The song originally appeared in the Alfred Hitchcock film
The Man Who Knew Too Much, where it serves an important role in the film's plot. In the film, Day plays a retired popular singer, Jo Conway McKenna, who, along with her husband (played by
Jimmy Stewart) and son, becomes embroiled in a plot to assassinate a foreign prime minister. After foiling the assassination attempt, Jo and her husband are invited by the prime minister to the embassy, where they believe their young son is being held by the conspirators. Jo sits at a piano and plays "Que Sera, Sera", singing loudly in the hope of reaching her son. Upon hearing his mother play the familiar song, her son whistles along, allowing her husband to find and rescue him just before he was to be murdered by the conspirators to the assassination attempt. "Que Sera Sera" came to be considered Doris Day's
signature song, and she went on to sing it in later films and TV appearances. In 1960's ''
Please Don't Eat the Daisies, she sings a snippet of the song to her co-star, David Niven, who plays her husband. In the 1966 film The Glass Bottom Boat she sings a snippet accompanied by Arthur Godfrey on ukulele. From 1968 to 1973, she sang a rerecorded version as the theme song for her sitcom The Doris Day Show. The 1999 Studio Ghibli film My Neighbors the Yamadas'' features a Japanese cover of the song toward the end of the film. Director Isao Takahata wrote the translation for the lyrics, with an arrangement by Neko Saitou. Versions of the song have appeared on a number of film and television soundtracks, often juxtaposed with dark or disastrous events either to create an effect of
black comedy or convey a poignant message. For example, in
The Simpsons episode "
Bart's Comet", the song is sung by the citizens of Springfield in anticipation of an impending comet strike that threatens to wipe out the town and kill them all. In an episode of
The Muppet Show starring
Vincent Price, Shakey Sanchez, a pink/purple red-and-purple-haired Muppet, sings the song after Behemoth eats him and sings "
I've Got You Under My Skin". Previously, the song was featured over the opening and the ending credits of
Heathers, a dark teen comedy dealing with murder and suicide. The version over the opening credits is performed by
Syd Straw and the version over the ending credits is performed by
Sly and the Family Stone. In
Gilmore Girls, the song appeared in a season 2 episode as a musical cue to juxtapose Lorelai falling through their termite-ridden porch. In 2009, the song appeared in a climactic scene in
Mary and Max as Mary is about to commit suicide. A 2010 commercial for
Thai Life Insurance also juxtaposes the song and its message with a choir of disabled children performing to it. In 1956, the song was covered by
The Lennon Sisters on
The Lawrence Welk Show. The song has since gained millions of views on
YouTube. On December 21, 1996, it was covered by the Bina Vokalia Children's Choir under the direction of Pranadjaja on
Dendang Buah Hati concert. It was also used in the series
From in 2022. In 2026, it was also used in the first episode of the anime series
Shiboyugi. == As football chant ==