Bedford business route U.S. Route 220 Business is a route following the original alignment of its parent. In 1973, US 220 became a freeway between
Bedford and
Altoona, Pennsylvania, and the old tract of the route near Bedford became a business loop. Currently, US 220 has been partnered with
Interstate 99; however, the freeway segment south of the
Pennsylvania Turnpike is currently not yet part of the interstate system, which may or may not affect the future status of this road. South of the borough, the route winds over the hilly approach to the town at much steeper grades than does the freeway. It then reaches several stoplights as it serves as a north-south main street. After exiting the municipality, it briefly becomes four lanes as it accommodates a variety of travel services at the interchanges with the Turnpike and I-99. Travelling north, the route flattens out, before meeting US 220 at I-99 Exit 3.
Blair County business route U.S. Route 220 Business is a route following the original alignment of its parent. The route begins at Exit 15 of Interstate 99, in the southernmost point of
Blair County, Pennsylvania. After travelling over a largely rural two-lane segment, it briefly becomes four lanes as it enters metropolitan Altoona; the highway then spends nearly a mile co-signed with two-lane
U.S. Route 22. Afterward, it becomes Plank Road between
Hollidaysburg and Altoona, feature four-lanes, a center turning lane, and a copious commercial development. Eventually the route becomes the more suburban Pleasant Valley Boulevard, splitting off into Valley View Boulevard between 23rd street and 2nd street with Pleasant Valley and Valley View being one-way roads, before they rejoin again into Pleasant Valley again, and it transitions to a two-laner before leaving the urban area. A cosign with
Pennsylvania Route 764 occurs, as the route travels toward
Tyrone, through which it serves as a narrow main street. After heading through several more small towns, the route rejoins I-99 at Exit 52.
Centre County alternate route U.S. Route 220 Alternate is a route following the original alignment of its parent. As part of the ongoing completion of
Interstate 99, U.S. 220 was shifted on to the Mount Nittany Expressway around
State College, Pennsylvania. This portion received an alternate instead of a business designation because it deviates from the route's current course. The route begins in
Huston Township, and is multiplexed consecutively with
Pennsylvania Route 504,
Pennsylvania Route 144,
Pennsylvania Route 150, and
Interstate 80 in its final .
Williamsport truck route U.S. Route 220 Truck is a
truck route established to help trucks from US 220 south access US 220 north and trucks from US 220 north access US 220 south. The route was signed in 2013 and is located in
Williamsport, Pennsylvania. ==Former==