Pachuca Pizarro started his youth career with
Orinegros Ciudad Madero, and joined the
Pachuca Youth System in 2011. Pizarro made his debut with the
senior team on 14 September 2012 coming in on as a substitute in the 71st minute in a 3–2 win over
Morelia. At the time of his debut, he played as a
right-back. On 19 February 2013, during a
Copa MX group stage match against
Dorados de Sinaloa, he would score his first goal in a 5–2 loss.
Guadalajara In December 2016, Pachuca announced the transfer of Pizarro to Guadalajara in a deal reportedly worth up to $15 million, which also involved
Víctor Guzmán permanently joining Pachuca. On 7 January 2017, Pizarro made his debut against
Club Universidad Nacional, playing the whole match in which Guadalajara won 2–1. A week later, Pizarro scored his first goal for Guadalajara against
Monterrey from a long range shot, the game ended 2–2. In April, Guadalajara won the
Clausura Copa MX final against Morelia. The following month, Pizarro would prove to be vital during the
Clausura championship, managing to score in the first leg of the final against
Tigres UANL as Guadalajara would go on to win the title, finishing an eleven-year-long drought of league titles. As a result, Guadalajara won their first
Double since the
1969–70 season. In the first leg of the
2018 CONCACAF Champions League Finals against
Major League Soccer team
Toronto FC, Pizarro scored the first goal of the match within the second minute, in an eventual 2–1 victory, also being named
Man of the Match. As Guadalajara went on to win the finals following a
penalty shoot-out victory of 4–2, Pizarro won the Best Young Player award and was listed on the Best XI of the
tournament.
Monterrey On 4 June 2018, after much media speculation, Guadalajara sporting director
Francisco Gabriel de Anda officially announced that Pizarro was being transferred to fellow league club
Monterrey, for a reported $16 million, making him the costliest interleague transfer in Liga MX history. Rejoining former Pachuca manager
Diego Alonso, Pizarro would make his debut with Monterrey on 21 July 2018 in a 1–0 victory against his youth club, Pachuca. On 5 November, he would score his first goal with the team in a 2–0 win over
Veracruz. He was an integral part of the team as he helped Monterrey win the
2019 CONCACAF Champions League Finals title against
crosstown rivals Tigres UANL, their fourth title. This made Pizarro alongside teammate
Angel Zaldívar the first players to win the tournament in back–to–back years with two different teams. Following the end of his first season with Monterrey, he was listed in the Best XI of the
Clausura. Following an impressive campaign with Mexico over the summer,
Sky Sport Italia linked Pizarro with
A.C. Milan. On 14 December, following Monterrey's 3–2 quarter-final victory over
Al Sadd at the
2019 FIFA Club World Cup, he was named
Man of the Match. At the end of the month, he would win the
Apertura championship against
América, with Pizzaro being handed a starting berth in both legs of the final.
Inter Miami On 14 February 2020, Pizarro left Monterrey for
Major League Soccer expansion side
Inter Miami, following a protracted dispute between the clubs about the activation of his release clause, rejoining head coach Diego Alonso for a third time, his coach at both Pachuca and Monterrey. The following day, despite not officially being announced as a signing for the club, Pizarro scored the first goal for Miami in a 2–1 preseason friendly loss to
Philadelphia Union. That same day, Monterrey filed a complaint with
FIFA against Pizarro and Inter Miami for improper contact between the player and Inter Miami co-owner
David Beckham while Pizarro was still under contract with Monterrey. FIFA's investigation was still on-going when news of the complaint broke on 4 March. On 17 February, Pizarro's move to Miami was made official, labeled as the club's second
Designated Player. Pizarro played in the team's league debut on 1 March, in a 1–0 loss to
Los Angeles FC. The following week, he scored the team's first league goal in a 1–2 loss against
D.C. United. Toward the end of
his first season, he, alongside teammate
Lewis Morgan, was nominated for the
Landon Donovan MVP Award. On 4 January 2022, Pizarro returned to
Monterrey on a one-year loan. On 14 July 2023, Inter Miami and Pizarro agreed to mutually terminate their contract. The move had him rejoin former Guadalajara manager Matías Almeyda and former Guadalajara teammate
Orbelín Pineda. On 16 September 2024, Pizarro returned to México to join
Mazatlán. On 13 June 2025, Pizarro signed with
Juárez. ==International career==