Pre-draft Desir was featured along with
Jadeveon Clowney,
Bishop Sankey,
Blake Bortles, and
Marqise Lee on
ESPN's Draft Academy, which aired before the
2014 NFL draft.
Cleveland Browns 2014 season The
Cleveland Browns selected Desir in the fourth round with the 127th overall pick in the 2014 NFL draft. He became the first player from Lindenwood to ever be selected in the
NFL draft and was the 15th
cornerback drafted in 2014. On May 29, 2014, the Browns signed Desir to a four-year, $2.62 million contract that includes a
signing bonus of $407,612. Throughout
training camp, Desir competed to be a backup cornerback against
Isaiah Trufant and
Leon McFadden. Head coach
Mike Pettine named Desir the fourth cornerback on the
depth chart to begin the regular season, behind
Joe Haden,
Buster Skrine, and
Justin Gilbert. Desir was inactive as a healthy scratch for the first 12 games of the regular season. On November 30, 2014, Desir made his professional regular season debut during a 26–10 loss at the
Buffalo Bills in Week 13. On December 21, 2014, Desir earned his first career start and collected a season-high seven solo tackles and broke up two pass attempts during a 17–13 loss at the
Carolina Panthers in Week 16. He finished his rookie season in 2014 with nine solo tackles and two pass deflections in five games and one start.
2015 season During training camp, Desir competed for a roster spot as the third cornerback against Gilbert,
Charles Gaines,
Robert Nelson, and
K'Waun Williams. Head coach
Mike Pettine named Desir the fourth cornerback on the Browns' depth chart to begin the regular season. He was listed on the depth chart behind
Joe Haden,
Tramon Williams, and
K'Waun Williams. In Week 6, Desir collected a season-high 12 combined tackles (ten solo) and deflected one pass during a 26–23 loss against the
Denver Broncos. He was inactive during the Browns' Week 12 loss against the
Baltimore Ravens and a Week 14 victory against the
San Francisco 49ers. Desir finished the
2015 NFL season with 37 combined tackles (30 solo) and five pass deflections in 14 games and six starts. Throughout training camp, Desir competed for a roster spot as a backup cornerback against Gilbert,
Charles Gaines,
Trey Williams, and
Jamar Taylor. On September 3, the Browns officially waived Desir as part of their final roster cuts.
San Diego Chargers On September 4, 2016, the
San Diego Chargers claimed Desir off of waivers. Head coach
Mike McCoy named Desir the fifth cornerback on the Chargers' depth chart to begin the regular season, behind
Jason Verrett,
Brandon Flowers,
Casey Hayward, and
Craig Mager. On October 22, the Chargers released Desir, but re-signed him two days later, only for him to be released again on October 29.
Seattle Seahawks (first stint) On November 2, 2016, the
Seattle Seahawks signed Desir to their
practice squad. On January 16, 2017, the Seahawks signed Desir to a one-year, $790,000 reserve/future contract. Throughout training camp, Desir competed to be a backup cornerback against
Mike Tyson,
Tramaine Brock,
Neiko Thorpe,
Demetrius McCray, and
DeAndre Elliott. On September 2, the Seahawks waived Desir as part of their final roster cuts.
Indianapolis Colts 2017 season On September 3, 2017, the
Indianapolis Colts claimed Desir off of waivers. Head coach
Chuck Pagano named Desir the sixth cornerback on the Colts' depth chart, behind
Vontae Davis,
Rashaan Melvin,
Nate Hairston,
Quincy Wilson, and
Kenny Moore II. Desir earned a starting role in Week 8 after he surpassed Hairston, Wilson, and Moore on the depth chart. He replaced Davis, who was released on November 9. On November 12, Desir collected a season-high eight combined tackles, deflected two passes, and made his first career interception during a 20–17 loss against the
Pittsburgh Steelers in Week 10. Desir intercepted a pass by Steelers' quarterback
Ben Roethlisberger, that was originally intended for wide receiver
Martavis Bryant, during the first quarter. On December 3, Desir suffered a shoulder injury as the Colts lost 30–10 at the
Jacksonville Jaguars. The next day, the Colts placed Desir on
injured reserve. He finished the season with 32 combined tackles (21 solo), seven pass deflections, and one interception in nine games and six starts. Throughout training camp, Desir competed to be a starting cornerback against Hairston, Wilson, and Moore. Head coach
Frank Reich named Desir the third cornerback on the Colts' depth chart to begin the regular season, behind Moore and Hairston. On September 30, Desir made five solo tackles, broke up a pass attempt, and intercepted a pass during a 37–34 loss against the
Houston Texans. In Week 6, he collected a season-high nine combined tackles during a 42–34 loss at the
New York Jets. He finished the
2018 NFL season with 79 combined tackles (60 solo), eight pass deflections, and one interception in 16 games and 12 starts.
2019 season On March 13, 2019, Desir signed a three-year, $22.5 million contract extension with the Colts with $12 million guaranteed. In Week 7 against the
Houston Texans, Desir recorded his first interception of the season off
Deshaun Watson in the 30–23 win. In Week 16 against the
Carolina Panthers, Desir recorded two interceptions off passes thrown by rookie quarterback
Will Grier during the 38–6 win. On March 21, 2020, Desir was released by the Indianapolis Colts.
New York Jets On April 2, 2020, the
New York Jets signed Desir to a one-year contract worth up to $5.5 million. In Week 2 against the
San Francisco 49ers, Desir recorded his first interception as a Jet off a pass thrown by
Nick Mullens during the 31–13 loss. In Week 4 against the
Denver Broncos on
Thursday Night Football, Desir recorded two interceptions off of passes thrown by quarterback
Brett Rypien, including a pick six, in the 37–28 loss. He also gave up a 48-yard touchdown reception to Broncos rookie wide receiver
Jerry Jeudy during the game. On November 17, Desir was waived by the Jets. Despite being waived, Desir was named the Jets nominee for the
Walter Payton Man of the Year Award.
Baltimore Ravens On November 28, 2020, Desir was signed to the
Baltimore Ravens' practice squad. He was elevated to the active roster on December 8, December 19, and December 26 for the team's Weeks 13, 15, and 16 games against the
Dallas Cowboys,
Jacksonville Jaguars, and
New York Giants, and reverted to the practice squad after each game. He was elevated again on January 15, 2021, for the team's divisional playoff game against the
Buffalo Bills, and reverted to the practice squad again following the game. Desir's practice squad contract with the team expired after the season on January 25.
Seattle Seahawks (second stint) Desir signed with the
Seattle Seahawks on April 23, 2021. He was released by the Seahawks on August 24.
Tampa Bay Buccaneers in 2021 On September 13, 2021, Desir was signed by the
Tampa Bay Buccaneers to the team's practice squad. He was promoted to the active roster on October 2. Desir played in twelve games with the team, both as a cornerback and on special teams. == NFL career statistics ==