prisons, hospitals, institutions, clinics, and foundations in order to see how citizens would react to the drug without knowing exactly what was happening to them. Early CIA efforts focused on
LSD-25, which later came to dominate many of MKUltra's programs. The CIA wanted to know if they could make Soviet spies defect against their will and whether the Soviets could do the same to the CIA's own operatives. Documents obtained from the CIA by
John D. Marks under
Freedom of Information in 1976 showed that, in 1953, the CIA considered purchasing 10 kilograms of LSD, enough for 100 million doses. The proposed purchase aimed to stop other countries from controlling the supply. The documents showed that the CIA purchased some quantities of LSD from
Sandoz Laboratories in Switzerland. Once Project MKUltra started, in April 1953, experiments included administering LSD to mental patients, prisoners, drug addicts, and prostitutes – "people who could not fight back", as one agency officer put it. In one case, they administered LSD to a mental patient in Kentucky for 174 days. Military personnel who received the mind-altering drugs were also threatened with
court-martial if they told anyone about the experiments. LSD and other drugs were often administered
without the subject's knowledge or
informed consent, a violation of the
Nuremberg Code the U.S. had agreed to follow after World War II. Many veterans who were subjected to experimentation later sought legal and monetary reparations. In other experiments where people were given LSD without their knowledge, they were interrogated under bright lights with doctors in the background taking notes. They told subjects they would extend their "trips" if they refused to reveal their secrets. The people subjected to these interrogations were CIA employees, U.S. military personnel, and agents suspected of working for the Soviet Bloc during the Cold War. Long-term debilitation and several deaths resulted from this. At the invitation of
Stanford psychology graduate student Vik Lovell, an acquaintance of
Allen Ginsberg,
Ken Kesey volunteered to take part in what turned out to be a
CIA-financed study under the aegis of MKUltra, at the
Menlo Park Veterans' Hospital where he worked as a night aide. The project studied the effects of
hallucinogens and other
psychoactive drugs, particularly
LSD,
psilocybin,
mescaline,
cocaine,
AMT, and
DMT on people. The Office of Security used LSD in interrogations, but
Sidney Gottlieb, the chemist who directed MKUltra, had other ideas: he thought it could be used in covert operations. Since its effects were temporary, he believed it could be given to high-ranking officials and in this way affect the course of important meetings, speeches, etc. Since he realized there was a difference in testing the drug in a laboratory and using it in clandestine operations, he initiated a series of experiments where LSD was given to people in "normal" settings without warning. At first, everyone in Technical Services tried it; a typical experiment involved two people in a room where they observed each other for hours and took notes. As the experimentation progressed, a point arrived where outsiders were drugged with no explanation whatsoever and surprise acid trips became something of an occupational hazard among CIA operatives. Adverse reactions often occurred, such as an operative who received the drug in his morning coffee, became psychotic and ran across Washington, D.C., seeing a monster in every car passing him. The experiments continued even after
Frank Olson, an army chemist who had never taken LSD, was covertly dosed by his CIA supervisor and nine days later plunged to his death from the window of a 13th-story New York City hotel room, supposedly as a result of deep depression induced by the drug. According to
Stephen Kinzer, Olson had approached his superiors some time earlier, doubting the morality of the project, and asked to resign from the CIA. Some subjects' participation was consensual, and in these cases they appeared to be singled out for even more extreme experiments. In one case, seven drug-addicted African-American participants at the National Institute of Mental Health Addiction Research Center in
Kentucky were given LSD for 77 consecutive days. MKUltra's researchers later dismissed LSD as too unpredictable in its results. They gave up on the notion that LSD was "the secret that was going to unlock the universe", but it still had a place in the cloak-and-dagger arsenal. However, by 1962, the CIA and the army developed a series of super-hallucinogens such as the highly touted
BZ, which was thought to hold greater promise as a mind control weapon. This resulted in the withdrawal of support by many academics and private researchers, and LSD research became less of a priority altogether. The barbiturates were released into the person first, and as soon as the person began to fall asleep, the amphetamines were released. Other experiments involved
heroin,
morphine,
temazepam (used under code name MKSEARCH),
mescaline,
psilocybin,
scopolamine,
alcohol and
sodium pentothal. A 1955 MKUltra document details research objectives to identify drugs that could be used as cognitive enhancers, disease mimetics, euphoriants “without letdown,” and agents to diminish ambition, among other uses.
Hypnosis Declassified MKUltra documents indicate they studied
hypnosis in the early 1950s. Experimental goals included creating "hypnotically induced anxieties", "hypnotically increasing ability to learn and recall complex written matter", studying hypnosis and
polygraph examinations, "hypnotically increasing ability to observe and recall complex arrangements of physical objects", and studying "relationship of personality to susceptibility to hypnosis". They conducted experiments with drug-induced hypnosis and with
anterograde and
retrograde amnesia while under the influence of such drugs. ==Experiments on Canadians==