The Kingdom of Sophene was ruled by the Orontid dynasty of
Armenian origin, which was descended from
Orontes I, a
Bactrian nobleman who was the son-in-law of the
Achaemenid King of Kings Artaxerxes II (). According to the Greek writer
Strabo (died 24 AD) in his
Geographica, Sophene first emerged as a distinct kingdom under
Zariadres (), who was installed as its ruler by the Seleucid king
Antiochus III the Great (). He further adds that following the defeat of Antiochus III against the
Romans, Zariadres declared independence. However this report is strongly contradicted by epigraphic and numismatic evidence. Sophene most likely emerged as a distinct kingdom in the 3rd-century BC, during the gradual decline of Seleucid influence in the Near East and the split of the Orontid dynasty into several branches. Three rulers belonging to a different Orontid branch, Sames I,
Arsames I and
Xerxes ruled the western part of
Greater Armenia, perhaps from
Commagene to
Arzanene. == Building activity ==