•
Francis Uche Agabige, Nigerian politician, member of the Imo State House of Assembly •
Francis Alcantara (born 1992), professional tennis player from the Philippines •
Francis Alÿs (born 1959), Belgian-born, Mexico-based artist •
Francis Andersen (1925–2020), Australian scholar in the fields of biblical studies and Hebrew •
Francis Bacon (1561–1626), English philosopher, statesman, scientist, lawyer, jurist, author and pioneer of the scientific method •
Francis Bacon (artist) (1909–1992), Irish-born English artist •
Francis Baines (Jesuit) (1648–1710), English Jesuit •
Francis "Fritz" Barzilauskas (1920–1990), American National Football League player •
Francis Bernard (disambiguation), multiple people •
Francis Bohlen (1868–1942), American professor of law at the University of Pennsylvania Law School •
Francis Bouillon (born 1975), American-Canadian ice hockey player •
Francis S. Bowling (1916–1997), justice of the Supreme Court of Mississippi •
Francis Martin Patrick "Frankie" Boyle (born 1972), British stand-up comedian •
Francis Brewu (born 2006), American football defensive tackle •
Francis Brill (1836–1913), American farmer and politician •
Francis Buchholz (1954–2026), German bass guitarist •
Francis Cabrel (born 1953), French singer-songwriter, composer and guitarist •
Francis Capra (born 1983), American actor •
Sir Francis Chichester (1901–1972), British businessman, pioneering aviator and solo sailor •
Francis Collins (born 1950), American physician-scientist •
Francis Ford Coppola (born 1939), American film-director, producer, and screenwriter •
Francis Coquelin (born 1991), French professional footballer •
Francis Marion Crawford (1854–1909), American writer •
Francis Crick (1916–2004), British molecular biologist and winner of the 1962 Nobel Prize in Physiology or Medicine •
Francis Napier Denison (1866–1940), Canadian meteorologist, inventor, seismologist, and astronomer •
Francis Xavier Dercum (1858-1931), American physician •
Francis E. Donoghue (1872–1952), member of Illinois State House of Representatives •
Francis Donald Logan (1930–2022), American historian •
Francis Drake (1540–1596), English sea captain •
Francis Elliott (journalist), British journalist •
Francis Fentress (1873–1930), justice of the Tennessee Supreme Court •
Francis Scott Fitzgerald (1896–1940), American novelist and short story writer •
Francis B. Foley (1887–1973), American metallurgist •
Francis Fontaine (1845–1901), American poet and novelist •
Francis Fukuyama (born 1952), American political scientist •
Francis Galluppi (born 1988), American filmmaker •
Sir Francis Galton (1822–1911), British polymath •
Francois Xavier Gouraud (1877-1913), French physician and dietitian •
Francis Greenslade, Australian comedic actor •
Francis Griffith (disambiguation) •
Francis Grignon (born 1944), French politician •
Francis Grose, English antiquary, draughtsman, and lexicographer •
Francis C. Heitmeier (born 1950), American politician •
Francis Alick "Frankie" Howerd (1917–1992), British comedian and actor •
Francis Huré (1916–2021) French resistant, diplomat and writer •
Francis Irving, British computer programmer and activist for freedom of information •
Francis Scott Key (1779–1843), writer of the American national anthem, "The Star-Spangled Banner" •
Francis Kilcoyne (died 1985), American President of Brooklyn College •
Francis Kobangoye (born 1990), Gabonese basketball player •
Francis Kompaon (born 1986), T46 Papua New Guinean athlete •
Francis Lai (1932–2018), French composer, noted for his film scores •
Francis Lawrence (born 1971), American filmmaker and producer •
Francis van Londersele (born 1953), French directeur sportif •
Francis Magalona (1964–2009), Filipino rapper, singer, songwriter, entrepreneur and television personality •
Francis Magee (born 1959), Irish actor •
Francis Magundayao (born 1999), Filipino actor and model •
Francis Manapul (born 1979), Canadian comic book artist and writer •
Francis March (1825–1911), American polymath, academic, philologist, and lexicographer •
Francis Marion, also known as the Swamp Fox, military officer in the American Revolutionary War •
Francis Marrash, Syrian scholar, publicist, writer, poet, and physician •
Francis Matthews (1927–2014), British actor, known for voicing
Captain Scarlet •
Francis Maude, British Conservative politician •
Francis J. McCaffrey (1917–1989), American lawyer and politician from The Bronx, New York •
Francis J. McCaffrey Jr. (1902–1972), American lawyer and politician from Brooklyn, New York •
Francis McDonald (1891–1968), American actor •
Francis Davis Millet (1848–1912), American artist and RMS
Titanic sinking victim •
Francis Molo (born 1994), New Zealand-Australian rugby league player •
Francis Narh (born 1994), Ghanaian footballer •
Francis Ng (born 1961), Hong Kong actor and director •
Francis Ngannou (born 1986), Cameroonian-French mixed martial artist •
Francis Obikwelu (born 1978), retired Nigerian-born Portuguese sprinter •
Francis Omaswa, Ugandan cardiovascular surgeon, academic and administrator •
Francis Ouimet (1893–1967), American amateur golfer •
Francis Owen (1886–1975), Canadian philologist and military officer •
Francis Owusu (born 1994), American football player •
Francis Paré (born 1987), Canadian-Belarusian professional ice hockey forward •
Francis Pasion (1978–2016), Filipino independent film and television drama director •
Francis E. Patterson (1821-1862), American military officer •
Francis Peacock (1723–1807), Scottish dance teacher and musician •
Francis "Frank" Pearson (1937–2003), British drag queen known as Foo Foo Lammar •
Francis Penrose (1817–1903), English architect, archaeologist, astronomer and sportsman rower •
Francis Petre (1847–1918), New Zealand-born architect based in Dunedin •
Francis Pollock (1876–1957), Canadian science fiction writer •
Francis Ponge (1899-1988), French essayist and poet •
Francis Poulenc (1899-1963), French composer and pianist •
Francis Pound (1948-2017), New Zealand art historian, curator and writer •
Francis J. Quirico (1911–1999), justice of the Massachusetts Supreme Judicial Court •
Francis Repellin (born 1969), French nordic combined skier •
Sir Francis Ronalds (1788–1873), English scientist and inventor •
Francis Rosa (1920–2012), American sports journalist •
Francis Rossi (born 1949), British musician •
Francis Rundall (1908–1987), British diplomat •
Francis Saunderson (1754–1827), Anglo-Irish politician •
Francis Alexander Shields (1941-2003), American businessman and executive at Revlon in New York City •
Francis Albert "Frank" Sinatra (1915–1998), American singer, actor, and producer •
Francis Sultana, Maltese-born furniture and interior designer •
Francis Tolentino (born 1960), Filipino politician and senator •
Francis Tuttle (1920–1997), American educator •
Francis Valentino, American musician •
Francis Webb (disambiguation), multiple people •
Francis Parker Yockey, American writer, lawyer and philosopher •
Francis Zamora (born 1977), Filipino politician, businessman, and basketball player
Aristocracy •
Francis I, Holy Roman Emperor (1708–1765), also Francis III, Duke of Lorraine
France •
Francis I of France, King of France (1494–1547) •
Francis II of France, King of France (1544–1560) •
Francis I, Duke of Brittany (1414–1450) •
Francis II, Duke of Brittany (1433–1488) •
Francis III, Duke of Brittany (1518–1536) •
Francis I, Duke of Lorraine (1517–1545) •
Francis II, Duke of Lorraine (1572–1632)
German-speaking countries •
Francis II, Holy Roman Emperor, also Francis I, Emperor of Austria (1768–1835) •
Franz, Duke of Bavaria (born 1933), called "Francis II" by Jacobite supporters
Iberian monarchies •
Prince Francis Joseph of Braganza (1878–1919), Infante of Portugal, 2nd son of
Miguel II, legitimist claimant to the throne of Portugal •
Francis of Spain (1822–1902), Duke of Cádiz, King Consort of Queen
Isabella II Italy •
Francis I of the Two Sicilies (1777–1830) •
Francis II of the Two Sicilies (1836–1894) •
Francis IV, Duke of Modena (1779–1846) •
Francis V, Duke of Modena (1819–1875)
Hungary •
Francis I Rákóczi, Prince of Transylvania (1645–1676) •
Francis II Rákóczi, Duke of Hungary and Prince Transylvania (1676–1735)
Scandinavia •
Francis of Denmark (1497–1511), Prince of Denmark, Norway and Sweden
Religious figures •
Pope Francis (1936–2025) •
Francis of Assisi (1181/1182–1226), Italian Catholic
friar and saint •
Francis de Sales (1567–1622), French Catholic
bishop and saint •
Francis Xavier (1506–1552), Basque Catholic Jesuit missionary and saint •
Francis George, OMI (1937–2015), cardinal and
Archbishop of Chicago (1997–2014) •
Chico Xavier or
Francisco Cândido Xavier, (1910-2002), popular Brazilian philanthropist and
spiritist medium ==Fictional characters==