Sendejo went undrafted in the
2010 NFL draft, and did not receive any offers to sign as an
undrafted free agent. He attended
rookie minicamp with the
Tampa Bay Buccaneers, but did not receive a contract offer upon completion. Sendejo also attended a tryout with the
New Orleans Saints, but did not receive any further interest from the team.
Sacramento Mountain Lions On August 20, 2010, it was reported that Sendejo signed a contract with the
Sacramento Mountain Lions of the United Football League (UFL). He started at safety for the Mountain Lions and finished the
2010 UFL season with 48 combined tackles (31 solo), seven pass breakups, and two interceptions in eight games and eight starts. He tied for the second most
tackles in the league during the 2010 season and led the Mountain Lions in total tackles and interceptions.
Dallas Cowboys 2010 On November 24, 2010, the
Dallas Cowboys signed Sendejo to a two-year, $725,000 contract to join their
practice squad as an
unrestricted free agent. On November 29, 2010, Sendejo was promoted to the active roster. On December 12, 2010, Sendejo made his NFL debut during a 30–27 loss against the
Philadelphia Eagles. On December 19, 2010, Sendejo recorded his first career tackle on kick returner
Brandon Banks during a 33–30 victory against the
Washington Redskins. Sendejo and teammate
Sam Hurd tackled Banks on a 22-yard kick return in the second quarter. He finished his rookie season with one tackle in two games. Throughout training camp, Sendejo competed for a roster spot as a backup safety against Collin Zych and
Danny McCray. On September 3, 2011, the Dallas Cowboys waived Sendejo as part of their final roster cuts.
New York Jets On September 4, 2011, the
New York Jets claimed Sendejo off of waivers and signed him to their active roster. His signing was marred in minor controversy as it was speculated the New York Jets signed him in a bid to gain intelligence of the Dallas Cowboys' defense. At the time, the New York Jets' head coach was
Rex Ryan and his twin brother,
Rob Ryan, was the Dallas Cowboys' defensive coordinator. Cowboys' quarterback
Tony Romo stated during a press conference that Rob Ryan had made minor adjustments to the defense to prevent any information to possibly be passed on to the Jets. On September 13, 2011, the New York Jets waived Sendejo. The following day, Sendejo was signed to the Jets' practice squad after clearing waivers. On September 27, 2011, the Jets released Sendejo from their practice squad. After his release, Sendejo verified that the Jets coaching staff had in fact asked him about the Dallas Cowboys' defense, but mainly asked him to verify some tendencies. He finished the 2011 season with three combined tackles (two solo) in three games and zero starts.
2012 Sendejo entered training camp and competed for a roster spot as a backup safety against
Jamarca Sanford,
Robert Blanton, and
Eric Frampton. Head coach
Leslie Frazier named Sendejo the third strong safety on the depth chart to begin the regular season, behind rookie
Harrison Smith and Jamarca Sanford. He was inactive for the
Minnesota Vikings' season-opening 26–23 victory against the
Jacksonville Jaguars after sustaining an ankle injury during the preseason. He missed another two games (Weeks 4–5) after aggravating his ankle injury. In Week 7, he made a solo tackle on
Patrick Peterson during a five-yard punt return in the third quarter of a 21–14 win against the
Arizona Cardinals. Sendejo played primarily on special teams in 2012 and finished the season with six solo tackles in 13 games and zero starts.
2013 Sendejo became an exclusive rights free agent in 2013 and was required to re-sign with the Vikings if he was offered a contract. On March 15, 2013, the Minnesota Vikings signed Sendejo to a one-year,
$630,000 contract for the required veteran league minimum. Throughout
training camp, Sendejo competed to be the starting strong safety against
Mistral Raymond, Robert Blanton, Jamarca Sanford, Brandan Bishop, and
Darius Eubanks. Head coach Leslie Frazier officially named Sendejo a backup strong safety, behind Jamarca Sanford and Mistral Raymond, to start the regular season. On September 19, 2013, the Minnesota Vikings signed Sendejo to a two-year, $2 million
contract extension that includes $400,000 guaranteed and a
signing bonus $200,000. On September 29, 2013, Sendejo earned his first career start in place of Jamarca Sanford, who was inactive due to a
hamstring injury. Sendejo recorded four solo tackles in a 34–27 victory against the
Pittsburgh Steelers in London during their Week 4 contest. In Week 7, Sendejo made his first start at free safety and recorded six combined tackles during a 23–7 loss at the
New York Giants. He started nine consecutive games at free safety (Weeks 7–15) after Harrison Smith was placed on injured reserve/designation to return due to a turf toe injury. On November 7, 2013, he collected a career-high 16 combined tackles (eight solo) in the Vikings' 34–27 victory against the
Washington Redskins in Week 10. The following week, Sendejo had 11 combined tackles (six solo) during a 41–20 loss at the
Seattle Seahawks in Week 11. On December 8, 2013, Sendejo recorded three combined tackles, two pass deflections, and made his first career interception in a 29–26 loss to the
Baltimore Ravens. He intercepted a pass by quarterback
Joe Flacco that was originally intended for tight end
Ed Dickson in the fourth quarter. He finished
2013 with a career-high 84 combined tackles (52 solo), two pass deflections, and an interception in 16 games and ten starts.
2014 On August 4, 2014, the Minnesota Vikings activated Sendejo off of their physically unable to perform list after he fully recovered from back surgery he underwent in April. He competed against
Robert Blanton and
Antone Exum to be the starting strong safety. Head coach
Mike Zimmer named Sendejo the backup free safety, behind Harrison Smith, to start the 2014 regular season. In Week 15, he started in place of Blanton, who was unable to play due to a leg injury. Sendejo recorded six combined tackles, in Blanton's absence, as the Vikings lost 16–14 at the
Detroit Lions. Defensive coordinator
George Edwards chose to keep Sendejo as the starting strong safety for the remaining two games (Weeks 16–17), although Blanton had recovered from his leg injury. On December 28, 2014, Sendejo collected a season-high nine combined tackles during a 13–9 win against the
Chicago Bears in Week 17. He finished the season with 27 combined tackles (20 solo) and a forced fumble in 16 games and three starts. Head coach
Mike Zimmer named Sendejo the starting strong safety to start the regular season, opposite free safety
Harrison Smith. He started in the
Minnesota Vikings' season-opener at the
San Francisco 49ers and made three solo tackles and blocked a field goal in their 20–3 loss. He was sidelined for the Vikings' Week 4 loss at the
Denver Broncos due to a knee injury. On November 8, 2015, Sendejo collected seven combined tackles, a pass deflection, and was credited with half a sack to mark the first of his career during a 21–18 overtime victory against the
St. Louis Rams in Week 9. He sacked quarterback
Nick Foles for an eight-yard loss with teammate
Linval Joseph in the third quarter. Sendejo aggravated his knee injury and was inactive for two more games (Weeks 13–14). In Week 16, he made three solo tackles, a pass deflection, and intercepted a pass by
Eli Manning during a 49–17 win against the
New York Giants. On January 3, 2016, Sendejo collected a season-high 14 combined tackles (nine solo) in the Vikings' 20–13 win against the
Green Bay Packers in Week 17. He finished the
2015 season with 74 combined tackles (58 solo), three passes defensed, and one interception in 13 games and 13 starts. He was inactive for the Vikings' Week 8 loss at the
Chicago Bears after injuring his ankle the previous week. Sendejo finished the
2016 season with 69 combined tackles (45 solo), four pass deflections, two fumble recoveries, two interceptions, and was credited with half a sack in 14 games and 14 starts.
2017 Sendejo entered training camp slated as the starting strong safety. Head coach Mike Zimmer officially named Sendejo and Harrison Smith the starting safety duo to begin the 2017 regular season. On September 24, 2017, Sendejo recorded five combined tackles, two pass deflections, and intercepted a pass attempt by quarterback
Jameis Winston in the Vikings' 34–17 victory against the
Tampa Bay Buccaneers. On December 10, 2017, Sendejo recorded nine combined tackles, deflected a pass, and made an interception off a pass by
Cam Newton in a 31–24 loss at the
Carolina Panthers. He completed the 2017 season with 80 combined tackles (54 solo), seven passes defensed, and two interceptions in 13 games and 13 starts. The
Minnesota Vikings finished atop of their division with a 13–3 record and earned a first round bye. On January 10, 2018, Sendejo collected four solo tackles, deflected two passes, and made an interception during Minnesota's to 29–24 comeback victory against the
New Orleans Saints in the NFC Divisional Round. He intercepted a pass attempt thrown by quarterback
Drew Brees in the first quarter that was originally intended for wide receiver
Ted Ginn Jr. The following week, Sendejo collected four solo tackles as the Minnesota Vikings were routed 38–7 by the
Philadelphia Eagles in the
NFC Championship Game.
2018 In 2018, Sendejo started the first five games before suffering a groin injury in Week 5 against the Philadelphia Eagles. He was inactive the next six games before being placed on injured reserve on November 27, 2018. On March 11, 2019, the Vikings declined the option on Sendejo's contract, making him an unrestricted free agent.
Philadelphia Eagles On March 18, 2019, the
Philadelphia Eagles signed Sendejo to a one-year contract. In week 2 against the
Atlanta Falcons, he recorded his second career sack on
Matt Ryan in the 24–20 loss. In week 6 against the
Minnesota Vikings, he recorded an interception off former teammate
Kirk Cousins in the 38–20 loss. He was waived on November 5, 2019.
Minnesota Vikings (second stint) On November 6, 2019, Sendejo was claimed off waivers by the Minnesota Vikings. In Sendejo's first game back with the Vikings, he recorded a team high 7 tackles and intercepted a pass thrown by
Brandon Allen in the 27–23 comeback win over the
Denver Broncos in week 11. In week 14 against the
Detroit Lions, Sendejo intercepted a pass thrown by rookie quarterback
David Blough late in the fourth quarter to seal a 20–7 Vikings win.
Cleveland Browns On March 27, 2020, Sendejo signed a one-year contract with the
Cleveland Browns. He was placed on the reserve/
COVID-19 list by the team on December 29, and activated on January 7, 2021.
Indianapolis Colts On September 14, 2021, Sendejo was signed by the
Indianapolis Colts. ==NFL statistics==