•
Age of Empires: The Rise of Rome: The campaign in "Pax Romana: 1. Actium" has a history section that talks about Antony and Cleopatra falling in love, the navy battle in Egypt, and their downfall by suicide. The player must sink Cleopatra's barge in order to win the campaign. •
Anachronism Set 2 includes Cleopatra. • ''
Assassin's Creed II'': In the backstory of the game, Cleopatra is included in a list of tyrannical rulers targeted by the assassins. She is killed by a female assassin named Amunet, who assassinates her using an asp to make the queen's death appear to be a suicide. • ''
Assassin's Creed Origins'': Cleopatra plays a more active role in the story of this later entry to the franchise, first as an ally to the Hidden Ones, a predecessor to the Assassin Brotherhood, and later as an enemy along with
Julius Caesar. Her killer Amunet, once known as Aya of
Alexandria, also plays a major role as a leader of the Hidden Ones and ex-wife of the protagonist,
Bayek of Siwa. •
BreakAway's and
Impressions's
Cleopatra: Queen of the Nile (2000) •
Double Dragon 3: The Rosetta Stone – Cleopatra appears as an end boss in the final level of the arcade game. •
Cleopatra and the Society of Architects •
Cleopatra Fortune •
Civilization II •
Civilization III •
Civilization VI •
Civilization Revolution • Cleopatra is a playable character in the Mobile/PC Game
Rise of Kingdoms. •
''Dante's Inferno'' •
Fate/Grand Order: Cleopatra is an Assassin class servant. She is the antagonist of a Halloween event, where she wishes to reunite with Caesar and is dismayed to find that he has grown fat. •
Kheops Studio's ''Cleopatra: A Queen's Destiny'' (2007) •
Night at the Museum: Battle of the Smithsonian •
Scribblenauts and its sequels •
Shadow of Rome: Iris and Charmian, twins who appear throughout the game who employ the character Sextus and his gladiators, are implied to be working for Cleopatra, even though it is never confirmed. •
Total War: Rome II •
International Game Technology has a series of Cleopatra slot machines. ==Literature==