In 1999, the organisation spoke out about the lack of humanitarian support in Kosovo and Chechnya, having set up field missions to help civilians affected by the respective political situations. Although MSF had worked in the Kosovo region since 1993, the onset of the
Kosovo War prompted the movement of tens of thousands of refugees, and a decline in suitable living conditions. MSF provided shelter, water and health care to civilians affected by
NATO's strategic bombing campaigns. A serious crisis within MSF erupted in connection with the organisation's work in Kosovo when the Greek section of MSF was expelled from the organisation. The Greek MSF section had gained access to Serbia at the cost of accepting Serb government imposed limits on where it could go and what it could seeterms that the rest of the MSF movement had refused. A non-MSF source alleged that the exclusion of the Greek section happened because its members extended aid to both Albanian and Serbian civilians in Pristina during NATO's bombing. The rift was healed only in 2005 with the re-admission of the Greek section to MSF. A similar situation was found in Chechnya, whose civilian population was largely forced from their homes into unhealthy conditions and subjected to the violence of the
Second Chechen War. MSF has been working in Haiti since 1991, but since President
Jean-Bertrand Aristide was forced from power, the country has seen a large increase in civilian attacks and rape by armed groups. In addition to providing surgical and psychological support in existing hospitalsoffering the only free surgery available in
Port-au-Princefield missions have been set up to rebuild water and waste management systems and treat survivors of major flooding caused by
Hurricane Jeanne; patients with HIV/AIDS and malaria, both of which are widespread in the country, also receive better treatment and monitoring. As a result of 12 January
2010 Haiti earthquake, reports from Haiti indicated that all three of the organisation's hospitals had been severely damaged; one collapsing completely and the other two having to be abandoned. Following the quake, MSF sent about nine planes loaded with medical equipment and a field hospital to help treat the victims. However, the landings of some of the planes had to be delayed due to the massive number of humanitarian and military flights coming in. The
Kashmir conflict in
North India resulted in a more recent MSF intervention (the first field mission was set up in 1999) to help civilians displaced by fighting in
Jammu and Kashmir, as well as in
Manipur. Psychological support is a major target of missions, but teams have also set up programmes to treat tuberculosis, HIV/AIDS and malaria. Mental health support has been of significant importance for MSF in much of southern Asia since the
2004 Indian Ocean earthquake. MSF went through a long process of self-examination and discussion in 2005–2006. Many issues were debated, including the treatment of "nationals" as well as "fair employment" and self-criticism. MSF issued a statement for safe abortion following ''
Dobbs v. Jackson Women's Health Organization''.
Sub-Saharan Africa (2005) MSF has been active in a large number of African countries for decades, sometimes serving as the sole provider of health care, food, and water. Although MSF has consistently attempted to increase media coverage of the situation in Africa to increase international support, long-term field missions are still necessary. Treating and educating the public about
HIV/AIDS in
sub-Saharan Africa, which sees the most deaths and cases of the disease in the world, is a major task for volunteers. Of the 14.6 million people in need of anti-retroviral treatment the WHO estimated that only 5.25 million people were receiving it in developing countries, and MSF continues to urge governments and companies to increase research and development into HIV/AIDS treatments to decrease cost and increase availability.
Sierra Leone In the late 1990s, MSF missions were set up to treat tuberculosis and
anaemia in residents of the
Aral Sea area, and look after civilians affected by drug-resistant disease, famine, and epidemics of cholera and AIDS. They vaccinated 3 million Nigerians against
meningitis during an epidemic in 1996 and denounced the
Taliban's neglect of health care for women in 1997. Arguably, the most significant country in which MSF set up field missions in the late 1990s was Sierra Leone, which was involved in a
civil war at the time. In 1998, volunteers began assisting in surgeries in
Freetown to help with an increasing number of
amputees, and collecting statistics on civilians (men, women and children) being attacked by large groups of men claiming to represent
ECOMOG. The groups of men were travelling between villages and systematically chopping off one or both of each resident's arms, raping women, gunning down families, razing houses, and forcing survivors to leave the area. Long-term projects following the end of the civil war included psychological support and
phantom limb pain management.
Sudan Since 1979, MSF has been providing medical humanitarian assistance in
Sudan, a nation plagued by starvation and the
civil war, prevalent malnutrition and one of the highest maternal mortality rates in the world. In March 2009, it is reported that MSF has employed 4,590 field staff in Sudan tackling issues such as armed conflicts, epidemic diseases, health care and social exclusion. MSF's continued presence and work in
Sudan is one of the organisation's largest interventions. MSF provides a range of health care services including nutritional support, reproductive healthcare, kala-azar treatment, counselling services and surgery to the people living in
Sudan. Common diseases prevalent in
Sudan include
tuberculosis,
kala-azar also known as
visceral leishmaniasis,
meningitis,
measles,
cholera, and
malaria.
Kala-azar in Sudan Kala-azar, also known as
visceral leishmaniasis, has been one of the major health problems in
Sudan. After the Comprehensive Peace Agreement between North and
Southern Sudan on 9 January 2005, the increase in stability within the region helped further efforts in healthcare delivery. Médicins Sans Frontières tested a combination of
sodium stibogluconate and
paromomycin, which would reduce treatment duration (from 30 to 17 days) and cost in 2008. In March 2010, MSF set up its first kala-azar treatment centre in Eastern Sudan, providing free treatment for this otherwise deadly disease. If left untreated, there is a fatality rate of 99% within 1–4 months of infection. Since the treatment centre was set up, MSF has cured more than 27,000 kala-azar patients with a success rate of approximately 90–95%. There are plans to open an additional kala-azar treatment centre in
Malakal, Southern Sudan, to cope with the overwhelming number of patients that are seeking treatment. MSF has been providing necessary medical supplies to hospitals and training Sudanese health professionals to help them deal with kala-azar. MSF, Sudanese Ministry of Health and other national and international institutions are combining efforts to improve on the treatment and diagnosis of kala-azar. Research on its cures and vaccines are currently being conducted. Hundreds, including women and children were killed. Valuable items including medical equipment and drugs were lost during the raid and parts of the MSF facilities were destroyed in a fire. but continues to work in other areas to provide food to tens of thousands of displaced civilians, as well as treat survivors of mass rapes and widespread fighting. The treatment and possible vaccination against diseases such as
cholera,
measles,
polio,
Marburg fever,
sleeping sickness,
HIV/AIDS, and
bubonic plague is also important to prevent or slow down epidemics.
Uganda MSF has been active in Uganda since 1980, and provided relief to civilians during the country's guerrilla war during the
Second Obote Period. However, the formation of the
Lord's Resistance Army saw the beginning of a long campaign of violence in northern Uganda and southern Sudan. Civilians were subjected to mass killings and rapes, torture, and abductions of children, who would later serve as sex slaves or
child soldiers. Faced with more than 1.5 million people displaced from their homes, MSF set up relief programmes in
internally displaced person (IDP) camps to provide clean water, food and sanitation. Diseases such as
tuberculosis, measles, polio, cholera,
ebola, and HIV/AIDS occur in epidemics in the country, and volunteers provide vaccinations (in the cases of measles and polio) and/or treatment to the residents. Mental health is also an important aspect of medical treatment for MSF teams in Uganda since most people refuse to leave the IDP camps for constant fear of being attacked.
Ivory Coast MSF first camp set up a field mission in Côte d'Ivoire in 1990, but ongoing violence and the
2002 division of the country by rebel groups and the government led to several massacres, and MSF teams have even begun to suspect that an ethnic cleansing is occurring. tuberculosis treatment and the re-opening of hospitals closed by fighting are projects run by MSF, which is the only group providing aid in much of the country. MSF has strongly promoted the use of
contraception in Africa.
West African Ebola outbreak During the Ebola outbreak in West Africa in 2014, MSF met serious medical demands largely on its own, after the organisation's early warnings were largely ignored.
Burundi MSF-Burundi has aided in attending to casualties suffered in the
2019 Burundi landslides.
Asia Sri Lanka MSF is involved in Sri Lanka, where a
26-year civil war ended in 2009 and MSF has adapted its activities there to continue its mission. For example, it helps with physical therapy for patients with spinal cord injuries. It conducts counseling sessions, and has set up an "operating theatre for reconstructive orthopaedic surgery and supplied specialist surgeons, anaesthetists and nurses to operate on patients with complicated war-related injuries".
Cambodia MSF first provided medical help to civilians and refugees who have escaped to camps along the Thai-Cambodian border in 1979. Due to long decades of war, a proper
health care system in the country was severely lacking. In 1999, Cambodia was hit with a malaria epidemic. The situation of the epidemic was aggravated by a lack of qualified practitioners and poor quality control which led to a market of fake antimalarial drugs. Counterfeit antimalarial drugs were responsible for the deaths of at least 30 people during the epidemic. This has prompted efforts by MSF to set up and fund a malaria outreach project and utilise Village Malaria Workers. MSF also introduced a switching of first-line treatment to a combination therapy (Artesunate and Mefloquine) to combat resistance and fatality of old drugs that were used to treat the disease traditionally. Cambodia is one of the hardest hit HIV/AIDS countries in Southeast Asia. In 2001, MSF started introducing antiretroviral (ARV) therapy to AIDS patients for free. This therapy prolongs the patients' lives and is a long-term treatment. In 2002, MSF established chronic diseases clinics with the Cambodian Ministry of Health in various provinces to integrate HIV/AIDS treatment, alongside hypertension, diabetes, and arthritis which have high prevalence rate. This aims to reduce facility-related stigma as patients are able to seek treatment in a multi-purpose clinic in contrast to a HIV/AIDS specialised treatment centre. MSF also provided humanitarian aid in times of natural disaster such as a major flood in 2002 which affected up to 1.47 million people. MSF introduced a community-based tuberculosis programme in 2004 in remote villages, where village volunteers are delegated to facilitate the medication of patients. In partnership with local health authorities and other NGOs, MSF encouraged decentralized clinics and rendered localized treatments to more rural areas from 2006. Since 2007, MSF has extended general health care, counselling, HIV/AIDS and TB treatment to prisons in Phnom Penh via mobile clinics. However, poor sanitation and lack of health care still prevails in most Cambodian prisons as they remain as some of the world's most crowded prisons. In 2007, MSF worked with the Cambodian Ministry of Health to provide psychosocial and technical support in offering pediatric HIV/AIDS treatment to affected children. MSF also provided medical supplies and staff to help in one of the worst dengue outbreaks in 2007, which had more than 40,000 people hospitalized, killing 407 people, primarily children. In 2010, Southern and Eastern provinces of Cambodia were hit with a cholera epidemic and MSF responded by providing medical support that were adapted for usage in the country. Cambodia is one of 22 countries listed by WHO as having a high burden of tuberculosis. WHO estimates that 64% of all Cambodians carry the tuberculosis mycobacterium. Hence, MSF has since shifted its focus away from HIV/AIDS to tuberculosis, handing over most HIV-related programs to local health authorities.
Middle East and North Africa Libya The
2011 Libyan civil war prompted efforts by MSF to set up a hospital and mental health services to help locals affected by the conflict. The fighting created a backlog of patients that needed surgery. With parts of the country slowly returning to livable, MSF started working with local health personnel to address the needs. The need for psychological counseling increased and MSF set up mental health services to address the fears and stress of people living in tents without water and electricity. As of late 2016, MSF was the only International Aid organisation with actual presence in the country. MSF was ordered in November 2025 to leave Libya without any apparent explanation.
Search and Rescue in the Mediterranean Sea MSF is providing Maritime
Search and rescue (SAR) services on the Mediterranean Sea to save the lives of migrants attempting to cross with unseaworthy boats. The Mission started in 2015 after the EU ended its major SAR
operation Mare Nostrum, severely diminishing much needed SAR capacities in the Mediterranean. Throughout the mission MSF has operated its own vessels like the
Bourbon Argos (2015–2016),
Dignity 1 (2015–2016) and
VOS Prudence (2016–2017). MSF has also provided medical teams to support other NGOs and their ships like the
MOAS Phoenix (2015) or the
Aquarius (2017–2018) and
Ocean Viking (2019–2020) with
SOS Méditerranée and
Mediterranea Saving Humans. In August 2017 MSF decided to suspend the activities of the
VOS Prudence protesting restrictions and threats by the Libyan "Coast Guard". In December 2018 MSF and SOS Méditerranée were forced to end operations of the
Aquarius, at that date the last remaining vessel supported by MSF. This came after attacks by EU states that stripped the vessel of its registration and produced criminal accusations against MSF. Up to then 80,000 people had been rescued or assisted since the beginning of the mission. Operations resumed with
Ocean Viking in July 2019, but the ship was seized in Sicily in July 2020. Within a month this resulted in the rescue of some 400 people. In December 2024 MSF announced the suspension of further operations of the vessel. During the 2023 and 2024, due to bureaucratic blockages by the Italian government, it had spent some 160 days in port. In November 2025, the 20m-long vessel
Oyvon began in service as a replacement for the larger
Geo Barents, with a crew of 10 MSF activists under the German flag.
Yemen MSF is involved in trying to help with the humanitarian crisis caused by the
Yemeni Civil War. The organisation operates eleven hospitals and health centres in Yemen and provides support to another 18 hospitals or health centres. According to MSF, since October 2015, four of its hospitals and one ambulance have been destroyed by Saudi-led coalition airstrikes. In August 2016, an airstrike on Abs hospital killed 19 people, including one MSF staff member, and wounded 24.
Italy MSF has been active in Italy since 1999, providing comprehensive assistance – including humanitarian, medical, psychological, and socio-health support – to migrants, asylum seekers, and refugees across the country. Over the years, its efforts have spanned various initiatives, from aiding migrant arrivals to operating within reception centers and informal settlements in different regions of Italy. As of Spring 2024, MSF is involved in projects across three key locations in Italy. In
Calabria, it delivers medical and psychological aid during migrant arrivals and ensures ongoing care within the region's reception centers. In
Ventimiglia, situated on the Italo-French border, MSF operates a mobile clinic specifically catering to migrants passing through the area. Meanwhile, in
Palermo, in collaboration with local health authorities, MSF has launched a program to support foreign individuals who have survived torture and other deliberate acts of violence. Moreover, MSF Italy possesses the capability to provide psychological first aid to individuals who have undergone particularly traumatic experiences during their
Mediterranean Sea crossings. ==Organisation of activities==