Lancaster County PA 441 begins at an intersection with the western terminus of
PA 999 in the community of
Washington Boro, located on the east bank of the
Susquehanna River in
Manor Township,
Lancaster County. From here, the route heads north-northwest on two-lane undivided Water Street. The road runs between the Susquehanna River and
Norfolk Southern's
Port Road Branch railroad line to the west and homes to the east. PA 441 heads out of Washington Boro and runs northwest through wooded areas with some homes alongside the railroad tracks and the river. The route passes through a small section of
West Hempfield Township before it enters the borough of
Columbia, where the name becomes South Front Street. The road runs between the Port Road Branch to the southwest and Norfolk Southern's Columbia Secondary to the northeast as it heads into commercial areas and open lots. PA 441 crosses the Columbia Secondary at-grade and continues northwest along North Front Street through industrial areas. The route passes under the
Columbia–Wrightsville Bridge that carries
PA 462 over the Susquehanna River. The route passes to the east of Three Mile Island, which is the location of the former
Three Mile Island Nuclear Generating Station, the site of a
partial nuclear meltdown in 1979. Past the former nuclear power plant, the road curves northwest and then north as it runs through wooded areas of homes with the river and railroad tracks to the west of the road. PA 441 crosses the Royalton Branch at-grade and enters the borough of
Royalton, heading northwest through residential areas along Canal Street. The route becomes parallel to
Amtrak's
Keystone Corridor railroad line to the east and crosses the
Swatara Creek into the borough of
Middletown. Here, PA 441 follows Ann Street northwest and intersects South Union Street, passing through residential areas. The road curves north and comes to a bridge over Norfolk Southern's Royalton Branch, Amtrak's Keystone Corridor, and the
Middletown and Hummelstown Railroad at the
Middletown station serving the Amtrak line before it reaches an intersection with PA 230. At this point, PA 441 turns east to form a
concurrency with PA 230 along West Main Street, a three-lane road with a
center left-turn lane, running along the border between
Lower Swatara Township to the north and Middletown to the south. The road passes north of the Middletown station along Amtrak's Keystone Corridor before it heads northeast away from the railroad tracks and fully enters Middletown. PA 230/PA 441 passes businesses before running through residential areas as a two-lane road. PA 441 splits from PA 230 by turning north onto North Union Street. The route passes more homes and heads to the east of a cemetery, becoming the border between Lower Swatara Township to the west and the borough of Middletown to the east as it continues north and comes to a bridge over the
Pennsylvania Turnpike (
I-76). PA 441 curves northwest and fully enters Lower Swatara Township, where the name becomes Oberlin Road. The road passes north of
Middletown Area High School and winds northwest through a mix of farm fields and woods with some homes. The route turns north and comes to a bridge over the
PA 283 freeway at its interchange with the northern terminus of the
Airport Connector, with PA 441 passing over PA 283 on the same bridge as the ramps connecting to the Airport Connector from PA 283. PA 441 has access to PA 283 by way of Fulling Mill Road to the north of the interchange, which heads west to a ramp to westbound PA 283 and east to North Union Street, which heads south to intersect PA 283 at a
diamond interchange. PA 441 has no direct access to the Airport Connector. From here, the route heads north as a brief divided highway near the Fulling Mill Road intersection before it again becomes a two-lane undivided road and turns west into residential areas in the community of
Ebenezer. The road continues west-northwest through a mix of farmland and homes before it crosses Laurel Run into
Swatara Township. PA 441 becomes Lindle Road and runs through more farms and trees before continuing west into business areas as a four-lane road. The route comes to an interchange with
I-283, at which point it becomes a divided highway. Past this, PA 441 turns southeast onto Eisenhower Boulevard, a three-lane road with a center left-turn lane that passes businesses. The route turns west onto two-lane undivided Highland Street and passes through fields before it comes to the residential community of
Oberlin. PA 441 turns northwest onto North Harrisburg Street and heads past more homes, running through the community of
Oberlin Gardens. The road passes between woods to the southwest and commercial development to the northeast and turns west, passing to the south of the former
Harrisburg Mall. The route crosses
Spring Creek and the
Capital Area Greenbelt trail and curves north past more commercial development along South 28th Street before it turns west onto Sycamore Street. PA 441 continues past businesses and comes to its northern terminus at an intersection with SR 3010 (Paxton Street) to the east of the
Harrisburg city line. ==History==