In Pennsylvania, US 322 is signed as 28th Division Highway, in honor of the
28th Infantry Division.
Ohio to Brookville US 322 enters Pennsylvania from
Ohio in
Crawford County, heading southeast on two-lane undivided Williamsfield Road. The road runs through rural areas on the southwest border of
Pymatuning State Park, which is home to the
Pymatuning Reservoir. Past the state park, the route crosses into
Mercer County and heads into the borough of
Jamestown, becoming Gibson Street and coming to an intersection with
PA 58. At this point, the two routes head east for a
concurrency along Liberty Street, crossing the
Shenango River. US 322 splits from PA 58 by turning north onto Depot Street. The route leaves Jamestown and crosses back into Crawford County, becoming an unnamed road. The road curves northeast and comes to the community of
Hartstown, where it becomes Liberty Street and reaches an intersection with
PA 18. At this point, PA 18 turns northeast for a concurrency with US 322 and the road comes to a bridge over the
Canadian National's
Bessemer Subdivision railroad line as it curves northeast and continues as an unnamed road. Farther northeast, the road enters the borough of
Conneaut Lake and becomes State Street, turning north onto South 4th Street to come to an intersection with
US 6/
PA 285 in the center of the borough. At this point, US 322/PA 18 turn east to join US 6 and PA 285 on Water Street. A block later, PA 285 splits to the south. US 6/US 322/PA 18 become a five-lane road with a
center left-turn lane and head east out of the borough, passing to the south of
Conneaut Lake. PA 18 splits from US 6/US 322 by turning to the north, with US 6/US 322 continuing east-northeast on Conneaut Lake Road. The road heads into a business area to the west of the city of
Meadville and comes to a
roundabout with
US 19 and the southern terminus of
PA 98, at which point US 19 becomes concurrent with US 6 and US 322. The roadway becomes a four-lane
divided highway and comes to a
cloverleaf interchange with
I-79. Past this interchange, the three routes reach an intersection with the southern terminus of
PA 102 before curving north and entering Meadville upon crossing
French Creek and a
Western New York and Pennsylvania Railroad line. The road becomes French Creek Parkway before US 322 splits from US 6 and US 19 by turning to the east onto two-lane undivided Linden Street. The route runs through developed areas and turns south onto South Main Street before leaving Meadville. The road becomes Cochranton Road and runs through rural areas to the east of French Creek and the Western New York and Pennsylvania Railroad line. US 322 curves to the southeast and the name changes to Meadville Road. The route becomes an unnamed road and passes through the northern part of the borough of
Cochranton before it comes to an intersection with
PA 173. Past this intersection, the road curves to the south. The route crosses into Mercer County, where it makes a turn to the east. US 322 heads into
Venango County and runs east, curving southeast in the community of
Hannasville. The road enters the borough of
Sugarcreek, where it crosses
Sugar Creek and comes to an intersection with the southern terminus of
PA 427. From here, the route curves south to run east of the parallel Sugar Creek before turning east and running north of French Creek and the Western New York and Pennsylvania Railroad line. US 322 turns south alongside the creek and railroad tracks before it curves east and enters the city of
Franklin. At this point, the road becomes Grant Street and passes through developed areas of the city, curving northeast and back to the east. US 322 reaches an intersection with the southern terminus of
PA 417, at which point it turns south onto four-lane undivided 13th Street, crossing the Western New York and Pennsylvania Railroad line at-grade. The road turns into a divided highway and crosses French Creek, becoming undivided again and heading into the downtown area of Franklin. US 322 comes to an intersection with
US 62/
PA 8, at which point it turns east for a concurrency with the two routes on four-lane undivided Liberty Street. The road turns southeast and leaves the downtown area, narrowing to one lane westbound before US 62/PA 8 split from US 322 by turning to the northeast. US 322 continues south along two-lane undivided Liberty Street before it turns east onto 8th Street and crosses the
Allegheny River, leaving Franklin. From here, the route becomes an unnamed road and curves south parallel to the river, running through rural areas. The road turns to the east and passes through the community of
Venango before the Allegheny River curves south away from the road, with the road gaining a second eastbound lane as it climbs a hill. US 322 narrows to two lanes prior to reaching the community of
Cranberry. Here, the route passes businesses and heads to the south of the Cranberry Mall before it intersects the southern terminus of
PA 257. Past this intersection, the road runs through rural land, crossing
East Sandy Creek and reaching a junction with the northern terminus of
PA 38. passing a rock cut US 22/US 322 enters
Juniata County and continues through the water gap, coming to an eastbound access point to a fishing and boating area along the Juniata River. Farther east, the freeway curves to the southeast and exits the Lewistown Narrows, heading further from the river and coming to a diamond interchange with Arch Rock Road. The two routes head northeast and then southeast, crossing
Lost Creek before turning south and reaching a diamond interchange with
PA 35 east of the borough of
Mifflintown. US 22/US 322 comes to a partial cloverleaf interchange with the northern terminus of
PA 75 northeast of the borough of
Port Royal. The freeway continues southeast, turning to the east-northeast. Farther east, the two routes come to a partial cloverleaf interchange with
PA 333 on the northern border of the borough of
Thompsontown. Past Thompsontown, US 22/US 322 has a westbound exit and eastbound entrance with Pfoutz Valley Road. After this interchange, the freeway runs closely parallel to the north bank of the Juniata River as it passes through a water gap in
Tuscarora Mountain.
Harrisburg to New Jersey US 322 heads east along with I-81 on a six-lane freeway that is part of the
Capital Beltway that circles Harrisburg. The freeway leaves the city limits of Harrisburg and runs through suburban areas. I-81/US 322 comes to a partial cloverleaf interchange with
Progress Avenue before reaching a directional T interchange with the northern terminus of
I-83. At this point, US 322 and the Capital Beltway split from I-81 by heading south along I-83. The four-lane freeway runs south-southeast to the east of Harrisburg, coming to a partial cloverleaf interchange with US 22 that serves the communities of
Progress to the west and
Colonial Park to the east. Past here, I-83/US 322 reaches a diamond interchange with Union Deposit Road. Farther south, US 322 splits from I-83 at a eastbound exit and westbound entrance and heads south along four-lane divided Eisenhower Boulevard, immediately coming to a partial cloverleaf interchange with Derry Street. The road passes under Norfolk Southern's
Harrisburg Line and reaches the Eisenhower Interchange with connections to I-83, the northern terminus of
I-283, and Paxton Street, where US 322 splits from Eisenhower Boulevard to head east along a four-lane freeway. The freeway heads near suburban areas with some industrial development and comes to an interchange with Penhar Drive. Past this interchange, the freeway ends and US 322 continues east as a four-lane divided highway. Farther east, the route becomes Paxton Street and it runs east. The road turns into an unnamed freeway and crosses the
Swatara Creek, bypassing the borough of
Hummelstown to the south. The freeway runs along the southern border of Hummelstown and passes between developed areas of the borough to the north and rural areas to the south, crossing the
Middletown and Hummelstown Railroad at-grade. While bypassing Hummelstown, US 322 comes to a eastbound exit and westbound entrance with South Hanover Street/Middletown Road and a westbound exit and eastbound entrance with Quarry Road/Waltonville Road; a two-lane undivided
frontage road to the south of US 322 connects these two interchanges. From here, the freeway curves northeast and leaves Hummelstown, reaching a partial cloverleaf interchange with the western terminus of the eastern segment of
US 422 and the eastern terminus of PA 39. At this point, the freeway continues as US 422, which soon becomes an at-grade divided highway, while US 322 exits to continue east along West Governor Road, a three-lane road with a center left-turn lane. The road heads into the southern part of the community of
Hershey and runs through developed areas, passing to the north of
Penn State Milton S. Hershey Medical Center and
Penn State Health Children's Hospital. The route narrows to two lanes before intersecting
PA 743. US 322 becomes East Governor Road and heads between
Hershey High School to the north and farmland to the south before passing through the campus of the
Milton Hershey School, coming to roundabouts at Homestead Lane and Meadow Lane serving the school. The road leaves Hershey and runs through agricultural areas in the
Lebanon Valley. The route crosses the
Conestoga River and passes through the community of
Hinkletown. Farther southeast, US 322 runs through the community of
Reidenbach before it reaches the community of
Blue Ball, where it has an intersection with
PA 23. The road runs near some development and forms a short concurrency with
PA 897. From here, the route continues east through agricultural areas, passing through the communities of
Fetterville and
Beartown. At this point, US 322 travels east-southeast across Welsh Mountain. US 322 enters
Chester County and becomes Horseshoe Pike, continuing southeast through rural areas to the borough of
Honey Brook. At this point, the route runs southeast through the borough, where it intersects
PA 10. Upon leaving Honey Brook, the road continues through rural areas with increasing development, crossing the
West Branch Brandywine Creek. Farther southeast, US 322 reaches an intersection with
PA 82 in the community of
Brandywine Manor. From here, the route runs southeast through suburban areas with some rural land, passing through the communities of
Little Washington and
Guthriesville. The road comes to a partial cloverleaf interchange with the
US 30 freeway, where it briefly becomes a divided highway. Past this interchange, US 322 passes north of a
park and ride lot and becomes Manor Avenue, a three-lane road with a center left-turn lane that enters the borough of
Downingtown. Here, the route passes through developed areas, heading to the south of
Downingtown West High School, and narrows to two lanes before coming to an intersection with
US 30 Bus. At this point, US 322 turns northeast for a concurrency with US 30 Bus. on
West Lancaster Avenue, crossing the
East Branch Brandywine Creek and heading in the downtown area of Downingtown on East Lancaster Avenue. US 322 splits from US 30 Bus. by turning south onto Brandywine Avenue, with
US 322 Truck heading east along with US 30 Bus. The route passes under
Amtrak's
Keystone Corridor railroad line and intersects the other end of US 322 Truck at Boot Road along the southern border of Downingtown. From here, the road curves southeast and passes over the East Branch Brandywine Creek and under the abandoned
Brandywine Valley Viaduct. At this point, US 322 becomes Downingtown Pike and runs parallel to the creek through a mix of rural and suburban areas. The route turns east and crosses the creek, at which point the East Branch Brandywine Creek turns south away from the road. US 322 widens to four lanes and turns east onto the West Chester Bypass, a
two-lane expressway.
US 322 Bus. continues southeast along Downingtown Pike toward the borough of
West Chester. The route follows the bypass east-northeast through suburban areas to the north of West Chester, coming to an at-grade intersection with North New Street, then a westbound exit to northbound Pottstown Pike (the former routing of
PA 100) and eastbound entrance from southbound Pottstown Pike. The road continues northeast and curves east as it comes to an at-grade intersection with Phoenixville Pike (the former routing of
PA 29), then passes under an abandoned railroad line before merging into the southbound direction of the
US 202 freeway at a partial interchange. US 202/US 322 continues south-southeast along the West Chester Bypass as a four-lane freeway bypassing West Chester to the east, coming to a partial cloverleaf interchange with Paoli Pike. A short distance later, the two routes reach a partial cloverleaf interchange with
PA 3. The bypass continues south to a diamond interchange at Westtown Road before it curves southwest, passing over the
West Chester Railroad. The freeway portion of the bypass then ends at an at-grade intersection with South Matlack Street. Following this, the bypass continues to its terminus at a trumpet interchange with the eastern terminus of US 322 Bus., which heads north (west) into West Chester on South High Street, providing access to the campus of
West Chester University. At this point, US 202/US 322 exit and head southeast along four-lane divided Wilmington Pike, passing through suburban areas. The road comes to a
jughandle-controlled intersection at Stetson Middle School Drive/Skiles Boulevard before it crosses
PA 926 in the community of
Darlington Corners. US 202/US 322 crosses into
Delaware County and continues southeast along Wilmington-West Chester Pike, coming to an intersection with Oakland Road that has an eastbound jughandle. The road comes to the community of
Painters Crossing and reaches an intersection with
US 1, where US 322 splits from US 202 by heading east along with US 1 on four-lane divided
Baltimore Pike. The road continues east to the community of
Concordville, where US 322 splits from US 1 by heading southeast along Conchester Highway, a four-lane divided highway. The route runs through suburban areas, passing over Smithbridge Road and narrowing to a two-lane undivided road before coming to an interchange with the northern terminus of
PA 261. The road continues east and passes over Chichester Avenue before it widens into a four-lane divided highway and reaches an interchange with
PA 452. Farther east, US 322 passes over
CSX's
Philadelphia Subdivision railroad line and comes to an interchange with Bethel Road. The route passes north of CSX's Twin Oaks Rail Yard, an automotive unloading facility, before it comes to an interchange with
I-95 and Highland Avenue. At this interchange, US 322 merges onto northbound I-95; this interchange consists of full access between US 322 and Highland Avenue and partial access between US 322 and I-95. At this point, US 322 joins I-95 on the Delaware Expressway, a seven-lane freeway with four northbound lanes and three southbound lanes and enters the city of
Chester, passing through urban areas. The freeway leaves the city limits and US 322 splits from I-95 to head southeast on a freeway at a directional T interchange; this interchange includes a ramp from westbound US 322 to Concord Road. The route crosses back into Chester as it follows a five-lane freeway with three eastbound lanes and two westbound lanes that is maintained by the
Delaware River Port Authority. The freeway comes to a westbound exit and eastbound entrance with
US 13 Bus. before it passes over Amtrak's
Northeast Corridor railroad line and reaches an eastbound exit and westbound entrance with
US 13/
PA 291. At this point, US 322 heads onto the
Commodore Barry Bridge, passing over
Conrail Shared Assets Operations'
Chester Industrial Track line and running to the northeast of
Subaru Park, the home stadium of the
Philadelphia Union of
Major League Soccer, before it crosses the
Delaware River into
New Jersey. ==History==