"Human Nature" received generally positive reviews upon release. From
Billboard magazine,
Larry Flick called it a "wickedly catchy jeep/pop jam in which La M unapologetically snaps at her more close-minded critics", and highlighted her "playfully snide and aggressive" vocals. Sal Cinquemani from
Slant Magazine opined that, "whether licking her wounds over lovers or critics, Madonna has never sounded more emotionally vulnerable or more cerebrally plugged in than she does here". Similarly, author
Mark Bego felt that on the song, "[Madonna] displays a fleeting touch of vulnerability". From
The Baltimore Sun,
J.D. Considine said that "Human Nature" and album track "Survival" were, "the closest thing you'll find [in
Bedtime Stories] to career commentary". For
Rolling Stone, Barbara O'Dair referred to "Human Nature" as an "infectiously funky [...] drive-by on her critics, complete with a keening synth line straight outta
Dre".
Lucy O'Brien, author of
Madonna: Like an Icon, deemed "Human Nature" one of the "quirkiest" tracks on
Bedtime Stories, "throbbing with a tightly restrained but devastating anger".
Chris Wade opined that the song "lifted the sadness" emanated from the first few tracks from the album: "[T]here's a great beat to this, a brilliant vocal where Madonna answers herself with whispers and an unforgettable chorus". While Melissa Ruggieri from
USA Today compared it to the work of
TLC,
Pitchforks
Owen Pallett wrote that, "with its anti-slut-shaming slogan", "Human Nature" is one of Madonna's "most effective grooves" and one of her best songs. Mark Sutherland from
NME declared it a "self-reverential 'steamy'
Prince-esque romp". Barry Walters for the
San Francisco Examiner, said that "Human Nature" has the catchiest chorus among all the other album tracks. Despite singling out its "clever" samples and interpolations, Quentin Harrison from website Albumism opined that the "petulant" "Human Nature" interrupts
Bedtime Stories "demure [and] introspective" tone, and "would have been better served up as a
B-side". Writing for
The Boston Globe, Steve Morse wasn't impressed with the track: "'Express yourself, don't repress yourself', she purrs in the whispery 'Human Nature', but that's hardly a new thought for [Madonna]. She seems lost at this point".
Entertainment Weeklys Jim Farber felt Madonna came across as "petty [...] self-righteous and smug [in 'Human Nature']". Rikky Rooksby, author of
The Complete Guide to the Music of Madonna, gave an unfavorable review: "Musically, ['Human Nature'] wears out its welcome [...] [It's] a very bitter, put-down song". Matthew Jacobs from
HuffPost placed the song at number 7 of his ranking of Madonna's singles, calling it an "R&B blitz that remains one of [her] most original songs". On
Gay Star News ranking, the single came in at number 15; Joe Morgan called it the "ultimate middle finger to her critics". Jude Rogers, from
The Guardian also named it Madonna's 15th greatest, and her "best excursion into the sounds of hip-hop and R&B". Nayer Missim from
PinkNews considered "Human Nature" Madonna's 26th greatest song, and
Entertainment Weeklys Chuck Arnold her 24th; the former said that, "sounding like
Britney before Britney, Madonna gives her critics a deserved thrashing", while the latter deeemed it a "defiant declaration". In
Parades ranking, where it came in at number 13, Samuel R. Murrian classiffied "Human Nature" as a "mesmerizing, funny and angry R&B earworm". Writing for
The A.V. Club, Stephen Thomas Erlewine placed the track in the 36th position of the publication's ranking of Madonna's singles: "The opposite of an apology [...] Madonna rarely unleashed vitriol on record, which makes the nastiness of 'Human Nature' unusually thrilling". Joe Lynch saw the song as a precursor to Madonna's 2015 song "
Unapologetic Bitch", and one that, "holds up as one of [her] finest '90s singles".
Idolators Mike Wass referred to the song as a "razor-sharp feminist manifesto", and one of the most "autobiographical in the living legend's holy discography". For
The Couch Sessions, "Human Nature" is a "dark, brooding masterpiece". == Chart performance ==