This section lists all the mad scientists in different media appearances:
Mad scientists and evil geniuses in literature • Otto Hantzen (
Les Mystères de Demain) - A German mad scientist, who, along with female accomplice Hindu mystic
Yogha, battles his former colleague
Oronius from
Mount Everest to
Atlantis. •
Victor Frankenstein (
Frankenstein) - A scientist who stole body parts from graves and used them to create his
monster. •
Dr. Henry Jekyll (
Strange Case of Dr Jekyll and Mr Hyde) - A scientist who searches for alteration of the human body and to separate the evil from the good, which led to him developing the evil form of Edward Hyde. •
Mad scientists of Stanisław Lem, quite a few mad geniuses, many of whom strove to "inflict social
panacea on entire populations", a part of Lem's philosophical analysis of
social engineering. • Dr. Moreau (
The Island of Doctor Moreau) - A vivisectionist who has fled a scandal to live on a remote island in the Pacific to pursue his research of perfecting his Beast Folk. •
Professor Moriarty - The evil genius antagonist of
Sherlock Holmes. •
Dr. Julius No (
Dr. No)
Mad scientists in live-action films • Mr. Barron (''
Miss Peregrine's Home for Peculiar Children'') • Dr. Simon Barsinister (
Underdog) - An adaption of the cartoon character, who was scarred and crippled in an accident. • Nathan Bateman (
Ex Machina) •
Dr. René Emile Belloq (
Raiders of the Lost Ark) - An adventuring
archeologist and antagonist for Indiana Jones in targeting the
Ark of the Covenant. • Dr. Ralph Benson (
The Mad Doctor of Market Street) • Professor Gerard Beckert (
Frostbite) - A mad geneticist and Nazi
World War II veteran who creates genetically enhanced
vampires out of the unsuspecting youth of a
Norrland-town near the
Arctic Circle. • Dr. Theodore Bohmer (
The Ghost of Frankenstein) • Dr. Paul Carruthers (
The Devil Bat) • Dr. Phillip Channard (
Hellbound: Hellraiser II) •
Conal Cochran (
Halloween III: Season of the Witch) - He plans to resurrect macabre aspects of the Gaelic festival Samhain, which he connects to witchcraft. • Dr. Franz Edelmann (
House of Dracula) - A honorable doctor who was transfused with the blood of
Count Dracula, causing him to go insane and become a murderer. •
Dr. Evil (
Austin Powers) • Casanova Frankenstein (
Mystery Men) - A criminal mastermind in Champion City. • Frederick Frankenstein (
Young Frankenstein) - The grandson of
Victor Frankenstein, who at first is embarrassed by his grandfather's deeds and insists that his name is pronounced "Fronkensteen," but eventually creates his own
monster. • Henry Frankenstein (
Frankenstein) - The film's version of Victor Frankenstein. • Dr. Frank N. Furter (
The Rocky Horror Picture Show) • Dr. Gogol (
Mad Love) •
Dr. Lawrence Gordon (
Saw) - An uncaring surgeon until he survived a "test" orchestrated by the
Jigsaw Killer. After the experience changed his viewpoint on life, Gordon became Jigsaw's apprentice and began applying his medical skills to Jigsaw's traps. Following Jigsaw's death, Gordon became his successor. • Dr. Josef Heiter (
The Human Centipede (First Sequence)) - A
Josef Mengele-esque surgeon known for his surgical atrocity, which he calls the "Human Centipede". • Dr. Hoenneger (
The Wolfman) - A German doctor who worked at an insane asylum and used
medical torture to "treat"
Lawrence Talbot's
lycanthropy. • Dr. Horrible (''
Dr. Horrible's Sing-Along Blog'') • Dr.
Ashley Kafka (
The Amazing Spider-Man 2) - A German doctor who experiments on the patients of the
Ravencroft Institute. •
John Kramer (
Saw) - A former civil engineer who spends the last months of his life testing people's will to live by placing them in deadly traps. • Dr. Nick Laslowicz (
The Centrifuge Brain Project) • Dr. Mannering (
Frankenstein Meets the Wolf Man) • Dr. Wolfe MacFarlane (
The Body Snatcher) • Dr. Cal Meacham (
This Island Earth) - An earth scientist who is kidnapped to solve the problem of defending the planet Metaluna. • Dr. Harold Medford (
Them!) - He led the team that wiped out the giant ants. • Dr. Gustav Niemann (
House of Frankenstein) - A mad doctor who escaped prison for revenge, took over a horror carnival exhibit that included
Count Dracula and later encountered
Frankenstein's monster and the
Wolf Man. • Philo (
UHF) •
Doctor Septimus Pretorius (
Bride of Frankenstein) - A mad doctor and Henry Frankenstein's teacher who followed in Henry Frankenstein's footsteps in creating living beings. He blackmailed Frankenstein into helping him to create a
female companion for Frankenstein's monster. •
Rotwang (
Metropolis) • Dr. Shinzo Mafune (
Terror of Mechagodzilla) - A bitter oceanographer who had previously been ridiculed for his obsessive research into the brain patterns of sea creatures. He allies with the invading Black Hole Planet 3 Aliens, unleashing the mind-controlled
kaiju Titanosaurus - whom he had personally discovered - to assist their newly-rebuilt
Mechagodzilla. • Dr. Carl Stoner (
Sssssss) - A delusional scientist attempting to create a method of transforming humans into snakes. • Dr. Strangelove (
Dr. Strangelove) - A former
Nazi scientist who was the scientific advisor to the
President of the United States during the brink of
apocalypse. • Dr. Alexander Thorkel (
Dr. Cyclops) • Dr. Jane Tiptree (
Carnosaur) - A mad scientist who plans to recreate dinosaurs and destroy humanity. • Dr. Richard Vollin (
The Raven) • Dr. Eric Vornoff (
Bride of the Monster) • Dr.
Herbert West (
Re-Animator) • Peter Weyland (
Prometheus) •
Dr. Henry Wu (
Jurassic Park) - The chief
geneticist at Jurassic Park and head of the team that resurrected dinosaurs via cloning. • Dr. XXX (
The Mad Doctor)
Mad scientists in live-action television • Dr. Arthur Arden / Hans Grüper (
American Horror Story: Asylum) •
Walter Bishop (
Fringe) - A scientist who was responsible for opening a doorway into another universe to save an alternate version of his son Peter from dying. His actions resulted in the gradual breakdown of both universes and inadvertently started a war between them. • Martin Brenner (
Stranger Things) - He was the scientist who experimented on
Eleven. •
Davros (
Doctor Who) - The creator of the
Daleks. •
Dr. Laurence Erhardt (
Mystery Science Theater 3000) •
Dr. Clayton Forrester (
Mystery Science Theater 3000) •
TV's Frank (
Mystery Science Theater 3000) • Kinga Forrester (
Mystery Science Theater 3000) •
Pearl Forrester (
Mystery Science Theater 3000) • Dr. Benjamin Jeffcoat (
My Secret Identity) •
Dr. Loveless (
The Wild Wild West) •
The Master (
Doctor Who) - A renegade alien who seeks universal conquest. • Masahiko Minami (
Kamen Rider 555) • Dr. Jonathan Reiss (
Lara Croft Tomb Raider: The Cradle of Life) - A disease specialist who sought to obtain
Pandora's box. • Dr. Wilhelm Rolf (
Days of Our Lives) • Dr. Shrinker (
Doctor Shrinker)
Mad scientists in animated television • Hugo A-Go-Go (
Batfink) - Batfink's most recurring enemy. • Dr. Arkeville (
The Transformers) - A self-proclaimed evil genius who allies himself with the
Decepticons. • Lord Boxman (''
OK K.O.! Let's Be Heroes'') - An evil robotics engineer and CEO of Boxmore. • Professor Bug (
The Backyardigans) - A pseudo-
steampunk mad scientist portrayed by Pablo, who bugs all the robots in Mega City in the episode "Robot Rampage". • Professor Finbarr Calamitous (
The Adventures of Jimmy Neutron, Boy Genius) - A recurring enemy of Jimmy Neutron. • Dr. Cerebral (
Atomic Betty) - A mad alien scientist, consisting of a brain with a face floating within a glass tank upon a mechanical body, who seeks to control the universe and wipe out all organic life out of a belief that mechanical beings are more efficient. • Dr. Claw (
Inspector Gadget) - The leader of MAD. •
Dr. Heinz Doofenshmirtz (
Phineas and Ferb) - A mad scientist whose goal is to take over the Tri-State Area. • Dr. Drakken (
Kim Possible) - A blue-skinned mad scientist determined to take over the world in order to prove his genius. • Miles Dredd (
Max Steel) - The main antagonist of
Max Steel. •
Princess Entrapta (
She-Ra: Princess of Power and
She-Ra and the Princesses of Power) - The Evil Horde's robotics engineer and inventor. • Dr. Flug (
Villainous) - An intelligent and inventive mad scientist who creates the gadgets and machines that Black Hat attempts to sell. •
Mojo Jojo (
The Powerpuff Girls) - A mad scientist chimpanzee that plots to take over the world and destroy the Powerpuff Girls. He was also Professor Utonium's former pet and partially responsible for the creation of the Powerpuff Girls. • Van Kleiss (
Generator Rex) - A British scientist who can manipulate the earth. • Dr. Lullah (
StuGo) - She was responsible for turning animals into humanoid mutants, creating other lifeforms, and conducting experiments, as well as passing her island off as a summer camp that six children attend. • Mandark (''
Dexter's Laboratory'') - Dexter's rival, an evil genius who wants to destroy Dexter's laboratory and take over the world. • Mane-iac (
My Little Pony: Friendship Is Magic) - A mad scientist in chemical engineering, specializing in the production of detergents. •
Marvin the Martian (
Looney Tunes) - A would-be planet conqueror. •
Megatron (
Transformers) - The leader of the
Decepticons. • Dr. Alphonse Mephesto (
South Park) - A mad scientist who specializes in genetic engineering and creates strange creatures with his talents. He also performs experiments ranging from simple DNA tests to creating a genetic clone of
Stan Marsh for his son's science project. •
Doctor Mindbender (
G.I. Joe: Renegades) - A mad young genius in charge of Cobra's secret Bio-Viper project. • Dr. Namba (
Pokémon) - An evil scientist who works for
Team Rocket, where he mostly oversees Cassidy and Butch. •
Plankton (
SpongeBob SquarePants) - A
copepod evil genius who specializes in building robotic inventions, including his sidekick
Karen. •
Vlad Plasmius (
Danny Phantom) - A half-ghost evil inventor. • Dr. Cinnamon J Scudworth (
Clone High) - A mad scientist who created clones of historic figures, employed by The Secret Board of Shadowy Figures. • Dr. Anton Sevarius (
Gargoyles) - A mad scientist and geneticist involved in several projects in the
Gargoyles storyline. His most notable act is the creation of Talon and the Mutates. • Jack Spicer (
Xiaolin Showdown) - A self-proclaimed evil boy genius. • Doctor Two-Brains (
WordGirl) - A scientist who accidentally fused a mouse brain with his own, giving him an evil split personality. • Professor Venomous (''
OK K.O.! Let's Be Heroes'') - An international terrorist and evil inventor. • Dr. Weird (
Aqua Teen Hunger Force) - The smartest, maddest, and scientistest scientist in the universe, whose experiments often cause problems for the Aqua Teens.
Mad scientists in animated films • Buddy Pine / Syndrome (
The Incredibles) -
Mr. Incredible's fan/aspiring sidekick-turned-supervillain, who uses his scientific prowess to give himself enhanced abilities. • Dr. Finkelstein (
The Nightmare Before Christmas) • Victor "Vector" Perkins (
Despicable Me)
Mad scientists in anime and manga •
Naoko Akagi (
Neon Genesis Evangelion) •
Ritsuko Akagi (
Neon Genesis Evangelion) - The daughter of Naoko Akagi, • Dr. Hiroshi Agasa (
Case Closed) - An absent-minded professor who invents several devices to aid
Jimmy Kudo, •
Bondrewd (
Made in Abyss) - A White Whistle known as "Bondrewd the Novel", who is in charge of Idofront, the Cave Riders' forward Operating Base in the fifth layer. He was responsible for several unethical experiments on children, including the one which transformed Nanachi and Mitty into Hollows. • Dr. Hell (
Mazinger Z) - A mad scientist who is obsessed with taking over the world with his army of robotic monsters known as Mechanical Beast or Kikaiju. • Senku Ishigami (
Dr. Stone) - A genius with vast scientific knowledge, who is able to invent various kinds of tools and gadgets quickly and efficiently. As a child, he designed and built a functioning miniature rocket ship. Senkuu also possesses an analytical mind, being able to correctly discern the situation he is in. •
Mayuri Kurotsuchi (
Bleach) - A sadistic and cruel
shinigami who uses his position as the leader of the Soul Society's Shinigami Research and Development Institute to conduct experiments. •
Desty Nova (
Battle Angel Alita) - A wicked genius whose work is fueled by philosophy, who is highly skilled at
nanotechnology. •
Rintaro Okabe (
Steins;Gate) - An eccentric yet kind-hearted inventor who embraces the typical image of a mad scientist. His experiments lead to the invention of
time travel. •
Orochimaru (
Naruto) - A
shinobi obsessed with immortality and obtaining knowledge of all jutsu. He conducted many illegal and unethical experiments that resulted in him becoming a wanted criminal. •
Franken Stein (
Soul Eater) •
Kaolla Su (
Love Hina) - An exchange student and princess of the island of Molmol. She frequently invents dangerous devices and wants to turn her kingdom into a technological powerhouse that will conquer Japan. •
Professor Souichi Tomoe (
Sailor Moon) - The father of
Hotaru Tomoe and the leader of
Death Busters, who was once a world-renowned scientist in the field of genetic engineering. After being forced out of the scientific community for his unethical experiments, he sold his findings to companies and bought the Sankakusu District to continue his research to create "Super Beings". He vesselized one of the
Daimon eggs, Germatoid, to become a human-Daimon hybrid, selling his soul to
Master Pharaoh 90 and willfully discarding his humanity. After becoming a hybrid, he creates various Daimons while working to perfect the stability of Daimon/human hybrids. •
Daruma Ujiko (
My Hero Academia) - A mad scientist associated with the series' main antagonists, the League of Villains. •
Kabuto Yakushi (
Naruto) - Orochimaru's assistant who takes part in many of his master's illegal experiments in addition to conducting his own, which include raising the dead. • Dr. Z (
Dinosaur King) - The leader of the Alpha Gang who wanted to use the Dinosaur Cards to rule the world.
Mad scientists in comics Mad scientists in DC Comics •
Doctor Death - The first supervillain Batman ever faces, a chemist and producer of biological weapons. •
Dollmaker - A serial killer and insane surgeon who makes dolls out of human flesh. •
Gorilla Grodd •
Professor Ivo - A supervillain and creator of
Amazo, who is obsessed with immortality. •
Lex Luthor - A scientific genius who is the nemesis of
Superman. •
Man-Bat •
Mr. Freeze •
Orca •
Doctor Poison - An enemy of Wonder Woman and a mad scientist, who specializes in chemistry and poisons. •
Poison Ivy - A supervillain scientist with an affinity towards plant life. •
Doctor Sivana - The world's wickedest scientist and archenemy of
Captain Marvel. •
Hugo Strange - A mad scientist and enemy of Batman who deduced his secret identity. •
T. O. Morrow •
Ultra-Humanite Mad scientists in Marvel Comics •
Curt Connors - A college professor and expert on reptiles, who created a formula to regrow his missing arm, but ended up turning himself into the Lizard. •
Doctor Doom - An evil scientist, engineer, genius, and conqueror. Like Mister Fantastic, he is regarded as one of the most intelligent people on Earth. •
Doctor Octopus - A narcissistic
roboticist and
nuclear physicist who is an enemy of Spider-Man. •
High Evolutionary - A British scientist who specializes in mutating animals into anthropomorphic forms. •
Jackal - A college professor who has a vendetta against Spider-Man due to the death of his girlfriend
Gwen Stacy, whom he secretly loved. He creates multiple clones of the Spider-Man as well as a clone of Gwen to attack and torment him, eventually turning himself into a jackal-like beast. •
Leader - An enemy of the Hulk who was mutated by gamma radiation and possesses superhuman intelligence. •
Mister Sinister - An enemy of the X-Men who specializes in genetic engineering. •
Morbius - A scientist whose experiment with
vampire bat DNA turned him into a pseudo-vampire. •
Norman Osborn - A billionaire CEO of
Oscorp and Spider-Man's nemesis, who is sometimes portrayed as a scientist with brilliant intellect. He crafts a Halloween-themed costume called the
Green Goblin while having developed a personality associated with it. •
Bolivar Trask - A scientist who created the
Sentinels, a series of
mutant-hunting robots. •
Baron Zemo - A Nazi and archenemy of Captain America. •
Arnim Zola - A former
Nazi scientist who escaped death by transferring his consciousness into a mechanical body. In the present day, he is a member of the
Hydra terrorist organization.
Mad scientists in other comics • Dr. Jonathan Septimus (
Blake and Mortimer) - A
mad scientist vengeful due to perceived slights by his colleagues, who appears in
The Yellow "M" and
The Septimus Wave. • Joachim Sickbock (
Tom Poes) - A
mad scientist who often proves to be a threat to the protagonists. •
Baxter Stockman (
Teenage Mutant Ninja Turtles) - A mad scientist and archenemy of the
Teenage Mutant Ninja Turtles. Other media adaptions had him working for
Shredder and the
Foot Clan. •
Othar Tryggvassen (
Girl Genius) - A powerful "spark", or
mad scientist, bent on destroying all sparks, including himself.
Mad scientists in video games • Doctor Nitrus Brio (
Crash Bandicoot) - A timid and meek scientist who assisted Doctor Neo Cortex in the first game, often using beakers of chemicals. •
Doctor Neo Cortex (
Crash Bandicoot) - An evil doctor who is the creator and archenemy of the franchise's titular hero
Crash Bandicoot and has an oversized head. He seeks to conquer the world using Power Crystals. • Dr. Crygor (
WarioWare) • Dr. Daniel Dickens (
Angels of Death) - The main character's therapist. •
Victor Donovan (
Dead or Alive) - The main antagonist of the
Dead or Alive series. • Dr. "Mundo" Edmundo (
League of Legends) - A sociopath medical doctor who specializes in the study of the pain response and how to inflict pain. His experiments have caused him to take on a monstrous form and a deceptively dimwitted speech pattern. •
Dr. Ivo "Eggman" Robotnik (
Sonic the Hedgehog) - A mad scientist and archenemy of
Sonic the Hedgehog, who specializes in robotics and other fields of engineering and invents various aircraft, robots and vehicles, imprisoning animals inside of working robotic shells and experimenting with types of mutations. He aims to capture the
Chaos Emeralds. • Doctor N. Gin (
Crash Bandicoot) - A masochistic scientist who assists Neo Cortex. •
GLaDOS/Caroline (
Portal) - The main antagonist of the
Portal franchise. She was Cave Johnson's assistant before taking over the facility. •
Professor Hojo (
Final Fantasy VII) - The head of Shinra's science department. He is a sociopathic, amoral bioengineer whose experiments drive the game's plot forward, having a role in the backstories of
Cloud Strife,
Zack Fair,
Vincent Valentine, and
Sephiroth. • Alexandria Hypatia (
Dishonored 2) - The chief alchemist at the Addermire Institute who gains a separate serial killer personality after an experiment goes wrong. • Elijah Kamski (
Detroit: Become Human) • Professor Von Kriplespac (''
Conker's Bad Fur Day'') • Dr. M (
Sly Cooper) - A
mandrill who was the brains of Sly's father's gang. Feeling that he was being held back, he set up a fortress on Kaine Island to break into the Cooper Vault and claim the wealth for himself. •
The Medic (
Team Fortress 2) - One of nine playable classes, who rejects the
Hippocratic Oath. He is able to heal other characters and temporarily make them invincible using his Medigun. He previously had a medical licence, but lost it due to misplacing a patient's skeleton. •
Dr. Nefarious (
Ratchet & Clank) - A recurring adversary to
Ratchet and Clank and
Captain Qwark. • Rintarō Okabe / Kyōma Hōōin (
Steins;Gate) - A self-proclaimed mad scientist in his Kyōma Hōōin persona, taken from a television show he watched as a child. • General Wilhelm "Deathshead" Strasse (
Wolfenstein) - The major antagonist of the series, who leads the Nazis' research projects. • Agnes Tachyon (
Umamusume: Pretty Derby) - An eccentric scientist based on the
real-life racehorse of the same name obsessed with experimentation and research to enhance the capabilities of Umamusume. She is the co-protagonist of the film
Umamusume: Pretty Derby – Beginning of a New Era. •
Vexen (
Kingdom Hearts) - A founding member of
Organization XIII and the head of the Replica Program, which creates artificial humanoids that serve as vessels for hearts. • Viktor (
League of Legends) - A scientist who replaced his body with a machine and wants to enhance the human race. •
Dr. Wily (
Mega Man) - The primary antagonist of the original
Mega Man series. • Yuri (
Red Alert 2) - A Soviet psychic and founder of the Psychic Corps. During
World War II, he took part in
Joseph Stalin's secret project, whose aim was to create mind-control technology, and an army which specialized in psychic warfare. ==Other==