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List of EC numbers (EC 1)

This list contains a list of EC numbers for the first group, EC 1, oxidoreductases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee. The database is developed and maintained by Andrew McDonald.

EC 1.1 Acting on the CH-OH group of donors
EC 1.1.1 With Nicotinamide adenine dinucleotide or NADP as acceptor • : alcohol dehydrogenase • : alcohol dehydrogenase (NADP+) • : homoserine dehydrogenase • : (R,R)-butanediol dehydrogenase • EC 1.1.1.5: acetoin dehydrogenase. Now EC 1.1.1.303, diacetyl reductase [(R)-acetoin forming] and EC 1.1.1.304, diacetyl reductase [(S)-acetoin forming] • : glycerol dehydrogenase • : propanediol-phosphate dehydrogenase • : glycerol-3-phosphate dehydrogenase (NAD+) • : D-xylulose reductase • : L-xylulose reductase • : D-arabinitol 4-dehydrogenase • : L-arabinitol 4-dehydrogenase • : L-arabinitol 2-dehydrogenase • : L-iditol 2-dehydrogenase • : D-iditol 2-dehydrogenase • : galactitol 2-dehydrogenase • : mannitol-1-phosphate 5-dehydrogenase • : inositol 2-dehydrogenase • : glucuronate reductase • : glucuronolactone reductase • : (-)-menthol dehydrogenase • : (+)-neomenthol dehydrogenase • : aldose reductase • : UDP-glucose 6-dehydrogenase • : (R)-4-hydroxyphenyllactate dehydrogenase • : histidinol dehydrogenase| • : quinate/shikimate dehydrogenase (NAD+) • : shikimate dehydrogenase (NADP+) • : glyoxylate reductase • : L-lactate dehydrogenase • : D-lactate dehydrogenase • : glycerate dehydrogenase • : 3-hydroxybutyrate dehydrogenase • : 3-hydroxyisobutyrate dehydrogenase • : mevaldate reductase • : mevaldate reductase (NADPH) • : hydroxymethylglutaryl-CoA reductase (NADPH) • : 3-hydroxyacyl-CoA dehydrogenase • : acetoacetyl-CoA reductase • : malate dehydrogenase • : malate dehydrogenase (oxaloacetate-decarboxylating) • : malate dehydrogenase (decarboxylating) • : malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) • : isocitrate dehydrogenase (NAD+) • : isocitrate dehydrogenase (NADP+) • : phosphogluconate 2-dehydrogenase • : phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) • : L-gulonate 3-dehydrogenase • : L-arabinose 1-dehydrogenase • : glucose 1-dehydrogenase [NAD(P)+)] • : D-galactose 1-dehydrogenase • : glucose-6-phosphate dehydrogenase (NADP+) • : 3α-hydroxysteroid 3-dehydrogenase (Si-specific) • : 3(or 17)β-hydroxysteroid dehydrogenase • : 3α-hydroxycholanate dehydrogenase (NAD+) • : 3α(or 20β)-hydroxysteroid dehydrogenase • : allyl-alcohol dehydrogenase • : lactaldehyde reductase (NADPH) • : ribitol 2-dehydrogenase • : fructuronate reductase • : tagaturonate reductase • : 3-hydroxypropionate dehydrogenase • : 2-hydroxy-3-oxopropionate reductase • : 4-hydroxybutyrate dehydrogenase • : 17β-estradiol 17-dehydrogenase • EC 1.1.1.63: testosterone 17β-dehydrogenase. Now EC 1.1.1.239, 3α(17β)-hydroxysteroid dehydrogenase (NAD+) • : testosterone 17β-dehydrogenase (NADP+) • : pyridoxine 4-dehydrogenase • : ω-hydroxydecanoate dehydrogenase • : mannitol 2-dehydrogenase • EC 1.1.1.68: 5,10-methylenetetrahydrofolate reductase. Now EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H] • : gluconate 5-dehydrogenase • EC 1.1.1.70: D-glucuronolactone dehydrogenase. Now included with EC 1.2.1.3 aldehyde dehydrogenase (NAD+) • : alcohol dehydrogenase [NAD(P)+] • : glycerol dehydrogenase (NADP+) • : octanol dehydrogenase • EC 1.1.1.74: D-aminopropanol dehydrogenase (reaction due to EC 1.1.1.4 (R,R)-butanediol dehydrogenase) • : (R)-aminopropanol dehydrogenase • : (S,S)-butanediol dehydrogenase • : lactaldehyde reductase • : methylglyoxal reductase (NADH-dependent) • : glyoxylate reductase (NADP+) • : isopropanol dehydrogenase (NADP+) • : hydroxypyruvate reductase • : malate dehydrogenase (NADP+) • : D-malate dehydrogenase (decarboxylating) • : dimethylmalate dehydrogenase • : 3-isopropylmalate dehydrogenase • : ketol-acid reductoisomerase (NADP+) • : homoisocitrate dehydrogenase • : hydroxymethylglutaryl-CoA reductase • EC 1.1.1.89: dihydroxyisovalerate dehydrogenase (isomerizing). Now included with EC 1.1.1.86 ketol-acid reductoisomerase • : aryl-alcohol dehydrogenase • : aryl-alcohol dehydrogenase (NADP+) • : oxaloglycolate reductase (decarboxylating) • : tartrate dehydrogenase • : glycerol-3-phosphate dehydrogenase [NAD(P)+] • : phosphoglycerate dehydrogenase • : diiodophenylpyruvate reductase • : 3-hydroxybenzyl-alcohol dehydrogenase • : (R)-2-hydroxy-fatty-acid dehydrogenase • : (S)-2-hydroxy-fatty-acid dehydrogenase • : 3-oxoacyl-(acyl-carrier-protein) reductase|3-oxoacyl-[acyl-carrier-protein] reductase • : acylglycerone-phosphate reductase • : 3-dehydrosphinganine reductase • : L-threonine 3-dehydrogenase • : 4-oxoproline reductase • : all-trans-retinol dehydrogenase (NAD+) • : pantoate 4-dehydrogenase • : pyridoxal 4-dehydrogenase • : carnitine 3-dehydrogenase • EC 1.1.1.109: Now EC 1.3.1.28, 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase • : aromatic 2-oxoacid reductase • : 3-(imidazol-5-yl)lactate dehydrogenase • : indanol dehydrogenase • : L-xylose 1-dehydrogenase • : apiose 1-reductase • : ribose 1-dehydrogenase (NADP+) • : D-arabinose 1-dehydrogenase (NAD+) • : D-arabinose 1-dehydrogenase [NAD(P)+] • : glucose 1-dehydrogenase (NAD+) • : glucose 1-dehydrogenase (NADP+) • : galactose 1-dehydrogenase (NADP+) • : aldose 1-dehydrogenase (NAD+) • : D-threo-aldose 1-dehydrogenase • : sorbose 5-dehydrogenase (NADP+) • : fructose 5-dehydrogenase (NADP+) • : 2-deoxy-D-gluconate 3-dehydrogenase • : 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase • : 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase • EC 1.1.1.128: The reaction described is covered by EC 1.1.1.264, L-idonate 5-dehydrogenase. • : L-threonate 3-dehydrogenase • : 3-dehydro-L-gulonate 2-dehydrogenase • : mannuronate reductase • : GDP-mannose 6-dehydrogenase • : dTDP-4-dehydrorhamnose reductase • : dTDP-6-deoxy-L-talose 4-dehydrogenase (NADP+) • : GDP-6-deoxy-D-talose 4-dehydrogenase • : UDP-N-acetylglucosamine 6-dehydrogenase • : ribitol-5-phosphate 2-dehydrogenase • : mannitol 2-dehydrogenase (NADP+) • EC 1.1.1.139: polyol dehydrogenase (NADP+). Now included with EC 1.1.1.21 aldehyde reductase • : sorbitol-6-phosphate 2-dehydrogenase • : 15-hydroxyprostaglandin dehydrogenase (NAD+) • : D-pinitol dehydrogenase • : sequoyitol dehydrogenase • : perillyl-alcohol dehydrogenase • : 3β-hydroxy-Δ5-steroid dehydrogenase • : 11β-hydroxysteroid dehydrogenase • : 16α-hydroxysteroid dehydrogenase • : estradiol 17α-dehydrogenase • : 20α-hydroxysteroid dehydrogenase • : 21-hydroxysteroid dehydrogenase (NAD+) • : 21-hydroxysteroid dehydrogenase (NADP+) • : 3α-hydroxy-5β-androstane-17-one 3α-dehydrogenase • : sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) • : ureidoglycolate dehydrogenase • EC 1.1.1.155: homoisocitrate dehydrogenase. The enzyme is identical to EC 1.1.1.87, homoisocitrate dehydrogenase • : glycerol 2-dehydrogenase (NADP+) • : 3-hydroxybutyryl-CoA dehydrogenase • EC 1.1.1.158: Now EC 1.3.1.98, UDP-N-acetylmuramate dehydrogenase • : 7α-hydroxysteroid dehydrogenase • : dihydrobunolol dehydrogenase • EC 1.1.1.161: The activity is part of EC 1.14.13.15, cholestanetriol 26-monooxygenase • : erythrulose reductase • : cyclopentanol dehydrogenase • : hexadecanol dehydrogenase • : 2-alkyn-1-ol dehydrogenase • : hydroxycyclohexanecarboxylate dehydrogenase • : hydroxymalonate dehydrogenase • : 2-dehydropantolactone reductase (Re-specific) • : 2-dehydropantoate 2-reductase • : 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating) • EC 1.1.1.171: Now EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H] • : 2-oxoadipate reductase • : L-rhamnose 1-dehydrogenase • : cyclohexane-1,2-diol dehydrogenase • : D-xylose 1-dehydrogenase • : 12α-hydroxysteroid dehydrogenase • : glycerol-3-phosphate 1-dehydrogenase (NADP+) • : 3-hydroxy-2-methylbutyryl-CoA dehydrogenase • : D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) • EC 1.1.1.180: Now included with EC 1.1.1.131 mannuronate reductase • : cholest-5-ene-3β,7α-diol 3β-dehydrogenase • EC 1.1.1.182: Now included with EC 1.1.1.198 (+)-borneol dehydrogenase, EC 1.1.1.227 (-)-borneol dehydrogenase and EC 1.1.1.228 (+)-sabinol dehydrogenase • : geraniol dehydrogenase (NADP+) • : carbonyl reductase (NADPH) • : L-glycol dehydrogenase • : dTDP-galactose 6-dehydrogenase • : GDP-4-dehydro-D-rhamnose reductase • : prostaglandin-F synthase • : prostaglandin-E2 9-reductase • : indole-3-acetaldehyde reductase (NADH) • : indole-3-acetaldehyde reductase (NADPH) • : long-chain-alcohol dehydrogenase • : 5-amino-6-(5-phosphoribosylamino)uracil reductase • : coniferyl-alcohol dehydrogenase • : cinnamyl-alcohol dehydrogenase • : 15-hydroxyprostaglandin-D dehydrogenase (NADP+) • : 15-hydroxyprostaglandin dehydrogenase (NADP+) • : (+)-borneol dehydrogenase • : (S)-usnate reductase • : aldose-6-phosphate reductase (NADPH) • : (+)-sabinol dehydrogenase • : galactitol-1-phosphate 5-dehydrogenase • : tetrahydroxynaphthalene reductase • EC 1.1.1.253: Now EC 1.5.1.33, pteridine reductase • : (S)-carnitine 3-dehydrogenase • : mannitol dehydrogenase • : fluoren-9-ol dehydrogenase • : 4-(hydroxymethyl)benzenesulfonate dehydrogenase • : 6-hydroxyhexanoate dehydrogenase • : 3-hydroxypimeloyl-CoA dehydrogenase • : sulcatone reductase • : sn-glycerol-1-phosphate dehydrogenase • : 4-hydroxythreonine-4-phosphate dehydrogenase • : 1,5-anhydro-D-fructose reductase • : L-idonate 5-dehydrogenase • : 3-methylbutanal reductase • : dTDP-4-dehydro-6-deoxyglucose reductase • : 1-deoxy-D-xylulose-5-phosphate reductoisomerase • : 2-(R)-hydroxypropyl-CoM dehydrogenase • : 2-(S)-hydroxypropyl-CoM dehydrogenase • : 3β-hydroxysteroid 3-dehydrogenase • : GDP-L-fucose synthase • : D-2-hydroxyacid dehydrogenase (NADP+) • : vellosimine dehydrogenase • : 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming) • : (+)-trans-carveol dehydrogenase • : serine 3-dehydrogenase (NADP+) • : 3β-hydroxy-5β-steroid dehydrogenase • : 3β-hydroxy-5α-steroid dehydrogenase • : (R)-3-hydroxyacid-ester dehydrogenase • : (S)-3-hydroxyacid-ester dehydrogenase • : GDP-4-dehydro-6-deoxy-D-mannose reductase • : Quinate/shikimate dehydrogenase • : methylglyoxal reductase (NADPH-dependent) • : S-(hydroxymethyl)glutathione dehydrogenase • : 3′′-deamino-3′′-oxonicotianamine reductase • : isocitrate—homoisocitrate dehydrogenase • : D-arabinitol dehydrogenase (NADP+) • : xanthoxin dehydrogenase • : sorbose reductase • : 4-phosphoerythronate dehydrogenase • : 2-hydroxymethylglutarate dehydrogenase • : 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) • EC 1.1.1.293: tropinone reductase I. This enzyme was already in the Enzyme List as EC 1.1.1.206, tropine dehydrogenase so EC 1.1.1.293 has been withdrawn at the public-review stage • : chlorophyll(ide) b reductase • : momilactone-A synthase • : dihydrocarveol dehydrogenase • : limonene-1,2-diol dehydrogenase • : 3-hydroxypropionate dehydrogenase (NADP+) • : malate dehydrogenase [NAD(P)+)] • : NADP-retinol dehydrogenase • : D-arabitol-phosphate dehydrogenase • : 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5′-phosphate reductase • : Diacetyl reductase ((R)-acetoin forming) • : Diacetyl reductase ((S)-acetoin forming) • : UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) • : S-(hydroxymethyl)mycothiol dehydrogenase • : D-xylose reductase • : sulfopropanediol 3-dehydrogenase • : phosphonoacetaldehyde reductase (NADH) • : (S)-sulfolactate dehydrogenase • : (S)-1-phenylethanol dehydrogenase • : 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase • : sulfoacetaldehyde reductase • EC 1.1.1.314: Now known to be catalyzed by EC 1.14.14.95, germacrene A hydroxylase • : 11-cis-retinol dehydrogenase • : L-galactose 1-dehydrogenase • : perakine reductase • : eugenol synthase • : isoeugenol synthase • : benzil reductase [(S)-benzoin forming] • : benzil reductase [(R)-benzoin forming] • : (–)-endo-fenchol dehydrogenase • : (+)-thujan-3-ol dehydrogenase • : 8-hydroxygeraniol dehydrogenase • : sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming) • : zerumbone synthase • : 5-exo-hydroxycamphor dehydrogenase • : nicotine blue oxidoreductase • : 2-deoxy-scyllo-inosamine dehydrogenase • : very-long-chain 3-oxoacyl-CoA reductase • : secoisolariciresinol dehydrogenase • : chanoclavine-I dehydrogenase • : decaprenylphospho-β-D-erythro-pentofuranosid-2-ulose 2-reductase • : methylecgonone reductase • : UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase • : UDP-N-acetyl-D-mannosamine dehydrogenase • : L-2-hydroxycarboxylate dehydrogenase (NAD+) • : (2R)-3-sulfolactate dehydrogenase (NADP+) • : dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) • : 1-deoxy-11β-hydroxypentalenate dehydrogenase • : CDP-abequose synthase • : CDP-paratose synthase • EC 1.1.1.343: phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating) • EC 1.1.1.344: dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+] • EC 1.1.1.345: D-2-hydroxyacid dehydrogenase (NAD+) • EC 1.1.1.346: 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) • EC 1.1.1.347: geraniol dehydrogenase (NAD+) • EC 1.1.1.348: (3R)-2′-hydroxyisoflavanone reductase • EC 1.1.1.349: norsolorinic acid ketoreductase • EC 1.1.1.350: ureidoglycolate dehydrogenase (NAD+) • EC 1.1.1.351: phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating] • EC 1.1.1.352: 5′-hydroxyaverantin dehydrogenase • EC 1.1.1.353: versiconal hemiacetal acetate reductase • EC 1.1.1.354: farnesol dehydrogenase (NAD+) • EC 1.1.1.355: 2′-dehydrokanamycin reductase • EC 1.1.1.356: GDP-L-colitose synthase • EC 1.1.1.357: 3α-hydroxysteroid 3-dehydrogenase • EC 1.1.1.358: 2-dehydropantolactone reductase • EC 1.1.1.359: aldose 1-dehydrogenase [NAD(P)+] • EC 1.1.1.360: glucose/galactose 1-dehydrogenase • EC 1.1.1.361: glucose-6-phosphate 3-dehydrogenase • EC 1.1.1.362: aklaviketone reductase • EC 1.1.1.363: glucose-6-phosphate dehydrogenase [NAD(P)+] • EC 1.1.1.364: dTDP-4-dehydro-6-deoxy-α-D-gulose 4-ketoreductase • EC 1.1.1.365: D-galacturonate reductase • EC 1.1.1.366: L-idonate 5-dehydrogenase (NAD+) • EC 1.1.1.367: UDP-2-acetamido-2,6-β-L-arabino-hexul-4-ose reductase • EC 1.1.1.368: 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase • EC 1.1.1.369: D-chiro-inositol 1-dehydrogenase • EC 1.1.1.370: scyllo-inositol 2-dehydrogenase (NAD+) • EC 1.1.1.371: scyllo-inositol 2-dehydrogenase (NADP+) • EC 1.1.1.372: D/L-glyceraldehyde reductase • EC 1.1.1.373: sulfolactaldehyde 3-reductase • EC 1.1.1.374: UDP-N-acetylglucosamine 3-dehydrogenase • EC 1.1.1.375: L-2-hydroxycarboxylate dehydrogenase [NAD(P)+] • EC 1.1.1.376: L-arabinose 1-dehydrogenase [NAD(P)+] • EC 1.1.1.377: L-rhamnose 1-dehydrogenase (NADP+) • EC 1.1.1.378: L-rhamnose 1-dehydrogenase [NAD(P)+] • EC 1.1.1.379: (R)-mandelate dehydrogenase • EC 1.1.1.380: L-gulonate 5-dehydrogenase • EC 1.1.1.381: 3-hydroxy acid dehydrogenase • EC 1.1.1.382: ketol-acid reductoisomerase (NAD+) • EC 1.1.1.383: ketol-acid reductoisomerase [NAD(P)+] • EC 1.1.1.384: dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose 3-reductase • EC 1.1.1.385: dihydroanticapsin dehydrogenase • EC 1.1.1.386: ipsdienol dehydrogenase • EC 1.1.1.387: L-serine 3-dehydrogenase (NAD+) • EC 1.1.1.388: glucose-6-phosphate dehydrogenase (NAD+) • EC 1.1.1.389: 2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase • EC 1.1.1.390: sulfoquinovose 1-dehydrogenase • EC 1.1.1.391: 3β-hydroxycholanate 3-dehydrogenase (NAD+) • EC 1.1.1.392: 3α-hydroxycholanate dehydrogenase (NADP+) • EC 1.1.1.393: 3β-hydroxycholanate 3-dehydrogenase (NADP+) • EC 1.1.1.394: aurachin B dehydrogenase • EC 1.1.1.395: 3α-hydroxy bile acid-CoA-ester 3-dehydrogenase • EC 1.1.1.396: bacteriochlorophyllide a dehydrogenase • EC 1.1.1.397: β-methylindole-3-pyruvate reductase • EC 1.1.1.398: 2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase • EC 1.1.1.399: 2-oxoglutarate reductase • EC 1.1.1.400: 2-methyl-1,2-propanediol dehydrogenase • EC 1.1.1.401: 2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+) • EC 1.1.1.402: D-erythritol 1-phosphate dehydrogenase • EC 1.1.1.403: D-threitol dehydrogenase (NAD+) • EC 1.1.1.404: tetrachlorobenzoquinone reductase • EC 1.1.1.405: ribitol-5-phosphate 2-dehydrogenase (NADP+) • EC 1.1.1.406: galactitol 2-dehydrogenase (L-tagatose-forming) • EC 1.1.1.407: D-altritol 5-dehydrogenase • EC 1.1.1.408: 4-phospho-D-threonate 3-dehydrogenase • EC 1.1.1.409: 4-phospho-D-erythronate 3-dehydrogenase • EC 1.1.1.410: D-erythronate 2-dehydrogenase • EC 1.1.1.411: L-threonate 2-dehydrogenase • EC 1.1.1.412: 2-alkyl-3-oxoalkanoate reductase • EC 1.1.1.413: A-factor type γ-butyrolactone 1′-reductase (1S-forming) • EC 1.1.1.414: L-galactonate 5-dehydrogenase • EC 1.1.1.415: noscapine synthase • EC 1.1.1.416: isopyridoxal dehydrogenase (5-pyridoxolactone-forming) • EC 1.1.1.417: 3β-hydroxysteroid-4β-carboxylate 3-dehydrogenase (decarboxylating) • EC 1.1.1.418: plant 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating) • EC 1.1.1.419: nepetalactol dehydrogenase • EC 1.1.1.420: D-apiose dehydrogenase • EC 1.1.1.421: D-apionate oxidoisomerase • EC 1.1.1.422: pseudoephedrine dehydrogenase • EC 1.1.1.423: (1R,2S)-ephedrine 1-dehydrogenase • EC 1.1.1.424: D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming) • EC 1.1.1.425: levoglucosan dehydrogenase • EC 1.1.1.426: UDP-N-acetyl-α-D-quinovosamine dehydrogenase EC 1.1.2 With a cytochrome as acceptor • EC 1.1.2.1: glycerolphosphate dehydrogenase. As the acceptor is now known, the enzyme has been transferred to EC 1.1.5.3, glycerol-3-phosphate dehydrogenase. • : mannitol dehydrogenase (cytochrome) • : L-lactate dehydrogenase (cytochrome) • : D-lactate dehydrogenase (cytochrome) • : D-lactate dehydrogenase (cytochrome c-553) • : polyvinyl alcohol dehydrogenase (cytochrome) • : methanol dehydrogenase (cytochrome c) • : alcohol dehydrogenase (cytochrome c) • : 1-butanol dehydrogenase (cytochrome c) • : lanthanide-dependent methanol dehydrogenase • : glucoside 3-dehydrogenase (cytochrome c) EC 1.1.3 With oxygen as acceptor • EC 1.1.3.1: Now included with EC 1.1.3.15 (S)-2-hydroxy-acid oxidase • : L-lactate oxidase • : malate oxidase • : glucose oxidase • : hexose oxidase • : cholesterol oxidase • : aryl-alcohol oxidase • : L-gulonolactone oxidase • : galactose oxidase • : pyranose oxidase • : L-sorbose oxidase • : pyridoxine 4-oxidase • : alcohol oxidase • : catechol oxidase (dimerizing) • : (S)-2-hydroxy-acid oxidase • : ecdysone oxidase • : choline oxidase • : Secondary-alcohol oxidase • : 4-hydroxymandelate oxidase • : long-chain-alcohol oxidase • : glycerol-3-phosphate oxidase • EC 1.1.3.22: Now EC 1.17.3.2, xanthine oxidase. The enzyme was incorrectly classified as acting on a CH-OH group • : Thiamine oxidase • : L-galactonolactone oxidase • EC 1.1.3.25: Now included with EC 1.1.99.18, cellobiose dehydrogenase (acceptor) • EC 1.1.3.26: Now EC 1.21.3.2, columbamine oxidase • : hydroxyphytanate oxidase • : nucleoside oxidase • : N-acylhexosamine oxidase • : polyvinyl-alcohol oxidase • EC 1.1.3.31: deleted, cannot be distinguished from EC 1.1.3.13, alcohol oxidase • EC 1.1.3.32: Now EC 1.14.21.1, (S)-stylopine synthase • EC 1.1.3.33: Now EC 1.14.21.2, (S)-cheilanthifoline synthase • EC 1.1.3.34: Now EC 1.14.21.3, berbamunine synthase • EC 1.1.3.35: Now EC 1.14.21.4, salutaridine synthase • EC 1.1.3.36: Now EC 1.14.21.5, (S)-canadine synthase • : D-arabinono-1,4-lactone oxidase • : vanillyl-alcohol oxidase • : nucleoside oxidase (H2O2-forming) • : D-mannitol oxidase • : xylitol oxidase • : prosolanapyrone-II oxidase • : paromamine 6′-oxidase • : 6′′′-hydroxyneomycin C oxidase • EC 1.1.3.45: aclacinomycin-N oxidase • EC 1.1.3.46: 4-hydroxymandelate oxidase • EC 1.1.3.47: 5-(hydroxymethyl)furfural oxidase • EC 1.1.3.48: 3-deoxy-α-D-manno-octulosonate 8-oxidase • EC 1.1.3.49: (R)-mandelonitrile oxidase EC 1.1.4 With a disulfide as acceptor • EC 1.1.4.1: Now EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive) • EC 1.1.4.2: Now EC 1.17.4.5, vitamin-K-epoxide reductase (warfarin-insensitive) EC 1.1.5 With a quinone or similar compound as acceptor • EC 1.1.5.1: deleted, see EC 1.1.99.18 cellobiose dehydrogenase (acceptor) • : quinoprotein glucose dehydrogenase • : glycerol-3-phosphate dehydrogenase (quinone) • : malate dehydrogenase (quinone) • : alcohol dehydrogenase (quinone) • : formate dehydrogenase-N • : cyclic alcohol dehydrogenase (quinone) • : quinate dehydrogenase (quinone) EC 1.1.9 With a copper protein as acceptor • : alcohol dehydrogenase (azurin) EC 1.1.98 With other, known, acceptors • EC 1.1.98.1: Now EC 1.1.9.1, alcohol dehydrogenase (azurin) • : glucose-6-phosphate dehydrogenase (coenzyme-F420) • : decaprenylphospho-β-D-ribofuranose 2-oxidase • EC 1.1.98.3: decaprenylphospho-β-D-ribofuranose 2-dehydrogenase • EC 1.1.98.4: F420H2:quinone oxidoreductase • EC 1.1.98.5: secondary-alcohol dehydrogenase (coenzyme-F420) • EC 1.1.98.6: ribonucleoside-triphosphate reductase (formate) • EC 1.1.98.7: serine-type anaerobic sulfatase-maturating enzyme EC 1.1.99 With unknown physiological acceptors • : choline dehydrogenase • : L-2-hydroxyglutarate dehydrogenase • : gluconate 2-dehydrogenase (acceptor) • : dehydrogluconate dehydrogenase • EC 1.1.99.5: now EC 1.1.5.3, glycerol-3-phosphate dehydrogenase • : D-2-hydroxy-acid dehydrogenase • : lactate—malate transhydrogenase • EC 1.1.99.8: Now EC 1.1.2.7, methanol dehydrogenase (cytochrome c) and EC 1.1.2.8, alcohol dehydrogenase (cytochrome c). • : pyridoxine 5-dehydrogenase • EC 1.1.99.10: Now EC 1.1.5.9, glucose 1-dehydrogenase (FAD, quinone) • EC 1.1.99.11: Now classified as EC 1.1.5.14, fructose 5-dehydrogenase • : sorbose dehydrogenase • : glucoside 3-dehydrogenase • : glycolate dehydrogenase • EC 1.1.99.15: Now EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H] • EC 1.1.99.16: Now EC EC 1.1.5.4, malate dehydrogenase (quinone) • EC 1.1.99.17: Now EC 1.1.5.2, quinoprotein glucose dehydrogenase • : cellobiose dehydrogenase (acceptor) • EC 1.1.99.19: Now EC 1.17.99.4, uracil/thymine dehydrogenase • : alkan-1-ol dehydrogenase (acceptor) • : D-sorbitol dehydrogenase (acceptor) • : glycerol dehydrogenase (acceptor) • EC 1.1.99.23: Now EC 1.1.2.6, polyvinyl alcohol dehydrogenase (cytochrome) • : hydroxyacid-oxoacid transhydrogenase • EC 1.1.99.25: Now EC 1.1.5.8, quinate dehydrogenase (quinone), • : 3-hydroxycyclohexanone dehydrogenase • : (R)-pantolactone dehydrogenase (flavin) • : glucose-fructose oxidoreductase • : pyranose dehydrogenase (acceptor) • : 2-oxoacid reductase • : (S)-mandelate dehydrogenase • : L-sorbose 1-dehydrogenase • EC 1.1.99.33: Now EC 1.17.99.7, formate dehydrogenase (acceptor) • EC 1.1.99.34: now EC 1.1.98.2, glucose-6-phosphate dehydrogenase (coenzyme-F420) • : soluble quinoprotein glucose dehydrogenase • : alcohol dehydrogenase (nicotinoprotein) • : methanol dehydrogenase (nicotinoprotein) • : 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent) • : D-2-hydroxyglutarate dehydrogenase • EC 1.1.99.40: (R)-2-hydroxyglutarate—pyruvate transhydrogenase • EC 1.1.99.41: 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase • EC 1.1.99.42: 4-pyridoxic acid dehydrogenase ==EC 1.2 Acting on the aldehyde or oxo group of donors==
EC 1.2 Acting on the aldehyde or oxo group of donors
EC 1.2.1 With NAD+ or NADP+ as acceptor • EC 1.2.1.1: deleted, replaced by EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase and EC 4.4.1.22, S-(hydroxymethyl)glutathione synthase • EC 1.2.1.2: Now EC 1.17.1.9, formate dehydrogenase • : aldehyde dehydrogenase (NAD+) • : aldehyde dehydrogenase (NADP+) • : aldehyde dehydrogenase (NAD(P)+) • EC 1.2.1.6: deleted (was benzaldehyde dehydrogenase) • : benzaldehyde dehydrogenase (NADP+) • : betaine-aldehyde dehydrogenase • : glyceraldehyde-3-phosphate dehydrogenase (NADP+) • : acetaldehyde dehydrogenase (acetylating) • : aspartate-semialdehyde dehydrogenase • : glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) • : glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) • EC 1.2.1.14: Now EC 1.1.1.205, IMP dehydrogenase • : malonate-semialdehyde dehydrogenase • : succinate-semialdehyde dehydrogenase [NAD(P)+] • : glyoxylate dehydrogenase (acylating) • : malonate-semialdehyde dehydrogenase (acetylating) • : aminobutyraldehyde dehydrogenase • : glutarate-semialdehyde dehydrogenase • : glycolaldehyde dehydrogenase • : lactaldehyde dehydrogenase • : 2-oxoaldehyde dehydrogenase (NAD+) • : succinate-semialdehyde dehydrogenase (NAD+) • : branched-chain α-keto acid dehydrogenase system • : 2,5-dioxovalerate dehydrogenase • : methylmalonate-semialdehyde dehydrogenase (CoA-acylating) • : benzaldehyde dehydrogenase (NAD+) • : aryl-aldehyde dehydrogenase • : aryl-aldehyde dehydrogenase (NADP+) • : L-aminoadipate-semialdehyde dehydrogenase • : aminomuconate-semialdehyde dehydrogenase • : (R)-dehydropantoate dehydrogenase • EC 1.2.1.34: Now EC 1.1.1.131, mannuronate reductase • EC 1.2.1.35: Now EC 1.1.1.203, uronate dehydrogenase • : retinal dehydrogenase • EC 1.2.1.37: Now EC 1.17.1.4, xanthine dehydrogenase • : N-acetyl-γ-glutamyl-phosphate reductase • : phenylacetaldehyde dehydrogenase • EC 1.2.1.40: part of EC 1.14.13.15, cholestanetriol 26-monooxygenase • : glutamate-5-semialdehyde dehydrogenase • : hexadecanal dehydrogenase (acylating) • EC 1.2.1.43: Now EC 1.17.1.10, formate dehydrogenase (NADP+) • : cinnamoyl-CoA reductase • EC 1.2.1.45: Now EC 1.1.1.312, 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase • : formaldehyde dehydrogenase • : 4-trimethylammoniobutyraldehyde dehydrogenase • : long-chain-aldehyde dehydrogenase • : 2-oxoaldehyde dehydrogenase (NADP+) • : long-chain-fatty-acyl-CoA reductase • : pyruvate dehydrogenase (NADP+) • : deleted 2025 (was oxoglutarate dehydrogenase (NADP+)) • : 4-hydroxyphenylacetaldehyde dehydrogenase • : γ-guanidinobutyraldehyde dehydrogenase • EC 1.2.1.55: Now EC 1.1.1.279, (R)-3-hydroxyacid-ester dehydrogenase • EC 1.2.1.56: Now EC 1.1.1.280, (S)-3-hydroxyacid-ester dehydrogenase • : butanal dehydrogenase • : phenylglyoxylate dehydrogenase (acylating) • : glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) • : 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase • : 4-hydroxymuconic-semialdehyde dehydrogenase • : 4-formylbenzenesulfonate dehydrogenase • : 6-oxohexanoate dehydrogenase • : 4-hydroxybenzaldehyde dehydrogenase (NAD+) • : salicylaldehyde dehydrogenase • EC 1.2.1.66: Now EC 1.1.1.306, S-(hydroxymethyl)mycothiol dehydrogenase • : vanillin dehydrogenase • : coniferyl-aldehyde dehydrogenase • : fluoroacetaldehyde dehydrogenase • : glutamyl-tRNA reductase • : succinylglutamate-semialdehyde dehydrogenase • : erythrose-4-phosphate dehydrogenase • : sulfoacetaldehyde dehydrogenase • : abieta-7,13-dien-18-al dehydrogenase • : malonyl CoA reductase (malonate semialdehyde-forming) • : succinate-semialdehyde dehydrogenase (acylating) • : 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+) • : 2-formylbenzoate dehydrogenase • : succinate-semialdehyde dehydrogenase (NADP+) • : long-chain acyl-(acyl-carrier-protein) reductase|long-chain acyl-[acyl-carrier-protein] reductase • : sulfoacetaldehyde dehydrogenase (acylating) • : β-apo-4′-carotenal oxygenase • : 3-succinoylsemialdehyde-pyridine dehydrogenase • : alcohol-forming fatty acyl-CoA reductase • : 2-hydroxymuconate-6-semialdehyde dehydrogenase • : geranial dehydrogenase • EC 1.2.1.87: propanal dehydrogenase (CoA-propanoylating) • EC 1.2.1.88: L-glutamate γ-semialdehyde dehydrogenase • EC 1.2.1.89: D-glyceraldehyde dehydrogenase (NADP+) • EC 1.2.1.90: glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] • EC 1.2.1.91: 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase • EC 1.2.1.92: 3,6-anhydro-α-L-galactose dehydrogenase • EC 1.2.1.93: formate dehydrogenase (NAD+, ferredoxin). Now EC 1.17.1.11, formate dehydrogenase (NAD+, ferredoxin) * • EC 1.2.1.94: farnesal dehydrogenase • EC 1.2.1.95: L-2-aminoadipate reductase • EC 1.2.1.96: 4-hydroxybenzaldehyde dehydrogenase (++) • EC 1.2.1.97: 3-sulfolactaldehyde dehydrogenase • EC 1.2.1.98: 2-hydroxy-2-methylpropanal dehydrogenase • EC 1.2.1.99: 4-(γ-glutamylamino)butanal dehydrogenase • EC 1.2.1.100: 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase • EC 1.2.1.101: L-tyrosine reductase • EC 1.2.1.102: isopyridoxal dehydrogenase (5-pyridoxate-forming) • EC 1.2.1.103: (amino-group carrier protein)-6-phospho-L-2-aminoadipate reductase|[amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase • EC 1.2.1.104: pyruvate dehydrogenase system • EC 1.2.1.105: 2-oxoglutarate dehydrogenase system • EC 1.2.1.106: (amino-group carrier protein)-5-phospho-L-glutamate reductase|[amino-group carrier protein]-5-phospho-L-glutamate reductase • EC 1.2.1.107: glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring) EC 1.2.2 With a cytochrome as acceptor • : formate dehydrogenase (cytochrome) • EC 1.2.2.2: Now covered by EC 1.2.5.1, pyruvate dehydrogenase (quinone) • EC 1.2.2.3: Now EC 1.17.2.3, formate dehydrogenase (cytochrome-c-553) • EC 1.2.2.4: Now classified as EC 1.2.5.3, aerobic carbon monoxide dehydrogenase EC 1.2.3 With oxygen as acceptor • : aldehyde oxidase • EC 1.2.3.2: Now EC 1.17.3.2, xanthine oxidase • : pyruvate oxidase • : oxalate oxidase • : glyoxylate oxidase • : pyruvate oxidase (CoA-acetylating) • : indole-3-acetaldehyde oxidase • : pyridoxal oxidase • : aryl-aldehyde oxidase • EC 1.2.3.10: deleted, activity due to EC 1.2.2.4 carbon-monoxide dehydrogenase (cytochrome b-561) • EC 1.2.3.11: Now included with EC 1.2.3.1, aldehyde oxidase • EC 1.2.3.12: Now included with EC 1.2.3.1, aldehyde oxidase • EC 1.2.3.13: Now EC 1.14.13.82, vanillate monooxygenase • : Abscisic-aldehyde oxidase • EC 1.2.3.15: (methyl)glyoxal oxidase EC 1.2.4 With a disulfide as acceptor • : pyruvate dehydrogenase (acetyl-transferring) • : oxoglutarate dehydrogenase (succinyl-transferring) • EC 1.2.4.3: Now included with EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) • : 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) EC 1.2.5 With a quinone or similar compound as acceptor • : pyruvate dehydrogenase (quinone) • EC 1.2.5.2: aldehyde dehydrogenase (quinone) • EC 1.2.5.3: aerobic carbon monoxide dehydrogenase EC 1.2.7 With an iron–sulfur protein as acceptor • : pyruvate synthase • EC 1.2.7.2: Now included with EC 1.2.7.1, pyruvate synthase. • : 2-oxoglutarate synthase • : anaerobic carbon monoxide dehydrogenase • : aldehyde ferredoxin oxidoreductase • : glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) • : 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) • : indolepyruvate ferredoxin oxidoreductase • EC 1.2.7.9: deleted, identical to EC 1.2.7.3, 2-oxoglutarate synthase • : oxalate oxidoreductase • EC 1.2.7.11: 2-oxoacid oxidoreductase (ferredoxin) • EC 1.2.7.12: formylmethanofuran dehydrogenase EC 1.2.98: With other, known physiological acceptors • EC 1.2.98.1: formaldehyde dismutase EC 1.2.99: With unknown physiological acceptors • EC 1.2.99.1: Now EC 1.17.99.4, uracil/thymine dehydrogenase • EC 1.2.99.2: Now EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin) • EC 1.2.99.3: Now EC 1.2.5.2, aldehyde dehydrogenase (quinone) • EC 1.2.99.4: Now EC 1.2.98.1, formaldehyde dismutase • EC 1.2.99.5: Now EC 1.2.7.12, formylmethanofuran dehydrogenase • : carboxylate reductase • : aldehyde dehydrogenase (FAD-independent) • EC 1.2.99.8: glyceraldehyde dehydrogenase (FAD-containing) • EC 1.2.99.9: Now EC 1.17.98.3, formate dehydrogenase (coenzyme F420) • EC 1.2.99.10: 4,4′-diapolycopenoate synthase ==EC 1.3 Acting on the CH-CH group of donors==
EC 1.3 Acting on the CH-CH group of donors
EC 1.3.1 With NAD+ or NADP+ as acceptor • : dihydrouracil dehydrogenase (NAD+) • : dihydropyrimidine dehydrogenase (NADP+) • : Δ4-3-oxosteroid 5β-reductase • EC 1.3.1.4: transferred to EC 1.3.1.22, 3-oxo-5α-steroid 4-dehydrogenase (NADP+) • : cucurbitacin Δ23-reductase • : fumarate reductase (NADH) • : meso-tartrate dehydrogenase • : acyl-CoA dehydrogenase (NADP+) • : enoyl-(acyl-carrier-protein) reductase (NADH)|enoyl-[acyl-carrier-protein] reductase (NADH) • : enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific)|enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) • : 2-coumarate reductase • : prephenate dehydrogenase • : prephenate dehydrogenase (NADP+) • : dihydroorotate dehydrogenase (NAD+) • : dihydroorotate dehydrogenase (NADP+) • : β-nitroacrylate reductase • : 3-methyleneoxindole reductase • : kynurenate-7,8-dihydrodiol dehydrogenase • : cis-1,2-dihydrobenzene-1,2-diol dehydrogenase • : trans-1,2-dihydrobenzene-1,2-diol dehydrogenase • : 7-dehydrocholesterol reductase • : 3-oxo-5α-steroid 4-dehydrogenase (NADP+) • EC 1.3.1.23: Identical to EC 1.3.1.3, Δ4-3-oxosteroid 5β-reductase • : biliverdin reductase • : 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase • EC 1.3.1.26: Now EC 1.17.1.8, 4-hydroxy-tetrahydrodipicolinate reductase • : 2-hexadecenal reductase • : 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase • : cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase • EC 1.3.1.30: transferred to EC 1.3.1.22, 3-oxo-5α-steroid 4-dehydrogenase (NADP+) • : 2-enoate reductase • : maleylacetate reductase • : protochlorophyllide reductase • : 2,4 Dienoyl-CoA reductase (NADPH) • EC 1.3.1.35: Now EC 1.14.19.22, microsomal oleoyl-lipid 12-desaturase • : geissoschizine dehydrogenase • : cis-2-enoyl-CoA reductase (NADPH) • : trans-2-enoyl-CoA reductase (NADPH) • : trans-2-enoyl-CoA reductase (NADPH) • : 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase • : xanthommatin reductase • : 12-oxophytodienoate reductase • : arogenate dehydrogenase • : trans-2-enoyl-CoA reductase (NAD+) • : 2′-hydroxyisoflavone reductase • : biochanin-A reductase • : α-santonin 1,2-reductase • : 13,14-dehydro-15-oxoprostaglandin 13-reductase • : cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase • EC 1.3.1.50: n Now EC 1.1.1.252 tetrahydroxynaphthalene reductase • : 2′-hydroxydaidzein reductase • EC 1.3.1.52: Now EC 1.3.8.5, 2-methyl-branched-chain-enoyl-CoA reductase • : (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase • : precorrin-6A reductase • EC 1.3.1.55: identical to EC 1.3.1.25, 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase • : cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase • : phloroglucinol reductase • : 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase • EC 1.3.1.59: There is no evidence that the enzyme exists • : dibenzothiophene dihydrodiol dehydrogenase • EC 1.3.1.61: identical to EC 1.3.1.53, (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase • : pimeloyl-CoA dehydrogenase • EC 1.3.1.63: Now EC 1.21.1.2, 2,4-dichlorobenzoyl-CoA reductase • : phthalate 4,5-cis-dihydrodiol dehydrogenase • : 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase • : cis-dihydroethylcatechol dehydrogenase • : cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase • : 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase • : zeatin reductase • : Δ14-sterol reductase • : Δ24(241)-sterol reductase • : Δ24-sterol reductase • : 1,2-dihydrovomilenine reductase • : 2-alkenal reductase [NAD(P)+] • : 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH) • : precorrin-2 dehydrogenase • : anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming] • : arogenate dehydrogenase (NADP+) • : arogenate dehydrogenase (NAD(P)+) • EC 1.3.1.80: Now classified as EC 1.3.7.12, red chlorophyll catabolite reductase • : (+)-pulegone reductase • : (-)-isopiperitenone reductase • : geranylgeranyl diphosphate reductase • : acrylyl-CoA reductase (NADPH) • : crotonyl-CoA carboxylase/reductase • : crotonyl-CoA reductase • : 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase • : tRNA-dihydrouridine16/17 synthase (NAD(P)+) • : tRNA-dihydrouridine47 synthase (NAD(P)+) • : tRNA-dihydrouridine20a/20b synthase (NAD(P)+) • : tRNA-dihydrouridine20 synthase (NAD(P)+) • : artemisinic aldehyde Δ11(13)-reductase • : very-long-chain enoyl-CoA reductase • : polyprenol reductase • : acrylyl-CoA reductase (NADH) • : Botryococcus squalene synthase • : botryococcene synthase • EC 1.3.1.98: Now known to be catalyzed by two different enzymes, EC 1.3.1.122, (S)-8-oxocitronellyl enol synthase, and EC 5.5.1.34, (+)-cis,trans-nepetalactol synthase • EC 1.3.1.100: chanoclavine-I aldehyde reductase • EC 1.3.1.101: 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H] • EC 1.3.1.102: 2-alkenal reductase (NADP+) • EC 1.3.1.103: 2-haloacrylate reductase • EC 1.3.1.104: enoyl-(acyl-carrier-protein) reductase (NADPH)|enoyl-[acyl-carrier-protein] reductase (NADPH) • EC 1.3.1.105: 2-methylene-furan-3-one reductase • EC 1.3.1.106: cobalt-precorrin-6A reductase • EC 1.3.1.107: sanguinarine reductase • EC 1.3.1.108: caffeoyl-CoA reductase • EC 1.3.1.109: butanoyl-CoA dehydrogenase complex (NAD+, ferredoxin) • EC 1.3.1.110: lactate dehydrogenase (NAD+,ferredoxin) • EC 1.3.1.111: geranylgeranyl-bacteriochlorophyllide a reductase • EC 1.3.1.112: anthocyanidin reductase [(2S)-flavan-3-ol-forming] • EC 1.3.1.113: (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase • EC 1.3.1.114: 3-dehydro-bile acid Δ4,6-reductase • EC 1.3.1.115: 3-oxocholoyl-CoA 4-desaturase • EC 1.3.1.116: 7β-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase • EC 1.3.1.117: hydroxycinnamoyl-CoA reductase • EC 1.3.1.118: meromycolic acid enoyl-(acyl-carrier-protein) reductase|meromycolic acid enoyl-[acyl-carrier-protein] reductase • EC 1.3.1.119: chlorobenzene dihydrodiol dehydrogenase • EC 1.3.1.120: cyclohexane-1-carbonyl-CoA reductase NADP+) • EC 1.3.1.121: 4-amino-4-deoxyprephenate dehydrogenase • EC 1.3.1.122: (S)-8-oxocitronellyl enol synthase • EC 1.3.1.123: 8-oxogeranial reductase • EC 1.3.1.124: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] EC 1.3.2 With a cytochrome as acceptor • : now EC 1.3.99.2 • : now EC 1.3.99.3 • : galactonolactone dehydrogenase EC 1.3.3 With oxygen as acceptor • : dihydroorotate oxidase • : Now Δ7-sterol 5(6)-desaturase • : coproporphyrinogen oxidase • : protoporphyrinogen oxidase • : bilirubin oxidase • : acyl-CoA oxidase • : dihydrouracil oxidase • : tetrahydroberberine oxidase • : Now secologanin synthase • : tryptophan a,b-oxidase • : pyrroloquinoline-quinone synthase • : l-galactonolactone oxidase EC 1.3.5 With a quinone or related compound as acceptor • : succinate dehydrogenase (quinone) • : dihydroorotate dehydrogenase (quinone) • : protoporphyrinogen IX dehydrogenase (menaquinone) • : fumarate reductase (quinol) • : 15-cis-phytoene desaturase • : 9,9'-dicis-zeta-carotene desaturase EC 1.3.7 With an iron–sulfur protein as acceptor • : 6-hydroxynicotinate reductase • : 15,16-dihydrobiliverdin:ferredoxin oxidoreductase • : phycoerythrobilin:ferredoxin oxidoreductase • : phytochromobilin:ferredoxin oxidoreductase • : phycocyanobilin:ferredoxin oxidoreductase • : phycoerythrobilin synthase • : ferredoxin:protochlorophyllide reductase (ATP-dependent) • : benzoyl-CoA reductase • : 4-hydroxybenzoyl-CoA reductase • : pentalenolactone synthase • : chlorophyllide a reductase EC 1.3.8 With a flavin as acceptor • : short-chain acyl-CoA dehydrogenase • : 4,4′-diapophytoene desaturase (4,4′-diapolycopene-forming) • : (R)-benzylsuccinyl-CoA dehydrogenase • : isovaleryl-CoA dehydrogenase • : 2-methyl-branched-chain-enoyl-CoA reductase • : glutaryl-CoA dehydrogenase (ETF) • : medium-chain acyl-CoA dehydrogenase • : long-chain acyl-CoA dehydrogenase • : very-long-chain acyl-CoA dehydrogenase • EC 1.3.8.10: cyclohex-1-ene-1-carbonyl-CoA dehydrogenase • EC 1.3.8.11: cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein) • EC 1.3.8.12: (2S)-methylsuccinyl-CoA dehydrogenase • EC 1.3.8.13: crotonobetainyl-CoA reductase • EC 1.3.8.14: L-prolyl-(peptidyl-carrier protein) dehydrogenase|L-prolyl-[peptidyl-carrier protein] dehydrogenase • EC 1.3.8.15: 3-(aryl)acrylate reductase • EC 1.3.8.16: 2-amino-4-deoxychorismate dehydrogenase • EC 1.3.8.17: dehydro coenzyme F420 reductase EC 1.3.98 With other,known physiological acceptors • : dihydroorotate dehydrogenase (fumarate) • EC 1.3.98.2: Now EC 1.3.4.1, fumarate reductase (CoM/CoB) • EC 1.3.98.3: coproporphyrinogen dehydrogenase • EC 1.3.98.4: 5a,11a-dehydrotetracycline reductase • EC 1.3.98.5: hydrogen peroxide-dependent heme synthase • EC 1.3.98.6: AdoMet-dependent heme synthase • EC 1.3.98.7: (mycofactocin precursor peptide)-tyrosine decarboxylase|[mycofactocin precursor peptide]-tyrosine decarboxylase EC 1.3.99 With unknown physiological acceptors • EC 1.3.99.1: The activity is included in EC 1.3.5.1, succinate dehydrogenase (quinone) • EC 1.3.99.2: Now EC 1.3.8.1, butyryl-CoA dehydrogenase. • EC 1.3.99.3: now EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase • : 3-oxosteroid 1-dehydrogenase • : 3-oxo-5α-steroid 4-dehydrogenase (acceptor) • : 3-oxo-5β-steroid 4-dehydrogenase • EC 1.3.99.7: Now EC 1.3.8.6, glutaryl-CoA dehydrogenase • : 2-furoyl-CoA dehydrogenase • EC 1.3.99.9: Now EC 1.21.99.1, β-cyclopiazonate dehydrogenase • EC 1.3.99.10: Now EC 1.3.8.4, isovaleryl-CoA dehydrogenase • EC 1.3.99.11: transferred to EC 1.3.5.2, dihydroorotate dehydrogenase • EC 1.3.99.12: Now classified as EC 1.3.8.5, 2-methyl-branched-chain-enoyl-CoA reductase • : Now EC 1.3.8.8, long-chain-acyl-CoA dehydrogenase • : cyclohexanone dehydrogenase • EC 1.3.99.15: Now EC 1.3.7.8 • : isoquinoline 1-oxidoreductase • : quinoline 2-oxidoreductase • : quinaldate 4-oxidoreductase • : quinoline-4-carboxylate 2-oxidoreductase • EC 1.3.99.20: Now EC 1.3.7.9, 4-hydroxybenzoyl-CoA reductase • EC 1.3.99.21: Now EC 1.3.8.3, (R)-benzylsuccinyl-CoA dehydrogenase • EC 1.3.99.22: Now EC 1.3.98.3, coproporphyrinogen dehydrogenase • : all-trans-retinol 13,14-reductase • EC 1.3.99.24: Now EC 1.3.8.16, 2-amino-4-deoxychorismate dehydrogenase • : carvone reductase • : all-trans-ζ-carotene desaturase • : 1-hydroxycarotenoid 3,4-desaturase • : phytoene desaturase (neurosporene-forming) • : phytoene desaturase (zeta-carotene-forming) • : phytoene desaturase (3,4-didehydrolycopene-forming) • : phytoene desaturase (lycopene-forming) • : glutaryl-CoA dehydrogenase (non-decarboxylating) • EC 1.3.99.33: urocanate reductase • EC 1.3.99.34: Now classified as EC 1.3.7.11, 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase • EC 1.3.99.35: Now EC 1.3.7.15, chlorophyllide a reductase * • EC 1.3.99.36: cypemycin cysteine dehydrogenase (decarboxylating) • EC 1.3.99.37: 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase • EC 1.3.99.38: menaquinone-9 β-reductase • EC 1.3.99.39: carotenoid φ-ring synthase • EC 1.3.99.40: carotenoid χ-ring synthase ==EC 1.4 Acting on the CH-NH2 group of donors==
EC 1.4 Acting on the CH-NH2 group of donors
EC 1.4.1 With NAD+ or NADP+ as acceptor • : alanine dehydrogenase • : glutamate dehydrogenase • : glutamate dehydrogenase (NAD(P)+) • : glutamate dehydrogenase (NADP+) • : L-amino-acid dehydrogenase • EC 1.4.1.6: deleted, Now included with EC 1.21.4.1, D-proline reductase (dithiol) • : serine 2-dehydrogenase • : valine dehydrogenase (NADP+) • : leucine dehydrogenase • : glycine dehydrogenase • : L-erythro-3,5-diaminohexanoate dehydrogenase • : 2,4-diaminopentanoate dehydrogenase • : glutamate synthase (NADPH) • : glutamate synthase (NADH) • : lysine dehydrogenase • : diaminopimelate dehydrogenase • : N-methylalanine dehydrogenase • : lysine 6-dehydrogenase • : tryptophan dehydrogenase • : phenylalanine dehydrogenase • : aspartate dehydrogenase • EC 1.4.1.22: there is no overall consumption of NAD+ during the reaction. As a result, transfer of the enzyme from EC 4.3.1.12 was not necessary and EC 1.4.1.22 was withdrawn before being made official • : valine dehydrogenase (NAD+) • : 3-dehydroquinate synthase II • EC 1.4.1.25: L-arginine dehydrogenase • EC 1.4.1.26: 2,4-diaminopentanoate dehydrogenase (NAD+) • EC 1.4.1.27: glycine cleavage system EC 1.4.2 With a cytochrome as acceptor • : glycine dehydrogenase (cytochrome) • : pseudooxynicotine oxidase EC 1.4.3 With oxygen as acceptor • : D-aspartate oxidase • : L-amino-acid oxidase • : D-amino-acid oxidase • : monoamine oxidase • : pyridoxal 5′-phosphate synthase • EC 1.4.3.6: replaced by two enzymes, EC 1.4.3.21 (primary-amine oxidase) and EC 1.4.3.22 (diamine oxidase) • : D-glutamate oxidase • : ethanolamine oxidase • EC 1.4.3.9: Now included with EC 1.4.3.4 amine oxidase (flavin-containing) • : putrescine oxidase • : L-glutamate oxidase • : cyclohexylamine oxidase • : protein-lysine 6-oxidase • : L-lysine oxidase • : D-glutamate(D-aspartate) oxidase • : L-aspartate oxidase • EC 1.4.3.17: Now EC 1.3.3.10, tryptophan α,β-oxidase • EC 1.4.3.18: Not approved as the enzyme was shown to be a dehydrogenase and not an oxidase (see EC 1.5.99.12, cytokinin dehydrogenase) • : glycine oxidase • : L-lysine 6-oxidase • : primary-amine oxidase • : diamine oxidase • : 7-chloro-L-tryptophan oxidase • EC 1.4.3.24: Now EC 1.4.2.3, pseudooxynicotine oxidase • EC 1.4.3.25: L-arginine oxidase • EC 1.4.3.26: pre-mycofactocin synthase EC 1.4.4 With a disulfide as acceptor • EC 1.4.4.1: Now EC 1.21.4.1, D-proline reductase (dithiol) • : glycine dehydrogenase (aminomethyl-transferring) EC 1.4.5 With a quinone or other compound as acceptor • : D-amino acid dehydrogenase (quinone) EC 1.4.7 With an iron–sulfur protein as acceptor • : glutamate synthase (ferredoxin) EC 1.4.9 With a copper protein as acceptor • : methylamine dehydrogenase (amicyanin) • : aralkylamine dehydrogenase (azurin) EC 1.4.98 With other, known physiological acceptors • : NOW 1.4.9.1 methylamine dehydrogenase (amicyanin) EC 1.4.99 With unknown physiological acceptors • EC 1.4.99.1: Now EC 1.4.99.6, D-arginine dehydrogenase • : taurine dehydrogenase • EC 1.4.99.3: Now EC 1.4.9.1, methylamine dehydrogenase (amicyanin) • EC 1.4.99.4: Now EC 1.4.9.2, aralkylamine dehydrogenase (azurin) • : glycine dehydrogenase (cyanide-forming) • EC 1.4.99.6: D-arginine dehydrogenase ==EC 1.5 Acting on the CH-NH group of donors==
EC 1.5 Acting on the CH-NH group of [[Electron donor|donors]]
EC 1.5.1 With NAD+ or NADP+ as acceptor • : 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NAD(P)H) • : pyrroline-5-carboxylate reductase • : dihydrofolate reductase • EC 1.5.1.4: Now included with EC 1.5.1.3 dihydrofolate reductase • : methylenetetrahydrofolate dehydrogenase (NADP+) • : formyltetrahydrofolate dehydrogenase • : saccharopine dehydrogenase (NAD+, L-lysine-forming) • : saccharopine dehydrogenase (NADP+, L-lysine-forming) • : saccharopine dehydrogenase (NAD+, L-glutamate-forming) • : saccharopine dehydrogenase (NADP+, L-glutamate-forming) • : D-octopine dehydrogenase • EC 1.5.1.12: Now EC 1.2.1.88, L-glutamate γ-semialdehyde dehydrogenase • EC 1.5.1.13: Now EC 1.17.1.5, nicotinate dehydrogenase • EC 1.5.1.14: Now included with EC 1.5.1.21 Δ1-piperideine-2-carboxylate reductase • : methylenetetrahydrofolate dehydrogenase (NAD+) • : D-lysopine dehydrogenase • : alanopine dehydrogenase • : ephedrine dehydrogenase • : D-nopaline dehydrogenase • : methylenetetrahydrofolate reductase (NAD(P)H) • : 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) • : strombine dehydrogenase • : tauropine dehydrogenase • : N5-(carboxyethyl)ornithine synthase • : thiomorpholine-carboxylate dehydrogenase • : β-alanopine dehydrogenase • : 1,2-dehydroreticulinium reductase (NADPH) • : opine dehydrogenase • EC 1.5.1.29: Now covered by EC 1.5.1.38 [FMN reductase (NADPH)], EC 1.5.1.39 [FMN reductase [NAD(P)H])] and EC 1.5.1.41 (riboflavin reductase [NAD(P)H]) • : flavin reductase (NADPH) • : berberine reductase • : vomilenine reductase • : pteridine reductase • : 6,7-dihydropteridine reductase • EC 1.5.1.35: identical to EC 1.2.1.19, aminobutyraldehyde dehydrogenase, as the substrates 1-pyrroline and 4-aminobutanal are interconvertible • : flavin reductase (NADH) • : FAD reductase (NADH) • : FMN reductase (NADPH) • : FMN reductase (NAD(P)H) • : 8-hydroxy-5-deazaflavin:NADPH oxidoreductase • : riboflavin reductase (NAD(P)H) • : FMN reductase (NADH) • : carboxynorspermidine synthase • : festuclavine dehydrogenase • : FAD reductase (NAD(P)H) • EC 1.5.1.46: agroclavine dehydrogenase • EC 1.5.1.47: dihydromethanopterin reductase [NAD(P)+] • EC 1.5.1.48: 2-methyl-1-pyrroline reductase • EC 1.5.1.49: 1-pyrroline-2-carboxylate reductase [NAD(P)H] • EC 1.5.1.50: dihydromonapterin reductase • EC 1.5.1.51: N-((2S)-2-amino-2-carboxyethyl)-L-lutamate dehydrogenase|N-[(2S)-2-amino-2-carboxyethyl]-L-lutamate dehydrogenase • EC 1.5.1.52: staphylopine dehydrogenase • EC 1.5.1.53: methylenetetrahydrofolate reductase (NADPH) • EC 1.5.1.54: methylenetetrahydrofolate reductase (NADH) EC 1.5.3 With oxygen as acceptor • : sarcosine oxidase • : N-methyl-L-amino-acid oxidase • EC 1.5.3.3: deleted • : N6-methyl-lysine oxidase • : (S)-6-hydroxynicotine oxidase • : (R)-6-hydroxynicotine oxidase • : L-pipecolate oxidase • EC 1.5.3.8: Now included with EC 1.3.3.8, tetrahydroberberine oxidase • EC 1.5.3.9: Now EC 1.21.3.3, reticuline oxidase • : dimethylglycine oxidase • EC 1.5.3.11: Now included with EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase) • : dihydrobenzophenanthridine oxidase • : N1-acetylpolyamine oxidase • : polyamine oxidase (propane-1,3-diamine-forming) • : N8-acetylspermidine oxidase (propane-1,3-diamine-forming) • : spermine oxidase • : non-specific polyamine oxidase • : L-saccharopine oxidase • : 4-methylaminobutanoate oxidase (formaldehyde-forming) • : N-alkylglycine oxidase • : 4-methylaminobutanoate oxidase (methylamine-forming) • EC 1.5.3.22: coenzyme F420H2 oxidase • EC 1.5.3.23: glyphosate oxidoreductase EC 1.5.4 With a disulfide as acceptor • : pyrimidodiazepine synthase EC 1.5.5 With a quinone or similar compound as acceptor • : electron-transferring-flavoprotein dehydrogenase • EC 1.5.5.2: proline dehydrogenase • EC 1.5.5.3: hydroxyproline dehydrogenase EC 1.5.7 With an iron–sulfur protein as acceptor • : methylenetetrahydrofolate reductase (ferredoxin) • EC 1.5.7.2: coenzyme F420 oxidoreductase (ferredoxin) EC 1.5.8 With a flavin or flavoprotein as acceptor • : dimethylamine dehydrogenase • : trimethylamine dehydrogenase • : sarcosine dehydrogenase • : dimethylglycine dehydrogenase EC 1.5.98 With other, known, physiological acceptors • EC 1.5.98.1: ethylenetetrahydromethanopterin dehydrogenase • EC 1.5.98.2: 5,10-methylenetetrahydromethanopterin reductase • EC 1.5.98.3: coenzyme F420:methanophenazine dehydrogenase EC 1.5.99 With unknown physiological acceptors • EC 1.5.99.1: Now EC 1.5.8.3, sarcosine dehydrogenase • EC 1.5.99.2: Now EC 1.5.8.4, dimethylglycine dehydrogenase • : L-pipecolate dehydrogenase • : nicotine dehydrogenase • : methylglutamate dehydrogenase • : spermidine dehydrogenase • EC 1.5.99.7: Now EC 1.5.8.2, trimethylamine dehydrogenase • EC 1.5.99.8: Now EC 1.5.5.2, proline dehydrogenase • EC 1.5.99.9: transferred to EC 1.5.98.1, methylenetetrahydromethanopterin dehydrogenase • EC 1.5.99.10: Now EC 1.5.8.1, dimethylamine dehydrogenase • EC 1.5.99.11: transferred to EC 1.5.98.2, 5,10-methylenetetrahydromethanopterin reductase • : cytokinin dehydrogenase • : D-proline dehydrogenase • : 6-hydroxypseudooxynicotine dehydrogenase • EC 1.5.99.15: dihydromethanopterin reductase (acceptor) ==EC 1.6 Acting on NADH or NADPH==
EC 1.6 Acting on NADH or NADPH
EC 1.6.1 With NAD or NADP as acceptor • : NAD(P)+ transhydrogenase (Si-specific) • : NAD(P)+ transhydrogenase (Re/Si-specific) EC 1.6.2 With a heme protein as acceptor • EC 1.6.2.1: now EC 1.6.99.3 NADH dehydrogenase • : cytochrome-b5 reductase • EC 1.6.2.3: deleted • : NADPH—hemoprotein reductase • : NADPH—cytochrome-c2 reductase • : leghemoglobin reductase EC 1.6.3 With oxygen as acceptor • : NAD(P)H oxidase (H2O2-forming) • EC 1.6.3.2: NAD(P)H oxidase (H2O-forming) • EC 1.6.3.3: NADH oxidase (H2O2-forming) • EC 1.6.3.4: NADH oxidase (H2O-forming) • EC 1.6.3.5: renalase EC 1.6.4 With a disulfide as acceptor (deleted sub-class) • EC 1.6.4.1: now cystine reductase • EC 1.6.4.2: now glutathione-disulfide reductase • EC 1.6.4.3: now dihydrolipoyl dehydrogenase • EC 1.6.4.4: now protein-disulfide reductase • EC 1.6.4.5: now thioredoxin-disulfide reductase • EC 1.6.4.6: now CoA-glutathione reductase • EC 1.6.4.7: now asparagusate reductase • EC 1.6.4.8: now trypanothione-disulfide reductase • EC 1.6.4.9: now bis-γ-glutamylcystine reductase • EC 1.6.4.10: now CoA-disulfide reductase EC 1.6.5 With a quinone or similar compound as acceptor • EC 1.6.5.1: deleted • : NAD(P)H dehydrogenase (quinone) • EC 1.6.5.3: now NADH:ubiquinone reductase (H+-translocating) • : monodehydroascorbate reductase (NADH) • : NADPH:quinone reductase • : p-benzoquinone reductase (NADPH) • : 2-hydroxy-1,4-benzoquinone reductase • : Now , NADH:ubiquinone reductase (Na+-transporting) • : NADH:ubiquinone reductase (non-electrogenic) • : NADPH dehydrogenase (quinone) • EC 1.6.5.11: Identical to , NADH:quinone reductase (non-electrogenic) • EC 1.6.5.12: demethylphylloquinone reductase EC 1.6.6 With a nitrogenous group as acceptor • EC 1.6.6.1: Now , nitrate reductase (NADH) • EC 1.6.6.2: Now , nitrate reductase [NAD(P)H] • EC 1.6.6.3: Now , nitrate reductase (NADPH) • EC 1.6.6.4: Now , nitrite reductase [NAD(P)H] • EC 1.6.6.5: Now , nitrite reductase (NO-forming) • EC 1.6.6.6: Now , hyponitrite reductase • EC 1.6.6.7: Now , azobenzene reductase • EC 1.6.6.8: Now , GMP reductase • EC 1.6.6.9: Now known to be catalysed by , trimethylamine-N-oxide reductase • EC 1.6.6.10: Now , nitroquinoline-N-oxide reductase] • EC 1.6.6.11: Now , hydroxylamine reductase (NADH) • EC 1.6.6.12: Now , 4-(dimethylamino)phenylazoxybenzene reductase • EC 1.6.6.13: Now , N-hydroxy-2-acetamidofluorene reductase EC 1.6.7 With an iron–sulfur protein as acceptor (deleted sub-subclass) • EC 1.6.7.1: now ferredoxin—NADP+ reductase • EC 1.6.7.2: now rubredoxin—NAD+ reductase • EC 1.6.7.3: now ferredoxin—NAD+ reductase EC 1.6.8 With a flavin as acceptor (deleted sub-subclass) • EC 1.6.8.1: Now FMN reductase • EC 1.6.8.2: Now flavin reductase EC 1.6.99 With unknown physiological acceptors • : NADPH dehydrogenase • EC 1.6.99.2: Now , NAD(P)H dehydrogenase (quinone • EC 1.6.99.3: The activity is covered by , NADH:ubiquinone reductase (H+-translocating) • EC 1.6.99.4: Now , ferredoxin—NADP+ reductase • EC 1.6.99.5: Now , NADH dehydrogenase (quinone) • EC 1.6.99.6: Now , NADPH dehydrogenase (quinone) • EC 1.6.99.7: Now , 6,7-dihydropteridine reductase • EC 1.6.99.8: Deleted • EC 1.6.99.9: Now , cob(II)alamin reductase • EC 1.6.99.10: included in , 6,7-dihydropteridine reductase • EC 1.6.99.11: Deleted • EC 1.6.99.12: Now , cyanocobalamin reductase (cyanide-eliminating) • EC 1.6.99.13: Now , ferric-chelate reductase ==EC 1.7 Acting on other nitrogenous compounds as donors==
EC 1.7 Acting on other nitrogenous compounds as donors
EC 1.7.1 With NAD+ or NADP+ as acceptor • : nitrate reductase (NADH) • : nitrate reductase (NAD(P)H) • : nitrate reductase (NADPH) • : nitrite reductase (NAD(P)H) • : hyponitrite reductase • : azobenzene reductase • : GMP reductase • EC 1.7.1.8: deleted • : nitroquinoline-N-oxide reductase • : hydroxylamine reductase (NADH) • : 4-(dimethylamino)phenylazoxybenzene reductase • : N-hydroxy-2-acetamidofluorene reductase • : preQ1 synthase • : nitric oxide reductase (NAD(P), nitrous oxide-forming) • : nitrite reductase (NADH) • : nitrobenzene nitroreductase • : FMN-dependent NADH-azoreductase EC 1.7.2 With a cytochrome as acceptor • : nitrite reductase (NO-forming) • : nitrite reductase (cytochrome; ammonia-forming) • : trimethylamine-N-oxide reductase • : nitrous-oxide reductase • : nitric oxide reductase (cytochrome c) • : hydroxylamine dehydrogenase • : hydrazine synthase • : hydrazine dehydrogenase EC 1.7.3 With oxygen as acceptor • : nitroalkane oxidase • : acetylindoxyl oxidase • : factor-independent urate hydroxylase • EC 1.7.3.4: Now covered by , hydroxylamine dehydrogenase, and , hydroxylamine oxidase (cytochrome) • : 3-aci-nitropropanoate oxidase • : hydroxylamine oxidase (cytochrome) EC 1.7.5 With a quinone or similar compound as acceptor • : nitrate reductase (quinone) • : nitric oxide reductase (menaquinol) EC 1.7.6 With a nitrogenous group as acceptor • : nitrite dismutase EC 1.7.7 With an iron–sulfur protein as acceptor • : ferredoxin—nitrite reductase • : ferredoxin—nitrate reductase EC 1.7.99 With other acceptors • : hydroxylamine reductase • EC 1.7.99.2: deleted: reaction may have been due to the combined action of nitrous-oxide reductase and nitric-oxide reductase • EC 1.7.99.3: Now included with , nitrite reductase (NO-forming) • EC 1.7.99.4: Now , nitrate reductase (NADH), , nitrate reductase [NAD(P)H], , nitrate reductase (NADPH), , nitrate reductase (quinone), , nitrate reductase (ferredoxin) and , nitrate reductase (cytochrome) • EC 1.7.99.5: Now included with , methylenetetrahydrofolate reductase [NAD(P)H] • EC 1.7.99.6: Now nitrous-oxide reductase • EC 1.7.99.7: Now nitric oxide reductase (cytochrome c) • : hydroxylamine oxidoreductase • EC 1.7.99.8: Now classified as , hydrazine dehydrogenase ==EC 1.8 Acting on a sulfur group of donors==
EC 1.8 Acting on a sulfur group of donors
EC 1.8.1 With NAD+ or NADP+ as acceptor • EC 1.8.1.1: deleted • : sulfite reductase (NADPH) • EC 1.8.1.3: deleted; reaction shown to be due to , flavin-containing monooxygenase • : dihydrolipoyl dehydrogenase • : 2-oxopropyl-CoM reductase (carboxylating) • : cystine reductase • : glutathione-disulfide reductase • : protein-disulfide reductase • : thioredoxin-disulfide reductase • : CoA-glutathione reductase • : asparagusate reductase • : trypanothione-disulfide reductase • : bis-γ-glutamylcystine reductase • : CoA-disulfide reductase • : mycothione reductase • : glutathione amide reductase • : dimethylsulfone reductase • : NAD(P)H sulfur oxidoreductase (CoA-dependent) • : sulfide dehydrogenase • : 4,4′-dithiodibutanoate disulfide reductase • : dissimilatory dimethyldisulfide reductase • : dissimilatory sulfite reductase EC 1.8.2 With a cytochrome as acceptor • : sulfite dehydrogenase (cytochrome) • : thiosulfate dehydrogenase • : sulfide-cytochrome-c reductase (flavocytochrome c) • : dimethyl sulfide:cytochrome c2 reductase • : thiosulfate reductase (cytochrome) • : S-disulfanyl-L-cysteine oxidoreductase • : thiocyanate desulfurase EC 1.8.3 With oxygen as acceptor • : sulfite oxidase • : thiol oxidase • : glutathione oxidase • : methanethiol oxidase • : prenylcysteine oxidase • : farnesylcysteine lyase • : formylglycine-generating enzyme EC 1.8.4 With a disulfide as acceptor • : glutathione—homocystine transhydrogenase • : protein-disulfide reductase (glutathione) • : glutathione—CoA-glutathione transhydrogenase • : glutathione—cystine transhydrogenase • EC 1.8.4.5: Now , L-methionine (S)-S-oxide reductase and , L-methionine (R)-S-oxide reductase • EC 1.8.4.6: due to , peptide-methionine (S)-S-oxide reductase • : enzyme-thiol transhydrogenase (glutathione-disulfide) • : phosphoadenylyl-sulfate reductase (thioredoxin) • : adenylyl-sulfate reductase (glutathione) • : adenylyl-sulfate reductase (thioredoxin) • : peptide-methionine (S)-S-oxide reductase • : peptide-methionine (R)-S-oxide reductase • : L-methionine (S)-S-oxide reductase • : L-methionine (R)-S-oxide reductase • : protein dithiol oxidoreductase (disulfide-forming) • : thioredoxin:protein disulfide reductase EC 1.8.5 With a quinone or similar compound as acceptor • : glutathione dehydrogenase (ascorbate) • : thiosulfate dehydrogenase (quinone) • : respiratory dimethylsulfoxide reductase • : bacterial sulfide:quinone reductase • : thiosulfate reductase (quinone) • : sulfite dehydrogenase (quinone) • : glutathionyl-hydroquinone reductase • : eukaryotic sulfide quinone oxidoreductase • : protein dithiol:quinone oxidoreductase DsbB • : DsrC-trisulfide reductase EC 1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass) • : Now included with glutathione transferase EC 1.8.7 With an iron–sulfur protein as acceptor • : assimilatory sulfite reductase (ferredoxin) • : ferredoxin:thioredoxin reductase • : ferredoxin:CoB-CoM heterodisulfide reductase EC 1.8.98 With other, known, acceptors • : dihydromethanophenazine:CoB-CoM heterodisulfide reductase • : sulfiredoxin EC 1.8.99 With other acceptors • EC 1.8.99.1: Now covered by , assimilatory sulfite reductase (NADPH) and , assimilatory sulfite reductase (ferredoxin) • : adenylyl-sulfate reductase • EC 1.8.99.3: an in vitro artifact of , dissimilatory sulfite reductase • EC 1.8.99.4: Now , phosphoadenylyl-sulfate reductase (thioredoxin) • EC 1.8.99.5: Now , dissimilatory sulfite reductase ==EC 1.9 Acting on a heme group of donors==
EC 1.9 Acting on a heme group of donors
EC 1.9.3 With oxygen as acceptor • EC 1.9.3.1: Now , cytochrome-c oxidase • EC 1.9.3.2: Now included with , nitrite reductase (NO-forming) EC 1.9.6 With a nitrogenous group as acceptor • : nitrate reductase (cytochrome) EC 1.9.98 With other, known, physiological acceptors • : iron—cytochrome-c reductase EC 1.9.99 With other acceptors • EC 1.9.99.1: Now , iron—cytochrome-c reductase ==EC 1.10 Acting on diphenols and related substances as donors==
EC 1.10 Acting on diphenols and related substances as donors
EC 1.10.1 With NAD+ or NADP+ as acceptor • : trans-acenaphthene-1,2-diol dehydrogenase EC 1.10.2 With a cytochrome as acceptor • EC 1.10.2.1: The activity is covered by , ascorbate ferrireductase (transmembrane) • EC 1.10.2.2: Now , quinol—cytochrome-c reductase EC 1.10.3 With oxygen as acceptor • : catechol oxidase • : laccase • : L-ascorbate oxidase • : o-aminophenol oxidase • : 3-hydroxyanthranilate oxidase • : rifamycin-B oxidase • EC 1.10.3.7: Now , sulochrin oxidase [(+)-bisdechlorogeodin-forming] • EC 1.10.3.8: Now , sulochrin oxidase [(-)-bisdechlorogeodin-forming] • : photosystem II • EC 1.10.3.10: Now , ubiquinol oxidase (H+-transporting) • : ubiquinol oxidase (non-electrogenic) • : Now , menaquinol oxidase (H+-transporting) • EC 1.10.3.13: Now , caldariellaquinol oxidase (H+-transporting) • EC 1.10.3.14: Now , ubiquinol oxidase (electrogenic, proton-motive force generating) • : grixazone synthase • : dihydrophenazinedicarboxylate synthase • : superoxide oxidase EC 1.10.5 With a quinone or related compound as acceptor • : ribosyldihydronicotinamide dehydrogenase (quinone) EC 1.10.9 With a copper protein as acceptor • EC 1.10.9.1: Now , plastoquinol—plastocyanin reductase EC 1.10.99 With unknown physiological acceptors • EC 1.10.99.1: Now plastoquinol—plastocyanin reductase • EC 1.10.99.2: Now ribosyldihydronicotinamide dehydrogenase (quinone) • EC 1.10.99.3: Now violaxanthin de-epoxidase ==EC 1.11 Acting on a peroxide as acceptor==
EC 1.11 Acting on a peroxide as acceptor
EC 1.11.1 Peroxidases • : NADH peroxidase • : NADPH peroxidase • : fatty-acid peroxidase • EC 1.11.1.4: Now tryptophan 2,3-dioxygenase • : cytochrome-c peroxidase • : catalase • : peroxidase • : iodide peroxidase • : glutathione peroxidase • : chloride peroxidase • : L-ascorbate peroxidase • : phospholipid-hydroperoxide glutathione peroxidase • : manganese peroxidase • : lignin peroxidase • EC 1.11.1.15: Now described by , thioredoxin-dependent peroxiredoxin; , glutaredoxin-dependent peroxiredoxin; , NADH-dependent peroxiredoxin; , glutathione-dependent peroxiredoxin; , lipoyl-dependent peroxiredoxin; and , mycoredoxin-dependent peroxiredoxin • : versatile peroxidase • : glutathione amide-dependent peroxidase • : bromide peroxidase • : dye decolorizing peroxidase • : prostamide/prostaglandin F2α synthase • : catalase-peroxidase • : hydroperoxy fatty acid reductase • : (S)-2-hydroxypropylphosphonic acid epoxidase • : thioredoxin-dependent peroxiredoxin • : glutaredoxin-dependent peroxiredoxin • : NADH-dependent peroxiredoxin • : glutathione-dependent peroxiredoxin • : lipoyl-dependent peroxiredoxin • : mycoredoxin-dependent peroxiredoxin EC 1.11.2 Peroxygenase • : unspecific peroxygenase • : myeloperoxidase • : plant seed peroxygenase • : fatty-acid peroxygenase • : 3-methyl-L-tyrosine peroxygenase • : L-tyrosine peroxygenase ==EC 1.12 Acting on hydrogen as donor==
EC 1.12 Acting on hydrogen as donor
EC 1.12.1 With NAD+ or NADP+ as acceptor • : Now EC 1.12.7.2, ferredoxin hydrogenase • : hydrogen dehydrogenase • : hydrogen dehydrogenase (NADP+) • : hydrogenase (NAD+, ferredoxin) • : hydrogen dehydrogenase [NAD(P)+] EC 1.12.2 With a cytochrome as acceptor • : cytochrome-c3 hydrogenase EC 1.12.5 With a quinone or similar compound as acceptor • : hydrogen:quinone oxidoreductase EC 1.12.7 With an iron–sulfur protein as acceptor • EC 1.12.7.1: Now , ferredoxin hydrogenase • : ferredoxin hydrogenase EC 1.12.98 With other known acceptors • : coenzyme F420 hydrogenase • : 5,10-methenyltetrahydromethanopterin hydrogenase • : Methanosarcina-phenazine hydrogenase • : Sulfhydrogenase EC 1.12.99 With unknown physiological acceptors • EC 1.12.99.1: Now , coenzyme F420 hydrogenase • EC 1.12.99.2: Now shown to be two enzymes, , Methanosarcina-phenazine hydrogenase and , CoB—CoM heterodisulfide reductase • EC 1.12.99.3: Now , hydrogen:quinone oxidoreductase • EC 1.12.99.4: Now , 5,10-methenyltetrahydromethanopterin hydrogenase • EC 1.12.99.5: Identical to , 3-hydroxy-4-oxoquinoline 2,4-dioxygenase • : hydrogenase (acceptor) ==EC 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)==
EC 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
EC 1.13.11 With incorporation of two atoms of oxygen • : catechol 1,2-dioxygenase • : catechol 2,3-dioxygenase • : protocatechuate 3,4-dioxygenase • : gentisate 1,2-dioxygenase • : homogentisate 1,2-dioxygenase • : 3-hydroxyanthranilate 3,4-dioxygenase • EC 1.13.11.7: deleted • : protocatechuate 4,5-dioxygenase • : 2,5-dihydroxypyridine 5,6-dioxygenase • : 7,8-dihydroxykynurenate 8,8a-dioxygenase • : tryptophan 2,3-dioxygenase • : linoleate 13S-lipoxygenas • EC 1.13.11.13: The activity is the sum of several enzymatic and spontaneous reactions • : 2,3-dihydroxybenzoate 3,4-dioxygenase • : 3,4-dihydroxyphenylacetate 2,3-dioxygenase • : 3-carboxyethylcatechol 2,3-dioxygenase • : indole 2,3-dioxygenase • : persulfide dioxygenase • : cysteamine dioxygenase • : cysteine dioxygenase • EC 1.13.11.21: Now , β-carotene 15,15′-monooxygenase • : caffeate 3,4-dioxygenase • : 2,3-dihydroxyindole 2,3-dioxygenase • : quercetin 2,3-dioxygenase • : 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase • : peptide-tryptophan 2,3-dioxygenase • : 4-hydroxyphenylpyruvate dioxygenase • : 2,3-dihydroxybenzoate 2,3-dioxygenase • : stizolobate synthase • : stizolobinate synthase • : arachidonate 12-lipoxygenase • EC 1.13.11.32: Now , nitronate monooxygenase • : arachidonate 15-lipoxygenase • : arachidonate 5-lipoxygenase • : pyrogallol 1,2-oxygenase • : chloridazon-catechol dioxygenase • : hydroxyquinol 1,2-dioxygenase • : 1-hydroxy-2-naphthoate 1,2-dioxygenase • : biphenyl-2,3-diol 1,2-dioxygenase • : arachidonate 8-lipoxygenase • : 2,4′-dihydroxyacetophenone dioxygenase • EC 1.13.11.42: identical to , tryptophan 2,3-dioxygenase • : lignostilbene αβ-dioxygenase • EC 1.13.11.44: Activity is covered by , linoleate 8R-lipoxygenase and , 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase • : linoleate 11-lipoxygenase • : 4-hydroxymandelate synthase • : 3-hydroxy-4-oxoquinoline 2,4-dioxygenase • : 3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase • : chlorite O2-lyase • : acetylacetone-cleaving enzyme • : 9-cis-epoxycarotenoid dioxygenase • : indoleamine 2,3-dioxygenase • : acireductone dioxygenase (Ni2+-requiring) • : acireductone dioxygenase [iron(II)-requiring] • : sulfur oxygenase/reductase • : 1,2-dihydroxynaphthalene dioxygenase • : gallate dioxygenase • : linoleate 9S-lipoxygenase • : torulene dioxygenase • : inoleate 8R-lipoxygenase • : linolenate 9R-lipoxygenase • : linoleate 10R-lipoxygenase • : β-carotene 15,15′-dioxygenase • : 5-nitrosalicylate dioxygenase • : carotenoid isomerooxygenase • : hydroquinone 1,2-dioxygenase • : 8′-apo-β-carotenoid 14′,13′-cleaving dioxygenase • : 9-cis-β-carotene 9′,10′-cleaving dioxygenase • : carlactone synthase • : all-trans-10′-apo-β-carotenal 13,14-cleaving dioxygenase • : carotenoid-9′,10′-cleaving dioxygenase • : 2-hydroxyethylphosphonate dioxygenase • : methylphosphonate synthase • : 2-aminophenol 1,6-dioxygenase • : all-trans-8′-apo-β-carotenal 15,15′-oxygenase • : 2-amino-5-chlorophenol 1,6-dioxygenase • : oleate 10S-lipoxygenase • : 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming) • : aerobic 5,6-dimethylbenzimidazole synthase • : (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase • : 7,8-dihydroneopterin oxygenase • : 8′-apo-carotenoid 13,14-cleaving dioxygenase • : 4-hydroxy-3-prenylphenylpyruvate oxygenase • : crocetin dialdehyde synthase • : exo-cleaving rubber dioxygenase • : 5-aminosalicylate 1,2-dioxygenase • : endo-cleaving rubber dioxygenase • : isoeugenol monooxygenase • : (hydroxymethyl)phosphonate dioxygenase • : (1-hydroxy-2-(trimethylamino)ethyl)phosphonate dioxygenase (glycine-betaine-forming)|[1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming) • : 3-mercaptopropionate dioxygenase • : fatty acid α-dioxygenase EC 1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) • : arginine 2-monooxygenase • : lysine 2-monooxygenase • : tryptophan 2-monooxygenase • : lactate 2-monooxygenase • : Renilla-type luciferase • : Cypridina-luciferin 2-monooxygenase • : firefly luciferase • : Watasenia-luciferin 2-monooxygenase • : phenylalanine 2-monooxygenase • EC 1.13.12.10: Reaction covered by , L-lysine 6-monooxygenase (NADPH) • EC n1.13.12.11: The activity is due to , flavin-containing monooxygenase • EC 1.13.12.12: transferred to , 8-apo-β-carotenoid 14′,13′-cleaving dioxygenase • : Oplophorus-luciferin 2-monooxygenase • EC 1.13.12.14: Now , chlorophyllide-a oxygenase • : 3,4-dihydroxyphenylalanine oxidative deaminase • : nitronate monooxygenase • : dichloroarcyriaflavin A synthase • : dinoflagellate luciferase • : 2-oxoglutarate dioxygenase (ethene-forming) • : noranthrone monooxygenase • : tetracenomycin-F1 monooxygenase • : deoxynogalonate monooxygenase • : 4-hydroxy-3-prenylbenzoate synthase • : calcium-regulated photoprotein EC 1.13.99 Miscellaneous • : inositol oxygenase • EC 1.13.99.2: Now , benzoate 1,2-dioxygenase • : tryptophan 2′-dioxygenase • EC 1.13.99.4: Now , 4-chlorophenylacetate 3,4-dioxygenase • EC 1.13.99.5: now , 3-hydroxy-4-oxoquinoline 2,4-dioxygenase ==EC 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen==
EC 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
EC 1.14.1 With NADH or NADPH as one donor (deleted sub-subclass) • EC 1.14.1.1: now , unspecific monooxygenase • EC 1.14.1.2: now , kynurenine 3-monooxygenase • EC 1.14.1.3: deleted, covered by , squalene monooxygenase and , lanosterol synthase • EC 1.14.1.4: now , kynurenine 7,8-hydroxylase • EC 1.14.1.5: now ; imidazoleacetate 4-monooxygenase • EC 1.14.1.6: now , steroid 11β-monooxygenase • EC 1.14.1.7: now , steroid 17α-monooxygenase • EC 1.14.1.8: now , steroid 21-monooxygenase • EC 1.14.1.9: deleted • EC 1.14.1.10: now estradiol 6β-monooxygenase • EC 1.14.1.11: deleted EC 1.14.2 With ascorbate as one donor (deleted sub-subclass) • EC 1.14.2.1: now , dopamine β-monooxygenase • EC 1.14.2.2: now , 4-hydroxyphenylpyruvate dioxygenase EC 1.14.3 With reduced pteridine as one donor (deleted sub-subclass) • EC 1.14.3.1: now , phenylalanine 4-monooxygenase EC 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors • : γ-butyrobetaine dioxygenase • : procollagen-proline dioxygenase • : pyrimidine-deoxynucleoside 2′-dioxygenase • : procollagen-lysine 5-dioxygenase • EC 1.14.11.5: Now included with thymine dioxygenase • : thymine dioxygenase • : procollagen-proline 3-dioxygenase • : trimethyllysine dioxygenase • : flavanone 3-dioxygenase • : pyrimidine-deoxynucleoside 1′-dioxygenase • : hyoscyamine (6S)-dioxygenase • : gibberellin-44 dioxygenase • : gibberellin 2β-dioxygenase • EC 1.14.11.14: Now , 6β-hydroxyhyoscyamine epoxidase • : gibberellin 3β-dioxygenase • : peptide-aspartate β-dioxygenase • : taurine dioxygenase • : phytanoyl-CoA dioxygenase • EC 1.14.11.19: Now , anthocyanidin synthase • : deacetoxyvindoline 4-hydroxylase • : clavaminate synthase • EC 1.14.11.22: Now , flavone synthase • EC 1.14.11.23: Now , flavonol synthase • : 2′-deoxymugineic-acid 2′-dioxygenase • : mugineic-acid 3-dioxygenase • : deacetoxycephalosporin-C hydroxylase • : (histone-H3)-lysine-36 demethylase|[histone H3]-dimethyl-L-lysine36 demethylase • : proline 3-hydroxylase • : hypoxia-inducible factor-proline dioxygenase • : hypoxia-inducible factor-asparagine dioxygenase • : thebaine 6-O-demethylase • : codeine 3-O-demethylase • : DNA oxidative demethylase • EC 1.14.11.34: Now , 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming) • : 1-deoxypentalenic acid 11β-hydroxylase • : pentalenolactone F synthase • : pentalenolactone F synthase • : kanamycin B dioxygenase • : verruculogen synthase • : L-asparagine hydroxylase • : enduracididine β-hydroxylase • : L-arginine hydroxylase • : tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase • : (S)-dichlorprop dioxygenase (2-oxoglutarate) • : (R)-dichlorprop dioxygenase (2-oxoglutarate) • : L-isoleucine 4-hydroxylase • : 2-aminoethylphosphonate dioxygenase • : (50S ribosomal protein L16)-arginine 3-hydroxylase|[50S ribosomal protein L16]-arginine 3-hydroxylase • : xanthine dioxygenase • : uridine-5′-phosphate dioxygenase • EC|1.14.11.50: Now , (–)-deoxypodophyllotoxin synthase • : DNA N6-methyladenine demethylase • : validamycin A dioxygenase • : mRNA N6-methyladenine demethylase • : mRNA N1-methyladenine demethylase • : ectoine hydroxylase • : L-proline cis-4-hydroxylase • : L-proline trans-4-hydroxylase • : ornithine lipid ester-linked acyl 2-hydroxylase • : 2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase • : scopoletin 8-hydroxylase • : feruloyl-CoA 6-hydroxylase • : trans-4-coumaroyl-CoA 2-hydroxylase • : peptidyl-lysine (3S)-dioxygenase • : glutarate dioxygenase • : (histone H3)-dimethyl-L-lysine^9 demethylase|[histone H3]-dimethyl-L-lysine9 demethylase • : (histone H3)-trimethylL-lysine^9 demethylase|[histone H3]-trimethylL-lysine9 demethylase • : (histone H3)-trimethyl-LL-lysine^4 demethylase|[histone H3]-trimethyl-LL-lysine4 demethylase • : (histone H3)-trimethyl-L-lysine^27 demethylase|[histone H3]-trimethyl-L-lysine27 demethylase • : (histone H3)-trimethyl-L-lysine^37 demethylase|[histone H3]-trimethyl-L-lysine37 demethylase • : 7-deoxycylindrospermopsin hydroxylase • : methylphosphonate hydroxylase • : (2-(trimethylamino)ethyl)phosphonate dioxygenase|[2-(trimethylamino)ethyl]phosphonate dioxygenase • : (protein)-arginine 3-hydroxylase|[protein]-arginine 3-hydroxylase • : L-isoleucine 31-dioxygenase • : 31-hydroxy-L-isoleucine 4-dioxygenase • : L-glutamate 3(R)-hydroxylase • : alkyl sulfatase EC 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor • : anthranilate 1,2-dioxygenase (deaminating, decarboxylating) • EC 1.14.12.2: Now anthranilate 3-monooxygenase (deaminating) • : benzene 1,2-dioxygenase • EC 1.14.12.4: , 3-hydroxy-2-methylpyridinecarboxylate monooxygenase • EC 1.14.12.5: Now , 5-pyridoxate monooxygenase • EC 1.14.12.6: Now , 2-hydroxycyclohexanone 2-monooxygenase • : phthalate 4,5-dioxygenase • : 4-sulfobenzoate 3,4-dioxygenase • : 4-chlorophenylacetate 3,4-dioxygenase • : benzoate 1,2-dioxygenase • : toluene dioxygenase • : naphthalene 1,2-dioxygenase • : 2-halobenzoate 1,2-dioxygenase • : 2-aminobenzenesulfonate 2,3-dioxygenase • : terephthalate 1,2-dioxygenase • : 2-hydroxyquinoline 5,6-dioxygenase • : nitric oxide dioxygenase • : biphenyl 2,3-dioxygenase • : 3-phenylpropionate dioxygenase • EC 1.14.12.20: Now classified as , pheophorbide a oxygenase. • EC 1.14.12.21: Now , benzoyl-CoA 2,3-epoxidase • : carbazole 1,9a-dioxygenase • : nitroarene dioxygenase • : 2,4-dinitrotoluene dioxygenase • : p-cumate 2,3-dioxygenase • : chlorobenzene dioxygenase EC 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor • : salicylate 1-monooxygenase • : 4-hydroxybenzoate 3-monooxygenase • EC 1.14.13.3: Now , 4-hydroxyphenylacetate 3-monooxygenase • : melilotate 3-monooxygenase • : imidazoleacetate 4-monooxygenase • : orcinol 2-monooxygenase • : phenol 2-monooxygenase • : flavin-containing monooxygenase • : kynurenine 3-monooxygenase • : 2,6-dihydroxypyridine 3-monooxygenase • EC 1.14.13.11: Now , trans-cinnamate 4-monooxygenase • EC 1.14.13.12: Now , benzoate 4-monooxygenase • EC 1.14.13.13: Now classified as , calcidiol 1-monooxygenase • : trans-cinnamate 2-monooxygenase • EC 1.14.13.15: Now , cholestanetriol 26-monooxygenase • : cyclopentanone monooxygenase • EC 1.14.13.17: Now , cholesterol 7α-monooxygenase • : 4-hydroxyphenylacetate 1-monooxygenase • : taxifolin 8-monooxygenase • : 2,4-dichlorophenol 6-monooxygenase • EC 1.14.13.21: Now , flavonoid 3′-monooxygenase • : cyclohexanone monooxygenase • : 3-hydroxybenzoate 4-monooxygenase • : 3-hydroxybenzoate 6-monooxygenase • : methane monooxygenase (soluble) • EC 1.14.13.26: Now classified as , phosphatidylcholine 12-monooxygenase • : 4-aminobenzoate 1-monooxygenase • EC 1.14.13.28: Now , 3,9-dihydroxypterocarpan 6a-monooxygenase • : 4-nitrophenol 2-monooxygenase • EC 1.14.13.30: Now , leukotriene-B4 20-monooxygenase • : 2-nitrophenol 2-monooxygenase • : albendazole monooxygenase • : 4-hydroxybenzoate 3-monooxygenase (NAD(P)H) • : leukotriene-E4 20-monooxygenase • : anthranilate 3-monooxygenase (deaminating) • EC 1.14.13.36: Now , 5-O-(4-coumaroyl)-D-quinate 3′-monooxygenase • EC 1.14.13.37: Now , methyltetrahydroprotoberberine 14-monooxygenase • : anhydrotetracycline monooxygenase • : nitric-oxide synthase • : anthraniloyl-CoA monooxygenase • EC 1.14.13.41: Now , tyrosine N-monooxygenase • EC 1.14.13.42: The activity is covered by , 4-hydroxyphenylacetaldehyde oxime monooxygenase • : questin monooxygenase • : 2-hydroxybiphenyl 3-monooxygenase • EC 1.14.13.45: Now , CMP-N-acetylneuraminate monooxygenase • : (-)-menthol monooxygenase • EC 1.14.13.47: Now , (S)-limonene 3-monooxygenase • EC 1.14.13.48: Now classified as , (S)-limonene 6-monooxygenase • EC 1.14.13.49: Now classified as , (S)-limonene 7-monooxygenase • : pentachlorophenol monooxygenase • : 6-oxocineole dehydrogenase • EC 1.14.13.52: Now , isoflavone 3′-hydroxylase • EC 1.14.13.53: Now , 4′-methoxyisoflavone 2′-hydroxylase • : ketosteroid monooxygenase • EC 1.14.13.55: Now , protopine 6-monooxygenase • EC 1.14.13.56: Now , dihydrosanguinarine 10-monooxygenase • EC 1.14.13.57: Now , dihydrochelirubine 12-monooxygenase • : benzoyl-CoA 3-monooxygenase • : L-lysine N6-monooxygenase (NADPH) • EC 1.14.13.60: Now included with , 25-hydroxycholesterol 7α-hydroxylase • : 2-hydroxyquinoline 8-monooxygenase • : 4-hydroxyquinoline 3-monooxygenase • : 3-hydroxyphenylacetate 6-hydroxylase • : 4-hydroxybenzoate 1-hydroxylase • EC 1.14.13.65: deleted • : 2-hydroxycyclohexanone 2-monooxygenase • EC 1.14.13.67: Now , quinine 3-monooxygenase • EC 1.14.13.68: Now , 4-hydroxyphenylacetaldehyde oxime monooxygenase • : alkene monooxygenase • EC 1.14.13.70: Now , sterol 14α-demethylase • EC 1.14.13.71: Now , N-methylcoclaurine 3′-monooxygenase • EC 1.14.13.72: Now classified as , methylsterol monooxygenase • EC 1.14.13.73: Now , tabersonine 16-hydroxylase • EC 1.14.13.74: Now , 7-deoxyloganin 7-hydroxylase • EC 1.14.13.75: Now , vinorine hydroxylase • EC 1.14.13.76: Now , taxane 10β-hydroxylase • EC 1.14.13.77: Now , taxane 13α-hydroxylase • EC 1.14.13.78: Now , ent-kaurene monooxygenase • EC 1.14.13.79: Now , ent-kaurenoic acid oxidase • EC 1.14.13.80: Now classified as , (R)-limonene 6-monooxygenase • : magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase • : vanillate monooxygenase • : precorrin-3B synthase • : 4-hydroxyacetophenone monooxygenase • EC 1.14.13.85: Now , glyceollin synthase • EC 1.14.13.86: The activity is covered by , 2-hydroxyisoflavanone synthase • EC 1.14.13.87: Now , licodione synthase] • EC 1.14.13.88: Now , flavanoid 3,5-hydroxylase • EC 1.14.13.89: Now , isoflavone 2-hydroxylase • EC 1.14.13.90: Now , zeaxanthin epoxidase • EC 1.14.13.91: Now , deoxysarpagine hydroxylase • : phenylacetone monooxygenase • EC 1.14.13.93: Now , (+)-abscisic acid 8-hydroxylase • EC 1.14.13.94: Now , lithocholate 6β-hydroxylase • EC 1.14.13.95: Now included with , 5β-cholestane-3α,7α-diol 12α-hydroxylase • EC 1.14.13.96: Now , 5β-cholestane-3α,7α-diol 12α-hydroxylase • EC 1.14.13.97: Now , taurochenodeoxycholate 6α-hydroxylase • EC 1.14.13.98: Now , cholesterol 24-hydroxylase • EC 1.14.13.99: Now , 24-hydroxycholesterol 7α-hydroxylase • EC 1.14.13.100: Now classified as , 25/26-hydroxycholesterol 7α-hydroxylase • : senecionine N-oxygenase • EC 1.14.13.102: Now , psoralen synthase • EC 1.14.13.103: Now , 8-dimethylallylnaringenin 2-hydroxylase • : Now , (+)-menthofuran synthase • : monocyclic monoterpene ketone monooxygenase • EC 1.14.13.106: now classified as , epi-isozizaene 5-monooxygenase. • : limonene 1,2-monooxygenase • EC 1.14.13.108: Now , abieta-7,13-diene hydroxylase • EC 1.14.13.109: Now , abieta-7,13-dien-18-ol hydroxylase • EC 1.14.13.110: Now , geranylgeraniol 18-hydroxylase • : methanesulfonate monooxygenase • EC 1.14.13.112: Now , 3-epi-6-deoxocathasterone 23-monooxygenase • : FAD-dependent urate hydroxylase • : 6-hydroxynicotinate 3-monooxygenase • EC 1.14.13.115: Now , angelicin synthase • : Now , geranylhydroquinone 3-hydroxylase • EC 1.14.13.117: Now , isoleucine N-monooxygenase • EC 1.14.13.118: Now , valine N-monooxygenase • EC 1.14.13.119: Now , 5-epiaristolochene 1,3-dihydroxylase • EC 1.14.13.120: Now , costunolide synthase • EC 1.14.13.121: Now , premnaspirodiene oxygenase • : chlorophyllide-a oxygenase • EC 1.14.13.123: Now , germacrene A hydroxylase • EC 1.14.13.124: now classified as , phenylalanine N-monooxygenase • EC 1.14.13.125: Now , tryptophan N-monooxygenase • EC 1.14.13.126: Now , vitamin D3 24-hydroxylase • : 3-(3-hydroxyphenyl)propanoate hydroxylase • : 7-methylxanthine demethylase • EC 1.14.13.129: Now , β-carotene 3-hydroxylase • : pyrrole-2-carboxylate monooxygenase • : dimethyl-sulfide monooxygenase • EC 1.14.13.132: Now , squalene monooxygenase • EC 1.14.13.133: Now , pentalenene oxygenase • EC 1.14.13.134: Now , β-amyrin 11-oxidase • : 1-hydroxy-2-naphthoate hydroxylase • EC 1.14.13.136: Now , 2-hydroxyisoflavanone synthase • EC 1.14.13.137: Now , indole-2-monooxygenase • EC 1.14.13.138: Now , indolin-2-one monooxygenase • EC 1.14.13.139: Now , 3-hydroxyindolin-2-one monooxygenase • EC 1.14.13.140: Now , 2-hydroxy-1,4-benzoxazin-3-one monooxygenase. • EC 1.14.13.141: Now , cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] • EC 1.14.13.142: Now , 3-ketosteroid 9α-monooxygenase • EC 1.14.13.143: Now ent-isokaurene C2/C3-hydroxylase • EC 1.14.13.144: Now , 9β-pimara-7,15-diene oxidase • EC 1.14.13.145: Now , ent-cassa-12,15-diene 11-hydroxylase • : taxoid 14β-hydroxylase • EC 1.14.13.147: Now , taxoid 7β-hydroxylase • : trimethylamine monooxygenase • : phenylacetyl-CoA 1,2-epoxidase • EC 1.14.13.150: Now , α-humulene 10-hydroxylase • EC 1.14.13.151: Now , linalool 8-monooxygenase • EC 1.14.13.152: Now , geraniol 8-hydroxylase • : (+)-sabinene 3-hydroxylase • : erythromycin 12-hydroxylase • : α-pinene monooxygenase • EC 1.14.13.156: Now , 1,8-cineole 2-endo-monooxygenase • EC 1.14.13.157: Now , 1,8-cineole 2-exo-monooxygenase • EC 1.14.13.158: Now , amorpha-4,11-diene 12-monooxygenase • EC 1.14.13.159: Now , vitamin D 25-hydroxylase • : (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase • : (+)-camphor 6-exo-hydroxylase • EC 1.14.13.162: Now , 2,5-diketocamphane 1,2-monooxygenase • : 6-hydroxy-3-succinoylpyridine 3-monooxygenase • EC 1.14.13.164: withdrawn: see , carotenoid isomerooxygenase • EC 1.14.13.165: Now classified as , nitric-oxide synthase (flavodoxin) • : 4-nitrocatechol 4-monooxygenase • : 4-nitrophenol 4-monooxygenase • : indole-3-pyruvate monooxygenase • EC 1.14.13.169: Now , sphingolipid C4-monooxygenase • : pentalenolactone D synthase • : neopentalenolactone D synthase • : salicylate 5-hydroxylase • EC 1.14.13.173: Now , 11-oxo-β-amyrin 30-oxidase • EC 1.14.13.174: Now , averantin hydroxylase • EC 1.14.13.175: Now , aflatoxin B synthase • EC 1.14.13.176: Now , tryprostatin B 6-hydroxylase • EC 1.14.13.177: Now , fumitremorgin C monooxygenase • : methylxanthine N1-demethylase • : methylxanthine N3-demethylase • : aklavinone 12-hydroxylase • : 13-deoxydaunorubicin hydroxylase • : 2-heptyl-3-hydroxy-4(1H)-quinolone synthase • EC 1.14.13.183: Now , dammarenediol 12-hydroxylase • EC 1.14.13.184: Now , protopanaxadiol 6-hydroxylase • EC 1.14.13.185: Now , pikromycin synthase • EC 1.14.13.186: Now , 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase • : L-evernosamine nitrososynthase • EC 1.14.13.188: Now , 6-deoxyerythronolide B hydroxylase • : 5-methyl-1-naphthoate 3-hydroxylase • EC 1.14.13.190: Now , ferruginol synthase • EC 1.14.13.191: Now , ent-sandaracopimaradiene 3-hydroxylase • EC 1.14.13.192: Now , oryzalexin E synthase • EC 1.14.13.193: Now , oryzalexin D synthase • EC 1.14.13.194: Now , phylloquinone ω-hydroxylase • : L-ornithine N5-monooxygenase (NADPH) • : L-ornithine N5-monooxygenase [NAD(P)H] • EC 1.14.13.197: Now , dihydromonacolin L hydroxylase • EC 1.14.13.198: Now , monacolin L hydroxylase • EC 1.14.13.199: Now , docosahexaenoic acid ω-hydroxylase • : tetracenomycin A2 monooxygenase-dioxygenase • EC 1.14.13.201: Now , β-amyrin 28-monooxygenase • EC 1.14.13.202: Now , methyl farnesoate epoxidase • EC 1.14.13.203: Now , farnesoate epoxidase • EC 1.14.13.204: Now , long-chain acyl-CoA ω-monooxygenase • EC 1.14.13.205: Now , long-chain fatty acid ω-monooxygenase • EC 1.14.13.206: Now , laurate 7-monooxygenase • EC 1.14.13.207: Now , ipsdienol synthase • : benzoyl-CoA 2,3-epoxidase • : salicyloyl-CoA 5-hydroxylase • : 4-methyl-5-nitrocatechol 5-monooxygenase • : rifampicin monooxygenase • : 1,3,7-trimethyluric acid 5-monooxygenase • EC 1.14.13.213: Now , bursehernin 5-monooxygenase • EC 1.14.13.214: Now , (–)-4′-demethyl-deoxypodophyllotoxin 4-hydroxylase • : protoasukamycin 4-monooxygenase • : asperlicin C monooxygenase • : protodeoxyviolaceinate monooxygenase • : 5-methylphenazine-1-carboxylate 1-monooxygenase • : resorcinol 4-hydroxylase (NADPH) • : resorcinol 4-hydroxylase (NADH) • EC 1.14.13.221: Now , cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming] • : aurachin C monooxygenase/isomerase • : 3-hydroxy-4-methylanthranilyl-(aryl-carrier protein) 5-monooxygenase|3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase • : violacein synthase • : F-actin monooxygenase • : acetone monooxygenase (methyl acetate-forming) • : propane 2-monooxygenase • : jasmonic acid 12-hydroxylase • : tert-butyl alcohol monooxygenase • : butane monooxygenase (soluble) • : tetracycline 11a-monooxygenase • : 6-methylpretetramide 4-monooxygenase • : 4-hydroxy-6-methylpretetramide 12a-monooxygenase • : 5a,11a-dehydrotetracycline 5-monooxygenase • : indole-3-acetate monooxygenase • : toluene 4-monooxygenase • : aliphatic glucosinolate S-oxygenase • : dimethylamine monooxygenase • : carnitine monooxygenase • : 2-polyprenylphenol 6-hydroxylase • : 5-pyridoxate monooxygenase • : 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase • : toluene 2-monooxygenase • : phenol 2-monooxygenase (NADH) • : assimilatory dimethylsulfide S-monooxygenase • : 4β-methylsterol monooxygenase • : stachydrine N-demethylase EC 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • : unspecific monooxygenase • EC 1.14.14.2: Now included with unspecific monooxygenase • : alkanal monooxygenase (FMN-linked) • EC 1.14.14.4: identical to , choline monooxygenase. • : alkanesulfonate monooxygenase • EC 1.14.14.6: Now , methanesulfonate monooxygenase • EC 1.14.14.7: transferred to , tryptophan 7-halogenase • : anthranilate 3-monooxygenase (FAD) • : 4-hydroxyphenylacetate 3-monooxygenase • : nitrilotriacetate monooxygenase • : styrene monooxygenase • : 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase • : 4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase| 4-(γ-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase • : aromatase • : (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-(peptidyl-carrier protein SgcC2) monooxygenase|(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase • : steroid 21-monooxygenase • : squalene monooxygenase • : heme oxygenase (biliverdin-producing) • : steroid 17α-monooxygenase • : phenol 2-monooxygenase (FADH2) • : dibenzothiophene monooxygenase • : dibenzothiophene sulfone monooxygenase • : cholesterol 7α-monooxygenase • : vitamin D 25-hydroxylase • : cholesterol 24-hydroxylase • : 24-hydroxycholesterol 7α-hydroxylase • : resorcinol 4-hydroxylase (FADH2) • : long-chain alkane monooxygenase • : 25/26-hydroxycholesterol 7α-hydroxylase • : isobutylamine N-monooxygenase • : ipsdienol synthase • : 17α-hydroxyprogesterone deacetylase • : ethylenediaminetetraacetate monooxygenase • : methanesulfonate monooxygenase (FMNH2) • : dimethylsulfone monooxygenase • : tyrosine N-monooxygenase • : 4-hydroxyphenylacetaldehyde oxime monooxygenase • : valine N-monooxygenase • : isoleucine N-monooxygenase • : phenylalanine N-monooxygenase • : (E)-2-methylbutanal oxime monooxygenase • : homomethionine N-monooxygenase • : (methylsulfanyl)alkanaldoxime N-monooxygenase • : phenylacetaldehyde oxime monooxygenase • : aromatic aldoxime N-monooxygenase • : pimeloyl-(acyl-carrier protein) synthase|pimeloyl-[acyl-carrier protein] synthase • : nitric-oxide synthase (flavodoxin) • : jasmonoyl-L-amino acid 12-hydroxylase • : 12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase • : tabersonine 3-oxygenase • : (S)-limonene 6-monooxygenase • : (S)-limonene 7-monooxygenase • : (R)-limonene 6-monooxygenase • : phenylacetate 2-hydroxylase • : quinine 3-monooxygenase • : 1,8-cineole 2-exo-monooxygenase • : taurochenodeoxycholate 6α-hydroxylase • : trimethyltridecatetraene synthase • : dimethylnonatriene synthase • : ferruginol monooxygenase • : carnosic acid synthase • : salviol synthase • : β-amyrin 16β-monooxygenase • : β-amyrin 6β-monooxygenase • : sugiol synthase • : marmesin synthase • : 11-hydroxysugiol 20-monooxygenase • : syn-pimaradiene 3-monooxygenase • : ent-cassadiene hydroxylase • : ent-sandaracopimaradiene 3-hydroxylase • : cucurbitadienol 11-hydroxylase • : drimenol monooxygenase • : albendazole monooxygenase (sulfoxide-forming) • : albendazole monooxygenase (hydroxylating) • : fenbendazole monooxygenase (4′-hydroxylating) • : ent-isokaurene C2/C3-hydroxylase • : phenylacetonitrile α-monooxygenase • : phylloquinone ω-hydroxylase • : docosahexaenoic acid ω-hydroxylase • : long-chain fatty acid ω-monooxygenase • : flavanoid 3′,5′-hydroxylase • : flavonoid 3′-monooxygenase • : geraniol 8-hydroxylase • : linalool 8-monooxygenase • : 7-deoxyloganate 7-hydroxylase • : ent-kaurene monooxygenase • : 2-hydroxyisoflavanone synthase • : isoflavone 3′-hydroxylase • : 4′-methoxyisoflavone 2′-hydroxylase • : isoflavone 2′-hydroxylase • : trans-cinnamate 4-monooxygenase • : benzoate 4-monooxygenase • : 3,9-dihydroxypterocarpan 6a-monooxygenase • : leukotriene-B4 20-monooxygenase • : germacrene A hydroxylase • : 5-O-(4-coumaroyl)-D-quinate 3′-monooxygenase • : methyltetrahydroprotoberberine 14-monooxygenase • : protopine 6-monooxygenase • : (S)-limonene 3-monooxygenase • : dihydrosanguinarine 10-monooxygenase • : dihydrochelirubine 12-monooxygenase • : N-methylcoclaurine 3′-monooxygenase • : tabersonine 16-hydroxylase • : vinorine hydroxylase • : taxane 10β-hydroxylase • : taxane 13α-hydroxylase • : ent-kaurenoic acid monooxygenase • : 2,5-diketocamphane 1,2-monooxygenase • : 3-hydroxyindolin-2-one monooxygenase • : 2-hydroxy-1,4-benzoxazin-3-one monooxygenase • : 9β-pimara-7,15-diene oxidase • : ent-cassa-12,15-diene 11-hydroxylase • : α-humulene 10-hydroxylase • : amorpha-4,11-diene 12-monooxygenase • : 11-oxo-β-amyrin 30-oxidase • : averantin hydroxylase • : aflatoxin B synthase • : tryprostatin B 6-hydroxylase • : fumitremorgin C monooxygenase • : dammarenediol 12-hydroxylase • : protopanaxadiol 6-hydroxylase • : oryzalexin E synthase • : oryzalexin D synthase • : dihydromonacolin L hydroxylase • : monacolin L hydroxylase • : β-amyrin 28-monooxygenase • : methyl farnesoate epoxidase • : farnesoate epoxidase • : long-chain acyl-CoA ω-monooxygenase • : laurate 7-monooxygenase • : bursehernin 5′-monooxygenase • : (–)-4′-demethyl-deoxypodophyllotoxin 4-hydroxylase • : 1,8-cineole 2-endo-monooxygenase • : β-amyrin 24-hydroxylase • : glyceollin synthase • : deoxysarpagine hydroxylase • : (+)-abscisic acid 8′-hydroxylase • : lithocholate 6β-hydroxylase • : 5β-cholestane-3α,7α-diol 12α-hydroxylase • EC 1.14.14.140: Now included with , flavanone 2-hydroxylase • : psoralen synthase • : 8-dimethylallylnaringenin 2′-hydroxylase • : (+)-menthofuran synthase • : abieta-7,13-diene hydroxylase • : abieta-7,13-dien-18-ol hydroxylase • : geranylgeraniol 18-hydroxylase • : 3-epi-6-deoxocathasterone 23-monooxygenase • : angelicin synthase • : 5-epiaristolochene 1,3-dihydroxylase • : costunolide synthase • : premnaspirodiene oxygenase • : β-amyrin 11-oxidase • : indole-2-monooxygenase • : sterol 14α-demethylase • : 3,6-diketocamphane 1,2-monooxygenase • : tryptophan N-monooxygenase • : indolin-2-one monooxygenase • : carotenoid ε hydroxylase • : dolabradiene monooxygenase • : zealexin A1 synthase • : nepetalactol monooxygenase • : flavanone 2-hydroxylase • : (S)-1-hydroxy-N-methylcanadine 13-hydroxylase • : fraxetin 5-hydroxylase • : indole-3-carbonyl nitrile 4-hydroxylase • : (S)-N-methylcanadine 1-hydroxylase • : (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase • : germacrene A acid 8β-hydroxylase • : eupatolide synthase • : 8-epi-inunolide synthase • : β-amyrin 16α-hydroxylase • : 3,5,6-trichloropyridin-2-ol monooxygenase • : 2,4,6-trichlorophenol monooxygenase • : geranylhydroquinone 3′′-hydroxylase • : ferruginol synthase • : taxadiene 5α-hydroxylase • : ultra-long-chain fatty acid ω-hydroxylase • : taxoid 7beta-hydroxylase • : progesterone 11alpha-monooxygenase EC 1.14.15 With reduced iron–sulfur protein as one donor, and incorporation of one atom of oxygen • : camphor 5-monooxygenase • EC 1.14.15.2: Now , 2,5-diketocamphane 1,2-monooxygenase. • : alkane 1-monooxygenase • : steroid 11β-monooxygenase • : corticosterone 18-monooxygenase • : cholesterol monooxygenase (side-chain-cleaving) • : choline monooxygenase • : steroid 15β-monooxygenase • : spheroidene monooxygenase • : (+)-camphor 6-endo-hydroxylase • : pentalenic acid synthase • EC 1.14.15.12 : pimeloyl-[acyl-carrier protein] synthase. Now , pimeloyl-[acyl-carrier protein] synthase • : pulcherriminic acid synthase • : methyl-branched lipid ω-hydroxylase • : cholestanetriol 26-monooxygenase • : vitamin D3 24-hydroxylase • : pheophorbide a oxygenase • : calcidiol 1-monooxygenase • : C-19 steroid 1α-hydroxylase • : heme oxygenase (biliverdin-producing, ferredoxin) • : zeaxanthin epoxidase • : vitamin D 1,25-hydroxylase • : chloroacetanilide N-alkylformylase • : β-carotene 3-hydroxylase • : p-cymene methyl-monooxygenase • : toluene methyl-monooxygenase • : β-dihydromenaquinone-9 ω-hydroxylase • : cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming] • : cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] • : 3-ketosteroid 9α-monooxygenase • : 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase • : pentalenene oxygenase • : pikromycin synthase • : 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase • : 6-deoxyerythronolide B hydroxylase • : sterol 14α-demethylase (ferredoxin) • : luteothin monooxygenase • : N,N-dimethyl phenylurea N-demethylase • : epi-isozizaene 5-monooxygenase EC 1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor • : phenylalanine 4-monooxygenase • : tyrosine 3-monooxygenase • EC 1.14.16.3: withdrawn owing to insufficient evidence (anthranilate 3-monooxygenase) • : tryptophan 5-monooxygenase • : alkylglycerol monooxygenase • : mandelate 4-monooxygenase • : phenylalanine 3-monooxygenase EC 1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor • : dopamine β-monooxygenase • EC |1.14.17.2: deleted, now included with monophenol monooxygenase • : peptidylglycine monooxygenase • : aminocyclopropanecarboxylate oxidase EC 1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor • : tyrosinase • : CMP-N-acetylneuraminate monooxygenase • : methane monooxygenase (particulate) • : phosphatidylcholine 12-monooxygenase • : sphingolipid C4-monooxygenase • : 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase • : dihydroceramide fatty acyl 2-hydroxylase • EC 1.14.18.8: Now included with , 5β-cholestane-3α,7α-diol 12α-hydroxylase • : 4α-methylsterol monooxygenase • : plant 4,4-dimethylsterol C-4α-methyl-monooxygenase • : plant 4α-monomethylsterol monooxygenase • : 2-hydroxy fatty acid dioxygenase EC 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water • : stearoyl-CoA 9-desaturase • : acyl-(acyl-carrier-protein) desaturase| stearoyl-[acyl-carrier-protein] 9-desaturase • : linoleoyl-CoA desaturase • : acyl-lipid (11-3)-desaturase • : acyl-CoA 11-(Z)-desaturase • : acyl-CoA (9+3)-desaturase • EC 1.14.19.7: Now , (S)-2-hydroxypropylphosphonic acid epoxidase • : pentalenolactone synthase • : tryptophan 7-halogenase • : icosanoyl-CoA 5-desaturase • : acyl-(acyl-carrier-protein) 4-desaturase|acyl-[acyl-carrier-protein] 4-desaturase • : acyl-lipid ω-(9-4) desaturase • : acyl-CoA 15-desaturase • : linoleoyl-lipid Δ9 conjugase • : (11Z)-hexadec-11-enoyl-CoA conjugase • : linoleoyl-lipid Δ12 conjugase (11E,13Z-forming) • : sphingolipid 4-desaturase • : sphingolipid 8-(E)-desaturase • : sphingolipid 10-desaturase • : Δ7-sterol 5(6)-desaturase • : cholesterol 7-desaturase • : acyl-lipid ω-6 desaturase (cytochrome b5) • : acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) • : acyl-CoA 11-(E)-desaturase • : acyl-lipid ω-3 desaturase (cytochrome b5) • : acyl-(acyl-carrier-protein) 6-desaturase|acyl-[acyl-carrier-protein] 6-desaturase • : sn-2 palmitoyl-lipid 9-desaturase • : sn-1 stearoyl-lipid 9-desaturase • : sphingolipid 8-(E/Z)-desaturase • : acyl-lipid (8-3)-desaturase • : acyl-lipid (7-3)-desaturase • : palmitoyl-CoA 14-(E/Z)-desaturase • : Δ12 acyl-lipid conjugase (11E,13E-forming) • : acyl-lipid (9+3)-(E)-desaturase • : sn-2 acyl-lipid ω-3 desaturase (ferredoxin) • : sn-1 acyl-lipid ω-3 desaturase (ferredoxin) • : acyl-CoA 5-desaturase • : acyl-lipid Δ6-acetylenase • : acyl-lipid Δ12-acetylenase • : hex-5-enoyl-(acyl-carrier protein) acetylenase|hex-5-enoyl-[acyl-carrier protein] acetylenase • : sterol 22-desaturase • : palmitoyl-(glycerolipid) 7-desaturase|palmitoyl-[glycerolipid] 7-desaturase • : palmitoyl-(glycerolipid) 3-(E)-desaturase|palmitoyl-[glycerolipid] 3-(E)-desaturase • : acyl-CoA (8-3)-desaturase • : sn-1 oleoyl-lipid 12-desaturase • : sn-1 linoleoyl-lipid 6-desaturase • : acyl-lipid (9-3)-desaturase • : tert-amyl alcohol desaturase • : tetracycline 7-halogenase • : noroxomaritidine synthase • : (S)-corytuberine synthase • : camalexin synthase • : all-trans-retinol 3,4-desaturase • : 1,2-dehydroreticuline synthase • : 4-hydroxybenzoate brominase (decarboxylating) • : 1H-pyrrole-2-carbonyl-(peptidyl-carrier protein) chlorinase|1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase • : 1H-pyrrole-2-carbonyl-(peptidyl-carrier protein) brominase|1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase • : tryptophan 5-halogenase • : tryptophan 6-halogenase • : 7-chloro-L-tryptophan 6-halogenase • : dihydrorhizobitoxine desaturase • : secologanin synthase • : pseudobaptigenin synthase • : (S)-stylopine synthase • : (S)-cheilanthifoline synthase • : berbamunine synthase • : salutaridine synthase • : (S)-canadine synthase • : biflaviolin synthase • : mycocyclosin synthase • : fumitremorgin C synthase • : (–)-pluviatolide synthase • : (S)-nandinine synthase • : (+)-piperitol/(+)-sesamin synthase • : very-long-chain acyl-lipid ω-9 desaturase • : flavone synthase II • : plasmanylethanolamine desaturase • : decanoyl-(acyl-carrier protein) acetylenase|decanoyl-[acyl-carrier protein] acetylenase EC 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated • : deacetoxycephalosporin-C synthase • EC 1.14.20.2: Now , 2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase • : (5R)-carbapenem-3-carboxylate synthase • : anthocyanidin synthase • : flavone synthase I • : flavonol synthase • : 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming) • : (–)-deoxypodophyllotoxin synthase • : L-tyrosine isonitrile desaturase • : L-tyrosine isonitrile desaturase/decarboxylase • : 3-((Z)-2-isocyanoethenyl)-1H-indole synthase|3-[(Z)-2-isocyanoethenyl]-1H-indole synthase • : 3-((E)-2-isocyanoethenyl)-1H-indole synthase|3-[(E)-2-isocyanoethenyl]-1H-indole synthase • : 6β-hydroxyhyoscyamine epoxidase • : hapalindole-type alkaloid chlorinase • : L-threonyl-(L-threonyl-carrier protein) 4-chlorinase|L-threonyl-[L-threonyl-carrier protein] 4-chlorinase EC 1.14.21 With NADH or NADPH as one donor, and the other dehydrogenated • EC 1.14.21.1: Now , (S)-stylopine synthase • EC 1.14.21.2: Now , (S)-cheilanthifoline synthase • EC 1.14.21.3: Now , berbamunine synthase • EC 1.14.21.4: Now , salutaridine synthase • EC 1.14.21.5: Now , (S)-canadine synthase • EC 1.14.21.6: Now , Δ7-sterol 5(6)-desaturase • EC 1.14.21.7: Now , biflaviolin synthase • EC 1.14.21.8: Now , pseudobaptigenin synthase • EC 1.14.21.9: Now , mycocyclosin synthase * • EC 1.14.21.10: Now , fumitremorgin C synthase * • EC 1.14.21.11: Now , (–)-pluviatolide synthase * • EC 1.14.21.12: Now , (S)-nandinine synthase * EC 1.14.99 Miscellaneous • : prostaglandin-endoperoxide synthase • : kynurenine 7,8-hydroxylase • EC 1.14.99.3: Now , heme oxygenase (biliverdin-producing) • : progesterone monooxygenase • EC 1.14.99.5: Now , stearoyl-CoA 9-desaturase • EC 1.14.99.6: Now , acyl-[acyl-carrier-protein] desaturase • EC 1.14.99.7: Transferred to , squalene monooxygenase • EC 1.14.99.8: Now included with unspecific monooxygenase • EC 1.14.99.9: Now classified as , steroid 17α-monooxygenase • EC 1.14.99.10: Now , steroid 21-monooxygenase • : estradiol 6β-monooxygenase • : 4-androstene-3,17-dione monooxygenase • EC 1.14.99.13: Now , 3-hydroxybenzoate 4-monooxygenase • EC 1.14.99.14: Now , progesterone 11α-monooxygenase • : 4-methoxybenzoate monooxygenase (O-demethylating) • EC 1.14.99.16: Now , methylsterol monooxygenase • EC 1.14.99.17: Now , glyceryl-ether monooxygenase • EC 1.14.99.18: deleted • EC 1.14.99.19: Now classified as , plasmanylethanolamine desaturase • : phylloquinone monooxygenase (2,3-epoxidizing) • : Latia-luciferin monooxygenase (demethylating) • : ecdysone 20-monooxygenase • : 3-hydroxybenzoate 2-monooxygenase • : steroid 9α-monooxygenase • : Now , linoleoyl-CoA desaturase • : 2-hydroxypyridine 5-monooxygenase • EC 1.14.99.27: Now classified as , juglone 3-monooxygenase • EC 1.14.99.28: Now , linalool 8-monooxygenase • : deoxyhypusine monooxygenase • EC 1.14.99.30: Now , 9,9′-dicis-ζ-carotene desaturase. • EC 1.14.99.31: Now classified as , myristoyl-CoA 11-(E) desaturase • EC 1.14.99.32: Now classified as , acyl-CoA 11-(Z)-desaturase • EC 1.14.99.33: Now , acyl-lipid Δ12-acetylenase • : monoprenyl isoflavone epoxidase • : thiophene-2-carbonyl-CoA monooxygenase • EC 1.14.99.36: Now classified as , β-carotene 15,15′-dioxygenase • EC 1.14.99.37: Now , taxadiene 5α-hydroxylase • : cholesterol 25-hydroxylase • : ammonia monooxygenase • EC 1.14.99.40: Now , 5,6-dimethylbenzimidazole synthase • EC 1.14.99.41: Now , all-trans-8′-apo-β-carotenal 15,15′-oxygenase • EC 1.14.99.42: Now , crocetin dialdehyde synthase • EC 1.14.99.43: Now , β-amyrin 24-hydroxylase • : diapolycopene oxygenase • EC 1.14.99.45: Now , carotene ε-monooxygenase • : pyrimidine oxygenase • : (+)-larreatricin hydroxylase • : heme oxygenase (staphylobilin-producing) • EC 1.14.99.49: Now , 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase • : γ-glutamyl hercynylcysteine S-oxide synthase • : hercynylcysteine S-oxide synthase • : L-cysteinyl-L-histidinylsulfoxide synthase • : lytic chitin monooxygenase • : lytic cellulose monooxygenase (C1-hydroxylating) • : lytic starch monooxygenase • : lytic cellulose monooxygenase (C4-dehydrogenating) • : heme oxygenase (mycobilin-producing) • : heme oxygenase (biliverdin-IX-β and δ-forming) • : tryptamine 4-monooxygenase • : 3-demethoxyubiquinol 3-hydroxylase • : cyclooctat-9-en-7-ol 5-monooxygenase • : cyclooctatin synthase • : β-carotene 4-ketolase • : zeaxanthin 4-ketolase • : 4-amino-L-phenylalanyl-(CmlP-peptidyl-carrier-protein) 3-hydroxylase|4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase • : (histone H3)-N^6,N^6-dimethyl-L-lysine^4 FAD-dependent demethylase|[histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase • : α-N-dichloroacetyl-p-aminophenylserinol N-oxygenase • : 4-aminobenzoate N-oxygenase • : tRNA 2-(methylsulfanyl)-N6-isopentenyladenosine37 hydroxylase ==EC 1.15 Acting on superoxide as acceptor==
EC 1.15 Acting on superoxide as acceptor
EC 1.15.1 • : superoxide dismutase • : superoxide reductase ==EC 1.16 Oxidizing metal ions==
EC 1.16 Oxidizing metal ions
EC 1.16.1 With NAD+ or NADP+ as acceptor • : mercury(II) reductase • : diferric-transferrin reductase • EC 1.16.1.3: deleted since no specific enzyme catalysing this activity has been identified • : cob(II)alamin reductase • EC 1.16.1.5: deleted since the enzyme the entry was based on was later shown to be , pyruvate dehydrogenase (NADP+). • : cyanocobalamin reductase (cyanide-eliminating) • : ferric-chelate reductase • : (methionine synthase) reductase| [methionine synthase] reductase • : ferric-chelate reductase (NADPH) • : ferric-chelate reductase [NAD(P)H] EC 1.16.3 With oxygen as acceptor • : ferroxidase • : bacterial non-heme ferritin • : manganese oxidase EC 1.16.5 With a quinone or similar compound as acceptor • EC 1.16.5.1: Now , ascorbate ferrireductase (transmembrane) EC 1.16.8 With a flavin as acceptor • EC 1.16.8.1: activity now known to be catalyzed by , corrinoid adenosyltransferase EC 1.16.9 With a copper protein as acceptor • : iron:rusticyanin reductase EC 1.16.98 With other, known, physiological acceptors • EC 1.16.98.1: Now iron:rusticyanin reductase EC 1.16.99 With unknown physiological acceptors • : (Co(II) methylated amine-specific corrinoid protein) reductase|[Co(II) methylated amine-specific corrinoid protein] reductase ==EC 1.17 Acting on CH or CH2 groups==
EC 1.17 Acting on CH or CH2 groups
EC 1.17.1 With NAD or NADP as acceptor • : CDP-4-dehydro-6-deoxyglucose reductase • EC 1.17.1.2: now classified as , 4-hydroxy-3-methylbut-2-enyl diphosphate reductase • : leucoanthocyanidin reductase • : xanthine dehydrogenase • : nicotinate dehydrogenase • EC 1.17.1.6: Now , bile-acid 7α-dehydroxylase. It is now known that FAD is the acceptor and not NAD+ as was thought previously • EC 1.17.1.7: Now , 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase • : 4-hydroxy-tetrahydrodipicolinate reductase • : formate dehydrogenase • : formate dehydrogenase (NADP+) • : formate dehydrogenase (NAD+, ferredoxin) EC 1.17.2 With a cytochrome as acceptor • : nicotinate dehydrogenase (cytochrome) • : lupanine 17-hydroxylase (cytochrome c) • : formate dehydrogenase (cytochrome-c-553) EC 1.17.3 With oxygen as acceptor • : pteridine oxidase • : xanthine oxidase • : 6-hydroxynicotinate dehydrogenase • : juglone 3-hydroxylase EC 1.17.4 With a disulfide as acceptor • : ribonucleoside-diphosphate reductase • : ribonucleoside-triphosphate reductase (thioredoxin) • EC 1.17.4.3: transferred to , (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase. • : vitamin-K-epoxide reductase (warfarin-sensitive) • : vitamin-K-epoxide reductase (warfarin-insensitive) EC 1.17.5 With a quinone or similar compound as acceptor • : phenylacetyl-CoA dehydrogenase • : caffeine dehydrogenase • : formate dehydrogenase-N EC 1.17.7 With an iron–sulfur protein as acceptor • : (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin) • : 7-hydroxymethyl chlorophyll a reductase • : (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) • : 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase EC 1.17.98 With other, known, physiological acceptors • EC 1.17.98.1: bile-acid 7α-dehydroxylase. Now known to be catalyzed by multiple enzymes. • : bacteriochlorophyllide c C-71-hydroxylase • : formate dehydrogenase (coenzyme F420) • : formate dehydrogenase (hydrogenase) EC 1.17.99 With unknown physiological acceptors • EC 1.17.99.1: Now EC 1.17.9.1, 4-methylphenol dehydrogenase (hydroxylating) • : ethylbenzene hydroxylase • : 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase • : uracil/thymine dehydrogenase • EC 1.17.99.5: Now classified as EC 1.17.98.1, bile-acid 7α-dehydroxylase • : epoxyqueuosine reductase • EC 1.17.99.7: Now classified as EC 1.17.98.4, formate dehydrogenase (hydrogenase) • : limonene dehydrogenase • : heme a synthase • : steroid C-25 hydroxylase • : 3-oxo-Δ1-steroid hydratase/dehydrogenase ==EC 1.18 Acting on iron–sulfur proteins as donors==
EC 1.18 Acting on iron–sulfur proteins as donors
EC 1.18.1 With NAD+ or NADP+ as acceptor • : rubredoxin—NAD+ reductase • : ferredoxin—NADP+ reductase • : ferredoxin—NAD+ reductase • : rubredoxin—NAD(P)+ reductase • : Putidaredoxin—NAD+ reductase • : adrenodoxin-NADP+ reductase • : ferredoxin—NAD(P)+ reductase (naphthalene dioxygenase ferredoxin-specific) • EC 1.18.1.8: Now , ferredoxin—NAD+ oxidoreductase (Na+-transporting) EC 1.18.2 With dinitrogen as acceptor (deleted sub-subclass) • EC 1.18.2.1: now , nitrogenase EC 1.18.3 With H+ as acceptor (deleted sub-subclass) • EC 1.18.3.1: Now , ferredoxin hydrogenase EC 1.18.6 With dinitrogen as acceptor • : nitrogenase • : vanadium-dependent nitrogenase EC 1.18.96 With other, known, acceptors (deleted sub-subclass) • EC 1.18.96.1: Now , superoxide reductase EC 1.18.99 With H+ as acceptor (deleted sub-subclass) • EC 1.18.99.1: Now , ferredoxin hydrogenase ==EC 1.19 Acting on reduced flavodoxin as donor==
EC 1.19 Acting on reduced flavodoxin as donor
EC 1.19.1 With NAD+ or NADP+ as acceptor • : flavodoxin—NADP+ reductase EC 1.19.6 With dinitrogen as acceptor • : nitrogenase (flavodoxin) ==EC 1.20 Acting on phosphorus or arsenic in donors==
EC 1.20 Acting on phosphorus or arsenic in donors
EC 1.20.1 Acting on phosphorus or arsenic in donors, with NAD+ as acceptor • : phosphonate dehydrogenase EC 1.20.2 Acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor • : arsenate reductase (cytochrome c) EC 1.20.4 Acting on phosphorus or arsenic in donors, with disulfide as acceptor • : arsenate reductase (glutaredoxin) • : methylarsonate reductase • : mycoredoxin • : arsenate reductase (thioredoxin) EC 1.20.9 With a copper protein as acceptor • : arsenate reductase (azurin) EC 1.20.98 With other, known acceptors • EC 1.20.98.1: Now , arsenate reductase (azurin) EC 1.20.99 With unknown physiological acceptors • : arsenate reductase (donor) ==EC 1.21 Catalysing the reaction X-H + Y-H = X-Y==
Source: Wikipedia ↗
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